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    End sequence profiling
    1.
    发明授权
    End sequence profiling 有权
    结束序列分析

    公开(公告)号：US06785614B1

    公开(公告)日：2004-08-31

    申请号：US09586529

    申请日：2000-05-31

    申请人： Colin Collins ,  Stanislav Volik ,  Joe W. Gray

    发明人： Colin Collins ,  Stanislav Volik ,  Joe W. Gray

    IPC分类号： C12Q168

    CPC分类号： C12Q1/6869 ,  C12Q1/6827

    摘要： The present invention provides a novel method to identify rearrangements in a test genome, e.g., a tumor genome, when compared to a reference genome. This method provides major improvements over previous methods in terms of efficiency, rapidity, and cost-effectiveness. Briefly, this method involves generating or obtaining a large insert vector library from a test genome, sequencing the ends of the inserts in the library, and comparing the co-linearity of the sequenced ends in the library with corresponding sequences within a substantially-sequenced reference genome. This invention is useful for any of a number of applications, including for identifying rearrangements in tumor genomes and for determining genetic differences between closely related species as well as between different strains of the same species.

    摘要翻译： 当与参考基因组相比时，本发明提供了鉴定测试基因组例如肿瘤基因组中的重排的新方法。 这种方法在效率，快速性和成本效益方面提供了相对于先前方法的重大改进。 简而言之，该方法涉及从测试基因组产生或获得大的插入载体文库，对文库中插入片段的末端进行测序，并将文库中测序末端的共线性与基本测序的参考中的相应序列进行比较 基因组 本发明可用于许多应用中的任何一种，包括用于鉴定肿瘤基因组中的重排以及用于确定密切相关物种之间以及相同物种的不同菌株之间的遗传差异。

    DETECTING CYP24 EXPRESSION LEVEL AS A MARKER FOR PREDISPOSITION TO CANCER
    2.
    发明申请
    DETECTING CYP24 EXPRESSION LEVEL AS A MARKER FOR PREDISPOSITION TO CANCER 有权
    检测CYP24表达水平作为癌症预测标记

    公开(公告)号：US20120322674A1

    公开(公告)日：2012-12-20

    申请号：US13443639

    申请日：2012-04-10

    申请人： Donna G. Albertson ,  Daniel Pinkel ,  Colin Collins ,  Joe W. Gray ,  Bauke Ylstra

    发明人： Donna G. Albertson ,  Daniel Pinkel ,  Colin Collins ,  Joe W. Gray ,  Bauke Ylstra

    IPC分类号： C40B30/04 ,  C12N5/09 ,  C12Q1/26 ,  C40B30/06 ,  C12Q1/68 ,  G01N33/574

    CPC分类号： G01N33/5011 ,  C12Q1/48 ,  G01N33/57415 ,  G01N33/82

    摘要： This invention pertains to the discovery that an amplification of the CYP24 gene or an increase in CYP24 activity is a marker for the presence of, progression of, or predisposition to, a cancer (e.g., breast cancer). Using this information, this invention provides methods of detecting a predisposition to cancer in an animal. The methods involve (i) providing a biological sample from an animal (e.g. a human patient); (ii) detecting the level of CYP24 within the biological sample; and (iii) comparing the level of CYP24 with a level of CYP24 in a control sample taken from a normal, cancer-free tissue where an increased level of CYP24 in the biological sample compared to the level of CYP24 in the control sample indicates the presence of said cancer in said animal.

    摘要翻译： 本发明涉及以下发现：CYP24基因的扩增或CYP24活性的增加是癌症（例如乳腺癌）的存在，进展或倾向的标志物。 使用该信息，本发明提供了检测动物中癌症倾向的方法。 所述方法包括（i）从动物（例如人类患者）提供生物样品; （ii）检测生物样品中CYP24的水平; 和（iii）将CYP24的水平与来自正常的无癌组织的对照样品中的CYP24水平进行比较，其中生物样品中的CYP24水平与对照样品中的CYP24水平相比增加表明存在 的所述癌症。

    Detecting CYP24 expression level as a marker for predisposition to cancer
    5.
    发明授权
    Detecting CYP24 expression level as a marker for predisposition to cancer 有权
    检测CYP24表达水平作为癌症倾向的标志物

    公开(公告)号：US08685929B2

    公开(公告)日：2014-04-01

    申请号：US13443639

    申请日：2012-04-10

    申请人： Donna G. Albertson ,  Daniel Pinkel ,  Colin Collins ,  Joe W. Gray ,  Bauke Ylstra

    发明人： Donna G. Albertson ,  Daniel Pinkel ,  Colin Collins ,  Joe W. Gray ,  Bauke Ylstra

    IPC分类号： A01K61/00 ,  A61K31/00 ,  A61K38/00 ,  A61P35/00 ,  C12Q1/00 ,  C12Q1/68 ,  G01N1/00 ,  G01N21/75 ,  G01N33/00 ,  G01N33/48 ,  G01N33/567

    CPC分类号： G01N33/5011 ,  C12Q1/48 ,  G01N33/57415 ,  G01N33/82

    摘要： This invention pertains to the discovery that an amplification of the CYP24 gene or an increase in CYP24 activity is a marker for the presence of, progression of, or predisposition to, a cancer (e.g., breast cancer). Using this information, this invention provides methods of detecting a predisposition to cancer in an animal. The methods involve (i) providing a biological sample from an animal (e.g. a human patient); (ii) detecting the level of CYP24 within the biological sample; and (iii) comparing the level of CYP24 with a level of CYP24 in a control sample taken from a normal, cancer-free tissue where an increased level of CYP24 in the biological sample compared to the level of CYP24 in the control sample indicates the presence of said cancer in said animal.

    摘要翻译： 本发明涉及以下发现：CYP24基因的扩增或CYP24活性的增加是癌症（例如乳腺癌）的存在，进展或倾向的标志物。 使用该信息，本发明提供了检测动物中癌症倾向的方法。 所述方法包括（i）从动物（例如人类患者）提供生物样品; （ii）检测生物样品中CYP24的水平; 和（iii）将CYP24的水平与来自正常的无癌组织的对照样品中的CYP24水平进行比较，其中生物样品中的CYP24水平与对照样品中的CYP24水平相比增加表明存在 的所述癌症。

    DETECTING CYP24 EXPRESSION LEVEL AS A MARKER FOR PREDISPOSITION TO CANCER
    6.
    发明申请
    DETECTING CYP24 EXPRESSION LEVEL AS A MARKER FOR PREDISPOSITION TO CANCER 有权
    检测CYP24表达水平作为癌症预测标记

    公开(公告)号：US20100285023A1

    公开(公告)日：2010-11-11

    申请号：US12633643

    申请日：2009-12-08

    申请人： Donna G. Albertson ,  Daniel Pinkel ,  Colin Collins ,  Joe W. Gray ,  Bauke Ylstra

    发明人： Donna G. Albertson ,  Daniel Pinkel ,  Colin Collins ,  Joe W. Gray ,  Bauke Ylstra

    IPC分类号： A61K39/395 ,  A61K48/00 ,  A61P35/00

    CPC分类号： G01N33/5011 ,  C12Q1/48 ,  G01N33/57415 ,  G01N33/82

    摘要： This invention pertains to the discovery that an amplification of the CYP24 gene or an increase in CYP24 activity is a marker for the presence of, progression of, or predisposition to, a cancer (e.g., breast cancer). Using this information, this invention provides methods of detecting a predisposition to cancer in an animal. The methods involve (i) providing a biological sample from an animal (e.g. a human patient); (ii) detecting the level of CYP24 within the biological sample; and (iii) comparing the level of CYP24 with a level of CYP24 in a control sample taken from a normal, cancer-free tissue where an increased level of CYP24 in the biological sample compared to the level of CYP24 in the control sample indicates the presence of said cancer in said animal.

    摘要翻译： 本发明涉及以下发现：CYP24基因的扩增或CYP24活性的增加是癌症（例如乳腺癌）的存在，进展或倾向的标志物。 使用该信息，本发明提供了检测动物中癌症倾向的方法。 所述方法包括（i）从动物（例如人类患者）提供生物样品; （ii）检测生物样品中CYP24的水平; 和（iii）将CYP24的水平与来自正常的无癌组织的对照样品中的CYP24水平进行比较，其中生物样品中的CYP24水平与对照样品中的CYP24水平相比增加表明存在 的所述癌症。

    Detecting CYP24 expression level as a marker for predisposition to cancer
    7.
    发明授权
    Detecting CYP24 expression level as a marker for predisposition to cancer 有权
    检测CYP24表达水平作为癌症倾向的标志物

    公开(公告)号：US08173602B2

    公开(公告)日：2012-05-08

    申请号：US12633643

    申请日：2009-12-08

    申请人： Donna G. Albertson ,  Daniel Pinkel ,  Colin Collins ,  Joe W. Gray ,  Bauke Ylstra

    发明人： Donna G. Albertson ,  Daniel Pinkel ,  Colin Collins ,  Joe W. Gray ,  Bauke Ylstra

    IPC分类号： A01N61/00 ,  A61K31/00 ,  A61K38/00 ,  A61P35/00 ,  C12Q1/00 ,  C12Q1/68 ,  C12Q19/30 ,  G01N1/00 ,  G01N21/75 ,  G01N33/00 ,  G01N33/48 ,  G01N33/567

    CPC分类号： G01N33/5011 ,  C12Q1/48 ,  G01N33/57415 ,  G01N33/82

    摘要： This invention pertains to the discovery that an amplification of the CYP24 gene or an increase in CYP24 activity is a marker for the presence of, progression of, or predisposition to, a cancer (e.g., breast cancer). Using this information, this invention provides methods of detecting a predisposition to cancer in an animal. The methods involve (i) providing a biological sample from an animal (e.g. a human patient); (ii) detecting the level of CYP24 within the biological sample; and (iii) comparing the level of CYP24 with a level of CYP24 in a control sample taken from a normal, cancer-free tissue where an increased level of CYP24 in the biological sample compared to the level of CYP24 in the control sample indicates the presence of said cancer in said animal.

    摘要翻译： 本发明涉及以下发现：CYP24基因的扩增或CYP24活性的增加是癌症（例如乳腺癌）的存在，进展或倾向的标志物。 使用该信息，本发明提供了检测动物中癌症倾向的方法。 所述方法包括（i）从动物（例如人类患者）提供生物样品; （ii）检测生物样品中CYP24的水平; 和（iii）将CYP24的水平与来自正常的无癌组织的对照样品中的CYP24水平进行比较，其中生物样品中的CYP24水平与对照样品中的CYP24水平相比增加表明存在 的所述癌症。

    Detecting CYP24 expression level as a marker for predisposition to cancer
    8.
    发明授权
    Detecting CYP24 expression level as a marker for predisposition to cancer 有权
    检测CYP24表达水平作为癌症倾向的标志物

    公开(公告)号：US07648826B1

    公开(公告)日：2010-01-19

    申请号：US09285292

    申请日：1999-04-02

    申请人： Donna G. Albertson ,  Daniel Pinkel ,  Colin Collins ,  Joe W. Gray ,  Bauke Ystra

    发明人： Donna G. Albertson ,  Daniel Pinkel ,  Colin Collins ,  Joe W. Gray ,  Bauke Ystra

    IPC分类号： C12Q1/00 ,  C12Q1/68 ,  C12Q19/30 ,  G01N33/567 ,  G01N33/00 ,  G01N33/48 ,  G01N21/75 ,  G01N1/00 ,  A61K38/00

    CPC分类号： G01N33/5011 ,  C12Q1/48 ,  G01N33/57415 ,  G01N33/82

    摘要： This invention pertains to the discovery that an amplification of the CYP24 gene or an increase in CYP24 activity is a marker for the presence of, progression of, or predisposition to, a cancer (e.g., breast cancer). Using this information, this invention provides methods of detecting a predisposition to cancer in an animal. The methods involve (i) providing a biological sample from an animal (e.g. a human patient); (ii) detecting the level of CYP24 within the biological sample; and (iii) comparing the level of CYP24 with a level of CYP24 in a control sample taken from a normal, cancer-free tissue where an increased level of CYP24 in the biological sample compared to the level of CYP24 in the control sample indicates the presence of said cancer in said animal.

    摘要翻译： 本发明涉及以下发现：CYP24基因的扩增或CYP24活性的增加是癌症（例如乳腺癌）的存在，进展或倾向的标志物。 使用该信息，本发明提供了检测动物中癌症倾向的方法。 所述方法包括（i）从动物（例如人类患者）提供生物样品; （ii）检测生物样品中CYP24的水平; 和（iii）将CYP24的水平与来自正常的无癌组织的对照样品中的CYP24水平进行比较，其中生物样品中的CYP24水平与对照样品中的CYP24水平相比增加表明存在 的所述癌症。