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公开(公告)号：US20130266929A1
公开(公告)日：2013-10-10
申请号：US13858890
申请日：2013-04-08
申请人： CORSOLUTIONS LLC
IPC分类号： C12M1/36
摘要： An apparatus, system and method providing a fluid flow suitable to grow and maintain living cells in the fluid flow are disclosed. The apparatus includes a fluid displacement apparatus capable of providing at least one of positive and negative displacement of the fluid and configured to indirectly displace the fluid, an in-line flow sensor configured to directly measure the fluid flow, and a feed-back control in communication with the fluid displacement apparatus and the in-line flow sensor, wherein the feed-back control is configured to continuously control the fluid flow in response to the flow sensor measurements.
摘要翻译： 公开了一种提供适于在流体流中生长和维持活细胞的流体流的装置，系统和方法。 该装置包括能够提供流体的正位移和负位移中的至少一个并被配置为间接地移动流体的流体位移设备，配置成直接测量流体流的直列流量传感器，以及反馈控制 与流体位移设备和在线流量传感器的通信，其中反馈控制被配置为响应于流量传感器测量来连续地控制流体流动。
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公开(公告)号：US11187627B2
公开(公告)日：2021-11-30
申请号：US15494060
申请日：2017-04-21
申请人： CorSolutions LLC
摘要： A fluid sampler system includes a fluidic head including a gas aperture capable of communication with a pressurized gas source, a liquid conduit capable of communication with a sample reservoir, and a seal capable of forming a compression seal to the sample reservoir when gas pressure is applied to the sample reservoir through the gas aperture and capable of displacing a portion of the sample through the liquid conduit; and a positioning apparatus capable of positioning the fluidic head and the sample reservoir in communication with one another. A method for providing an aliquot of sample, includes forming a releasable compression seal to a reservoir including a liquid sample; pressurizing the reservoir with compressed gas; displacing an aliquot of the sample from the reservoir; and transferring the displaced aliquot of the sample to a location.
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公开(公告)号：US20150025461A1
公开(公告)日：2015-01-22
申请号：US14334237
申请日：2014-07-17
申请人： CorSolutions LLC
CPC分类号： F04B49/22 , A61M5/14216 , A61M5/14276 , A61M2205/0244 , F04B19/006 , F04B53/001
摘要： A system for the precise metering and delivery of discrete volumes is described. The system is composed of inexpensive components that can be easily assembled, allowing for cost-effective manufacturing of the system. The system can precisely meter and deliver fluids, solids in particulate or powder form, or alternatively it could mix discrete amounts of fluid and solid. Potential applications for the system and microfluidic device include subcutaneous, long-term, automated drug delivery, such as insulin for diabetics.
摘要翻译： 描述了用于精确计量和传送离散体积的系统。 该系统由易于组装的廉价组件组成，允许对系统进行成本有效的制造。 该系统可以精确地计量和输送流体，颗粒或粉末形式的固体，或者可以混合不同量的流体和固体。 用于系统和微流体装置的潜在应用包括皮下，长期，自动化的药物递送，例如糖尿病患者的胰岛素。
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公开(公告)号：US11815438B2
公开(公告)日：2023-11-14
申请号：US17520324
申请日：2021-11-05
申请人： CorSolutions LLC
CPC分类号： G01N1/14 , G01N35/08 , B01L3/0293 , B01L2400/0487 , G01N35/1016 , G01N2001/1427 , G01N2001/1445
摘要： A fluid sampler system includes a fluidic head including a gas aperture capable of communication with a pressurized gas source, a liquid conduit capable of communication with a sample reservoir, and a seal capable of forming a compression seal to the sample reservoir when gas pressure is applied to the sample reservoir through the gas aperture and capable of displacing a portion of the sample through the liquid conduit; and a positioning apparatus capable of positioning the fluidic head and the sample reservoir in communication with one another. A method for providing an aliquot of sample, includes forming a releasable compression seal to a reservoir including a liquid sample; pressurizing the reservoir with compressed gas; displacing an aliquot of the sample from the reservoir; and transferring the displaced aliquot of the sample to a location.
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公开(公告)号：US10174280B2
公开(公告)日：2019-01-08
申请号：US13858890
申请日：2013-04-08
申请人： CorSolutions LLC
摘要： An apparatus, system and method providing a fluid flow suitable to grow and maintain living cells in the fluid flow are disclosed. The apparatus includes a fluid displacement apparatus capable of providing at least one of positive and negative displacement of the fluid and configured to indirectly displace the fluid, an in-line flow sensor configured to directly measure the fluid flow, and a feed-back control in communication with the fluid displacement apparatus and the in-line flow sensor, wherein the feed-back control is configured to continuously control the fluid flow in response to the flow sensor measurements.
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公开(公告)号：US20220057301A1
公开(公告)日：2022-02-24
申请号：US17520324
申请日：2021-11-05
申请人： CorSolutions LLC
摘要： A fluid sampler system includes a fluidic head including a gas aperture capable of communication with a pressurized gas source, a liquid conduit capable of communication with a sample reservoir, and a seal capable of forming a compression seal to the sample reservoir when gas pressure is applied to the sample reservoir through the gas aperture and capable of displacing a portion of the sample through the liquid conduit; and a positioning apparatus capable of positioning the fluidic head and the sample reservoir in communication with one another. A method for providing an aliquot of sample, includes forming a releasable compression seal to a reservoir including a liquid sample; pressurizing the reservoir with compressed gas; displacing an aliquot of the sample from the reservoir; and transferring the displaced aliquot of the sample to a location.
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公开(公告)号：US20170307482A1
公开(公告)日：2017-10-26
申请号：US15494060
申请日：2017-04-21
申请人： CorSolutions LLC
IPC分类号： G01N1/14
CPC分类号： G01N1/14 , B01L3/0293 , B01L2400/0487 , G01N35/08 , G01N35/1016 , G01N2001/1427 , G01N2001/1445
摘要： A fluid sampler system includes a fluidic head including a gas aperture capable of communication with a pressurized gas source, a liquid conduit capable of communication with a sample reservoir, and a seal capable of forming a compression seal to the sample reservoir when gas pressure is applied to the sample reservoir through the gas aperture and capable of displacing a portion of the sample through the liquid conduit; and a positioning apparatus capable of positioning the fluidic head and the sample reservoir in communication with one another. A method for providing an aliquot of sample, includes forming a releasable compression seal to a reservoir including a liquid sample; pressurizing the reservoir with compressed gas; displacing an aliquot of the sample from the reservoir; and transferring the displaced aliquot of the sample to a location.
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公开(公告)号：US08617489B2
公开(公告)日：2013-12-31
申请号：US13930964
申请日：2013-06-28
申请人： CorSolutions LLC
IPC分类号： G01N15/06
CPC分类号： B01L3/502707 , B01L3/502715 , B01L9/527 , B01L2200/025 , B01L2200/0689 , B01L2200/143 , B01L2300/16 , B33Y80/00 , Y10T29/49 , Y10T436/11 , Y10T436/2575
摘要： The invention allows for the formation of robust, reproducible, non-permanent connections to microchips. The connections are formed using either indexing arms or multiple fitting holder heads which are capable of forming a compression seal to a port located at any position on the surface of the microchip. The sealing force is user-defined and can be tightly controlled with integrated force sensors. In addition, the sealing force is monitored with a force sensor and force compensation mechanism ensuring that the desired force is maintained. The device is compatible with all microchip architectures. Alterations to the microchip surface is avoided as connections are established using instrumentation rather than processing steps. Further, the process is automatable allowing for exchanging microchips and subsequently creating electrical and fluidic connections in an automated fashion. Optionally, the integration of leak sensors to monitor leaks are included.
摘要翻译： 本发明允许形成坚固的，可重现的，非永久性的与微芯片的连接。 连接是使用分度臂或多个配件保持器头形成的，其能够形成对位于微芯片表面上任何位置的端口的压缩密封。 密封力是用户定义的，可以通过集成力传感器进行严格控制。 另外，用力传感器和力补偿机构来监测密封力，确保保持所需的力。 该器件与所有微芯片架构兼容。 避免了使用仪器而不是处理步骤来建立连接到微芯片表面的变化。 此外，该过程是可自动化的，允许交换微芯片，并随后以自动方式创建电和流体连接。 可选地，包括泄漏传感器的集成以监测泄漏。
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公开(公告)号：US20130287647A1
公开(公告)日：2013-10-31
申请号：US13930964
申请日：2013-06-28
申请人： CorSolutions LLC
IPC分类号： B01L3/00
CPC分类号： B01L3/502707 , B01L3/502715 , B01L9/527 , B01L2200/025 , B01L2200/0689 , B01L2200/143 , B01L2300/16 , B33Y80/00 , Y10T29/49 , Y10T436/11 , Y10T436/2575
摘要： The invention allows for the formation of robust, reproducible, non-permanent connections to microchips. The connections are formed using either indexing arms or multiple fitting holder heads which are capable of forming a compression seal to a port located at any position on the surface of the microchip. The sealing force is user-defined and can be tightly controlled with integrated force sensors. In addition, the sealing force is monitored with a force sensor and force compensation mechanism ensuring that the desired force is maintained. The device is compatible with all microchip architectures. Alterations to the microchip surface is avoided as connections are established using instrumentation rather than processing steps. Further, the process is automatable allowing for exchanging microchips and subsequently creating electrical and fluidic connections in an automated fashion. Optionally, the integration of leak sensors to monitor leaks are included.
摘要翻译： 本发明允许形成坚固的，可重现的，非永久性的与微芯片的连接。 连接是使用分度臂或多个配件保持器头形成的，其能够形成对位于微芯片表面上任何位置的端口的压缩密封。 密封力是用户定义的，可以通过集成力传感器进行严格控制。 另外，用力传感器和力补偿机构来监测密封力，确保保持所需的力。 该器件与所有微芯片架构兼容。 避免了使用仪器而不是处理步骤来建立连接到微芯片表面的变化。 此外，该过程是可自动化的，允许交换微芯片，并随后以自动方式创建电和流体连接。 可选地，包括泄漏传感器的集成以监测泄漏。
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