利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

27 条记录 (耗时 0.027 秒)

    Clavanins
    6.
    发明授权
    Clavanins 失效
    克拉夫人

    公开(公告)号：US6040293A

    公开(公告)日：2000-03-21

    申请号：US810324

    申请日：1997-02-28

    申请人： Robert I. Lehrer ,  Chengquan Zhao ,  In-Hee Lee

    发明人： Robert I. Lehrer ,  Chengquan Zhao ,  In-Hee Lee

    IPC分类号： A61K38/00 ,  C07K14/435 ,  C12N1/21 ,  C12N15/12 ,  C07K14/00 ,  A61K37/02

    CPC分类号： C07K14/43504 ,  A61K38/00

    摘要： Novel microbial peptides called clavanins are of the formula[X'.sub.1 X.sub.2 B'.sub.3 X.sub.4 X.sub.5 ]U.sub.6 B.sub.7 X.sub.8 X.sub.9 B.sub.10 B.sub.11 X.sub.12 U.sub.13 Z.sub.14 X.sub.15 X.sub.16 B*.sub.17 U.sub.18 X.sub.19 U.sub.20 B.sub.21 X.sub.22 X.sub.23 ( 1)(SEQ ID NO:1)including the salts, esters, amides and acylated forms thereofwherein X is a hydrophobic amino acid residue or modified form thereof;X' is a small or a hydrophobic amino acid residue or a modified form thereof;B is a basic amino acid residue or modified form thereof;B' is basic or a polar/large amino acid residue or modified form thereof; andB* is a basic or a hydrophobic amino acid residue or a modified form thereof;U is a small amino acid residue or modified form thereof;Z is a polar/large amino acid residue or modified form thereof, and wherein 1-5 amino acids is deleted from the N-terminus.

    摘要翻译： 称为克拉维宁的新型微生物肽具有式[X'1X2B'3X4X5] U6B7X8X9B10B11X12U13Z14X15X16B * 17U18X19U20B21X22X23（1）（1）（SEQ ID NO：1），其包括其盐，酯，酰胺和酰化形式，其中X是疏水性氨基酸残基或经修饰 形式; X'是小或疏水性氨基酸残基或其修饰形式; B是碱性氨基酸残基或其修饰形式; B'是碱性或极性/大氨基酸残基或其修饰形式; B *是碱性或疏水性氨基酸残基或其修饰形式; U是小氨基酸残基或其修饰形式; Z是极性/大的氨基酸残基或其修饰形式，其中1-5个氨基酸从N-末端缺失。

    Retrocyclins: antiviral and antimicrobial peptides
    9.
    发明授权
    Retrocyclins: antiviral and antimicrobial peptides 有权
    逆转录酶：抗病毒和抗菌肽

    公开(公告)号：US06713078B2

    公开(公告)日：2004-03-30

    申请号：US10141645

    申请日：2002-05-06

    申请人： Robert I. Lehrer ,  Alan J. Waring ,  Alexander M. Cole ,  Teresa B. Hong

    发明人： Robert I. Lehrer ,  Alan J. Waring ,  Alexander M. Cole ,  Teresa B. Hong

    IPC分类号： A01N2500

    CPC分类号： C07K14/4723 ,  A61K38/00 ,  C07K7/64

    摘要： Retrocyclin peptides are small antimicrobial agents with potent activity against bacteria and viruses. The peptides are nonhemolytic, and exhibit minimal in vitro cytotoxicity. A pharmaceutical composition comprising retrocyclin as an active agent is administered therapeutically to a patient suffering from a bacterial and/or viral infection, or to an individual facing exposure to a bacterial and/or viral infection, especially one caused by the HIV-1 retrovirus or other sexually-transmitted pathogens.

    摘要翻译： 逆转录肽是针对细菌和病毒的有效活性的小抗微生物剂。 肽是非溶血性的，并且表现出最小的体外细胞毒性。 包含逆转录酶作为活性剂的药物组合物治疗性地给予患有细菌和/或病毒感染的患者或面临暴露于细菌和/或病毒感染的个体，特别是由HIV-1逆转录病毒或 其他性传播病原体。

    Novispirins: antimicrobial peptides
    10.
    发明授权
    Novispirins: antimicrobial peptides 有权

    公开(公告)号：US06492328B2

    公开(公告)日：2002-12-10

    申请号：US09840009

    申请日：2001-04-19

    申请人： Robert I. Lehrer ,  Alan J. Waring ,  Brian F. Tack

    发明人： Robert I. Lehrer ,  Alan J. Waring ,  Brian F. Tack

    IPC分类号： A61K3800

    CPC分类号： C07K7/08 ,  A61K38/00 ,  Y02A50/473

    摘要： Novispirin peptides are antimicrobial agents with potent activity against Gram-negative bacteria. The peptides are nonhemolytic, exhibit reduced in vitro cytotoxicity relative to other antimicrobial peptides, and were well-tolerated in vivo after intravenous injection. Novispirins also bind lipopolysaccharide (LPS), a property that may mitigate symptoms associated with Gram-negative bacterial infection. A pharmaceutical composition comprising novispirin as an active agent is administered to a patient suffering from or predisposed to a microbial infection, particularly Gram-negative bacterial infections.