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公开(公告)号：US6060288A
公开(公告)日：2000-05-09
申请号：US800840
申请日：1997-02-14
CPC分类号： C12Q1/6862 , C12Q1/686
摘要： This invention features methods, apparatus and kits for performing nucleic acid hybridization and amplification reactions on a support. Such methods and apparatus are useful in diagnostic and therapeutic processes for synthesizing nucleic acid and detecting target nucleic acids in a sample.
摘要翻译： 本发明的特征在于用于在载体上进行核酸杂交和扩增反应的方法，装置和试剂盒。 这样的方法和装置在用于合成核酸和检测样品中的靶核酸的诊断和治疗过程中是有用的。
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公开(公告)号：US06180770B2
公开(公告)日：2001-01-30
申请号：US09183092
申请日：1998-10-30
IPC分类号： C12Q168
摘要： Disclosed is a polymerizable complex containing a covalently attached nucleic acid molecule which, under appropriate conditions, is capable of copolymerization with a second polymerizable ethylene-containing monomer unit to form a polymerized layer. The polymerized layer containing attached nucleic acid is useful in a variety of contexts including, for example, hybridization assays. The polymerized layer containing the covalently attached nucleic acid molecule can be formed into a variety of shapes, or attached to a formed material through appropriate chemistry.
摘要翻译： 公开了含有共价连接的核酸分子的可聚合复合物，其在合适的条件下能够与第二可聚合的含乙烯单体单元共聚以形成聚合层。 含有连接核酸的聚合层可用于多种情况，包括例如杂交测定。 含有共价连接的核酸分子的聚合层可以形成多种形状，或通过适当的化学成分连接到成形材料上。
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公开(公告)号：US06692912B1
公开(公告)日：2004-02-17
申请号：US09550817
申请日：2000-04-18
IPC分类号： C12Q168
摘要： Disclosed is a polymerizable complex containing a covalently attached nucleic acid molecule which, under appropriate conditions, is capable of copolymerization with a second polymerizable ethylene-containing monomer unit to form a polymerized layer. The polymerized layer containing attached nucleic acid is useful in a variety of contexts including, for example, hybridization assays. The polymerized layer containing the covalently attached nucleic acid molecule can be formed into a variety of shapes, or attached to a formed material through appropriate chemistry.
摘要翻译： 公开了含有共价连接的核酸分子的可聚合复合物，其在合适的条件下能够与第二可聚合的含乙烯单体单元共聚以形成聚合层。 含有连接核酸的聚合层可用于多种情况，包括例如杂交测定。 含有共价连接的核酸分子的聚合层可以形成多种形状，或通过适当的化学成分连接到成形材料上。
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公开(公告)号：US6090592A
公开(公告)日：2000-07-18
申请号：US776859
申请日：1997-05-29
CPC分类号： C12Q1/686
摘要： This invention features methods and apparatus for performing nucleic acid hybridization and amplification processes on a support. Such methods and apparatus are useful for synthesizing nucleic acid and detecting target nucleic acid for diagnostics and therapeutics.
摘要翻译： PCT No.PCT / US95 / 09905 Sec。 371日期1997年5月29日 102（e）日期1997年5月29日PCT提交1995年8月3日PCT公布。 出版物WO96 / 04404 日期1996年2月15日本发明的特征在于在载体上进行核酸杂交和扩增过程的方法和装置。 这样的方法和装置可用于合成核酸并检测靶核酸用于诊断和治疗。
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5.发明授权公开(公告)号：US06468751B1
公开(公告)日：2002-10-22
申请号：US09591168
申请日：2000-06-09
IPC分类号： C12Q168
CPC分类号： C12Q1/686 , C12Q2565/518 , C12Q2563/107
摘要： This invention features methods and apparatus for performing nucleic acid hybridization and amplification processes on a support. Such methods and apparatus are useful for synthesizing nucleic acid and detecting target nucleic acid for diagnostics and therapeutics.
摘要翻译： 本发明的特征在于在载体上进行核酸杂交和扩增过程的方法和装置。 这样的方法和装置可用于合成核酸并检测靶核酸用于诊断和治疗。
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公开(公告)号：US5932711A
公开(公告)日：1999-08-03
申请号：US812105
申请日：1997-03-05
摘要： Disclosed is a polymerizable complex containing a covalently attached nucleic acid molecule which, under appropriate conditions, is capable of copolymerization with a second polymerizable ethylene-containing monomer unit to form a polymerized layer. The polymerized layer containing attached nucleic acid is useful in a variety of contexts including, for example, hybridization assays. The polymerized layer containing the covalently attached nucleic acid molecule can be formed into a variety of shapes, or attached to a formed material through appropriate chemistry.
摘要翻译： 公开了含有共价连接的核酸分子的可聚合复合物，其在合适的条件下能够与第二可聚合的含乙烯单体单元共聚以形成聚合层。 含有连接核酸的聚合层可用于多种情况，包括例如杂交测定。 含有共价连接的核酸分子的聚合层可以形成多种形状，或通过适当的化学成分连接到成形材料上。
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7.发明授权公开(公告)号：US06251660B1
公开(公告)日：2001-06-26
申请号：US09200126
申请日：1998-11-25
IPC分类号： C12M134
CPC分类号： C12Q1/689 , B01L3/502 , B01L3/505 , C12Q1/6834 , C12Q1/703 , C12Q2565/125 , C12Q2531/119
摘要： Devices and methods for detecting the presence, or absence of the presence of at least one target molecule employing a receptacle housing a reaction chamber comprised of at least one compartment containing suitable reagents for the detection of the target molecule are disclosed.
摘要翻译： 公开了用于检测存在或不存在至少一个靶分子存在的装置和方法，所述靶分子使用容纳包含至少一个包含用于检测靶分子的合适试剂的隔室的反应室的容器。
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公开(公告)号：US6143315A
公开(公告)日：2000-11-07
申请号：US365136
申请日：1999-07-30
申请人： Ming X. Wang , Christopher P. Adams
发明人： Ming X. Wang , Christopher P. Adams
CPC分类号： A61K9/0051 , A61K35/50 , G02B1/043
摘要： Methods for treating injured corneal tissue are described. The methods include contacting injured corneal tissue with a contact lens which includes an amniotic composition such that scarring of the injured corneal tissue is reduced. Methods for conditioning a contact lens for treatment of injured corneal tissue are also described. The methods include contacting the contact lens with an amniotic composition whereby the amniotic composition is deposited in or on the surface of said contact lens. Additionally, contact lens packages for treatment of injured corneal tissue are described. The contact lens package includes a container holding a contact lens which includes an amniotic composition and instructions for using the contact lens for treatment of injured corneal tissue.
摘要翻译： 描述了治疗角膜损伤损伤的方法。 所述方法包括使损伤的角膜组织与包括羊膜组合物的隐形眼镜接触，使得损伤的角膜组织的瘢痕形成减少。 还描述了用于调节用于治疗损伤的角膜组织的隐形眼镜的方法。 所述方法包括使隐形眼镜与羊膜组合物接触，由此将羊膜组合物沉积在所述隐形眼镜的表面中或其上。 另外，描述了用于治疗损伤的角膜组织的隐形眼镜包装。 隐形眼镜包装包括容纳隐形眼镜的容器，其包括羊膜组合物和使用隐形眼镜来治疗受伤的角膜组织的说明书。
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公开(公告)号：US07626400B2
公开(公告)日：2009-12-01
申请号：US11353882
申请日：2006-02-14
CPC分类号： H01Q19/065 , G01S13/42 , G01S13/426 , G01S13/88 , G01S13/89
摘要： In one aspect, the present invention provides an imager, preferably portable, that includes a source of electromagnetic radiation capable of generating radiation with one or more frequencies in a range of about 1 GHz to about 2000 GHz. An optical system that is optically coupled to the source focuses radiation received therefrom onto an object plane, and directs at least a portion of the focused radiation propagating back from the object plane onto an image plane. The imager further includes a scan mechanism coupled to the optical system for controlling thereof so as to move the focused radiation over the object plane. A detector optically coupled to the lens at the image plane detects at least a portion of the radiation propagating back from a plurality of scanned locations in the object plane, thereby generating a detection signal. A processor that is in communication with the detector generates an image of at least a portion of the object plane based on the detection signal.
摘要翻译： 在一个方面，本发明提供一种成像器，优选便携式的，其包括能够在约1GHz至约2000GHz的范围内产生具有一个或多个频率的辐射的电磁辐射源。 光学耦合到源的光学系统将从其接收的辐射聚焦到物平面上，并将从物体平面传播的聚焦辐射的至少一部分引导到图像平面上。 成像器还包括耦合到光学系统的扫描机构，用于对其进行控制，以便将被聚焦的辐射移动到物体平面上。 在图像平面处光学耦合到透镜的检测器检测从物体平面中的多个扫描位置传播回来的辐射的至少一部分，从而产生检测信号。 与检测器通信的处理器基于检测信号产生对象平面的至少一部分的图像。
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10.发明授权Inhibition of olfactory neurosensory function to treat eating disorders and obesity 有权抑制嗅觉神经功能治疗饮食失调和肥胖公开(公告)号：US07138107B2
公开(公告)日：2006-11-21
申请号：US10369188
申请日：2003-02-18
申请人： Christopher P. Adams , James Flynn
发明人： Christopher P. Adams , James Flynn
CPC分类号： A61K9/0043 , A61K31/00 , A61K31/277 , A61K31/455 , A61K31/554 , G01N33/6872 , G01N2500/00 , Y10S514/866 , Y10S514/909
摘要： The use of calcium channel blockers administered intra-nasally to inhibit olfactory sensory perception to treat eating disorders, including obesity, is described. Also described is a method of reducing food intake in a subject by administering a pharmaceutical composition comprising an effective amount of a calcium channel blocker to the nasal mucosa, as well as screening methods for drugs to be used in treating obesity or associated disorders.
摘要翻译： 描述了使用经鼻内施用的钙通道阻滞剂来抑制嗅觉感觉以治疗进食障碍，包括肥胖症。 还描述了通过向鼻粘膜施用包含有效量的钙通道阻断剂的药物组合物以及用于治疗肥胖症或相关疾病的药物的筛选方法来减少受试者的食物摄取的方法。
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