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    Process for preparing phosphonium salts
    3.
    发明授权
    Process for preparing phosphonium salts 失效
    鏻盐的制备方法

    公开(公告)号：US06423873B1

    公开(公告)日：2002-07-23

    申请号：US09791574

    申请日：2001-02-26

    申请人： Christoph Wegner ,  Michael John

    发明人： Christoph Wegner ,  Michael John

    IPC分类号： C07F954

    CPC分类号： C07F9/5428

    摘要： A process for preparing phosphonium salts of the general formula I in which the substituents have the following meanings, independently of one another: R aryl; X anion of an organic or inorganic acid selected from the group consisting of hydrohalic acids, sulfuric acid, sulfonic acids, phosphoric acid and C1-C6-alkanoic acids, by reacting 3,7,11-trimethyldodeca-1,4,6,10-tetraen-3-ol of the formula II with triarylphosphane and organic or inorganic acids selected from the abovementioned group, wherein in a two-stage process a) initially a tertiary phosphonium salt of the formula III  in which the radicals R and X have the abovementioned meanings, is prepared at temperatures in the range from −20 to 40° C., and b) the tertiary phosphonium salt of the formula III which is formed is rearranged to the primary phosphonium salt of the formula I at temperatures in the range from 40 to 100° C.

    摘要翻译： 一种制备通式Iin的鏻盐的方法，其中取代基具有以下含义：R芳基;选自以下的有机或无机酸的X阴离子：氢卤酸，硫酸，磺酸， 磷酸和C 1 -C 6链烷酸，通过使式II的3,7,11-三甲基十二碳-1,4,6,10-四烯-3-醇与三芳基膦和选自上述基团的有机或无机酸反应，其中 在两步法中）最初在-20至40℃的温度范围内制备其中基团R和X具有上述含义的式III的叔鏻盐，和b）叔鏻盐 所形成的式III的化合物在40至100℃的温度下重排成式I的主要鏻盐。

    Thermal isomerization of lycopene
    5.
    发明授权
    Thermal isomerization of lycopene 失效
    番茄红素的热异构化

    公开(公告)号：US07126036B2

    公开(公告)日：2006-10-24

    申请号：US10466477

    申请日：2002-01-24

    申请人： Christoph Wegner ,  Michael John

    发明人： Christoph Wegner ,  Michael John

    IPC分类号： C07C403/00

    CPC分类号： C07C5/22 ,  C07C11/21

    摘要： The present invention relates to a process for the thermal isomerization of a mixture of all-E-lycopene and its Z isomers of any composition to increase the proportion of all-E, wherein the isomerization takes place in a polar solvent in which lycopene is only slightly soluble.

    摘要翻译： 本发明涉及任何组合物的全部番茄红素及其Z异构体的混合物的热异构化的方法，以增加全部E的比例，其中异构化发生在仅番茄红素的极性溶剂中 微溶。

    Methods and systems for semi-automatic adjustment of medical monitoring and treatment
    6.
    发明申请
    Methods and systems for semi-automatic adjustment of medical monitoring and treatment 有权
    半自动调整医疗监护和治疗的方法和系统

    公开(公告)号：US20080071314A1

    公开(公告)日：2008-03-20

    申请号：US11932955

    申请日：2007-10-31

    申请人： Michael John

    发明人： Michael John

    IPC分类号： A61N1/00

    CPC分类号： A61N1/37247 ,  A61B5/00 ,  A61B5/4082 ,  A61B5/4094 ,  A61B5/4809 ,  A61B5/4812 ,  A61B5/4818 ,  A61N1/37258

    摘要： Systems and methods are described for adjusting the operation of implantable stimulation devices used to provide medical monitoring and treatment. Several hierarchical algorithms are described which operate according to conditionally obtaining a patient response to an alert signal. In one such strategy semi-automatic therapy adjustment occurs by automatically issuing patient alert messages when selected operations are to occur, and using a patient's response to the alert message that is provided within a selected time limit in order to contingently adjust therapy. Methods are also described for resolving conflicts which may occur when time information and sensed data information each indicate different patient states are occurring. Although treatment of neural and cardiac disorders is emphasized, the techniques can be applied to the monitoring and treatment of any medical disorder with an implanted device.

    摘要翻译： 描述了用于调整用于提供医疗监测和治疗的可植入刺激装置的操作的系统和方法。 描述了根据有条件地获得对警报信号的患者响应进行操作的几种分级算法。 在一种这样的策略中，半自动治疗调整是通过在选择的操作发生时自动发出病人警报消息，并且使用患者对在所选时限内提供的警报消息的响应来偶然地调整治疗。 还描述了用于解决当时间信息和感测数据信息各自表示不同的患者状态发生时可能发生的冲突的方法。 虽然强调了神经和心脏疾病的治疗，但是该技术可以应用于用植入装置监测和治疗任何医学障碍。

    Modular pallet system
    8.
    发明授权
    Modular pallet system 失效
    模块化托盘系统

    公开(公告)号：US5791261A

    公开(公告)日：1998-08-11

    申请号：US735802

    申请日：1996-10-21

    申请人： Michael John ,  Robert V. Daigle

    发明人： Michael John ,  Robert V. Daigle

    IPC分类号： B65D19/00 ,  B65D19/32

    CPC分类号： B65D19/0018 ,  B65D19/0022 ,  B65D19/0069 ,  B65D19/0075 ,  B65D2519/00034 ,  B65D2519/00069 ,  B65D2519/00104 ,  B65D2519/00288 ,  B65D2519/00308 ,  B65D2519/00318 ,  B65D2519/00333 ,  B65D2519/00373 ,  B65D2519/00557 ,  B65D2519/00567 ,  B65D2519/00572 ,  B65D2519/00756 ,  B65D2519/0083 ,  B65D2519/00835 ,  B65D2519/0084 ,  B65D2519/0094 ,  Y10S108/902

    摘要： A modular pallet system definable in terms of xyz Cartesian coordinates includes a base structure in a lower xy plane having a x- and y-linear axis members internestable with each other at regions of orthogonal intersection to form a rectilinear matrix, each region of intersection of each linear member including an aperture of like geometry to each other aperture. The pallet system further includes a lower snap-lock elements, equal in number to that of the regions of orthogonal intersection, the snap elements proportioned for complemental securement within each of the apertures within each of the regions of orthogonal intersection of the x- and y-axis members with each other, each of the lower snap-lock elements including integrally projecting positive z-axis locking prongs. The system also includes a plurality of z-axis separators, equal in number to that of the regions of intersection within the lower xy plane, each of the separators proportioned, in all xy planes, for enclosure of the z-axis locking prongs of the lower snap-lock elements, the separators further including four integral z-axis sides, and open xy planes at upper and lower faces. The separators operate to define a rigid z-axis dimension of the pallet system.

    摘要翻译： 根据xyz笛卡尔坐标可定义的模块化托盘系统包括在xy平面中的基本结构，其具有在正交交叉的区域处彼此可相互成为直线矩阵的x和y线性轴构件，以形成直线矩阵， 每个线性构件包括彼此相似孔径的孔。 托盘系统还包括与正交交叉区域相同数量的下部卡扣锁定元件，所述卡扣元件成比例地用于在x和y的正交交叉的每个区域内的每个孔内的互补固定 所述下部卡扣锁定元件包括一体地突出的正z轴锁定插脚。 该系统还包括多个z轴分离器，其数量与下xy平面内的交叉区域的数量相等，每个分离器在所有xy平面中均匀分布，用于封闭z轴的锁定插脚 较低的卡锁元件，分离器还包括四个整体的z轴侧面，以及在上表面和下表面处打开xy平面。 分离器用于限定托盘系统的刚性z轴尺寸。

    Steaming device for skin treatment
    10.
    发明授权
    Steaming device for skin treatment 失效
    用于皮肤治疗的蒸汽装置

    公开(公告)号：US5607409A

    公开(公告)日：1997-03-04

    申请号：US543810

    申请日：1995-10-16

    申请人： Michael John

    发明人： Michael John

    IPC分类号： A61F7/00 ,  A61H33/06 ,  A61M35/00

    CPC分类号： A61F7/0085 ,  A61H33/063 ,  A61M35/00

    摘要： A steaming device for skin treatment includes a base, having an upper and lower surface, the base including a reservoir for water and a non-corrodible conductance element which is defined by two side-by-side vertically positioned electrodes which extend a part of the height of the reservoir. The electrodes diverge from each other as they approach the bottom of the bottom of the base to reduce current flow between them, this compensating for increased conductivity due to mineralization of the water near the bottom of the reservoir that occurs with vaporization and which mineralization would otherwise increase voltage between electrodes to a hazardous level. The device further includes a top portion including an upper and a lower area, and a container for therapeutic substances to be mingled with steam produced by the effect of the conductance element on the water. The device also includes an arm having a proximal and distal end, and hollow interior, in which the arm communicates with the top portion at the arm's proximal end and in which the arm includes an expulsory aperture enabling steam to escape at the distal end of the arm.

    摘要翻译： 用于皮肤处理的蒸汽装置包括具有上表面和下表面的基部，底部包括用于水的储存器和不可腐蚀的电导元件，其由两个并排垂直定位的电极限定，所述电极延伸部分 水库高度 当电极接近底部的底部时，电极彼此分开，以减少它们之间的电流，这补偿了由于随着蒸发而发生的储层底部附近的水的矿化，导致的导电性增加，否则会造成矿化 将电极间的电压提高到危险水平。 该装置还包括包括上部和下部区域的顶部部分，以及用于将电导元件作用在水上产生的蒸汽混合的治疗物质的容器。 该装置还包括具有近端和远端以及中空内部的臂，臂在臂的近端处与顶部部分连通，并且其中臂包括排出口，使得蒸汽能够在远端处逸出 臂。