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公开(公告)号：US20200350090A1
公开(公告)日：2020-11-05
申请号：US16930967
申请日：2020-07-16
摘要： An X-ray system for providing a converging X-rays comprises: (a) an X-ray source having an optical axis thereof; and an X-ray lens comprising at least one ring having a Bragg reflecting surface formed by a plurality of single-crystal tiles. Each tile individually comprises an adjusting arrangement enabling a tridimensional individual displacement thereof in angular and translational manner.
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公开(公告)号：US09586061B2
公开(公告)日：2017-03-07
申请号：US14457250
申请日：2014-08-12
申请人： CONVERGENT R.N.R LTD
发明人： Zeev Burshtein , Zeev Harel , Aharon Bar-David , Donald M. Korn
CPC分类号： A61N5/1049 , A61B6/06 , A61B6/4021 , A61B6/4035 , A61B6/483 , A61N5/1065 , A61N5/1077 , A61N5/1084 , A61N2005/1054 , A61N2005/1061 , A61N2005/1091 , A61N2005/1095 , G21K1/04 , G21K1/065 , G21K1/067 , G21K2201/064 , H05G1/70
摘要： An X-ray system comprises: (a) a source providing an X-ray diverging beam having treatment and imaging angular portions; (b) one or more lenses transforming the treatment portion of the X-ray beam into a converging beam directed to a target; (c) a first shutter located between the X-ray source and the target in the imaging portion of the X-ray radiation; the first shutter being selectively openable such that imaging portion of X-ray beam reaches the target; and (d) a detector configured to detect at least a portion of the imaging radiation after the imaging radiation has interacted with the target to provide imaging information of the target.
摘要翻译： X射线系统包括：（a）提供具有处理和成像角部分的X射线发散光束的光源; （b）一个或多个透镜将X射线束的处理部分转换成指向靶的会聚光束; （c）在X射线辐射的成像部分中位于X射线源和靶之间的第一快门; 所述第一挡板选择性地可打开，使得X射线束的成像部分到达所述目标; 以及（d）检测器，被配置为在所述成像辐射已经与所述目标物体相互作用之后检测所述成像辐射的至少一部分，以提供所述目标的成像信息。
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公开(公告)号：US12109439B2
公开(公告)日：2024-10-08
申请号：US17166064
申请日：2021-02-03
IPC分类号： A61N5/10
CPC分类号： A61N5/1075 , A61N5/1065 , A61N2005/1076 , A61N2005/1085
摘要： A method of a radiotherapy or radiosurgery treatment comprises steps of: (a) providing a converging x-ray beam source configured for emitting a converging X-ray beam propagating along an axis thereof; (b) emitting the converging x-ray beam towards a volume of treatment (VOT) having a length along the axis of the converging X-ray beam ranging between 2 mm and 5 cm within a patient's body such that a waist portion is within the VOT; (c) propagating the beam through tissues previously located relative to the VOT (PO); the VOT per se and tissues distally located to the VOT (DO). The converging X-ray beam characterized by a convergent angle ranging between 2 and 30 degrees providing 80% to 100% of a maximum dose is received by the VOT and less than 60% of the maximum dose is received by the PO and the DO.
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公开(公告)号：US10265510B2
公开(公告)日：2019-04-23
申请号：US15503006
申请日：2015-08-12
申请人： CONVERGENT R.N.R LTD
发明人： Zeev Harel , Zeev Burshtein , Aharon Bar-David , Miri Markovich
摘要： The present invention provides a method for activating a pro-drug in vivo comprising the steps of: (a) administering a pro-drag to a subject; (b) locating a target site which has been at least partially dosed with the pro-drug at a predetermined concentration; and (d) exposing the target site to X-ray radiation. The step of exposing the target site to X-ray radiation is characterized by providing a converging X-ray of a controllable waist, substantially uniform at the target site, sufficient to convert the pro-drug to an active drug, while the X-ray photon dosage at the target site is higher than the X-ray photon dosage at an adjacent non target site.
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公开(公告)号：US20150248942A1
公开(公告)日：2015-09-03
申请号：US14430683
申请日：2013-09-01
发明人： Aharon Bar-David , Zeev Burshtein , Zeev Harel
IPC分类号： G21K1/06
CPC分类号： G21K1/062 , A61N5/1042 , A61N5/1084 , A61N2005/1091 , A61N2005/1095 , G21K5/04 , G21K2201/064
摘要： An X-ray lens arrangement for forming a radiation pattern as a focal track is disclosed. The pattern comprises at least one 3-dimensional focal track of radiation. The aforesaid lens arrangement has a main axis passing through intensity weighted centroids of the X-ray source and the pattern. The lens arrangement includes at least one reflecting surface of continuously varying Rowland arcs. Each point belonging to the focal track is linked to each elemental point composing an emitting surface of said source by a corresponding Rowland arc.
摘要翻译： 公开了一种用于形成辐射图案作为焦点轨迹的X射线透镜装置。 该图案包括至少一个辐射的三维焦点轨迹。 上述透镜装置具有通过X射线源的强度加权质心和图案的主轴。 透镜装置包括连续变化的罗兰弧的至少一个反射表面。 属于焦点轨迹的每个点通过相应的罗兰弧连接到构成所述源的发射表面的每个元素点。
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公开(公告)号：US09953735B2
公开(公告)日：2018-04-24
申请号：US14430683
申请日：2013-09-01
申请人： CONVERGENT R.N.R LTD
发明人： Aharon Bar-David , Zeev Burshtein , Zeev Harel
CPC分类号： G21K1/062 , A61N5/1042 , A61N5/1084 , A61N2005/1091 , A61N2005/1095 , G21K5/04 , G21K2201/064
摘要： An X-ray lens arrangement for forming a radiation pattern as a focal track is disclosed. The pattern comprises at least one 3-dimensional focal track of radiation. The aforesaid lens arrangement has a main axis passing through intensity weighted centroids of the X-ray source and the pattern. The lens arrangement includes at least one reflecting surface of continuously varying Rowland arcs. Each point belonging to the focal track is linked to each elemental point composing an emitting surface of said source by a corresponding Rowland arc.
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公开(公告)号：US11972875B2
公开(公告)日：2024-04-30
申请号：US17762477
申请日：2020-09-23
CPC分类号： G21K1/06 , B23H7/02 , B23H9/008 , G21K2201/062
摘要： A method of manufacturing burr-edged reflecting tile elements for a mosaic X-ray lens configured for forming an X-ray beam comprises steps of: (a) providing a single crystal having first and second faces thereof being parallel therebetween; single crystal having crystallographic planes thereof being parallel to first and second faces of the single crystal; the first face dedicated for reflecting an X-ray beam to be incident thereto; (b) cutting the single crystal by means of a wire electrical discharging machine normally to the main faces. The step of cutting the single crystal comprises moving a wire within a cut in direction from the second face to the first face; such that burrs configured for reflecting the X-ray beam to be incident thereto are formed on edges of the cut.
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公开(公告)号：US11364392B2
公开(公告)日：2022-06-21
申请号：US17071098
申请日：2020-10-15
发明人： Aharon Bar-David , Michael Kleckner , Shirly Borukhin , Zeev Burshtein , Avigail Keller , Zeev Harel
IPC分类号： A61N5/10
摘要： A method of evaluating a maximal dose deposited by a non-uniform X-ray beam within a medium comprising the steps of: (a) irradiating said medium by said non-uniform X-ray beam penetrating into a depth of said medium along an axis of said X-ray beam; (b) incrementally measuring a number of transversal dose distributions at successive depths along said axis; (c) determining a maximum dose within each of said number of transversal dose distributions; and (d) calculating a 1-Dimensional depth dependence of said maximal doses obtained from said number of transversal dose distributions.
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公开(公告)号：US11250968B2
公开(公告)日：2022-02-15
申请号：US16930967
申请日：2020-07-16
摘要： An X-ray system for providing a converging X-rays comprises: (a) an X-ray source having an optical axis thereof; and an X-ray lens comprising at least one ring having a Bragg reflecting surface formed by a plurality of single-crystal tiles. Each tile individually comprises an adjusting arrangement enabling a tridimensional individual displacement thereof in angular and translational manner.
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公开(公告)号：US10099068B2
公开(公告)日：2018-10-16
申请号：US15414634
申请日：2017-01-25
申请人： CONVERGENT R.N.R LTD
发明人： Zeev Burshtein , Zeev Harel , Aharon Bar-David , Donald M. Korn
摘要： An X-ray system comprises: a source of an X-ray diverging beam having a central imaging portion and a peripheral treatment-portion; a lens transforming the peripheral treatment portion of the X-ray beam into a converging beam directed to a target; a shutter located between the X-ray source and the target in the central imaging portion of the X-ray radiation; and a detector of imaging radiation after interaction with the target and to provide imaging information of the target.
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