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公开(公告)号：US10948401B2
公开(公告)日：2021-03-16
申请号：US16079995
申请日：2017-02-24
IPC分类号： G01N21/07 , B04B15/00 , G01N33/557 , B82Y15/00 , G01N33/53 , C12Q1/68 , C12Q1/6816 , G01N33/543 , G01N15/14 , G01N15/00 , G01N15/10 , B04B13/00 , B04B15/02
摘要： An apparatus for measuring a characteristic of a sample using a centrifuge and optical components is disclosed. The centrifuge may be a standard benchtop centrifuge. The optical components may be sized and dimensioned to fit, along with the sample, inside the centrifuge.
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公开(公告)号：US20180291434A1
公开(公告)日：2018-10-11
申请号：US15888941
申请日：2018-02-05
IPC分类号： C12Q1/6816 , G01N33/53 , C12Q1/6813 , C12Q1/6804
摘要： The invention provides compositions comprising nucleic acid complexes for use in monitoring binding interactions and in measuring association and/or dissociation kinetics with or without force, detecting analytes, screening aptamers, and encoding/encrypting information. In some instances, the nucleic acid complexes are double- stranded nicked nucleic acids comprising a scaffold nucleic acid hybridized to one or more oligonucleotides. In some instances, a first and/or a second oligonucleotide are linked to moieties that are known to interact with each other or which are suspected of interacting with each other.
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公开(公告)号：US20170369935A1
公开(公告)日：2017-12-28
申请号：US15533473
申请日：2015-11-16
IPC分类号： C12Q1/68 , C12P19/34 , G01N27/447
CPC分类号： C12Q1/6818 , C12P19/34 , C12Q2563/131 , C12Q2565/125 , G01N27/447 , C12Q2565/133
摘要： The invention provides compositions comprising nucleic acid complexes for use in monitoring binding interactions and in measuring association and/or dissociation kinetics, detecting analytes including low concentration analytes, and screening library members. In some instances, the nucleic acid complexes are double-stranded nicked nucleic acids comprising a scaffold nucleic acid hybridized to one or more oligonucleotides. In some instances, a first, a second, a third, and optionally a fourth oligonucleotide are linked to moieties that are known to interact with each other or which are suspected of interacting with each other or of interacting with a common moiety such as an analyte. Changes in topology of the complex are used to determine the binding interactions of the various binding partners.
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公开(公告)号：US11198900B2
公开(公告)日：2021-12-14
申请号：US15533473
申请日：2015-11-16
IPC分类号： C12Q1/68 , C12Q1/6818 , C12P19/34 , G01N27/447
摘要： The invention provides compositions comprising nucleic acid complexes for use in monitoring binding interactions and in measuring association and/or dissociation kinetics, detecting analytes including low concentration analytes, and screening library members. In some instances, the nucleic acid complexes are double-stranded nicked nucleic acids comprising a scaffold nucleic acid hybridized to one or more oligonucleotides. In some instances, a first, a second, a third, and optionally a fourth oligonucleotide are linked to moieties that are known to interact with each other or which are suspected of interacting with each other or of interacting with a common moiety such as an analyte. Changes in topology of the complex are used to determine the binding interactions of the various binding partners.
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公开(公告)号：US20190064056A1
公开(公告)日：2019-02-28
申请号：US16079995
申请日：2017-02-24
IPC分类号： G01N21/07 , G01N33/557
摘要： An apparatus for measuring a characteristic of a sample using a centrifuge and optical components is disclosed. The centrifuge may be a standard benchtop centrifuge. The optical components may be sized and dimensioned to fit, along with the sample, inside the centrifuge.
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公开(公告)号：US20180223344A1
公开(公告)日：2018-08-09
申请号：US15738982
申请日：2016-06-27
申请人： Children's Medical Center Corporation , The Research Foundation for The State University of New York , President and Fellows of Harvard College
发明人： Arun Richard Chandrasekaran , Clinton H. Hansen , Mounir Ahmad Koussa , Kenneth Anders Halvorsen , Wesley Philip Wong
IPC分类号： C12Q1/6816 , C12Q1/6839 , G01N27/447 , G01N30/86
CPC分类号： C12Q1/6816 , C12Q1/6818 , C12Q1/6839 , G01N27/447 , G01N30/8675 , G01N2030/027 , C12Q2565/107 , C12Q2565/301
摘要： Provided herein are nucleic acid-based nanoswitches that can detect specific nucleic acids and other analytes types by for example a simple gel electrophoresis readout. Binding of the target to the nanoswitches induces a conformation change from a linear, open conformation to a looped, closed conformation. These nanoswitches may be used in diagnostic assays such as nucleic acid-based diagnostic assays, to detect, measure and/or purify a variety of targets including low abundance targets.
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公开(公告)号：US20140255939A1
公开(公告)日：2014-09-11
申请号：US14356282
申请日：2012-11-05
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6816 , C12Q1/6804 , C12Q1/6813 , G01N33/5308 , C12Q2525/313 , C12Q2563/107 , C12Q2565/601
摘要： The invention provides compositions comprising nucleic acid complexes for use in monitoring binding interactions and in measuring association and/or dissociation kinetics with or without force, detecting analytes, screening aptamers, and encoding/encrypting information. In some instances, the nucleic acid complexes are double-stranded nicked nucleic acids comprising a scaffold nucleic acid hybridized to one or more oligonucleotides. In some instances, a first and/or a second oligonucleotide are linked to moieties that are known to interact with each other or which are suspected of interacting with each other.
摘要翻译： 本发明提供了包含核酸复合物的组合物，其用于监测结合相互作用并且在测量或不用力测量缔合和/或解离动力学时，检测分析物，筛选适体以及编码/加密信息。 在一些情况下，核酸复合物是包含与一个或多个寡核苷酸杂交的支架核酸的双链切口核酸。 在一些情况下，第一和/或第二寡核苷酸连接到已知相互作用或被怀疑彼此相互作用的部分。
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公开(公告)号：US11913872B2
公开(公告)日：2024-02-27
申请号：US17167847
申请日：2021-02-04
IPC分类号： G01N21/07 , G01N33/53 , C12Q1/68 , C12Q1/6816 , G01N33/543 , G01N15/14 , G01N33/557 , G01N15/00 , G01N15/10 , B82Y15/00 , B04B13/00 , B04B15/02
CPC分类号： G01N21/07 , B82Y15/00 , C12Q1/68 , C12Q1/6816 , G01N15/1434 , G01N33/53 , G01N33/543 , G01N33/557 , B04B13/00 , B04B15/02 , G01N2015/0038 , G01N2015/0065 , G01N2015/1006 , G01N2201/021 , G01N2201/0423 , G01N2201/0693 , G01N2203/0089 , C12Q1/68 , C12Q2523/303 , C12Q2525/30
摘要： An apparatus for measuring a characteristic of a sample using a centrifuge and optical components is disclosed. The centrifuge may be a standard benchtop centrifuge. The optical components may be sized and dimensioned to fit, along with the sample, inside the centrifuge.
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公开(公告)号：US20210239602A1
公开(公告)日：2021-08-05
申请号：US17167847
申请日：2021-02-04
IPC分类号： G01N21/07 , B82Y15/00 , G01N33/53 , C12Q1/68 , C12Q1/6816 , G01N33/543 , G01N15/14 , G01N33/557
摘要： An apparatus for measuring a characteristic of a sample using a centrifuge and optical components is disclosed. The centrifuge may be a standard benchtop centrifuge. The optical components may be sized and dimensioned to fit, along with the sample, inside the centrifuge.
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公开(公告)号：US09914958B2
公开(公告)日：2018-03-13
申请号：US14356282
申请日：2012-11-05
CPC分类号： C12Q1/6816 , C12Q1/6804 , C12Q1/6813 , G01N33/5308 , C12Q2525/313 , C12Q2563/107 , C12Q2565/601
摘要： The invention provides compositions comprising nucleic acid complexes for use in monitoring binding interactions and in measuring association and/or dissociation kinetics with or without force, detecting analytes, screening aptamers, and encoding/encrypting information. In some instances, the nucleic acid complexes are double-stranded nicked nucleic acids comprising a scaffold nucleic acid hybridized to one or more oligonucleotides. In some instances, a first and/or a second oligonucleotide are linked to moieties that are known to interact with each other or which are suspected of interacting with each other.
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