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    Acellular antibordetella vaccine
    5.
    发明申请
    Acellular antibordetella vaccine 审中-公开
    无细胞抗菌肽疫苗

    公开(公告)号：US20100112009A1

    公开(公告)日：2010-05-06

    申请号：US12289732

    申请日：2008-11-03

    申请人： Pascale Gueirard ,  Nicole Guiso

    发明人： Pascale Gueirard ,  Nicole Guiso

    IPC分类号： A61K39/10

    CPC分类号： A61K39/099 ,  A61K2039/55505

    摘要： The invention relates to an immunogenic composition, characterized in that it comprises an adenyl cyclase-hemolysin (AC-Hly) protein, or an immunogenic portion of this AC-Hly, of a strain of Bordetella chosen from B. pertussis, B. parapertussis or B. bronchiseptica, and in that it comprises, in addition, a bacterial extract containing the expression products of the vrg genes of a strain of Bordetella chosen from B. pertussis, B. parapertussis or B. bronchiseptica, or a portion of these expression products which is sufficient to induce an immune response in a host to which the extract might be administered.

    摘要翻译： 本发明涉及一种免疫原性组合物，其特征在于其包含选自百日咳百日香酵母（B.百日咳酵母），副百日咳百日咳杆菌（B.百日咳杆菌）或百日咳杆菌（B.百日咳杆菌）的博德特氏杆菌菌株的腺苷酸环化酶 - 溶血素（AC-Hly）蛋白或该AC-Hly的免疫原性部分 支气管炎支气管炎，并且其还包含含有选自百日咳百日咳杆菌，副百日咳杆菌或支气管炎支气管炎的博德特氏菌的vrg基因的表达产物的细菌提取物，或这些表达产物的一部分 其足以在可以施用该提取物的宿主中诱导免疫应答。

    Acellular antibordetella vaccine
    6.
    发明授权
    Acellular antibordetella vaccine 失效
    无细胞抗菌肽疫苗

    公开(公告)号：US07465443B2

    公开(公告)日：2008-12-16

    申请号：US11229858

    申请日：2005-09-20

    申请人： Pascale Gueirard ,  Nicole Guiso

    发明人： Pascale Gueirard ,  Nicole Guiso

    IPC分类号： A01N63/00 ,  A61K48/00 ,  A61K45/00 ,  A61K39/00 ,  A61K39/02 ,  C12P21/04 ,  C12N1/02 ,  C12M1/00 ,  C12M3/00

    CPC分类号： C12N9/88 ,  A61K39/00 ,  A61K2039/52 ,  C07K14/235 ,  C12R1/01 ,  Y10S435/814

    摘要： The invention relates to an immunogenic composition, characterized in that it comprises an adenyl cyclase-hemolysin (AC-Hly) protein, or an immunogenic portion of this AC-Hly, of a strain of Bordetella chosen from B. pertussis, B. parapertussis or B. bronchiseptica, and in that it comprises, in addition, a bacterial extract containing the expression products of the vrg genes of a strain of Bordetella chosen from B. pertussis, B. parapertussis or B. bronchiseptica, or a portion of these expression products which is sufficient to induce an immune response in a host to which the extract might be administered.

    摘要翻译： 本发明涉及一种免疫原性组合物，其特征在于其包含选自百日咳百日香酵母（B.百日咳酵母），副百日咳百日咳杆菌（B.百日咳杆菌）或百日咳杆菌（B.百日咳杆菌）的博德特氏杆菌菌株的腺苷酸环化酶 - 溶血素（AC-Hly）蛋白或该AC-Hly的免疫原性部分 支气管炎支气管炎，并且其还包含含有选自百日咳百日咳杆菌，副百日咳杆菌或支气管炎支气管炎的博德特氏菌的vrg基因的表达产物的细菌提取物，或这些表达产物的一部分 其足以在可以施用该提取物的宿主中诱导免疫应答。

    Immunogenic compositions comprising vrg-gene products from Bordetella extracts
    7.
    发明授权
    Immunogenic compositions comprising vrg-gene products from Bordetella extracts 失效
    包含来自博德特氏菌提取物的vrg-基因产物的免疫原性组合物

    公开(公告)号：US07105317B2

    公开(公告)日：2006-09-12

    申请号：US10383876

    申请日：2003-03-10

    申请人： Pascale Gueirard ,  Nicole Guiso

    发明人： Pascale Gueirard ,  Nicole Guiso

    IPC分类号： C12P21/04 ,  A01N63/00 ,  A61K39/10 ,  A61K45/00 ,  C12M1/00 ,  C12M3/00 ,  C12N1/02

    CPC分类号： C12N9/88 ,  A61K39/00 ,  A61K2039/52 ,  C07K14/235 ,  C12R1/01 ,  Y10S435/814

    摘要： This invention relates to an immunogenic composition comprising a bacterial extract containing at least one expression products of the vrg genes of a strain of Bordetella chosen from B. pertussis, B. parapertussis, or B. bronchiseptica. The invention also relates to a method for producing the extract, comprising culturing the bacteria on blood medium to obtain isolated nonhemolytic colonies; inoculating cells of one or more colonies in liquid medium to give a suspension of cells; separating the cells from the liquid medium after culture; suspending the separated cells in a buffer comprising urea for at least an amount of time sufficient to form a bacterial lysate; and separating intact cells and insoluble material from soluble material, wherein the extract comprises the soluble material.

    摘要翻译： 本发明涉及包含细菌提取物的免疫原性组合物，所述细菌提取物含有选自百日咳百日咳杆菌，副百日咳杆菌或支气管炎支原体的博德特氏菌菌株的vrg基因的至少一种表达产物。 本发明还涉及一种生产提取物的方法，包括在血液培养基上培养细菌以获得分离的非溶血性菌落; 在液体培养基中接种一个或多个菌落的细胞以产生细胞悬浮液; 培养后将细胞与液体培养基分离; 将分离的细胞悬浮在包含尿素的缓冲液中至少一段时间以足以形成细菌裂解物; 并从可溶性材料中分离完整的细胞和不溶性材料，其中提取物包含可溶性材料。

    Acellular antibordetella vaccine
    8.
    发明授权
    Acellular antibordetella vaccine 失效
    无细胞抗菌肽疫苗

    公开(公告)号：US06387377B1

    公开(公告)日：2002-05-14

    申请号：US08574439

    申请日：1995-12-15

    申请人： Pascale Gueirard ,  Nicole Guiso

    发明人： Pascale Gueirard ,  Nicole Guiso

    IPC分类号： A61K3910

    CPC分类号： C12N9/88 ,  A61K39/00 ,  A61K2039/52 ,  C07K14/235 ,  C12R1/01 ,  Y10S435/814

    摘要： The invention relates to an immunogenic composition, characterized in that it comprises an adenyl cyclase-hemolysin (AC-Hly) protein, or an immunogenic portion of this AC-Hly, of a strain of Bordetella chosen from B. Tertussis, B. parapertussis or B. bronchiseptica, and in that it comprises, in addition, a bacterial extract containing the expression products of the vrg genes of a strain of Bordetella chosen from B. pertussis, B. parapertussis or B. bronchiseptica, or a portion of these expression products which is sufficient to induce an immune response in a host to which the extract might be administered.

    摘要翻译： 本发明涉及一种免疫原性组合物，其特征在于其包含选自B族百日咳杆菌，百日咳杆菌或百日咳杆菌的博德特氏菌菌株的腺苷酸环化酶 - 溶血素（AC-Hly）蛋白或该AC-Hly的免疫原性部分 支气管炎支气管炎，并且其还包含含有选自百日咳百日咳杆菌，副百日咳杆菌或支气管炎支气管炎的博德特氏菌的vrg基因的表达产物的细菌提取物，或这些表达产物的一部分 其足以在可以施用该提取物的宿主中诱导免疫应答。

    Bordetella pertussis and Bordetella parapertussis strains
    9.
    发明授权
    Bordetella pertussis and Bordetella parapertussis strains 失效
    百日咳博德特氏菌和百日咳杆菌菌株

    公开(公告)号：US6030625A

    公开(公告)日：2000-02-29

    申请号：US64626

    申请日：1998-04-23

    申请人： Pascale Gueirard ,  Nicole Guiso

    发明人： Pascale Gueirard ,  Nicole Guiso

    IPC分类号： A01N63/00 ,  A61K31/70 ,  A61K39/00 ,  A61K39/02 ,  A61K39/10 ,  A61K39/102 ,  A61P31/04 ,  C12N1/00 ,  C12N1/12 ,  C12N1/20 ,  C12N5/02 ,  C12N9/88 ,  C12R1/01

    CPC分类号： C12R1/01 ,  C12N9/88 ,  A61K2039/52

    摘要： An immunogenic composition, characterized in that it comprises an adenyl cyclase-hemolysin (Ac-Hly) protein, or an immunogenic portion of this AC-Hly, of a strain of Bordetella chosen from B. pertussis, B. parapertussis or B. bronchiseptica, and in that it comprises, in addition, a bacterial extract containing the expression products of the vrg genes of a strain of Bordetella chosen from B. pertussis, B. parapertussis or B. bronchiseptica, or a portion of these expression products which is sufficient to induce an immune response in a host to which the extract might be administered.

    摘要翻译： 一种免疫原性组合物，其特征在于，其包含选自百日咳百日咳杆菌，副百日咳杆菌或支气管炎支原体的博德特氏菌菌株的腺苷酸环化酶 - 溶血素（Ac-Hly）蛋白或该AC-Hly的免疫原性部分， 另外还包含含有选自百日咳百日咳杆菌，副百日咳杆菌或支气管炎支气管炎的博德特氏菌的vrg基因的表达产物的细菌提取物，或这些表达产物的一部分足以 在可能给予提取物的宿主中诱导免疫应答。

    Nucleic acids encoding protective epitopes of adenyl cyclase-haemolysin (AC-Hly)
    10.
    发明授权
    Nucleic acids encoding protective epitopes of adenyl cyclase-haemolysin (AC-Hly) 失效
    编码腺苷酸环化酶溶血素（AC-Hly）保护性表位的核酸

    公开(公告)号：US07902349B2

    公开(公告)日：2011-03-08

    申请号：US11177488

    申请日：2005-07-11

    申请人： Fotini Betsou ,  Peter Sebo ,  Nicole Guiso

    发明人： Fotini Betsou ,  Peter Sebo ,  Nicole Guiso

    IPC分类号： A61K39/40 ,  A61K39/02 ,  C07H21/04 ,  C12P21/04 ,  C12N9/22 ,  C12N1/21 ,  C12N15/74

    CPC分类号： C07K14/235 ,  A61K38/00 ,  A61K39/00 ,  A61K2039/51 ,  C07K16/40 ,  C12N9/88 ,  Y10S530/82 ,  Y10S530/825

    摘要： Purified nucleic acids comprising a nucleotide sequence encoding an immunogenic polypeptide of adenyl cyclase-haemolysin (AC-Hly), which induces formation of protective antibodies against an infection by a bacteria selected from the group consisting of B. pertussis, B. parapertussis, and B. bronchiseptica when the nucleic acid or polypeptide is administered to a human or animal host. The nucleic acids are useful, for example, to induce a protective immune response in a host against infection by a bacteria selected from the group consisting of B. pertussis, B. parapertussis, and B. bronchiseptica.

    摘要翻译： 纯化的核酸，其包含编码腺苷酸环化酶 - 溶血素（AC-Hly）的免疫原性多肽的核苷酸序列，其诱导针对选自百日咳百日咳杆菌，副百日咳杆菌和B族细菌的细菌感染的保护性抗体的形成 当将核酸或多肽施用于人或动物宿主时，支气管炎。 核酸可用于例如在宿主中诱导由选自百日咳百日咳杆菌，副百日咳百博和支气管炎支原体的细菌感染的保护性免疫应答。