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公开(公告)号：US11324765B2
公开(公告)日：2022-05-10
申请号：US17333614
申请日：2021-05-28
申请人： Children's Hospital Medical Center , The General Hospital Corporation , Instituto Nacional de Ciencias Medicas Y Nutricion
IPC分类号： A61K31/7016 , A61K47/62 , A23L33/00 , A61K31/702 , A61K35/20 , A61K47/50 , A61K47/61
摘要： A method of inhibiting inflammation with milk oligosaccharides or glycoconjugates containing the oligosaccharides.
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2.发明授权Use of secretor, lewis and sialyl antigen levels in clinical samples as predictors of risk for disease 有权在临床样本中使用分泌器，路易威and和唾液酸抗原水平作为疾病风险的预测因子公开(公告)号：US09132143B2
公开(公告)日：2015-09-15
申请号：US14493637
申请日：2014-09-23
申请人： Children's Hospital Medical Center , The General Hospital Corporation , Instituto Nacional de Ciencias Medicas Y Nutricion
IPC分类号： A61K45/06 , A61K31/7028 , G01N33/68 , G01N33/80 , A61K31/702 , A61K31/715 , A61K35/741 , A61K35/745 , A61K35/747 , A61K36/06 , A61K38/02
CPC分类号： A61K31/7028 , A61K31/702 , A61K31/715 , A61K35/741 , A61K35/745 , A61K35/747 , A61K36/06 , A61K38/02 , A61K45/06 , G01N33/6893 , G01N33/80 , G01N2800/067 , Y02A50/471 , Y02A50/473 , Y02A50/491 , Y02A50/52
摘要： An individual at risk for necrotizing enterocolitis and related disorders can be identified by measuring the level of at least one secretor antigen in a biological sample from the individual and comparing the measured level of the at least one secretor antigen to a predetermined value or a predetermined range of values. Among the secretor antigens which can be measured are: the H-1, H-2, Lewisb and Lewisy antigens and derivatives thereof (e.g., a sialylated form of Lewis a, Lewis x, Lewis b, Lewis y; H-1, H-2, Lewis a, Lewis x, Lewis b or Lewis y).
摘要翻译： 可以通过测量来自个体的生物样品中的至少一种分泌型抗原的水平来鉴定坏死性小肠结肠炎和相关疾病风险的个体，并将所测量的至少一种分泌型抗原的水平与预定值或预定范围进行比较 的价值观。 可以测量的分泌抗原是：H-1，H-2，Lewisb和Lewisy抗原及其衍生物（例如，路易斯a的唾液酸化形式，路易斯x，路易斯b，路易斯y; H-1，H -2，Lewis a，Lewis x，Lewis b或Lewis y）。
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3.发明申请USE OF SECRETOR, LEWIS AND SIALYL ANTIGEN LEVELS IN CLINICAL SAMPLES AS PREDICTORS OF RISK FOR DISEASE 有权临床样本中的秘密，LEWIS和SIALYL抗原水平的使用作为疾病风险的预测因素公开(公告)号：US20150079055A1
公开(公告)日：2015-03-19
申请号：US14493637
申请日：2014-09-23
申请人： Children's Hospital Medical Center , The General Hospital Corporation , Instituto Nacional de Ciencias Medicas Y Nutricion
IPC分类号： A61K31/7028 , A61K38/02 , A61K45/06 , A61K31/702
CPC分类号： A61K31/7028 , A61K31/702 , A61K31/715 , A61K35/741 , A61K35/745 , A61K35/747 , A61K36/06 , A61K38/02 , A61K45/06 , G01N33/6893 , G01N33/80 , G01N2800/067 , Y02A50/471 , Y02A50/473 , Y02A50/491 , Y02A50/52
摘要： An individual at risk for necrotizing enterocolitis and related disorders can be identified by measuring the level of at least one secretor antigen in a biological sample from the individual and comparing the measured level of the at least one secretor antigen to a predetermined value or a predetermined range of values. Among the secretor antigens which can be measured are: the H-1, H-2, Lewisb and Lewisy antigens and derivatives thereof (e.g., a sialylated form of Lewis a, Lewis x, Lewis b, Lewis y; H-1, H-2, Lewis a, Lewis x, Lewis b or Lewis y).
摘要翻译： 可以通过测量来自个体的生物样品中的至少一种分泌型抗原的水平来鉴定坏死性小肠结肠炎和相关疾病风险的个体，并将所测量的至少一种分泌型抗原的水平与预定值或预定范围进行比较 的价值观。 可以测量的分泌抗原是：H-1，H-2，Lewisb和Lewisy抗原及其衍生物（例如，路易斯a的唾液酸化形式，路易斯x，路易斯b，路易斯y; H-1，H -2，Lewis a，Lewis x，Lewis b或Lewis y）。
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公开(公告)号：US10098903B2
公开(公告)日：2018-10-16
申请号：US14700232
申请日：2015-04-30
申请人： Children's Hospital Medical Center , The General Hospital Corporation , Instituto Nacional de Ciencias Medicas Y Nutricion
IPC分类号： A61K31/7016 , A61K31/702 , A61K47/62 , A61K35/20 , A61K47/50 , A61K47/61
摘要： A method of inhibiting inflammation with milk oligosaccharides or glycoconjugates containing the oligosaccharides.
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5.发明申请Use of Secretor, Lewis and Sialyl Antigen Levels in Clinical Samples as Predictors of Risk for Disease 有权在临床样本中使用分泌者，Lewis和唾液酸抗原水平作为疾病风险的预测因子公开(公告)号：US20140140970A1
公开(公告)日：2014-05-22
申请号：US14044328
申请日：2013-10-02
IPC分类号： A61K31/715 , A61K36/06 , A61K31/702 , A61K35/74
CPC分类号： A61K31/7028 , A61K31/702 , A61K31/715 , A61K35/741 , A61K35/745 , A61K35/747 , A61K36/06 , A61K38/02 , A61K45/06 , G01N33/6893 , G01N33/80 , G01N2800/067 , Y02A50/471 , Y02A50/473 , Y02A50/491 , Y02A50/52
摘要： An individual at risk for necrotizing enterocolitis and related disorders can be identified by measuring the level of at least one secretor antigen in a biological sample from the individual and comparing the measured level of the at least one secretor antigen to a predetermined value or a predetermined range of values. Among the secretor antigens which can be measured are: the H-1, H-2, Lewisb and Lewisy antigens and derivatives thereof (e.g., a sialylated form of Lewis a, Lewis x, Lewis b, Lewis y; H-1, H-2, Lewis a, Lewis x, Lewis b or Lewis y).
摘要翻译： 可以通过测量来自个体的生物样品中的至少一种分泌型抗原的水平来鉴定坏死性小肠结肠炎和相关疾病风险的个体，并将所测量的至少一种分泌型抗原的水平与预定值或预定范围进行比较 的价值观。 可以测量的分泌抗原是：H-1，H-2，Lewisb和Lewisy抗原及其衍生物（例如，路易斯a的唾液酸化形式，Lewis x，Lewis b，Lewis y; H-1，H -2，Lewis a，Lewis x，Lewis b或Lewis y）。
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公开(公告)号：US20230101412A1
公开(公告)日：2023-03-30
申请号：US17736468
申请日：2022-05-04
申请人： Children's Hospital Medical Center , The General Hospital Corporation d/b/a Massachusetts General Hospital , Instituto Nacional de Ciencias Medicas Y Nutricion
IPC分类号： A61K31/7016 , A61K47/62 , A23L33/00 , A61K31/702
摘要： A method of inhibiting inflammation with milk oligosaccharides or glycoconjugates containing the oligosaccharides.
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公开(公告)号：US20210283155A1
公开(公告)日：2021-09-16
申请号：US17333614
申请日：2021-05-28
申请人： Children's Hospital Medical Center , The General Hospital Corporation d/b/a Massachusetts General Hospital , Instituto Nacional de Ciencias Medicas Y Nutricion
IPC分类号： A61K31/7016 , A61K47/62 , A23L33/00 , A61K31/702
摘要： A method of inhibiting inflammation with milk oligosaccharides or glycoconjugates containing the oligosaccharides.
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公开(公告)号：US11058697B2
公开(公告)日：2021-07-13
申请号：US15998799
申请日：2018-08-16
申请人： Children's Hospital Medical Center , The General Hospital Corporation , Instituto Nacional de Ciencias Medicas Y Nutricion
IPC分类号： A61K31/7016 , A23L33/00 , A61K31/702 , A61K47/62 , A61K35/20 , A61K47/50 , A61K47/61
摘要： A method of inhibiting inflammation with milk oligosaccharides or glycoconjugates containing the oligosaccharides.
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公开(公告)号：US20190099435A1
公开(公告)日：2019-04-04
申请号：US15998799
申请日：2018-08-16
申请人： Children's Hospital Medical Center , The General Hospital Corporation d/b/a Massachusetts General Hospital , Instituto Nacional de Ciencias Medicas Y Nutricion
IPC分类号： A61K31/7016 , A61K47/62 , A61K31/702 , A61K47/61 , A61K47/50 , A61K35/20
摘要： A method of inhibiting inflammation with milk oligosaccharides or glycoconjugates containing the oligosaccharides.
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公开(公告)号：US20150306120A1
公开(公告)日：2015-10-29
申请号：US14700232
申请日：2015-04-30
申请人： Children's Hospital Medical Center , The General Hospital Corporation , Instituto Nacional de Ciencias Medicas Y Nutricion
IPC分类号： A61K31/7016
CPC分类号： A61K31/7016 , A61K31/702 , A61K35/20 , A61K47/50 , A61K47/61 , A61K47/62
摘要： A method of inhibiting inflammation with milk oligosaccharides or glycoconjugates containing the oligosaccharides.
摘要翻译： 用含有寡糖的乳寡糖或糖缀合物抑制炎症的方法。
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