专利检索 ap:"Instituto Nacional de Ciencias Medicas Y Nutricion" 第 1 页

1.

发明授权
Inhibiting inflammation with milk oligosaccharides 有权

公开(公告)号：US11324765B2

公开(公告)日：2022-05-10

申请号：US17333614

申请日：2021-05-28

申请人： Children's Hospital Medical Center , The General Hospital Corporation , Instituto Nacional de Ciencias Medicas Y Nutricion

发明人： Ardythe L. Morrow , David S. Newburg , Guillermo M. Ruiz-Palacios

IPC分类号： A61K31/7016 , A61K47/62 , A23L33/00 , A61K31/702 , A61K35/20 , A61K47/50 , A61K47/61

摘要： A method of inhibiting inflammation with milk oligosaccharides or glycoconjugates containing the oligosaccharides.

2.

发明申请
INHIBITING INFLAMMATION WITH MILK OLIGOSACCHARIDES 审中-公开
标题翻译：抑制与乳汁低密度脂蛋白的炎症反应

公开(公告)号：US20150306120A1

公开(公告)日：2015-10-29

申请号：US14700232

申请日：2015-04-30

申请人： Children's Hospital Medical Center , The General Hospital Corporation , Instituto Nacional de Ciencias Medicas Y Nutricion

发明人： Ardythe L. Morrow , David S. Newburg , Guillermo M. Ruiz-Palacios

IPC分类号： A61K31/7016

CPC分类号： A61K31/7016 , A61K31/702 , A61K35/20 , A61K47/50 , A61K47/61 , A61K47/62

摘要： A method of inhibiting inflammation with milk oligosaccharides or glycoconjugates containing the oligosaccharides.

摘要翻译： 用含有寡糖的乳寡糖或糖缀合物抑制炎症的方法。

3.

发明申请
SCORPION VENOM BENZOQUINONE DERIVATIVES AND USES THEREOF 有权

公开(公告)号：US20210214303A1

公开(公告)日：2021-07-15

申请号：US17058962

申请日：2019-05-20

申请人： The Board of Trustees of the Leland Stanford Junior University , UNIVERSIDAD NACIONAL AUTONOMA DE MEXICO , INSTITUTO NACIONAL DE CIENCIAS MEDICAS Y NUTRICION SALVADOR ZUBIRAN

发明人： Richard Neil ZARE , Jose Ignacio VEYTIA-BUCHELI , Edson Norberto Carcamo NORIEGA , Gnanamani ELUMALAI , Shyam SATHYAMOORTHI , Lourival Domingos POSSANI POSTAY , Shibdas BANERJEE , Rogelio Enrique HERNANDEZ PANDO

IPC分类号： C07C323/22 , C07C319/20 , A61P35/02 , A61P31/04

摘要： Provided are colored 1,4-benzoquinone compounds obtained by oxidation of precursor molecules from the venom of the scorpion Diplocentrus melici (Diplocentridae family). Schemes for the chemical synthesis of these compounds using reagents commercially available are also provided. Biological assays show that the red compound (3,5-dimethoxy-2-(methylthio)cyclohexa-2,5-diene-1,4-dione) is very effective at killing Staphylococcus aureus and that the blue compound (5-methoxy-2,3-bis(methylthio)cyclohexa-2,5-diene-1,4-dione) has remarkable activity against Mycobacterium tuberculosis. The blue compound is effective against multi-drug-resistant tuberculosis (MDR-TB) and is not detrimental to lung epithelium. Both compounds were found to be cytotoxic to human neoplastic cell lines and to mononuclear cells (PBMCs).

4.

发明授权
Inhibiting inflammation with milk oligosaccharides 有权

公开(公告)号：US10098903B2

公开(公告)日：2018-10-16

申请号：US14700232

申请日：2015-04-30

申请人： Children's Hospital Medical Center , The General Hospital Corporation , Instituto Nacional de Ciencias Medicas Y Nutricion

发明人： Ardythe L. Morrow , David S. Newburg , Guillermo M. Ruiz-Palacios

IPC分类号： A61K31/7016 , A61K31/702 , A61K47/62 , A61K35/20 , A61K47/50 , A61K47/61

摘要： A method of inhibiting inflammation with milk oligosaccharides or glycoconjugates containing the oligosaccharides.

5.

发明公开
PYRIDOSTIGMINE FOR USE IN THE TREATMENT OF COVID-19 审中-公开

公开(公告)号：US20240180884A1

公开(公告)日：2024-06-06

申请号：US18286970

申请日：2021-04-13

申请人： INSTITUTO NACIONAL DE CIENCIAS MEDICAS Y NUTRICION SALVADOR ZUBIRAN

发明人： Sergio Ivan VALDES FERRER

IPC分类号： A61K31/4425 , A61P31/14

CPC分类号： A61K31/4425 , A61P31/14

摘要： The present invention relates to the use of pyridostigmine or a pharmaceutically acceptable salt thereof for the treatment of COVID-19.

6.

发明授权
Use of secretor, lewis and sialyl antigen levels in clinical samples as predictors of risk for disease 有权
标题翻译：在临床样本中使用分泌器，路易威and和唾液酸抗原水平作为疾病风险的预测因子

公开(公告)号：US09132143B2

公开(公告)日：2015-09-15

申请号：US14493637

申请日：2014-09-23

申请人： Children's Hospital Medical Center , The General Hospital Corporation , Instituto Nacional de Ciencias Medicas Y Nutricion

发明人： Ardythe L. Morrow , David S. Newburg , Guillermo M. Ruiz-Palacios

IPC分类号： A61K45/06 , A61K31/7028 , G01N33/68 , G01N33/80 , A61K31/702 , A61K31/715 , A61K35/741 , A61K35/745 , A61K35/747 , A61K36/06 , A61K38/02

CPC分类号： A61K31/7028 , A61K31/702 , A61K31/715 , A61K35/741 , A61K35/745 , A61K35/747 , A61K36/06 , A61K38/02 , A61K45/06 , G01N33/6893 , G01N33/80 , G01N2800/067 , Y02A50/471 , Y02A50/473 , Y02A50/491 , Y02A50/52

摘要： An individual at risk for necrotizing enterocolitis and related disorders can be identified by measuring the level of at least one secretor antigen in a biological sample from the individual and comparing the measured level of the at least one secretor antigen to a predetermined value or a predetermined range of values. Among the secretor antigens which can be measured are: the H-1, H-2, Lewisb and Lewisy antigens and derivatives thereof (e.g., a sialylated form of Lewis a, Lewis x, Lewis b, Lewis y; H-1, H-2, Lewis a, Lewis x, Lewis b or Lewis y).

摘要翻译： 可以通过测量来自个体的生物样品中的至少一种分泌型抗原的水平来鉴定坏死性小肠结肠炎和相关疾病风险的个体，并将所测量的至少一种分泌型抗原的水平与预定值或预定范围进行比较的价值观。可以测量的分泌抗原是：H-1，H-2，Lewisb和Lewisy抗原及其衍生物（例如，路易斯a的唾液酸化形式，路易斯x，路易斯b，路易斯y; H-1，H -2，Lewis a，Lewis x，Lewis b或Lewis y）。

7.

发明申请
USE OF SECRETOR, LEWIS AND SIALYL ANTIGEN LEVELS IN CLINICAL SAMPLES AS PREDICTORS OF RISK FOR DISEASE 有权
标题翻译：临床样本中的秘密，LEWIS和SIALYL抗原水平的使用作为疾病风险的预测因素

公开(公告)号：US20150079055A1

公开(公告)日：2015-03-19

申请号：US14493637

申请日：2014-09-23

申请人： Children's Hospital Medical Center , The General Hospital Corporation , Instituto Nacional de Ciencias Medicas Y Nutricion

发明人： Ardythe L. Morrow , David S. Newburg , Guillermo M. Ruiz-Palacios

IPC分类号： A61K31/7028 , A61K38/02 , A61K45/06 , A61K31/702

CPC分类号： A61K31/7028 , A61K31/702 , A61K31/715 , A61K35/741 , A61K35/745 , A61K35/747 , A61K36/06 , A61K38/02 , A61K45/06 , G01N33/6893 , G01N33/80 , G01N2800/067 , Y02A50/471 , Y02A50/473 , Y02A50/491 , Y02A50/52

摘要： An individual at risk for necrotizing enterocolitis and related disorders can be identified by measuring the level of at least one secretor antigen in a biological sample from the individual and comparing the measured level of the at least one secretor antigen to a predetermined value or a predetermined range of values. Among the secretor antigens which can be measured are: the H-1, H-2, Lewisb and Lewisy antigens and derivatives thereof (e.g., a sialylated form of Lewis a, Lewis x, Lewis b, Lewis y; H-1, H-2, Lewis a, Lewis x, Lewis b or Lewis y).

摘要翻译： 可以通过测量来自个体的生物样品中的至少一种分泌型抗原的水平来鉴定坏死性小肠结肠炎和相关疾病风险的个体，并将所测量的至少一种分泌型抗原的水平与预定值或预定范围进行比较的价值观。可以测量的分泌抗原是：H-1，H-2，Lewisb和Lewisy抗原及其衍生物（例如，路易斯a的唾液酸化形式，路易斯x，路易斯b，路易斯y; H-1，H -2，Lewis a，Lewis x，Lewis b或Lewis y）。