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公开(公告)号：US20060160885A1
公开(公告)日：2006-07-20
申请号：US11378947
申请日：2006-03-17
申请人： Chuen Chan , Julie Hamblin , Henry Kelly , Nigel King , Andrew Mason , Vipulkumar Patel , Stefan Senger , Gita Shah , Nigel Watson , Helen Weston , Caroline Whitworth , Robert Young
发明人： Chuen Chan , Julie Hamblin , Henry Kelly , Nigel King , Andrew Mason , Vipulkumar Patel , Stefan Senger , Gita Shah , Nigel Watson , Helen Weston , Caroline Whitworth , Robert Young
IPC分类号： A61K31/4015 , A61K31/4025 , C07D403/02
CPC分类号： A61K9/0031 , A61K9/0019 , A61K9/0024 , A61K9/0043 , A61K9/0056 , A61K9/0073 , A61K9/0095 , A61K9/02 , A61K9/12 , A61K31/4025 , A61K31/454 , A61K38/00 , C07K5/06034 , C07K5/06139 , C07K5/06191
摘要： The invention relates to compounds of formula (Ic) processes for their preparation, pharmaceutical compositions containing them and to their use in medicine, particularly use in the amelioration of a clinical condition for which a Factor Xa inhibitor is indicated.
摘要翻译： 本发明涉及式（Ic）化合物的制备方法，含有它们的药物组合物及其在药物中的用途，特别是用于改善指定因子Xa抑制剂的临床病症。
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公开(公告)号：US20060160886A1
公开(公告)日：2006-07-20
申请号：US11384094
申请日：2006-03-17
申请人： Chuen Chan , Julie Hamblin , Henry Kelly , Nigel King , Andrew Mason , Vipulkumar Patel , Stefan Senger , Gita Shah , Nigel Watson , Helen Weston , Caroline Whitworth , Robert Young
发明人： Chuen Chan , Julie Hamblin , Henry Kelly , Nigel King , Andrew Mason , Vipulkumar Patel , Stefan Senger , Gita Shah , Nigel Watson , Helen Weston , Caroline Whitworth , Robert Young
IPC分类号： A61K31/4025 , A61K31/4015 , C07D403/02
CPC分类号： A61K9/0031 , A61K9/0019 , A61K9/0024 , A61K9/0043 , A61K9/0056 , A61K9/0073 , A61K9/0095 , A61K9/02 , A61K9/12 , A61K31/4025 , A61K31/454 , A61K38/00 , C07K5/06034 , C07K5/06139 , C07K5/06191
摘要： The invention relates to compounds of formula (Ic) processes for their preparation, pharmaceutical compositions containing them and to their use in medicine, particularly use in the amelioration of a clinical condition for which a Factor Xa inhibitor is indicated.
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公开(公告)号：US20050107379A1
公开(公告)日：2005-05-19
申请号：US10479545
申请日：2002-06-06
申请人： Chuen Chan , Julie Hamblin , Henry Kelly , Nigel King , Andrew Mason , Vipulkumar Patel , Stefan Senger , Gita Shah , Nigel Watson , Helen Weston , Caroline Whitworth , Robert Young
发明人： Chuen Chan , Julie Hamblin , Henry Kelly , Nigel King , Andrew Mason , Vipulkumar Patel , Stefan Senger , Gita Shah , Nigel Watson , Helen Weston , Caroline Whitworth , Robert Young
IPC分类号： C07D409/14 , A61K31/40 , A61K31/5377 , A61P7/02 , A61P9/00 , A61P11/00 , A61P25/16 , A61P25/28 , A61P29/00 , A61P35/04 , A61P43/00 , C07D207/12 , C07D207/26 , C07D207/273 , C07D213/06 , C07D277/20 , C07D307/34 , C07D307/82 , C07D333/28 , C07D333/34 , C07D333/36 , C07D333/70 , C07D413/06 , C07D413/08 , C07D413/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07D495/04 , C07D413/02
CPC分类号： C07D413/14 , A61K31/5377 , C07D207/12 , C07D413/06 , C07D417/14 , C07D495/04
摘要： The invention relates to compounds of formula (I) processes for their preparation, pharmaceutical compositions containing them and to their use in medicine, particularly use in the amelioration of a clinical condition for which a Factor Xa inhibitor is indicated.
摘要翻译： 本发明涉及式（I）化合物的制备方法，含有它们的药物组合物及其在医药中的用途，特别是用于改善指定因子Xa抑制剂的临床病症。
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公开(公告)号：US20070155745A1
公开(公告)日：2007-07-05
申请号：US11548395
申请日：2006-10-11
申请人： Chuen Chan , Julie Hamblin , Henry Kelly , Nigel King , Andrew Mason , Vipulkumar Patel , Stefan Senger , Gita Shah , Nigel Watson , Helen Weston , Caroline Whitworth , Robert Young
发明人： Chuen Chan , Julie Hamblin , Henry Kelly , Nigel King , Andrew Mason , Vipulkumar Patel , Stefan Senger , Gita Shah , Nigel Watson , Helen Weston , Caroline Whitworth , Robert Young
IPC分类号： A61K31/5377 , C07D413/14
CPC分类号： C07D413/14 , A61K31/5377 , C07D207/12 , C07D413/06 , C07D417/14 , C07D495/04
摘要： The invention relates to compounds of formula (I) processes for their preparation, pharmaceutical compositions containing them and to their use in medicine, particularly use in the amelioration of a clinical condition for which a Factor Xa inhibitor is indicated.
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公开(公告)号：US20070142375A1
公开(公告)日：2007-06-21
申请号：US11548404
申请日：2006-10-11
申请人： Chuen CHAN , Julie Hamblin , Henry Kelly , Nigel King , Andrew Mason , Vipulkumar Patel , Stefan Senger , Gita Shah , Nigel Watson , Helen Weston , Caroline Whitworth , Robert Young
发明人： Chuen CHAN , Julie Hamblin , Henry Kelly , Nigel King , Andrew Mason , Vipulkumar Patel , Stefan Senger , Gita Shah , Nigel Watson , Helen Weston , Caroline Whitworth , Robert Young
IPC分类号： A61K31/5377 , C07D413/02
CPC分类号： C07D413/14 , A61K31/5377 , C07D207/12 , C07D413/06 , C07D417/14 , C07D495/04
摘要： The invention relates to compounds of formula (I) processes for their preparation, pharmaceutical compositions containing them and to their use in medicine, particularly use in the amelioration of a clinical condition for which a Factor Xa inhibitor is indicated.
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公开(公告)号：US20070142374A1
公开(公告)日：2007-06-21
申请号：US11548402
申请日：2006-10-11
申请人： Chuen CHAN , Julie Hamblin , Henry Kelly , Nigel King , Andrew Mason , Vipulkumar Patel , Stefan Senger , Gita Shah , Nigel Watson , Helen Weston , Carolin Whitworth , Robert Young
发明人： Chuen CHAN , Julie Hamblin , Henry Kelly , Nigel King , Andrew Mason , Vipulkumar Patel , Stefan Senger , Gita Shah , Nigel Watson , Helen Weston , Carolin Whitworth , Robert Young
IPC分类号： A61K31/5377
CPC分类号： C07D413/14 , A61K31/5377 , C07D207/12 , C07D413/06 , C07D417/14 , C07D495/04
摘要： The invention relates to compounds of formula (I) processes for their preparation, pharmaceutical compositions containing them and to their use in medicine, particularly use in the amelioration of a clinical condition for which a Factor Xa inhibitor is indicated.
摘要翻译： 本发明涉及式（I）化合物的制备方法，含有它们的药物组合物及其在医药中的用途，特别是用于改善指定因子Xa抑制剂的临床病症。
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公开(公告)号：US20050059726A1
公开(公告)日：2005-03-17
申请号：US10499529
申请日：2002-12-20
申请人： Alan Borthwick , Chuen Chan , Henry Kelly , Nigel King , Savvas Kleanthous , Andrew Mason , Ivan Pinto , Derek Pollard , Stefan Senger , Gita Shah , Nigel Watson , Robert Young
发明人： Alan Borthwick , Chuen Chan , Henry Kelly , Nigel King , Savvas Kleanthous , Andrew Mason , Ivan Pinto , Derek Pollard , Stefan Senger , Gita Shah , Nigel Watson , Robert Young
IPC分类号： A61K31/402 , A61K31/4025 , A61K31/4155 , A61K31/4178 , A61K31/422 , A61K31/427 , A61K31/4365 , A61K31/4439 , A61K31/455 , A61K31/4709 , A61K31/4725 , A61K31/497 , A61K31/506 , A61K31/5377 , A61K31/546 , A61P3/00 , A61P7/00 , A61P7/02 , A61P7/04 , A61P9/00 , A61P9/06 , A61P9/10 , A61P11/00 , A61P11/08 , A61P25/16 , A61P25/28 , A61P29/00 , A61P35/00 , A61P35/04 , A61P41/00 , A61P43/00 , C07D207/26 , C07D207/273 , C07D401/12 , C07D403/10 , C07D405/10 , C07D405/12 , C07D405/14 , C07D409/10 , C07D409/12 , C07D409/14 , C07D413/10 , C07D417/04 , C07D417/14 , C07D495/04 , A61K31/404 , C07D43/02 , C07D45/02 , C07D49/02
CPC分类号： C07D207/273 , C07D401/12 , C07D403/10 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/10 , C07D417/04
摘要： The present invention relates to novel compounds and pharmaceutically acceptable derivatives thereof. The invention also relates to processes for the preparation of the compounds, pharmaceutical compositions containing the compounds, and to the use of compounds in medicine, particularly in the amelioration of a clinical condition for which a Factor Xa inhibitor is indicated.
摘要翻译： 本发明涉及新化合物及其药学上可接受的衍生物。 本发明还涉及制备化合物的方法，含有该化合物的药物组合物，以及化合物在医药中的用途，特别是在改善指定因子Xa抑制剂的临床病症中。
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8.发明申请2-(3-Sulfonylamino-2-oxopyrrolidin-1-yl)propanamides as factor xa inhibitors 失效2-（3-磺酰基氨基-2-氧代吡咯烷-1-基）丙酰胺作为因子xa抑制剂公开(公告)号：US20050004119A1
公开(公告)日：2005-01-06
申请号：US10495586
申请日：2002-11-13
申请人： Alan Borthwick , Matthew Campbell , Chuen Chan , Henry Kelly , Nigel King , Savvas Kleanthous , Andrew Mason , Stefan Senger , Paul Smith , Nigel Watson , Robert Young
发明人： Alan Borthwick , Matthew Campbell , Chuen Chan , Henry Kelly , Nigel King , Savvas Kleanthous , Andrew Mason , Stefan Senger , Paul Smith , Nigel Watson , Robert Young
IPC分类号： A61K31/4015 , A61K31/4025 , A61K31/4155 , A61K31/4178 , A61K31/4439 , A61K31/454 , A61K31/501 , A61K31/5377 , A61K31/55 , A61K38/00 , A61K38/55 , A61P3/00 , A61P7/00 , A61P7/02 , A61P9/10 , A61P9/14 , A61P11/00 , A61P25/16 , A61P25/28 , A61P29/00 , A61P35/04 , A61P41/00 , A61P43/00 , C07D207/26 , C07D207/273 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D409/14 , C07K1/02 , C07K5/06 , A61K31/535
CPC分类号： C07D207/273 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D409/14
摘要： The invention relates to compounds of formula (I) pharmaceutical compositions containing the same as well as methods of treating patients suffering from a condition susceptible to amelioration by a Factor Xa inhibitor using the same.
摘要翻译： 本发明涉及式（I）化合物，其含有相同的药物组合物，以及治疗患有易因因子Xa抑制剂改善的病症的患者的方法。
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9.发明申请公开(公告)号：US20060166985A1
公开(公告)日：2006-07-27
申请号：US10537646
申请日：2003-12-04
申请人： Alan Borthwick , Chuen Chan , Henry Kelly , Simon Peace , Stefan Senger , Gita Shah , Stefan Smith , Steven Smith , Nigel Watson , Robert West , Robert Young
发明人： Alan Borthwick , Chuen Chan , Henry Kelly , Simon Peace , Stefan Senger , Gita Shah , Stefan Smith , Steven Smith , Nigel Watson , Robert West , Robert Young
IPC分类号： A61K31/5377 , A61K31/4015 , C07D413/02 , C07D207/273
CPC分类号： C07D207/273 , C07D401/12 , C07D405/12 , C07D409/06 , C07D409/12 , C07D409/14 , C07D413/06 , C07D413/14 , C07D417/06 , C07D417/12 , C07D417/14
摘要： The invention relates to novel chemical compounds, pharmaceutically acceptable derivatives thereof, processes for their preparation, pharmaceutical compositions containing them, and to their use in medicine, particularly use in the amelioration of a clinical condition for which a thrombin inhibitor is indicated.
摘要翻译： 本发明涉及新型化合物，其药学上可接受的衍生物，其制备方法，含有它们的药物组合物及其在医药中的用途，特别是用于改善指示凝血酶抑制剂的临床病症。
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10.发明申请1-Phenyl-2-oxo-3-sulfonylamino-pyrrolidine derivatives and related compounds as factor xa inhibitors for the treatment of acute vascular diseases 失效1-苯基-2-氧-3-磺酰氨基 - 吡咯烷衍生物和相关化合物作为治疗急性血管疾病的因子xa抑制剂公开(公告)号：US20060148879A1
公开(公告)日：2006-07-06
申请号：US10561545
申请日：2004-06-17
申请人： Alan Borthwick , Chuen Chan , Henry Kelly , Savvas Kleanthous , Andrew Mason , Nigel Watson
发明人： Alan Borthwick , Chuen Chan , Henry Kelly , Savvas Kleanthous , Andrew Mason , Nigel Watson
IPC分类号： A61K31/405 , A61K31/4025 , A61K31/4015 , C07D409/02
CPC分类号： C07D413/14 , C07D409/12 , C07D409/14
摘要： The invention relates to compounds of formula (I): wherein substituents are as defined.
摘要翻译： 本发明涉及式（I）的化合物：其中取代基如所定义。
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