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公开(公告)号：US10189856B2
公开(公告)日：2019-01-29
申请号：US13816020
申请日：2011-05-24
申请人： Claudia Hirth-Dietrich , Peter Sandner , Johannes-Peter Stasch , Andreas Knorr , Georges Von Degenfeld , Michael Hahn , Markus Follmann
发明人： Claudia Hirth-Dietrich , Peter Sandner , Johannes-Peter Stasch , Andreas Knorr , Georges Von Degenfeld , Michael Hahn , Markus Follmann
IPC分类号： A61K31/437 , A61K31/197 , A61K31/427 , A61K31/4439 , A61K31/506 , A61K31/519 , A61K31/5377 , A61K45/06 , C07D495/04 , C07D471/04 , A61K31/426 , C07C229/38 , C07D261/10 , C07D277/30 , C07D333/34 , C07D401/04 , C07D417/06 , C07D487/04
摘要： The use of sGC stimulators, sGC activators alone, or in combination with PDE5 inhibitors for the prevention and treatment of fibrotic diseases, such as systemic sclerosis, scleroderma, and the concomitant fibrosis of internal organs.
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2.发明申请Use of sGC stimulators, sGC activators, alone and combinations with PDE5 inhibitors for the treatment of systemic sclerosis (SSc). 审中-公开使用sGC刺激剂，sGC激活剂，单独使用和与PDE5抑制剂的组合治疗系统性硬化症（SSc）。公开(公告)号：US20140038956A1
公开(公告)日：2014-02-06
申请号：US13816020
申请日：2011-05-24
申请人： Claudia Hirth-Dietrich , Peter Sandner , Johannes-Peter Stasch , Andreas Knorr , Georges Von Degenfeld , Michael Hahn , Markus Follmann
发明人： Claudia Hirth-Dietrich , Peter Sandner , Johannes-Peter Stasch , Andreas Knorr , Georges Von Degenfeld , Michael Hahn , Markus Follmann
IPC分类号： C07D495/04 , C07C229/38 , C07D333/34 , C07D261/10 , C07D401/04 , C07D417/06 , C07D277/30 , C07D487/04 , A61K31/5377 , A61K31/506 , A61K31/197 , A61K31/4439 , A61K31/427 , A61K31/426 , A61K31/519 , A61K45/06 , C07D471/04
CPC分类号： C07D495/04 , A61K31/197 , A61K31/426 , A61K31/427 , A61K31/437 , A61K31/4439 , A61K31/506 , A61K31/519 , A61K31/5377 , A61K45/06 , C07C229/38 , C07D261/10 , C07D277/30 , C07D333/34 , C07D401/04 , C07D417/06 , C07D471/04 , C07D487/04 , A61K2300/00
摘要： The use of sGC stimulators, sGC activators alone, or in combination with PDE5 inhibitors for the prevention and treatment of fibrotic diseases, such as systemic sclerosis, scleroderma, and the concomitant fibrosis of internal organs.
摘要翻译： 单独使用sGC刺激剂，sGC激活剂或与PDE5抑制剂联合用于预防和治疗纤维化疾病，如系统性硬化症，硬皮病和伴随的内脏纤维化。
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3.发明申请sGC STIMULATORS OR sGC ACTIVATORS ALONE AND IN COMBINATION WITH PDE5 INHBITORS FOR THE TREATMENT OF CYSTIC FIBROSIS 审中-公开sGC刺激物或sGC激活剂单独和组合用于治疗CYSTIC FIBROSIS的PDE5抑制剂公开(公告)号：US20130035340A1
公开(公告)日：2013-02-07
申请号：US13577135
申请日：2011-02-03
CPC分类号： A61K45/06 , A61K31/18 , A61K31/194 , A61K31/427 , A61K31/4418 , A61K31/498 , A61K31/4985 , A61K31/506 , A61K31/519 , A61K31/53 , A61K2300/00
摘要： The present invention relates to soluble guanylate cyclase (sGC) and to phosphodiesterases (PDEs) and the pharmacology of sGC stimulators, sGC activators and PDE inhibitors. More particularly, the invention relates to the use of sGC stimulators and sGC activators in combination with PDE5 inhibitors for preparation of medicaments for the treatment of Cystic Fibrosis (CF).
摘要翻译： 本发明涉及可溶性鸟苷酸环化酶（sGC）和磷酸二酯酶（PDEs）以及sGC刺激剂，sGC激活剂和PDE抑制剂的药理学。 更具体地，本发明涉及sGC刺激剂和sGC激活剂与PDE5抑制剂组合用于制备用于治疗囊性纤维化（CF）的药物的用途。
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4.发明授权公开(公告)号：US09040566B2
公开(公告)日：2015-05-26
申请号：US13819790
申请日：2011-08-29
申请人： Jürgen Klar , Georges Von Degenfeld , Hans-Georg Lerchen , Barbara Albrecht-Küpper , Andreas Knorr , Peter Sandner , Daniel Meibom
发明人： Jürgen Klar , Georges Von Degenfeld , Hans-Georg Lerchen , Barbara Albrecht-Küpper , Andreas Knorr , Peter Sandner , Daniel Meibom
IPC分类号： A01N43/40 , A61K31/44 , C07D409/00 , C07D411/00 , C07D405/00 , C07D417/12 , A61K9/00 , A61K9/08 , A61K31/4439 , A61K45/06 , C07D413/12 , C07D417/14
CPC分类号： A61K31/4439 , A61K9/0048 , A61K9/08 , A61K38/05 , A61K45/06 , C07D413/12 , C07D417/12 , C07D417/14
摘要： The present invention relates to the use of selective adenosine A1 agonists, in particular the dicyanopyridines of formula (I), for the treatment and/or prophylaxis of glaucoma and ocular hypertension as well as the their use for the production of a medicament for the treatment and/or prophylaxis of glaucoma and ocular hypertension.
摘要翻译： 本发明涉及选择性腺苷A1激动剂，特别是式（I）的二氰基吡啶用于治疗和/或预防青光眼和高眼压症及其用于生产治疗药物的用途的用途 和/或预防青光眼和高眼压症。
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公开(公告)号：US20130210797A1
公开(公告)日：2013-08-15
申请号：US13819790
申请日：2011-08-29
申请人： Jürgen Klar , Georges Von Degenfeld , Hans-Georg Lerchen , Barbara Albrecht-Küpper , Andreas Knorr , Peter Sandner , Daniel Meiibom
发明人： Jürgen Klar , Georges Von Degenfeld , Hans-Georg Lerchen , Barbara Albrecht-Küpper , Andreas Knorr , Peter Sandner , Daniel Meiibom
IPC分类号： C07D417/12 , A61K45/06 , C07D417/14 , A61K31/4439 , C07D413/12
CPC分类号： A61K31/4439 , A61K9/0048 , A61K9/08 , A61K38/05 , A61K45/06 , C07D413/12 , C07D417/12 , C07D417/14
摘要： The present invention relates to the use of selective adenosine A1 agonists, in particular the dicyanopyridines of formula (I), for the treatment and/or prophylaxis of glaucoma and ocular hypertension as well as the their use for the production of a medicament for the treatment and/or prophylaxis of glaucoma and ocular hypertension.
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6.发明申请TOPICAL OPHTHALMOLOGICAL PHARMACEUTICAL COMPOSITION CONTAINING REGORAGENIB 审中-公开含有REGORAGENIB的局部OPHTHALMOLOGICAL PHARMACEUTICAL COMPOSITION公开(公告)号：US20140296301A1
公开(公告)日：2014-10-02
申请号：US14128356
申请日：2012-06-26
申请人： Michael Bottger , Georges Von Degenfeld , Julia Freundlieb , Claudia Hirth-Dietrich , Joerg Keldenich , Jurgen Klar , Uwe Muenster , Andreas Ohm , Annett Richter , Bernd Riedl
发明人： Michael Bottger , Georges Von Degenfeld , Julia Freundlieb , Claudia Hirth-Dietrich , Joerg Keldenich , Jurgen Klar , Uwe Muenster , Andreas Ohm , Annett Richter , Bernd Riedl
CPC分类号： A61K31/44 , A61K9/0048 , A61K9/10 , A61K31/4412 , A61K47/02 , A61K47/06 , A61K47/14
摘要： The present invention relates to topical ophthalmological pharmaceutical compositions containing regorafenib, a hydrate, solvate or pharmaceutically acceptable salt thereof or a polymorph thereof and its process of preparation and its use for treating ophthalmological disorders.
摘要翻译： 本发明涉及含有罗非非尼，其水合物，溶剂化物或其药学上可接受的盐或其多晶型物的局部眼科药物组合物及其制备方法及其用于治疗眼科疾病的用途。
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7.发明申请公开(公告)号：US20100144728A1
公开(公告)日：2010-06-10
申请号：US12596557
申请日：2008-04-10
IPC分类号： A61K31/5377 , A61P9/12
CPC分类号： A61K31/421 , A61K31/422 , A61K31/5377
摘要： The present invention relates to the use of factor Xa inhibitors, especially of oxazolidinones of the formula (I), for the treatment and/or prophylaxis of pulmonary hypertension, and to the use thereof for the manufacture of medicaments for the treatment and/or prophylaxis of pulmonary hypertension.
摘要翻译： 本发明涉及因子Xa抑制剂，特别是式（I）的恶唑烷酮的用途，用于治疗和/或预防肺动脉高压，以及其用于制备用于治疗和/或预防的药物的用途 的肺动脉高压。
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公开(公告)号：US20120129831A1
公开(公告)日：2012-05-24
申请号：US13322602
申请日：2010-05-14
申请人： Dirk Heimbach , Susanne Röhrig , Yolanda Cancho Grande , Dirk Schneider , Ulrich Rester , Eckhard Bender , Mark Meininghaus , Katja Zimmermann , Dmitry Zubov , Anja Buchmüller , Georges Von Degenfeld , Christoph Gerdes , Michael Gerisch , Mark Jean Gnoth , Kersten Matthias Gericke , Mario Jeske
发明人： Dirk Heimbach , Susanne Röhrig , Yolanda Cancho Grande , Dirk Schneider , Ulrich Rester , Eckhard Bender , Mark Meininghaus , Katja Zimmermann , Dmitry Zubov , Anja Buchmüller , Georges Von Degenfeld , Christoph Gerdes , Michael Gerisch , Mark Jean Gnoth , Kersten Matthias Gericke , Mario Jeske
IPC分类号： A61K31/454 , A61K31/4545 , A01N1/02 , A61P9/00 , A61P35/00 , C07D413/14 , A61P7/02
CPC分类号： C07D413/14
摘要： The invention relates to novel substituted piperidines, to processes for preparation thereof, to the use thereof for treatment and/or prophylaxis of diseases and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially of cardiovascular disorders and tumour disorders.
摘要翻译： 本发明涉及新型取代的哌啶，其制备方法，其用于治疗和/或预防疾病的用途及其用于生产用于治疗和/或预防疾病，特别是心血管疾病和肿瘤的药物的用途 疾病
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公开(公告)号：US08119663B2
公开(公告)日：2012-02-21
申请号：US12323454
申请日：2008-11-25
申请人： Dirk Heimbach , Susanne Röhrig , Dirk Schneider , Ulrich Rester , Eckhard Bender , Mark Meininghaus , Katja Zimmermann , Dmitry Zubov , Anja Buchmüller , Georges Von Degenfeld , Christoph Gerdes , Michael Gerisch , Mark Jean Gnoth , Yolanda Cancho Grande , Mario Jeske , Kersten Matthias Gericke
发明人： Dirk Heimbach , Susanne Röhrig , Dirk Schneider , Ulrich Rester , Eckhard Bender , Mark Meininghaus , Katja Zimmermann , Dmitry Zubov , Anja Buchmüller , Georges Von Degenfeld , Christoph Gerdes , Michael Gerisch , Mark Jean Gnoth , Yolanda Cancho Grande , Mario Jeske , Kersten Matthias Gericke
IPC分类号： A61K31/445 , C07D401/00
CPC分类号： C07D413/04 , C07D413/14 , C07D417/14
摘要： The invention relates to novel heteroaryl-substituted piperidines, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular of cardiovascular diseases and tumor diseases.
摘要翻译： 本发明涉及新颖的杂芳基取代的哌啶，其制备方法，其用于治疗和/或预防疾病及其用于制备用于治疗和/或预防疾病，特别是心血管疾病的药物的用途 和肿瘤疾病。
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10.发明申请AMINOACYL PRODRUGS AS AN ACTIVE PHARMACEUTICAL INGREDIENT FOR THROMBOEMBOLIC DISORDERS 审中-公开作为血栓性疾病的活性药物成分的氨基酸制剂公开(公告)号：US20110172232A1
公开(公告)日：2011-07-14
申请号：US12668590
申请日：2008-06-28
申请人： Hans-Georg Lerchen , Ursula Krenz , Michael Härter , Mark Jean Gnoth , Georges Von Degenfeld , Elke Dittrich-Wengenroth , Anja Buchmüller , Susanne Röhrig , Swen Allerheiligen , Elisabeth Perzborn , Christoph Gerdes , Karl-Heinz Schlemmer , Metin Akbaba
发明人： Hans-Georg Lerchen , Ursula Krenz , Michael Härter , Mark Jean Gnoth , Georges Von Degenfeld , Elke Dittrich-Wengenroth , Anja Buchmüller , Susanne Röhrig , Swen Allerheiligen , Elisabeth Perzborn , Christoph Gerdes , Karl-Heinz Schlemmer , Metin Akbaba
IPC分类号： A61K31/5377 , C07D413/14 , A61P7/02
CPC分类号： C07D413/14
摘要： The present application relates to prodrug derivatives of 5-chloro-N-({(5S)-3-[2-fluoro-4-(3-oxomorpholin-4-yl)phenyl]-2-oxo-1,3-oxazolidin-5-yl}methyl)thiophene-2-carboxamide, processes for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, especially of thromboembolic disorders.
摘要翻译： 本申请涉及5-氯-N - （{（5S）-3- [2-氟-4-（3-氧代吗啉-4-基）苯基] -2-氧代-1,3-恶唑烷的前药衍生物 -5-基}甲基）噻吩-2-甲酰胺，其制备方法，其用于治疗和/或预防疾病的用途及其用于制备用于治疗和/或预防疾病的药物的用途，特别是 血栓栓塞性疾病
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