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公开(公告)号：US09370564B2
公开(公告)日：2016-06-21
申请号：US13169605
申请日：2011-06-27
申请人： Claude LeClerc , Pierre Guermonprez , Daniel Ladant , Nicole Guiso , Nadia Khelef , Cecile Bauche , Catherine Fayolle , Mohammed El-Azami El-Idrissi
发明人： Claude LeClerc , Pierre Guermonprez , Daniel Ladant , Nicole Guiso , Nadia Khelef , Cecile Bauche , Catherine Fayolle , Mohammed El-Azami El-Idrissi
IPC分类号： A61K39/385 , C07K14/235 , A61K47/48 , A61K39/00
CPC分类号： A61K39/099 , A61K39/385 , A61K47/646 , A61K2039/57 , A61K2039/6037 , C12N9/88 , C12N15/85 , C12Y406/01001 , Y02A50/466
摘要： The invention relates to a novel use of a Bordetella adenylcyclase toxin in the manufacturing of vectors for targeting in vivo a molecule of interest, specifically to CD11b expressing cells. The invention also relates to an immunogenic composition that primes immune responses, to pharmaceutical compositions and to a new vector for molecule delivery to CD11b expressing cells.
摘要翻译： 本发明涉及博德特氏子腺苷环化酶毒素在制备用于靶向靶分子的载体中，特别是靶向CD11b表达细胞的新颖应用。 本发明还涉及引发免疫应答的免疫原性组合物，药物组合物和用于向CD11b表达细胞递送分子的新载体。
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公开(公告)号：US20160375119A1
公开(公告)日：2016-12-29
申请号：US15177029
申请日：2016-06-08
申请人： Claude LeClerc , Pierre Guermonprez , Daniel Ladant , Nicole Guiso , Nadia Khelef , Cecile Bauche , Catherine Fayolle , Mohammed El-Azami El-Idrissi
发明人： Claude LeClerc , Pierre Guermonprez , Daniel Ladant , Nicole Guiso , Nadia Khelef , Cecile Bauche , Catherine Fayolle , Mohammed El-Azami El-Idrissi
CPC分类号： A61K39/099 , A61K39/385 , A61K47/646 , A61K2039/57 , A61K2039/6037 , C12N9/88 , C12N15/85 , C12Y406/01001 , Y02A50/466
摘要： The invention relates to a novel use of a Bordetella adenylcyclase toxin in the manufacturing of vectors for targeting in vivo a molecule of interest, specifically to CD11b expressing cells. The invention also relates to an immunogenic composition that primes immune responses, to pharmaceutical compositions and to a new vector for molecule delivery to CD11b expressing cells.
摘要翻译： 本发明涉及博德特氏子腺苷环化酶毒素在制备用于靶向靶分子的载体中，特别是靶向CD11b表达细胞的新颖应用。 本发明还涉及引发免疫应答的免疫原性组合物，药物组合物和用于向CD11b表达细胞递送分子的新载体。
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公开(公告)号：US20050238637A1
公开(公告)日：2005-10-27
申请号：US11098404
申请日：2005-04-05
申请人： Claude Leclerc , Pierre Guermonprez , Daniel Ladant , Nicole Guiso , Nadia Khelef , Cecile Bauche , Catherine Fayolle , Mohammed El-Azami El-Idrissi
发明人： Claude Leclerc , Pierre Guermonprez , Daniel Ladant , Nicole Guiso , Nadia Khelef , Cecile Bauche , Catherine Fayolle , Mohammed El-Azami El-Idrissi
IPC分类号： C12N15/09 , A61K35/74 , A61K35/76 , A61K38/00 , A61K39/00 , A61K39/002 , A61K39/02 , A61K39/12 , A61K39/13 , A61K39/145 , A61K39/385 , A61K47/48 , A61P29/00 , A61P31/00 , A61P33/00 , A61P35/00 , A61P37/00 , A61P37/02 , C12N5/06 , C12N5/10 , C12N9/88 , A61K38/46 , A61K39/116
CPC分类号： A61K39/099 , A61K39/385 , A61K47/646 , A61K2039/57 , A61K2039/6037 , C12N9/88 , C12N15/85 , C12Y406/01001 , Y02A50/466
摘要： The invention relates to a novel use of a Bordetella adenylcyclase toxin in the manufacturing of vectors for targeting in vivo a molecule of interest, specifically to CD11b expressing cells. The invention also relates to an immunogenic composition that primes immune responses, to pharmaceutical compositions, and to a new vector for molecule delivery to CD11b expressing cells.
摘要翻译： 本发明涉及博德特氏子腺苷环化酶毒素在制备用于靶向靶分子的载体中，特别是靶向CD11b表达细胞的新颖应用。 本发明还涉及引发免疫应答，药物组合物的免疫原性组合物和用于分子递送至表达CD11b的细胞的新载体。
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公开(公告)号：US20120214206A1
公开(公告)日：2012-08-23
申请号：US13169605
申请日：2011-06-27
申请人： Claude LeClerc , Pierre Guermonprez , Daniel Ladant , Nicole Guiso , Nadia Khelef , Cécile Bauche , Catherine Fayolle , Mohammed El-Azami El-Idrissi
发明人： Claude LeClerc , Pierre Guermonprez , Daniel Ladant , Nicole Guiso , Nadia Khelef , Cécile Bauche , Catherine Fayolle , Mohammed El-Azami El-Idrissi
IPC分类号： C12P19/34
CPC分类号： A61K39/099 , A61K39/385 , A61K47/646 , A61K2039/57 , A61K2039/6037 , C12N9/88 , C12N15/85 , C12Y406/01001 , Y02A50/466
摘要： The invention relates to a novel use of a Bordetella adenylcyclase toxin in the manufacturing of vectors for targeting in vivo a molecule of interest, specifically to CD11b expressing cells. The invention also relates to an immunogenic composition that primes immune responses, to pharmaceutical compositions and to a new vector for molecule delivery to CD11b expressing cells.
摘要翻译： 本发明涉及博德特氏子腺苷环化酶毒素在制备用于靶向靶分子的载体中，特别是靶向CD11b表达细胞的新颖应用。 本发明还涉及引发免疫应答的免疫原性组合物，药物组合物和用于向CD11b表达细胞递送分子的新载体。
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5.发明授权Modified Bordetella adenylate cyclase comprising or lacking CD11b/CD18 interaction domain and uses thereof 有权包含或缺少CD11b / CD18相互作用结构域的修饰的Bordetella腺苷酸环化酶及其用途公开(公告)号：US07906123B1
公开(公告)日：2011-03-15
申请号：US11713708
申请日：2007-03-05
申请人： Claude Leclerc , Mohammed El-Azami El-Idrissi , Daniel Ladant , Cécile Bauche , Peter Sebo , Jirina Loucka , Radim Osicka
发明人： Claude Leclerc , Mohammed El-Azami El-Idrissi , Daniel Ladant , Cécile Bauche , Peter Sebo , Jirina Loucka , Radim Osicka
CPC分类号： C12N9/88 , A61K39/00 , A61K2039/53 , C12Y406/01001
摘要： The invention relates to modified Bordetella adenylate cyclase toxins which are deficient for CD11b/CD18 binding and to their use in the preparation of pharmaceutical composition for the treatment of whooping cough and/or for the protection against Bordetella infection. The invention also relates to specific fragments of Bordetella adenylate cyclase comprising the CD11b/CD18 interaction domain and their use, especially for targeting a molecule of interest to CD11b expressing cells.
摘要翻译： 本发明涉及对于CD11b / CD18结合缺陷的修饰的博德氏菌属腺苷酸环化酶毒素，以及它们在制备用于治疗百日咳和/或防止博德氏菌感染的药物组合物中的用途。 本发明还涉及包含CD11b / CD18相互作用结构域的博德氏菌属腺苷酸环化酶的特异性片段及其用途，特别是用于将感兴趣的分子靶向CD11b表达细胞。
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6.发明申请RECOMBINANT ADENYLATE CYCLASE TOXIN OF BORDETELLA INDUCES T CELL RESPONSES AGAINST TUMORAL ANTIGENS 审中-公开BORDETELLA的重组腺苷酸环化酶诱导针对肿瘤抗原的T细胞应答公开(公告)号：US20100310594A1
公开(公告)日：2010-12-09
申请号：US12731196
申请日：2010-03-25
申请人： Gilles Dadaglio , Claude Leclerc , Daniel Ladant , Benoit Van Den Eynde , Sandra Morel , Cecile Bauche
发明人： Gilles Dadaglio , Claude Leclerc , Daniel Ladant , Benoit Van Den Eynde , Sandra Morel , Cecile Bauche
CPC分类号： F16C33/7886 , A61K38/164 , A61K39/0011 , A61K39/099 , A61K39/39 , A61K47/6415 , A61K47/646 , A61K2039/6037 , A61K2039/6068 , C12N9/88 , C12Y406/01001 , F16C25/083
摘要： An immunogenic composition comprising a recombinant protein comprising a Bordetella CyaA, or a fragment thereof, and a peptide that corresponds to a tumor antigen is provided as a cancer treatment. Methods of treatment with this immunogenic composition are also provided. In an embodiment, the therapeutic composition is a treatment for melanoma, and comprises epitopes from the HLA*0201 epitope. These epitopes include Tyr or GnT-V, and are present in the recombinant proteins CyaA-E5-Tyr and CyaA-E5-GnT-V.
摘要翻译： 作为癌症治疗，提供了含有包含Bordetella CyaA或其片段的重组蛋白质和对应于肿瘤抗原的肽的免疫原性组合物。 还提供了用该免疫原性组合物治疗的方法。 在一个实施方案中，治疗组合物是黑素瘤的治疗，并且包含来自HLA * 0201表位的表位。 这些表位包括Tyr或GnT-V，并且存在于重组蛋白CyaA-E5-Tyr和CyaA-E5-GnT-V中。
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7.发明申请Recombinant adenylate cyclase toxin of Bordetella induces T cell responses against tumoral antigens 审中-公开博德特氏菌的重组腺苷酸环化酶毒素诱导针对肿瘤抗原的T细胞应答公开(公告)号：US20070026022A1
公开(公告)日：2007-02-01
申请号：US11436757
申请日：2006-05-19
申请人： Gilles Dadaglio , Claude Leclerc , Daniel Ladant , Benoit Eynde , Sandra Morel , Cecile Bauche
发明人： Gilles Dadaglio , Claude Leclerc , Daniel Ladant , Benoit Eynde , Sandra Morel , Cecile Bauche
IPC分类号： A61K39/10 , C07H21/04 , C12N1/21 , C07K14/235 , C12N15/74
CPC分类号： A61K39/0011 , A61K2039/53 , A61K2039/57 , A61K2039/6068 , C07K14/235 , C07K2319/40 , C12N9/88 , C12Y406/01001
摘要： An immunogenic composition comprising a recombinant protein comprising a Bordetella CyaA, or a fragment thereof, and a peptide that corresponds to a tumor antigen is provided as a cancer treatment. Methods of treatment with this immunogenic composition are also provided. In an embodiment, the therapeutic composition is a treatment for melanoma, and comprises epitopes from the HLA*0201 epitope. These epitopes include Tyr or GnT-V, and are present in the recombinant proteins CyaA-E5-Tyr and CyaA-E5-GnT-V.
摘要翻译： 作为癌症治疗，提供了含有包含Bordetella CyaA或其片段的重组蛋白质和对应于肿瘤抗原的肽的免疫原性组合物。 还提供了用该免疫原性组合物治疗的方法。 在一个实施方案中，治疗组合物是黑素瘤的治疗，并且包含来自HLA * 0201表位的表位。 这些表位包括Tyr或GnT-V，并且存在于重组蛋白CyaA-E5-Tyr和CyaA-E5-GnT-V中。
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8.发明申请Modified bordetella adenylate cyclase comprising or lacking CD11b/CD18 interaction domain and uses thereof 审中-公开包含或缺少CD11b / CD18相互作用结构域的修饰的腺苷酸环化酶及其用途公开(公告)号：US20060159697A1
公开(公告)日：2006-07-20
申请号：US11304590
申请日：2005-12-16
申请人： Claude Leclerc , Mohammed El-Idrissi , Daniel Ladant , Cecile Bauche , Peter Sebo , Jirina Loucka , Radim Osicka
发明人： Claude Leclerc , Mohammed El-Idrissi , Daniel Ladant , Cecile Bauche , Peter Sebo , Jirina Loucka , Radim Osicka
CPC分类号： C12N9/88 , A61K39/00 , A61K2039/53 , C12Y406/01001
摘要： The invention relates to modified Bordetella adenylate cyclase toxins which are deficient for CD11b/CD18 binding and to their use in the preparation of pharmaceutical composition for the treatment of whooping cough and/or for the protection against Bordetella infection. The invention also relates to specific fragments of Bordetella adenylate cyclase comprising the CD11b/CD18 interaction domain and their use, especially for targeting a molecule of interest to CD11b expressing cells.
摘要翻译： 本发明涉及对于CD11b / CD18结合缺陷的修饰的博德氏菌属腺苷酸环化酶毒素，以及它们在制备用于治疗百日咳和/或防止博德氏菌感染的药物组合物中的用途。 本发明还涉及包含CD11b / CD18相互作用结构域的博德氏菌属腺苷酸环化酶的特异性片段及其用途，特别是用于将感兴趣的分子靶向CD11b表达细胞。
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9.发明申请Recombinant adenylate cyclase toxin of bordetella induces T cell responses against tumoral antigens 有权博德特氏菌的重组腺苷酸环化酶毒素诱导针对肿瘤抗原的T细胞应答公开(公告)号：US20090117143A1
公开(公告)日：2009-05-07
申请号：US12232250
申请日：2008-09-12
申请人： Gilles Dadaglio , Claude Leclerc , Daniel Ladant , Benoit Van Den Eynde , Sandra Morel , Cecile Bauche
发明人： Gilles Dadaglio , Claude Leclerc , Daniel Ladant , Benoit Van Den Eynde , Sandra Morel , Cecile Bauche
CPC分类号： A61K38/164 , A61K39/0011 , A61K39/099 , A61K39/39 , A61K47/6415 , A61K47/646 , A61K2039/6037 , A61K2039/6068 , C12N9/88 , C12Y406/01001 , F16C19/06 , F16C25/083 , F16C27/066 , F16C33/7886
摘要： An immunogenic composition comprising a recombinant protein comprising a Bordetella CyaA, or a fragment thereof, and a peptide that corresponds to a tumor antigen is provided as a cancer treatment. Methods of treatment with this immunogenic composition are also provided. In an embodiment, the therapeutic composition is a treatment for melanoma, and comprises epitopes from the HLA*0201 epitope. These epitopes include Tyr or GnT-V, and are present in the recombinant proteins CyaA-E5-Tyr and CyaA-E5-GnT-V.
摘要翻译： 作为癌症治疗，提供了含有包含Bordetella CyaA或其片段的重组蛋白质和对应于肿瘤抗原的肽的免疫原性组合物。 还提供了用该免疫原性组合物治疗的方法。 在一个实施方案中，治疗组合物是黑素瘤的治疗，并且包含来自HLA * 0201表位的表位。 这些表位包括Tyr或GnT-V，并且存在于重组蛋白CyaA-E5-Tyr和CyaA-E5-GnT-V中。
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10.发明申请Recombinant adenylate cyclase toxin of Bordetella induces T cell responses against tumoral antigens 审中-公开博德特氏菌的重组腺苷酸环化酶毒素诱导针对肿瘤抗原的T细胞应答公开(公告)号：US20050271679A1
公开(公告)日：2005-12-08
申请号：US10994204
申请日：2004-11-22
申请人： Gilles Dadaglio , Claude Leclerc , Daniel Ladant , Benoit Van Den Eynde , Sandra Morel , Cecile Bauche
发明人： Gilles Dadaglio , Claude Leclerc , Daniel Ladant , Benoit Van Den Eynde , Sandra Morel , Cecile Bauche
IPC分类号： A61K38/16 , A61K39/00 , A61K39/02 , A61K39/385 , A61K39/39 , A61K47/48 , C07H21/04 , C12N1/21 , C12N9/02 , C12N9/88 , C12P21/04
CPC分类号： F16C33/7886 , A61K38/164 , A61K39/0011 , A61K39/099 , A61K39/39 , A61K47/6415 , A61K47/646 , A61K2039/6037 , A61K2039/6068 , C12N9/88 , C12Y406/01001 , F16C25/083
摘要： An immunogenic composition comprising a recombinant protein comprising a Bordetella CyaA, or a fragment thereof, and a peptide that corresponds to a tumor antigen is provided as a cancer treatment. Methods of treatment with this immunogenic composition are also provided. In an embodiment, the therapeutic composition is a treatment for melanoma, and comprises epitopes from the HLA*0201 epitope. These epitopes include Tyr or GnT-V, and are present in the recombinant proteins CyaA-E5-Tyr and CyaA-E5-GnT-V.
摘要翻译： 作为癌症治疗，提供了含有包含Bordetella CyaA或其片段的重组蛋白质和对应于肿瘤抗原的肽的免疫原性组合物。 还提供了用该免疫原性组合物治疗的方法。 在一个实施方案中，治疗组合物是黑素瘤的治疗，并且包含来自HLA * 0201表位的表位。 这些表位包括Tyr或GnT-V，并且存在于重组蛋白CyaA-E5-Tyr和CyaA-E5-GnT-V中。
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