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    Mutations in the mineralocorticoid receptor ligand binding domain polypeptide that permit structural determination of low affinity ligand complexes and screening methods employing same
    1.
    发明申请
    Mutations in the mineralocorticoid receptor ligand binding domain polypeptide that permit structural determination of low affinity ligand complexes and screening methods employing same 审中-公开
    允许结构测定低亲和力配体复合物的盐皮质激素受体配体结合域多肽的突变和使用其的筛选方法

    公开(公告)号：US20070219348A1

    公开(公告)日：2007-09-20

    申请号：US11377502

    申请日：2006-03-16

    申请人： Christopher Apolito ,  Randy Bledsoe ,  Millard Lambert ,  Kevin Madauss ,  Thomas Stanley ,  Eugene Stewart ,  Shawn Williams

    发明人： Christopher Apolito ,  Randy Bledsoe ,  Millard Lambert ,  Kevin Madauss ,  Thomas Stanley ,  Eugene Stewart ,  Shawn Williams

    IPC分类号： C07K14/715 ,  G06F19/00

    CPC分类号： C07K14/721

    摘要： An isolated mineralocorticoid receptor (MR) polypeptide, or functional portion thereof, having one or more mutations that alter the solubility or crystal-forming properties and confer the ability to generate soluble protein complexes with the MR and ligands that only weakly bind the native polypeptide, and a polynucleotide encoding it are disclosed. Representative mutations are C808S and S810L substitutions. Expression of the MR polypeptide in E. coli is also provided. A solved three-dimensional crystal structure of an MR ligand binding domain polypeptide is also disclosed, along with a crystalline form of the MR ligand binding domain polypeptide. Methods of modeling one or more molecular interactions of a native NR with a ligand having low affinity for the native NR utilizing a mutated MR, designing modulators of the biological activity of MR and other nuclear receptor, steroid receptor and glucocorticoid receptor polypeptides and nuclear receptor, steroid receptor and glucocorticoid receptor ligand binding domain polypeptides are also disclosed.

    摘要翻译： 具有一个或多个突变的分离的盐皮质激素受体（MR）多肽或其功能部分，所述突变改变溶解度或结晶形成性质并赋予与MR和仅仅弱结合天然多肽的配体产生可溶性蛋白质复合物的能力， 并公开了编码它的多核苷酸。 代表性突变是C808S和S810L取代。 还提供了MR多肽在大肠杆菌中的表达。 还公开了MR配体结合结构域多肽的解决的三维晶体结构以及MR配体结合结构域多肽的结晶形式。 使用天然NR与天然NR的亲和力低的配体的天然NR的一个或多个分子相互作用建模的方法，设计MR和其他核受体，类固醇受体和糖皮质激素受体多肽和核受体的生物活性的调节剂， 类固醇受体和糖皮质激素受体配体结合域多肽也被公开。

    Heteroatomic regioregular poly(3-substitutedthiophenes) as thin film conductors in diodes whcih are not light emitting or photovoltaic
    2.
    发明申请
    Heteroatomic regioregular poly(3-substitutedthiophenes) as thin film conductors in diodes whcih are not light emitting or photovoltaic 有权
    作为不发光或光电二极管的二极管中的薄膜导体的杂原子区域定向聚（3-取代噻吩）

    公开(公告)号：US20060118901A1

    公开(公告)日：2006-06-08

    申请号：US11274918

    申请日：2005-11-16

    申请人： Shawn Williams ,  Troy Hammond ,  Darin Laird

    发明人： Shawn Williams ,  Troy Hammond ,  Darin Laird

    IPC分类号： H01L29/47

    CPC分类号： H01L51/0036 ,  C08G61/126 ,  H01L51/002 ,  H01L51/0541 ,  Y02E10/549

    摘要： Regio-regular polythiophenes used in diodes which are not light emitting or photovoltaic. High quality, processable thin film polymer films can be made. The thin film can have a thickness of about 50 nm to about one micron, and the conductive thin film can be applied by spin casting, drop casting, screening, ink-jetting, transfer or roll coating. The polythiophenes can be homopolymers or copolymers. The regio-regular poly(3-substitutedthiophene) can be derivatized so that the 3-substituent is an alkyl, aryl, or alkyl/aryl moiety with a heteroatom substitution in either the α- or beta-position of the 3-substituent.

    摘要翻译： 在二极管中使用的Regio-regular聚噻吩不是发光或光电。 可以制成高品质，可加工的薄膜聚合物膜。 薄膜可以具有约50nm至约1微米的厚度，并且可以通过旋转浇铸，滴铸，筛选，喷墨，转印或辊涂来施加导电薄膜。 聚噻吩可以是均聚物或共聚物。 可以将区域规则聚（3-取代噻吩）衍生化，使得3-取代基是在3-取代基的α-位或β-位上具有杂原子取代的烷基，芳基或烷基/芳基部分。

    Heteroatomic regioregular poly (3-substitutedthiophenes) in electroluminescent devices
    4.
    发明申请
    Heteroatomic regioregular poly (3-substitutedthiophenes) in electroluminescent devices 有权
    电致发光器件中的杂原子区域定向聚（3-取代噻吩）

    公开(公告)号：US20060078761A1

    公开(公告)日：2006-04-13

    申请号：US11234374

    申请日：2005-09-26

    申请人： Shawn Williams ,  Darin Laird ,  Troy Hammond

    发明人： Shawn Williams ,  Darin Laird ,  Troy Hammond

    IPC分类号： H01L51/50 ,  H05B33/12

    CPC分类号： H01B1/127 ,  H01L51/0036 ,  H01L51/5048 ,  H01L51/5052 ,  H01L51/5088 ,  Y10S428/917

    摘要： Regioregular polythiophenes having heteroatoms in the substituents can be used in hole injection layer and hole transport layers for electroluminescent devices. Copolymers and organic oxidants can be used. Homopolymers can be used. Metallic impurities can be removed. The heteroatom can be oxygen and can be substituted at the 3-position. Advantages include versatility, synthetic control, and good thermal stability. Different device designs can be used.

    摘要翻译： 在取代基中具有杂原子的区域定向聚噻吩可用于电致发光器件的空穴注入层和空穴传输层。 可以使用共聚物和有机氧化剂。 可以使用均聚物。 可以去除金属杂质。 杂原子可以是氧并且可以在3位被取代。 优点包括通用性，合成控制和良好的热稳定性。 可以使用不同的设备设计。

    Integrated overhead side airbag module
    5.
    发明申请
    Integrated overhead side airbag module 有权
    集成架空侧气囊模块

    公开(公告)号：US20070152431A1

    公开(公告)日：2007-07-05

    申请号：US11325770

    申请日：2006-01-05

    申请人： John Rust ,  Joseph Lemmon ,  Michael Warnez ,  Shawn Williams ,  Babak Famili ,  Robert Kuhr

    发明人： John Rust ,  Joseph Lemmon ,  Michael Warnez ,  Shawn Williams ,  Babak Famili ,  Robert Kuhr

    IPC分类号： B60R21/213 ,  B60R21/215

    CPC分类号： B60R21/213

    摘要： An overhead trim system for a motor vehicle has a mounting bracket coupled to an overhead area of the motor vehicle and an integrally formed trim member. The integrally formed trim member is configured to extend along a selected length of a perimeter of the overhead area and defines a hinge. The integrally formed trim member is coupled to the mounting bracket to define a cavity configured for receipt of an airbag module. The hinge in a first position is capable of retaining the airbag module within the cavity and in a second position is capable of enabling the airbag module to expand.

    摘要翻译： 用于机动车辆的顶棚装饰系统具有联接到机动车辆的顶部区域的安装支架和整体形成的装饰构件。 整体形成的装饰构件构造成沿着顶部区域的周边的选定长度延伸并且限定铰链。 整体形成的装饰构件联接到安装支架以限定构造成用于接收气囊模块的空腔。 第一位置的铰链能够将气囊模块保持在空腔内，并且在第二位置能够使气囊模块膨胀。

    Latent doping of conducting polymers
    7.
    发明申请
    Latent doping of conducting polymers 有权
    导电聚合物的潜在掺杂

    公开(公告)号：US20070065590A1

    公开(公告)日：2007-03-22

    申请号：US11496024

    申请日：2006-07-31

    申请人： Shawn Williams ,  Darin Laird ,  Caton Goodman ,  Christopher Greco ,  Jaideep Rajput

    发明人： Shawn Williams ,  Darin Laird ,  Caton Goodman ,  Christopher Greco ,  Jaideep Rajput

    IPC分类号： C08G75/00 ,  B05D3/02

    CPC分类号： H01L51/002 ,  C08L65/00 ,  H01B1/127 ,  H01L51/0003 ,  H01L51/0036 ,  H01L51/5048 ,  H01L51/5052 ,  Y02E10/549

    摘要： Latent doping is provided wherein a conducting polymer is mixed with a dopant in solution without the doping reaction occurring unless solvent is removed. Regioregular polythiophenes are a particularly important embodiment. A composition comprising (i) at least one polymer comprising conjugation in the polymer backbone, (ii) at least one dopant for the polymer, (iii) at least one solvent for the polymer and latent dopant, wherein the polymer, the latent dopant, and the solvent are formulated so that the latent dopant does not substantially dope the polymer when formulated, but does substantially react with the polymer when the solvent is removed. Formulation of the composition can comprise adjusting the order of mixing, the amounts of the components, and the temperature. Methods of formulating the compositions and methods of using the compositions are also provided. OLED, PLED, photovoltaic, and other organic electronic devices can be fabricated.

    摘要翻译： 提供潜在掺杂，其中除非除去溶剂，否则导电聚合物与溶液中的掺杂剂混合而不发生掺杂反应。 区域聚噻吩是特别重要的实施方案。 一种组合物，其包含（i）至少一种包含在聚合物主链中共轭的聚合物，（ii）聚合物的至少一种掺杂剂，（iii）至少一种用于聚合物和潜在掺杂剂的溶剂，其中聚合物，潜在掺杂剂， 并且配制溶剂使得潜在掺杂剂在配制时基本上不掺杂聚合物，但当除去溶剂时基本上与聚合物反应。 组合物的配方可以包括调节混合的顺序，组分的量和温度。 还提供了配制组合物的方法和使用组合物的方法。 可以制造OLED，PLED，光电和其它有机电子器件。