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公开(公告)号：US5614496A
公开(公告)日：1997-03-25
申请号：US458634
申请日：1995-06-02
IPC分类号： G01B21/20 , A61K38/00 , A61K38/18 , A61K38/22 , A61K45/00 , A61P1/02 , A61P5/00 , A61P19/08 , A61P19/10 , A61P43/00 , C07K14/50 , C12P21/02 , G01N21/35 , G01N21/85 , G01N33/10 , A61K38/16 , C07K14/475
CPC分类号： C07K14/501 , A61K38/1825 , C07K14/50 , G01N21/85 , G01N33/10 , Y10S530/84
摘要： The present invention provides therapeutic compositions for the prevention and treatment of pathological conditions involving bone and dental tissue. The present invention also provides a method to promote bone repair and/or growth for the treatment of pathological conditions involving bone tissue, for example, osteoporosis, Paget's disease, osteopetrosis, and periodontal disease and fracture repair, and healing of bone defects by administering FGF-1 to an animal or human in need of treatment.
摘要翻译： 本发明提供了用于预防和治疗涉及骨和牙齿组织的病理状况的治疗组合物。 本发明还提供一种促进骨修复和/或生长的方法，用于治疗涉及骨组织的病理状况，例如骨质疏松症，佩吉特氏病，骨硬化症，牙周病和骨折修复，以及通过施用FGF来治疗骨缺损 -1给需要治疗的动物或人类。
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公开(公告)号：US5656598A
公开(公告)日：1997-08-12
申请号：US454964
申请日：1995-05-31
IPC分类号： C12P21/02 , A61K38/00 , A61K38/18 , A61K38/22 , A61K45/00 , A61K47/36 , A61K47/42 , A61P1/02 , A61P3/02 , A61P5/00 , A61P19/10 , A61P43/00 , C07K14/50 , C07K14/475
CPC分类号： C07K14/50 , A61K38/1825 , A61K9/0019 , A61K9/0063 , A61L27/227 , A61L27/54 , C07K14/501 , A61K9/08 , A61L2300/414 , A61L2430/02 , Y10S530/84
摘要： The present invention provides therapeutic compositions for the prevention and treatment of pathological conditions involving bone and dental tissue. The present invention also provides a method to promote bone repair and/or growth for the treatment of pathological conditions involving bone tissue, for example, osteoporosis, Paget's disease, osteopetrosis, and periodontal disease and fracture repair, and healing of bone defects by administering FGF-1 to an animal or human in need of such treatment.
摘要翻译： 本发明提供了用于预防和治疗涉及骨和牙齿组织的病理状况的治疗组合物。 本发明还提供一种促进骨修复和/或生长的方法，用于治疗涉及骨组织的病理状况，例如骨质疏松症，佩吉特氏病，骨硬化症，牙周病和骨折修复，以及通过施用FGF来治疗骨缺损 -1给需要这种治疗的动物或人类。
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公开(公告)号：US5408041A
公开(公告)日：1995-04-18
申请号：US180572
申请日：1994-01-13
申请人： Gregory R. Mundy , Gloria E. Gutierrez , Ian R. Garrett , Massimo Sabatini , Elzbieta Izbicka , Wilson Burgess , Gregg R. Crumley , Clarence C. Morse , Timothy R. Arnett
发明人： Gregory R. Mundy , Gloria E. Gutierrez , Ian R. Garrett , Massimo Sabatini , Elzbieta Izbicka , Wilson Burgess , Gregg R. Crumley , Clarence C. Morse , Timothy R. Arnett
IPC分类号： C12N15/09 , A61K35/32 , A61K38/00 , A61K38/22 , A61K39/395 , A61P3/00 , A61P43/00 , C07K1/16 , C07K1/20 , C07K1/22 , C07K14/51 , C07K14/65 , C07K16/00 , C07K16/22 , C12P21/02 , C07K1/00 , C07K3/00 , C07K15/00
摘要： The present invention relates to the development of bone growth factors as therapeutics for the prevention and treatment of pathological conditions involving bone tissue. The present invention provides biologically active proteinaceous factors comprising polypeptides containing the amino acid sequence M-A-G-L-G-D-E-F-G-D, [SEQ ID NO: 1], (X) F E T L F G A/V E D V I/D A L Q F V C G D, [SEQ ID NO: 2], or A-Y-I-P-I-E-T-L-E-G-I/G-E-L-V-D/Q-T-G/L-Q-F, [SEQ ID NO: 3], or biologically active fragments or sequence analogues thereof. Among the biological properties of the proteinaceous materials of the present invention is the capability to promote the growth and/or differentiation of osteoblastic cells.
摘要翻译： 本发明涉及作为预防和治疗涉及骨组织的病理状况的治疗剂的骨生长因子的发展。 本发明提供包含含有氨基酸序列MAGLGDEFGD，[SEQ ID NO：1]，（X）FETLFGA / VEDVI / DALQFVCGD，[SEQ ID NO：2]或AYIPIETLEGI / GELVD / QTG / LQF的多肽的生物活性蛋白质因子 ，[SEQ ID NO：3]或其生物活性片段或序列类似物。 本发明的蛋白质材料的生物学特性是促进成骨细胞生长和/或分化的能力。
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4.发明申请公开(公告)号：US20140024553A1
公开(公告)日：2014-01-23
申请号：US13988262
申请日：2012-04-30
IPC分类号： G01N33/574 , G06F19/00
CPC分类号： G01N33/57423 , G01N2800/60 , G06F19/00 , G16H50/20 , G16H50/70
摘要： The invention provides biomarkers and combinations of biomarkers useful in diagnosing lung diseases such as non-smail cell lung cancer or reactive airway disease. Measurements of these biomarkers are inputted into a classification system such as a support vector machine or AdaBoost to assist in determining the likelihood that an individual has a lung disease. Kits comprising agents for detecting the biomarkers and combination of biomarkers, as well as systems that assist in diagnosing lung diseases are also provided.
摘要翻译： 本发明提供了可用于诊断肺部疾病如非致病细胞肺癌或反应性气道疾病的生物标志物和生物标志物的组合。 将这些生物标志物的测量输入到诸如支持向量机或AdaBoost的分类系统中，以帮助确定个体患有肺部疾病的可能性。 还提供了包含用于检测生物标志物和生物标志物的组合的试剂盒以及有助于诊断肺部疾病的系统。
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5.发明申请METHOD OF UTILIZING AZELAIC ACID ESTERS TO MODULATE COMMUNICATIONS MEDIATED BY BIOLOGICAL MOLECULES 审中-公开利用氨基酸酯酶调节生物分子介导通讯的方法公开(公告)号：US20120251525A1
公开(公告)日：2012-10-04
申请号：US13449804
申请日：2012-04-18
IPC分类号： A61K31/23 , A61P37/02 , A61P35/00 , A61P25/00 , A61P9/10 , A61P17/10 , A61P31/04 , A61P3/00 , A61P29/00 , A61K39/395 , A61P31/12
CPC分类号： A61K31/23 , Y02A50/409 , Y02A50/411 , Y02A50/423 , Y02A50/463 , Y02A50/471
摘要： The treatment of disease in organisms using Macromolecular interaction modulators and Membrane active immunomodulators, particularly selected azelaic acid esters, individually and in combinations, to modulate communications between biological molecules.
摘要翻译： 使用大分子相互作用调节剂和膜活性免疫调节剂（特别是所选择的壬二酸酯）单独和组合地治疗生物体内的疾病，以调节生物分子之间的通信。
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6.发明申请Azelaic acid ester compositions and methods for diagnosing and treating tissue conditions using azelaic acid ester compositions and proteinaceous biomarkers 审中-公开壬二酸酯组合物和使用壬二酸酯组合物和蛋白质生物标志物诊断和处理组织条件的方法公开(公告)号：US20090326069A1
公开(公告)日：2009-12-31
申请号：US12459338
申请日：2009-06-30
IPC分类号： A61K31/225 , C07C69/48 , A61P29/00
CPC分类号： A61K31/225
摘要： Therapeutic and cosmetic treatments are performed through the application of azelaic acid ester compositions to patients suffering from or exhibiting tissue inflammation. The diagnosis, characterization and treatment of a patient suffering from or exhibiting tissue inflammation may be enhanced by using selected proteinaceous biomarkers obtained from analysis of said markers by means of multiplexed immunoassay and comparison to the biomarker levels of healthy tissue.
摘要翻译： 通过将壬二酸酯组合物施用于患有或显示组织炎症的患者进行治疗和美容治疗。 可以通过多次免疫测定和与健康组织的生物标志物水平的比较，通过使用从所述标记物的分析获得的所选择的蛋白质生物标志物来增强患有或表现组织炎症的患者的诊断，表征和治疗。
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7.发明申请Method of Identifying Biomarkers in Human Serum Indicative of Pathologies of Human Lung Tissues 有权识别人类血清中生物标志物的方法，指示人类肺组织的病理学公开(公告)号：US20090068685A1
公开(公告)日：2009-03-12
申请号：US12208437
申请日：2008-09-11
IPC分类号： G01N33/574 , G01N33/567
CPC分类号： G01N33/57423
摘要： A method of identifying altered biomarker expression levels in a human serum specimen to diagnose asthma or non-small celled lung cancers in humans. The existence of asthma or non-small celled lung cancers in a patient can be determined by subjecting a blood sample from the patient to a simple blood test to determine the expression levels of certain specific biomarkers. The expression levels of the specific biomarkers are compared to ranges of expression levels for the same biomarkers which are indicative of individuals known to have asthma, non-small cell lung cancers, or neither. Comparing the expression levels will determine the existence or non-existence of asthma or non-small cell lung cancer.
摘要翻译： 识别人血清标本中改变的生物标志物表达水平以诊断人类哮喘或非小细胞肺癌的方法。 可以通过使来自患者的血液样品进行简单的血液测试来确定某些特定生物标志物的表达水平来确定患者中哮喘或非小细胞肺癌的存在。 将特异性生物标志物的表达水平与指示已知具有哮喘，非小细胞肺癌或两者的个体的相同生物标志物的表达水平范围进行比较。 比较表达水平将决定哮喘或非小细胞肺癌的存在或不存在。
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8.发明申请公开(公告)号：US20190072554A1
公开(公告)日：2019-03-07
申请号：US15961307
申请日：2018-04-24
IPC分类号： G01N33/574 , G16H50/20 , G16H50/70 , G06F19/00
摘要： The invention provides biomarkers and combinations of biomarkers useful in diagnosing lung diseases such as non-small cell lung cancer or reactive airway disease. Measurements of these biomarkers are inputted into a classification system such as a support vector machine or AdaBoost to assist in determining the likelihood that an individual has a lung disease. Kits comprising agents for detecting the biomarkers and combination of biomarkers, as well as systems that assist in diagnosing lung diseases are also provided.
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公开(公告)号：US09952220B2
公开(公告)日：2018-04-24
申请号：US13988262
申请日：2012-04-30
IPC分类号： G01N33/574 , G16H50/20 , G16H50/70
CPC分类号： G01N33/57423 , G01N2800/60 , G06F19/00 , G16H50/20 , G16H50/70
摘要： The invention provides biomarkers and combinations of biomarkers useful in diagnosing lung diseases such as non-small cell lung cancer or reactive airway disease. Measurements of these biomarkers are inputted into a classification system such as a support vector machine or AdaBoost to assist in determining the likelihood that an individual has a lung disease. Kits comprising agents for detecting the biomarkers and combination of biomarkers, as well as systems that assist in diagnosing lung diseases are also provided.
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10.发明申请METHOD OF UTILIZING AZELAIC ACID ESTERS TO MODULATE COMMUNICATIONS MEDIATED BY BIOLOGICAL MOLECULES 审中-公开利用氨基酸酯酶调节生物分子介导通讯的方法公开(公告)号：US20140094516A1
公开(公告)日：2014-04-03
申请号：US14097854
申请日：2013-12-05
IPC分类号： A61K31/23
CPC分类号： A61K31/23 , Y02A50/409 , Y02A50/411 , Y02A50/423 , Y02A50/463 , Y02A50/471
摘要： The treatment of disease in organisms using Macromolecular interaction modulators and Membrane active immunomodulators, particularly selected azelaic acid esters, individually and in combinations, to modulate communications between biological molecules.
摘要翻译： 使用大分子相互作用调节剂和膜活性免疫调节剂（特别是所选择的壬二酸酯）单独和组合地治疗生物体内的疾病，以调节生物分子之间的通信。
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