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1.发明申请公开(公告)号：US20130295091A1
公开(公告)日：2013-11-07
申请号：US13978995
申请日：2012-01-10
IPC分类号： A61K39/395
CPC分类号： A61K39/39558 , A61K39/39541 , A61K2039/505 , C07K16/2875 , C07K16/2878 , C07K16/30 , C07K2317/565
摘要： The present invention relates to a combination therapy including tumor associated antigen binding antibodies.
摘要翻译： 本发明涉及包括肿瘤相关抗原结合抗体的组合疗法。
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公开(公告)号：US20140186363A1
公开(公告)日：2014-07-03
申请号：US14123584
申请日：2012-05-23
IPC分类号： C07K16/18
CPC分类号： C07K16/18 , C07K16/30 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/92
摘要： The present invention relates to MAGEA3 binding antibodies.
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公开(公告)号：US20140093514A1
公开(公告)日：2014-04-03
申请号：US14123593
申请日：2012-05-23
IPC分类号： C07K16/18
CPC分类号： C07K16/18 , C07K16/30 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/92
摘要： The present invention relates to MAGEA3 binding antibodies.
摘要翻译： 本发明涉及MAGEA3结合抗体。
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公开(公告)号：US09249230B2
公开(公告)日：2016-02-02
申请号：US12365784
申请日：2009-02-04
申请人： Mike Rothe , Martin Treder , Eric Borges , Susanne Hartmann , Larry L. Green
发明人： Mike Rothe , Martin Treder , Eric Borges , Susanne Hartmann , Larry L. Green
IPC分类号： A61K39/395 , C07K16/28 , C07K16/32 , G01N33/574 , A61K39/00
CPC分类号： C07K16/32 , A61K2039/505 , A61K2039/507 , C07K16/2863 , C07K2317/14 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/73 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C12N15/00 , C12N15/09 , C12N15/63 , C12N2800/00 , G01N33/574
摘要： The present invention relates to binding proteins that bind to HER-3 and polynucleotides encoding the same. Expression vectors and host cells comprising the same for the production of the binding protein of the invention are also provided. In addition, the invention provides compositions and methods for diagnosing and treating diseases associated with HER-3 mediated signal transduction and/or its ligand heregulin.
摘要翻译： 本发明涉及结合HER-3的结合蛋白和编码其的多核苷酸。 还提供了包含其用于产生本发明的结合蛋白的表达载体和宿主细胞。 此外，本发明提供用于诊断和治疗与HER-3介导的信号转导相关的疾病和/或其配体调节蛋白的组合物和方法。
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公开(公告)号：US20120058122A1
公开(公告)日：2012-03-08
申请号：US12761370
申请日：2010-04-15
申请人： Mike Rothe , Martin Treder , Susanne Hartmann , Daniel J. Freeman , Robert Radinsky , Eric Borges , Larry L. Green
发明人： Mike Rothe , Martin Treder , Susanne Hartmann , Daniel J. Freeman , Robert Radinsky , Eric Borges , Larry L. Green
IPC分类号： A61K39/395 , A61P35/00
CPC分类号： C07K16/32 , A61K2039/505 , A61K2039/507 , C07K16/2863 , C07K2317/14 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/73 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C12N15/00 , C12N15/09 , C12N15/63 , C12N2800/00 , G01N33/574
摘要： The present invention relates to binding proteins that bind to HER-3 and polynucleotides encoding the same. Expression vectors and host cells comprising the same for the production of the binding protein of the invention are also provided. In addition, the invention provides compositions and methods for diagnosing and treating diseases associated with HER-3 mediated signal transduction and/or its ligand heregulin.
摘要翻译： 本发明涉及结合HER-3的结合蛋白和编码其的多核苷酸。 还提供了包含其用于产生本发明的结合蛋白的表达载体和宿主细胞。 此外，本发明提供用于诊断和治疗与HER-3介导的信号转导相关的疾病和/或其配体调节蛋白的组合物和方法。
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公开(公告)号：US20080124345A1
公开(公告)日：2008-05-29
申请号：US11649722
申请日：2007-01-03
IPC分类号： A61K39/395 , A61P37/00 , C07H21/04 , C07K16/00 , C12N1/34 , C12N15/00 , C12N5/02 , C12N5/04 , G01N33/53
CPC分类号： C07K16/32 , A61K2039/505 , A61K2039/507 , C07K16/2863 , C07K2317/14 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/73 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C12N15/00 , C12N15/09 , C12N15/63 , C12N2800/00 , G01N33/574
摘要： The present invention relates to binding proteins that bind to HER-3 and polynucleotides encoding the same. Expression vectors and host cells comprising the same for the production of the binding protein of the invention are also provided. In addition, the invention provides compositions and methods for diagnosing and treating diseases associated with HER-3 mediated signal transduction and/or its ligand heregulin.
摘要翻译： 本发明涉及结合HER-3的结合蛋白和编码其的多核苷酸。 还提供了包含其用于产生本发明的结合蛋白的表达载体和宿主细胞。 此外，本发明提供用于诊断和治疗与HER-3介导的信号转导相关的疾病和/或其配体调节蛋白的组合物和方法。
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公开(公告)号：US08771695B2
公开(公告)日：2014-07-08
申请号：US12761370
申请日：2010-04-15
申请人： Mike Rothe , Martin Treder , Susanne Hartmann , Daniel J. Freeman , Robert Radinsky , Eric Borges
发明人： Mike Rothe , Martin Treder , Susanne Hartmann , Daniel J. Freeman , Robert Radinsky , Eric Borges
IPC分类号： A61K39/395
CPC分类号： C07K16/32 , A61K2039/505 , A61K2039/507 , C07K16/2863 , C07K2317/14 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/73 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C12N15/00 , C12N15/09 , C12N15/63 , C12N2800/00 , G01N33/574
摘要： The present invention relates to binding proteins that bind to HER-3 and polynucleotides encoding the same. Expression vectors and host cells comprising the same for the production of the binding protein of the invention are also provided. In addition, the invention provides compositions and methods for diagnosing and treating diseases associated with HER-3 mediated signal transduction and/or its ligand heregulin.
摘要翻译： 本发明涉及结合HER-3的结合蛋白和编码其的多核苷酸。 还提供了包含其用于产生本发明的结合蛋白的表达载体和宿主细胞。 此外，本发明提供用于诊断和治疗与HER-3介导的信号转导相关的疾病和/或其配体调节蛋白的组合物和方法。
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公开(公告)号：US20100183631A1
公开(公告)日：2010-07-22
申请号：US12365784
申请日：2009-02-04
IPC分类号： A61K39/395 , C07K16/30 , A61P35/00
CPC分类号： C07K16/32 , A61K2039/505 , A61K2039/507 , C07K16/2863 , C07K2317/14 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/73 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C12N15/00 , C12N15/09 , C12N15/63 , C12N2800/00 , G01N33/574
摘要： The present invention relates to binding proteins that bind to HER-3 and polynucleotides encoding the same. Expression vectors and host cells comprising the same for the production of the binding protein of the invention are also provided. In addition, the invention provides compositions and methods for diagnosing and treating diseases associated with HER-3 mediated signal transduction and/or its ligand heregulin.
摘要翻译： 本发明涉及结合HER-3的结合蛋白和编码其的多核苷酸。 还提供了包含其用于产生本发明的结合蛋白的表达载体和宿主细胞。 此外，本发明提供用于诊断和治疗与HER-3介导的信号转导相关的疾病和/或其配体调节蛋白的组合物和方法。
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公开(公告)号：US07705130B2
公开(公告)日：2010-04-27
申请号：US11649722
申请日：2007-01-03
申请人： Mike Rothe , Martin Treder , Susanne Hartmann , Eric Borges , Larry L. Green
发明人： Mike Rothe , Martin Treder , Susanne Hartmann , Eric Borges , Larry L. Green
IPC分类号： C07K16/00
CPC分类号： C07K16/32 , A61K2039/505 , A61K2039/507 , C07K16/2863 , C07K2317/14 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/73 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C12N15/00 , C12N15/09 , C12N15/63 , C12N2800/00 , G01N33/574
摘要： The present invention relates to binding proteins that bind to HER-3 and polynucleotides encoding the same. Expression vectors and host cells comprising the same for the production of the binding protein of the invention are also provided. In addition, the invention provides compositions and methods for diagnosing and treating diseases associated with HER-3 mediated signal transduction and/or its ligand heregulin.
摘要翻译： 本发明涉及结合HER-3的结合蛋白和编码其的多核苷酸。 还提供了包含其用于产生本发明的结合蛋白的表达载体和宿主细胞。 此外，本发明提供用于诊断和治疗与HER-3介导的信号转导相关的疾病和/或其配体调节蛋白的组合物和方法。
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公开(公告)号：US20100047829A1
公开(公告)日：2010-02-25
申请号：US12516682
申请日：2007-11-28
申请人： Mike Rothe , Martin Treder
发明人： Mike Rothe , Martin Treder
CPC分类号： G01N33/5748 , A61K39/395 , A61K2039/505 , C07K16/2863 , C07K16/32 , C07K2317/76 , G01N33/574 , G01N33/57407 , G01N33/57492 , G01N2333/71 , G01N2333/91205 , G01N2440/14 , G01N2800/205 , G01N2800/52
摘要： The present invention provides methods for the determination of the activation level of Receptor Tyrosine kinases, e.g. phosporylated HER3, for the selection of patients for disease treatment. Methods are also provided for the evaluation of the biological and pharmacodynamic effects of an active substance and/or its efficacy in disease treatment, utilizing a tissue sample from a test subject, for example tumor material or normal tissue such as skin or hair follicle. Further, methods for the treatment of HER receptor-associated diseases are disclosed.
摘要翻译： 本发明提供了用于测定受体酪氨酸激酶活化水平的方法，例如， 磷酸化HER3，用于选择患者进行疾病治疗。 还提供了用于评估活性物质的生物学和药效学效应和/或其在疾病治疗中的功效的方法，利用来自测试对象的组织样品，例如肿瘤材料或正常组织，例如皮肤或毛囊。 此外，公开了治疗HER受体相关疾病的方法。
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