公开(公告)号：US20060206655A1

公开(公告)日：2006-09-14

申请号：US11009391

申请日：2004-12-10

Applicant: Christopher Chappell ,  James Mitchell

Inventor： Christopher Chappell ,  James Mitchell

IPC: G06F13/36 ,  G06F13/00

CPC classification number: G06F13/4027

Abstract: Methods and apparatus, including computer program products, implementing techniques for forming an Advanced Switching (AS) packet by applying AS path binding information to a packet received over a Peripheral Component Interconnect-Express (PCIe) fabric according to a downstream port identifier associated with the packet, and sending the AS packet to an AS fabric. Methods and apparatus, including computer program products, implementing techniques for processing an AS packet received over an AS fabric by comparing an AS payload of the AS packet with one or more memory spaces associated with port identifiers, determining whether the AS payload comprises a base packet to be transmitted to the PCIe fabric based on the comparison, and if so, removing an AS header from the AS packet to reveal the base packet.

Abstract translation: 方法和装置，包括计算机程序产品，通过将AS路径绑定信息应用于通过外围组件互连Express（PCIe）结构接收的分组，根据与所述外部组件互连 - 快速（PCIe）结构相关联的下游端口标识符来形成高级交换（AS）分组的实现技术 分组，并将AS数据包发送到AS架构。 方法和装置，包括计算机程序产品，通过将AS分组的AS有效载荷与与端口标识符相关联的一个或多个存储空间进行比较来确定AS有效载荷是否包括基本分组 基于比较将其发送到PCIe结构，如果是，则从AS分组中去除AS报头以显示基本分组。

公开(公告)号：US20060050645A1

公开(公告)日：2006-03-09

申请号：US10934639

申请日：2004-09-03

Applicant: Christopher Chappell ,  James Mitchell

Inventor： Christopher Chappell ,  James Mitchell

IPC: H04L12/26

CPC classification number: H04L49/1507 ,  H04L49/555

Abstract: Methods and apparatus, including computer program products, implementing techniques for receiving a node configuration packet that includes a request for access to a memory space of an Advanced Switching device, performing a set of checks on a header of the received node configuration packet to determine whether the packet is valid, and processing the access request when the packet is determined to be valid.

Abstract translation: 包括计算机程序产品的方法和装置，用于接收包括对高级交换设备的存储空间的访问请求的节点配置分组的实现技术，对所接收的节点配置分组的报头执行一组检查以确定是否 分组是有效的，并且当分组被确定为有效时处理该访问请求。

公开(公告)号：US20060050733A1

公开(公告)日：2006-03-09

申请号：US10934642

申请日：2004-09-03

Applicant: Christopher Chappell ,  James Mitchell

Inventor： Christopher Chappell ,  James Mitchell

IPC: H04J3/22

CPC classification number: H04L12/4641

Abstract: Method and apparatus, including computer program products, implementing techniques for receiving packets including node configuration packets over a plurality of virtual channels of a switch fabric, each node configuration packet including a request for access to a memory space of an Advanced Switching (AS) device, and arbitrating access of the received node configuration packets to the memory space between the plurality of virtual channels.

Abstract translation: 包括计算机程序产品的方法和装置，用于在交换结构的多个虚拟信道上接收包括节点配置分组的分组的实现技术，每个节点配置分组包括访问高级交换（AS）设备的存储空间的请求 并且将所接收的节点配置分组的访问仲裁到所述多个虚拟信道之间的存储器空间。

公开(公告)号：US20060050652A1

公开(公告)日：2006-03-09

申请号：US10933822

申请日：2004-09-03

Applicant: Christopher Chappell ,  James Mitchell

Inventor： Christopher Chappell ,  James Mitchell

IPC: H04L12/28 ,  H04L12/56

CPC classification number: G06F13/4269 ,  H04L47/10 ,  H04L47/39

Abstract: Methods and apparatus, including computer program products, implementing techniques for retrieving a node configuration packet from a first queue. If the node configuration packet includes a read request, the techniques include determining if the node configuration packet is valid, and if so, processing the node configuration packet to retrieve data from a data structure associated with the device, generating a data packet including the retrieved data, and providing the generated data packet to a second queue. If the node configuration packet includes a write request, determining if the node configuration packet is valid, and if so, processing the node configuration packet to write data to a data structure associated with the device.

Abstract translation: 包括计算机程序产品的方法和装置，用于从第一队列检索节点配置分组的实现技术。 如果节点配置分组包括读请求，则技术包括确定节点配置分组是否有效，如果是，则处理该节点配置分组以从与该设备相关联的数据结构中检索数据，生成包括所检索的数据分组的数据分组 数据，并将生成的数据分组提供给第二队列。 如果节点配置分组包括写请求，则确定节点配置分组是否有效，如果是，则处理节点配置分组以将数据写入与该设备相关联的数据结构。

公开(公告)号：US10020526B2

公开(公告)日：2018-07-10

申请号：US13611709

申请日：2012-09-12

Applicant: Timothy J. Fuller ,  Lijun Zou ,  Ion C. Halalay ,  James Mitchell ,  Mark W. Verbrugge

Inventor： Timothy J. Fuller ,  Lijun Zou ,  Ion C. Halalay ,  James Mitchell ,  Mark W. Verbrugge

IPC: H01M8/1069 ,  H01M2/14 ,  H01M8/1081 ,  C08K3/16

CPC classification number: H01M8/1079 ,  C08K3/16 ,  H01M2/145 ,  H01M8/1081 ,  Y02P70/56 ,  Y10T29/49108 ,  Y10T29/49826

Abstract: A method for forming a membrane includes a step of dissolving a lithium salt in a solution including an ionomer that includes protogenic groups to form a modified solution. A membrane is formed from the solution containing the lithium salt and the ionomer that includes protogenic groups. The membrane is dried and then contacted with water to form a plurality of pores therein.

公开(公告)号：US09901080B2

公开(公告)日：2018-02-27

申请号：US15067543

申请日：2016-03-11

Applicant: Buck Institute for Research on Aging ,  Erasmus University Medical Center Rotterdam ,  James Mitchell ,  Wendy Toussaint

Inventor： Judith Campisi ,  Marco Demaria ,  Remi-Martin Laberge ,  Francis Rodier ,  James Mitchell ,  Jan H. J. Hoeijmakers ,  Wendy Toussaint

IPC: A01K67/027 ,  A61K49/00 ,  C12N15/85

CPC classification number: A01K67/0275 ,  A01K2217/052 ,  A01K2227/105 ,  A01K2267/0393 ,  A61K49/0008 ,  C12N15/8509 ,  C12N2015/859 ,  C12N2830/008

Abstract: This invention provides a transgenic mouse for studying the role of senescent cells on an age-related disorder or an age-sensitive trait. The transgene contains a p16 promoter sequence that controls expression of an enzyme so as to cause the enzyme to be expressed in senescent cells in the mouse. The enzyme converts a prodrug to a cytotoxic agent, so that treating the mouse with the prodrug results in the prodrug selectively killing the senescent cells. As a result, progression of an age-related disorder or an age-sensitive trait is delayed. Included is the 3MR mouse model, which also expresses bioluminescent and fluorescent markers under control of the p16 promoter so that senescent cells in the mice can be visualized.

公开(公告)号：US09631105B2

公开(公告)日：2017-04-25

申请号：US13568499

申请日：2012-08-07

Applicant: James Mitchell ,  Timothy J. Fuller

Inventor： James Mitchell ,  Timothy J. Fuller

IPC: H01M8/10 ,  B01J31/06 ,  C09D11/52 ,  H01M4/88 ,  H01M4/90 ,  H01M4/92 ,  H01M8/1007 ,  H01M8/1018

CPC classification number: C09D11/52 ,  H01M4/8807 ,  H01M4/8846 ,  H01M4/9075 ,  H01M4/925 ,  H01M8/1007 ,  H01M2008/1095 ,  Y02P70/56

Abstract: A metal electrode assembly for fuel cell applications includes a cathode catalyst layer, an anode catalyst layer, and an ion-conducting membrane disposed between the cathode catalyst layer and the anode catalyst layer. The cathode catalyst layer or the anode layer each independently including a catalyst composition and a first polymer wherein at least one of the cathode catalyst layer or the anode layer include a first polymer and polyphenylene sulfide-containing structures. A method for making a fuel cell catalyst layer is also provided.

公开(公告)号：US08853277B2

公开(公告)日：2014-10-07

申请号：US13512665

申请日：2010-11-30

Applicant: W. Marston Linehan ,  Tracey A. Rouault ,  James Mitchell ,  Murali K. Cherukuri

Inventor： W. Marston Linehan ,  Tracey A. Rouault ,  James Mitchell ,  Murali K. Cherukuri

IPC: A61K31/13 ,  A61K31/40 ,  A61K31/445 ,  A61K31/421

CPC classification number: A61K31/40 ,  A61K31/421 ,  A61K31/445

Abstract: The invention provides therapeutic methods that include administering a stable nitroxide to a subject that has, is suspected to have, or is at risk for having a condition associated with reduced VHL or elevated HIF-2α.

Abstract translation: 本发明提供了治疗方法，其包括向被怀疑具有或具有与降低的VHL或升高的HIF-2α相关的病症的风险的受试者施用稳定的氮氧自由基。

公开(公告)号：US20140045093A1

公开(公告)日：2014-02-13

申请号：US13568494

申请日：2012-08-07

Applicant: James Mitchell ,  Lijun Zou ,  Timothy J. Fuller

Inventor： James Mitchell ,  Lijun Zou ,  Timothy J. Fuller

IPC: H01M8/10 ,  B29C45/14 ,  B82Y30/00

CPC classification number: D06M15/256 ,  D06M2101/30 ,  H01M8/1027 ,  H01M8/1048 ,  H01M2008/1095

Abstract: A metal electrode assembly includes a cathode catalyst layer, an anode catalyst layer, and an ion conducting membrane disposed between the cathode catalyst layer and the anode catalyst layer. The ion conducting layer includes a polyphenylene sulfide mat with a first polymer imbibed therein. The polyphenylene sulfide mat includes the polyphenylene sulfide-containing structures. A method for forming the ion conducting layer is also provided.

Abstract translation: 金属电极组件包括阴极催化剂层，阳极催化剂层和设置在阴极催化剂层和阳极催化剂层之间的离子导电膜。 离子传导层包括其中吸收有第一聚合物的聚苯硫醚垫。 聚苯硫醚垫包括含聚苯硫醚的结构。 还提供了一种用于形成离子传导层的方法。

公开(公告)号：US20130330653A1

公开(公告)日：2013-12-12

申请号：US13492387

申请日：2012-06-08

Applicant: James Mitchell ,  Lijun Zou ,  Timothy J. Fuller ,  Gerald W. Fly

Inventor： James Mitchell ,  Lijun Zou ,  Timothy J. Fuller ,  Gerald W. Fly

IPC: C08G75/14 ,  H01M8/04 ,  H01M8/10

CPC classification number: B01D71/66 ,  D01F6/765 ,  D04H1/4326 ,  H01M4/8814 ,  H01M4/8875 ,  H01M4/92

Abstract: A method for making hollow metal tubes includes a step combining a polyphenylene sulfide-containing resin with a water soluble carrier resin to form a resinous mixture. The resinous mixture is then extruded to form an extruded resinous mixture. The extruded resinous mixture includes polyphenylene sulfide-containing fibers within the carrier resin. The extruded resinous mixture is contacted (i.e., washed) with water to separate the polyphenylene sulfide-containing fibers from the carrier resin. The polyphenylene sulfide-containing fibers are then formed into a membrane.

Abstract translation: 制造中空金属管的方法包括将含有聚苯硫醚的树脂与水溶性载体树脂组合以形成树脂混合物的步骤。 然后将树脂混合物挤出以形成挤出的树脂混合物。 挤出的树脂混合物包括载体树脂内的含聚苯硫醚的纤维。 将挤出的树脂混合物与水接触（即洗涤）以从载体树脂中分离含聚苯硫醚的纤维。 然后将含聚苯硫醚的纤维形成膜。