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    Hydroxylases and modulators thereof
    3.
    发明申请
    Hydroxylases and modulators thereof 失效
    羟基酶及其调节剂

    公开(公告)号：US20070048728A1

    公开(公告)日：2007-03-01

    申请号：US10531662

    申请日：2003-10-16

    申请人： Peter Ratcliffe ,  Christopher Pugh ,  Christopher Schofield ,  Kirsty Hewitson

    发明人： Peter Ratcliffe ,  Christopher Pugh ,  Christopher Schofield ,  Kirsty Hewitson

    IPC分类号： C12Q1/00 ,  G06F19/00 ,  C07D471/02 ,  C07D211/72

    CPC分类号： A61K31/16 ,  A61K31/395 ,  G06F19/16 ,  G06F19/706

    摘要： A method of identifying, screening, characterising or designing a chemical entity, which mimics or binds to FIH, is described. The method comprises comparing a structural model of FIH with a structural model for said chemical entity, wherein said structural model of FIH is derived from structural factors or structural coordinates determined by subjecting to X-ray diffraction measurements a crystal comprising FIH. Such chemical entities may be used in the treatment of a condition associated with increased or decreased HIF levels or activity.

    摘要翻译： 描述了识别，筛选，表征或设计模拟或结合FIH的化学实体的方法。 该方法包括将FIH的结构模型与所述化学实体的结构模型进行比较，其中FIH的结构模型来源于通过对包含FIH的晶体进行X射线衍射测量确定的结构因子或结构坐标。 这些化学实体可用于治疗与增加或降低的HIF水平或活性相关的病症。

    MN and hypoxia
    6.
    发明申请
    MN and hypoxia 审中-公开
    MN和缺氧

    公开(公告)号：US20060084123A1

    公开(公告)日：2006-04-20

    申请号：US11166997

    申请日：2005-06-24

    申请人： Adrian Harris ,  Peter Ratcliffe ,  Dirk Vordermark

    发明人： Adrian Harris ,  Peter Ratcliffe ,  Dirk Vordermark

    IPC分类号： G01N33/574

    CPC分类号： C12Q1/527 ,  G01N33/573 ,  G01N33/574

    摘要： The MN/CA IX protein is identified herein as a hypoxia marker. The MN/CA9 gene promoter is characterized, and the location of the HIF-1 binding site within the MN/CA9 promoter is identified. Further, the hypoxia inducibility of the MN/CA9 gene and the uses of such inducibility are disclosed. In one aspect, the invention provides diagnostic/prognostic tools for determining the presence of hypoxia in a tissue in a vertebrate, preferably a human, and for measuring the relative degree of hypoxia in said vertebrate. In another aspect, the invention provides methods using tumor biopsies to predict the radioresistance of a preneoplastic/neoplastic tissue in a vertebrate subject, preferably a human patient, for diseases in which MN/CA IX levels can be used to indicate radiobiologically relevant tumor hypoxia. Such predictive methods can be used as an aid in patient therapy selection.

    摘要翻译： 本文将MN / CA IX蛋白质鉴定为缺氧标记。 表征MN / CA9基因启动子，鉴定MN / CA9启动子内HIF-1结合位点的位置。 此外，公开了MN / CA9基因的缺氧诱导能力和这种诱导性的用途。 一方面，本发明提供用于确定脊椎动物，优选人类的组织中缺氧的存在并用于测量所述脊椎动物中的相对缺氧程度的诊断/预后工具。 在另一方面，本发明提供了使用肿瘤活组织检查来预测脊椎动物受试者，优选人类患者中对于其中可以使用MN / CA IX水平来表示放射生物学相关的肿瘤缺氧的疾病的肿瘤前/肿瘤组织的放射抗性的方法。 这种预测方法可用作患者治疗选择的辅助。

    Method and apparatus for displaying personalized information on a vehicle
    7.
    发明申请
    Method and apparatus for displaying personalized information on a vehicle 审中-公开
    用于在车辆上显示个性化信息的方法和装置

    公开(公告)号：US20080028650A1

    公开(公告)日：2008-02-07

    申请号：US11798835

    申请日：2007-05-17

    申请人： Peter Ratcliffe

    发明人： Peter Ratcliffe

    IPC分类号： G09F21/04

    CPC分类号： B60R13/005 ,  G09F7/00 ,  G09F21/04

    摘要： A way for a consumer to display personalized information is provided as a display device for displaying the personalized information or other objects, and an attachment mechanism that attaches the display device to a vehicle by way of a base and that is also detachable from the base. The personalized information may be placed on or inside the display device for the consumer, or the consumer may place the personalized information on or inside the display device himself. The personalized information may represent military affiliation, authorization, or may be any other personalized image or text. The base may be affixed to the vehicle by way of a magnet or other mechanism. The display device may include a recess for holding a can or cup. The display device may be pivoted relative to the base so that the display device may be displayed perpendicular or parallel to a plane defined by the vehicle's wheels.

    摘要翻译： 提供消费者显示个性化信息的方式作为显示个性化信息或其他对象的显示装置，以及通过基座将显示装置附接到车辆并且也可从基座拆卸的附接机构。 个性化信息可以放置在消费者的显示装​​置的内部或内部，或者消费者可以将个人化信息本身放置在显示装置内部或内部。 个性化信息可以表示军事联盟，授权，或可以是任何其他个性化图像或文本。 基座可以通过磁铁或其他机构固定在车辆上。 显示装置可以包括用于保持罐或杯的凹部。 显示装置可以相对于基座枢转，使得显示装置可以垂直或平行于由车辆的车轮限定的平面显示。

    Inhibitors of 2-oxoglutarate dioxygenase as gamma globin inducers
    8.
    发明申请
    Inhibitors of 2-oxoglutarate dioxygenase as gamma globin inducers 审中-公开
    2-氧戊二酸双加氧酶抑制剂作为γ珠蛋白诱导剂

    公开(公告)号：US20070042937A1

    公开(公告)日：2007-02-22

    申请号：US10566625

    申请日：2004-07-30

    申请人： Stephen Klaus ,  Peter Ratcliffe

    发明人： Stephen Klaus ,  Peter Ratcliffe

    IPC分类号： A61K38/40 ,  A61K48/00 ,  A61K31/7072 ,  A61K31/19

    CPC分类号： A61K31/7072 ,  A61K31/17 ,  A61K31/19 ,  A61K31/47 ,  Y02A50/411

    摘要： The present invention provides methods for increasing endogenous globin expression in a subject, specifically γ-globin expression. The invention also provides compounds and medicaments for use in the methods. The methods are particularly useful for increasing fetal hemoglobin production in a subject, and can be used to treat various disorders, e.g., β thalassemia and sickle cell disease.

    摘要翻译： 本发明提供增加受试者内源性珠蛋白表达，特别是γ-珠蛋白表达的方法。 本发明还提供了用于该方法的化合物和药物。 所述方法对于增加受试者的胎儿血红蛋白产生特别有用，并且可用于治疗各种疾病，例如β地中海贫血和镰状细胞病。