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公开(公告)号：US07800057B2
公开(公告)日：2010-09-21
申请号：US12131486
申请日：2008-06-02
CPC分类号： H01J49/165
摘要： Electrospray ionization sources interfaced to mass spectrometers have become widely used tools in analytical applications. Processes occurring in Electrospray (ES) ionization generally include the addition or removal of a charged species such as H+ or other cation to effect ionization of a sample species. Electrospray includes ionization processes that occur in the liquid and gas phase and in both phases ionization processes require a source or sink for such charged species. Electrolyte species, that aid in oxidation or reduction reactions occurring in Electrospray ionization, are added to sample solutions in many analytical applications to increase the ES ion signal amplitude detected by a mass spectrometer (MS). Electrolyte species that may be required to enhance an upstream sample preparation or separation process may be less compatible with the downstream ES processes and cause reduction in MS signal. A new set of Electrolytes has been found that increases positive and negative polarity analyte ion signal measured in ESMS analysis when compared with analyte ESMS signal achieved using more conventional electrolytes. The new electrolyte species increase ES MS signal when added directly to a sample solution or when added to a second solution flow in an Electrospray membrane probe. The new electrolytes can also be added to a reagent ion source configured in a combination Atmospheric pressure ion source to improve ionization efficiency.
摘要翻译： 与质谱仪接口的电喷雾离子源已成为分析应用中广泛使用的工具。 在电喷雾（ES）电离中发生的过程通常包括加入或除去诸如H +或其它阳离子的带电物质以实现样品物质的离子化。 电喷雾包括在液相和气相中发生的电离过程，并且在两相中，电离过程需要这种带电物质的源或汇。 在许多分析应用中，在电喷雾电离中发生氧化或还原反应的电解质物质被添加到样品溶液中以增加由质谱仪（MS）检测到的ES离子信号幅度。 可能需要增强上游样品制备或分离过程的电解质物质可能与下游ES过程较不相容，并导致MS信号的降低。 已经发现一组新的电解质在ESMS分析中测量的正极和负极性分析物离子信号与使用更常规电解质获得的分析物ESMS信号相比较。 新的电解质物质直接添加到样品溶液中或当添加到电喷雾膜探针中的第二溶液流中时，增加ES MS信号。 新的电解质也可以添加到组合大气压离子源的试剂离子源中，以提高电离效率。
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2.发明授权公开(公告)号：US08487243B2
公开(公告)日：2013-07-16
申请号：US13006934
申请日：2011-01-14
CPC分类号： B01D59/44 , G01N1/4005 , G01N30/00 , G01N30/7266 , H01J49/165 , Y10T436/212 , Y10T436/24
摘要： The invention provides a method and apparatus for trapping, releasing and/or separating sample components in solution passing through a channel with or without packing material present by passing ion current through the channel driven by an electric field. A portion of the ion current comprises cation and/or anion species generated from second solution flows separated from the sample solution flow path by semipermeable membranes. Cation and/or Anion ion species generated in the second solution flow regions are transferred into the sample solution flow path through ion selective semipermeable membranes. Ion current moving along the sample solution flow path is controlled by varying the composition of the second solutions and/or changing the voltage between membrane sections for a given sample solution composition. The sample composition may also be varied separately or in parallel to enhance trapping, release and/or separation efficiency and range. The invention when interfaced to an Atmospheric Pressure Ion Source, that may include Electrospray Ionization, with mass spectrometric analysis enables independent control of the on-line sample separation process and the Atmospheric Pressure Ion Source or Electrospray ionization processes.
摘要翻译： 本发明提供了一种用于通过使通过离子电流通过由电场驱动的通道而使存在的填充材料通过通道的溶液中的样品组分的捕获，释放和/或分离的方法和装置。 离子电流的一部分包括由通过半透膜从样品溶液流动路径分离的第二溶液流产生的阳离子和/或阴离子物质。 在第二溶液流动区域中产生的阳离子和/或阴离子物质通过离子选择性半透膜转移到样品溶液流动路径中。 沿着样品溶液流动路径移动的离子电流通过改变第二溶液的组成和/或改变给定样品溶液组合物的膜部分之间的电压来控制。 样品组合物也可以单独地或并行地改变以提高捕获，释放和/或分离效率和范围。 当与质谱分析相结合的可能包括电喷雾离子化的大气压力离子源的本发明可以独立控制在线样品分离过程和大气压力离子源或电喷雾离子化过程。
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3.再颁专利公开(公告)号：USRE44887E1
公开(公告)日：2014-05-13
申请号：US13070010
申请日：2011-03-23
CPC分类号： H01J49/165 , B01D61/00 , B01D61/425 , B01D2313/345 , G01N30/7266 , H01J49/0018 , H01J49/167
摘要： The invention provides a method and apparatus for trapping, releasing and/or separating sample components in solution passing through a channel with or without packing material present by passing ion current through the channel driven by an electric field. A portion of the ion current comprises cation and/or anion species generated from second solution flows separated from the sample solution flow path by semipermeable membranes. Cation and/or Anion ion species generated in the second solution flow regions are transferred into the sample solution flow path through ion selective semipermeable membranes. Ion current moving along the sample solution flow path is controlled by varying the composition of the second solutions and/or changing the voltage between membrane sections for a given sample solution composition. The sample composition may also be varied separately or in parallel to enhance trapping, release and/or separation efficiency and range. The invention when interfaced to an Atmospheric Pressure Ion Source, that may include Electrospray Ionization, with mass spectrometric analysis enables independent control of the on-line sample separation process and the Atmospheric Pressure Ion Source or Electrospray ionization processes.
摘要翻译： 本发明提供了一种用于通过使通过离子电流通过由电场驱动的通道而使存在的填充材料通过通道的溶液中的样品组分的捕获，释放和/或分离的方法和装置。 离子电流的一部分包括由通过半透膜从样品溶液流动路径分离的第二溶液流产生的阳离子和/或阴离子物质。 在第二溶液流动区域中产生的阳离子和/或阴离子物质通过离子选择性半透膜转移到样品溶液流动路径中。 沿着样品溶液流动路径移动的离子电流通过改变第二溶液的组成和/或改变给定样品溶液组合物的膜部分之间的电压来控制。 样品组合物也可以单独地或并行地改变以提高捕获，释放和/或分离效率和范围。 当与质谱分析相结合的可能包括电喷雾离子化的大气压离子源的本发明可以独立控制在线样品分离过程和大气压离子源或电喷雾离子化过程。
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公开(公告)号：US20090008547A1
公开(公告)日：2009-01-08
申请号：US12131486
申请日：2008-06-02
IPC分类号： B01D59/44
CPC分类号： H01J49/165
摘要： Electrospray ionization sources interfaced to mass spectrometers have become widely used tools in analytical applications. Processes occurring in Electrospray (ES) ionization generally include the addition or removal of a charged species such as H+ or other cation to effect ionization of a sample species. Electrospray includes ionization processes that occur in the liquid and gas phase and in both phases ionization processes require a source or sink for such charged species. Electrolyte species, that aid in oxidation or reduction reactions occurring in Electrospray ionization, are added to sample solutions in many analytical applications to increase the ES ion signal amplitude detected by a mass spectrometer (MS). Electrolyte species that may be required to enhance an upstream sample preparation or separation process may be less compatible with the downstream ES processes and cause reduction in MS signal. A new set of Electrolytes has been found that increases positive and negative polarity analyte ion signal measured in ESMS analysis when compared with analyte ESMS signal achieved using more conventional electrolytes. The new electrolyte species increase ES MS signal when added directly to a sample solution or when added to a second solution flow in an Electrospray membrane probe. The new electrolytes can also be added to a reagent ion source configured in a combination Atmospheric pressure ion source to improve ionization efficiency.
摘要翻译： 与质谱仪接口的电喷雾离子源已成为分析应用中广泛使用的工具。 在电喷雾（ES）电离中发生的过程通常包括加入或除去诸如H +或其它阳离子的带电物质以实现样品物质的离子化。 电喷雾包括在液相和气相中发生的电离过程，并且在两相中，电离过程需要这种带电物质的源或汇。 在许多分析应用中，在电喷雾电离中发生氧化或还原反应的电解质物质被添加到样品溶液中以增加由质谱仪（MS）检测到的ES离子信号幅度。 可能需要增强上游样品制备或分离过程的电解质物质可能与下游ES过程较不相容，并导致MS信号的降低。 已经发现一组新的电解质在ESMS分析中测量的正极和负极性分析物离子信号与使用更常规电解质获得的分析物ESMS信号相比较。 新的电解质物质直接添加到样品溶液中或当添加到电喷雾膜探针中的第二溶液流中时，增加ES MS信号。 新的电解质也可以添加到组合大气压离子源的试剂离子源中，以提高电离效率。
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公开(公告)号：US08723110B2
公开(公告)日：2014-05-13
申请号：US13218800
申请日：2011-08-26
IPC分类号： H01J49/00
CPC分类号： H01J49/165 , H01J49/0431 , H01J49/107 , H01J49/168 , H01J49/26
摘要： An apparatus for generating ions includes an Electrospray ionization source configured to provide a spray of charged droplets from a sample solution during operation of the apparatus; an atmospheric pressure chemical ionization (APCI) source including a corona discharge needle configured to produce a corona discharge that further ionizes the spray during operation of the apparatus; and a gas delivery system configured to deliver a gas flow to the corona discharge needle during operation of the apparatus, wherein the gas flow comprises a reagent ion gas which facilitates ionization of the spray by the corona discharge.
摘要翻译： 一种用于产生离子的装置包括：电喷雾离子化源，其构造成在装置运行期间提供来自样品溶液的带电液滴的喷雾; 包括电晕放电针的大气压化学电离源（APCI），其被配置为产生电晕放电，所述电晕放电在所述装置的操作期间进一步电离所述喷雾; 以及气体输送系统，其构造成在所述装置的操作期间将气流输送到所述电晕放电针，其中所述气流包括试剂离子气体，所述试剂离子气体有助于所述电晕放电引起所述喷雾的离子化。
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公开(公告)号：US08525105B2
公开(公告)日：2013-09-03
申请号：US12879532
申请日：2010-09-10
IPC分类号： H01J49/00
CPC分类号： H01J49/165
摘要： Electrospray ionization sources interfaced to mass spectrometers have become widely used tools in analytical applications Processes occurring in Electrospray (ES) ionization generally include the addition or removal of a charged species such as II+ or other cation to effect ionization of a sample species. Electrospray includes ionization processes that occur in the liquid and gas phase and in both phases ionization processes require a source or sink for such charged species. Electrolyte species, that aid in oxidation or reduction reactions occurring in Electrospray ionization, are added to sample solutions in many analytical applications to increase the ES ion signal amplitude detected by a mass spectrometer (MS). Electrolyte species that may be required to enhance an upstream sample preparation or separation process may be less compatible with the downstream ES processes and cause reduction in MS signal. A new set of Electrolytes has been found that increases positive and negative polarity analyte ion signal measured in ESMS analysis when compared with analyte ESMS signal achieved using more conventional electrolytes. The new electrolyte species increase ES MS signal when added directly to a sample solution or when added to a second solution flow in an Electrospray membrane probe. The new electrolytes can also be added to a reagent ion source configured in a combination Atmospheric pressure ion source to improve ionization efficiency.
摘要翻译： 与质谱仪接口的电喷雾离子源已成为分析应用中广泛使用的工具电喷雾（ES）电离中发生的过程通常包括加入或除去带电物质如II +或其他阳离子以实现样品物质的电离。 电喷雾包括在液相和气相中发生的电离过程，并且在两相中，电离过程需要这种带电物质的源或汇。 在许多分析应用中，在电喷雾电离中发生氧化或还原反应的电解质物质被添加到样品溶液中以增加由质谱仪（MS）检测到的ES离子信号幅度。 可能需要增强上游样品制备或分离过程的电解质物质可能与下游ES过程较不相容，并导致MS信号的降低。 已经发现一组新的电解质在ESMS分析中测量的正极和负极性分析物离子信号与使用更常规电解质获得的分析物ESMS信号相比较。 新的电解质物质直接添加到样品溶液中或当添加到电喷雾膜探针中的第二溶液流中时，增加ES MS信号。 新的电解质也可以添加到组合大气压离子源的试剂离子源中，以提高电离效率。
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公开(公告)号：US20110006198A1
公开(公告)日：2011-01-13
申请号：US12879532
申请日：2010-09-10
CPC分类号： H01J49/165
摘要： Electrospray ionization sources interfaced to mass spectrometers have become widely used tools in analytical applications Processes occurring in Electrospray (ES) ionization generally include the addition or removal of a charged species such as II+ or other cation to effect ionization of a sample species. Electrospray includes ionization processes that occur in the liquid and gas phase and in both phases ionization processes require a source or sink for such charged species. Electrolyte species, that aid in oxidation or reduction reactions occurring in Electrospray ionization, are added to sample solutions in many analytical applications to increase the ES ion signal amplitude detected by a mass spectrometer (MS). Electrolyte species that may be required to enhance an upstream sample preparation or separation process may be less compatible with the downstream ES processes and cause reduction in MS signal. A new set of Electrolytes has been found that increases positive and negative polarity analyte ion signal measured in ESMS analysis when compared with analyte ESMS signal achieved using more conventional electrolytes. The new electrolyte species increase ES MS signal when added directly to a sample solution or when added to a second solution flow in an Electrospray membrane probe. The new electrolytes can also be added to a reagent ion source configured in a combination Atmospheric pressure ion source to improve ionization efficiency.
摘要翻译： 与质谱仪接口的电喷雾离子源已成为分析应用中广泛使用的工具电喷雾（ES）电离中发生的过程通常包括加入或除去带电物质如II +或其他阳离子以实现样品物质的电离。 电喷雾包括在液相和气相中发生的电离过程，并且在两相中，电离过程需要这种带电物质的源或汇。 在许多分析应用中，在电喷雾电离中发生氧化或还原反应的电解质物质被添加到样品溶液中以增加由质谱仪（MS）检测到的ES离子信号幅度。 可能需要增强上游样品制备或分离过程的电解质物质可能与下游ES过程较不相容，并导致MS信号的降低。 已经发现一组新的电解质在ESMS分析中测量的正极和负极性分析物离子信号与使用更常规电解质获得的分析物ESMS信号相比较。 新的电解质物质直接添加到样品溶液中或当添加到电喷雾膜探针中的第二溶液流中时，增加ES MS信号。 新的电解质也可以添加到组合大气压离子源的试剂离子源中，以提高电离效率。
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8.发明申请公开(公告)号：US20190120712A1
公开(公告)日：2019-04-25
申请号：US16161260
申请日：2018-10-16
摘要： GaN/Al0.20Ga0.80N/GaN heterostructures Micro-Hall effect sensors providing simultaneous current and temperature detection over at least a best performance temperature range of −183° C. and 252° C.
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9.发明申请Method and system for providing storage and retrieval of clinical information 审中-公开提供临床信息存储和检索的方法和系统公开(公告)号：US20080103720A1
公开(公告)日：2008-05-01
申请号：US11586360
申请日：2006-10-25
申请人： Peter M. White , Thomas P. White
发明人： Peter M. White , Thomas P. White
摘要： The present invention provides a managed or “hosted” service offering that facilitates timely and accurate communication of clinical information, such as critical test results, within a health care environment. The inventive system enables pathologists, laboratory technicians, and laboratory staff to communicate to ordering physicians clinical information (such as lab results) in real-time via a traceable and verifiable communication system. According to the invention, a recipient of the clinical test results is prompted to verify the test results that he or she has just heard to confirm receipt of such results, as well as confirmation that the information provided was properly understood. The read back function ensures that the actual communication of complete clinical information (such as critical tests results) occurs in a seamless, real-time manner.
摘要翻译： 本发明提供了一种管理或“托管”服务提供，其有助于及时和准确地在医疗保健环境内的临床信息（例如关键测试结果）的通信。 本发明的系统使得病理学家，实验室技术人员和实验室工作人员可以通过可跟踪和可验证的通信系统实时地通信订购医师临床信息（例如实验室结果）。 根据本发明，提示临床测试结果的接受者验证他或她刚刚听到的测试结果以确认接收到这样的结果，以及确认所提供的信息被正确理解。 回读功能确保完整的临床信息（如关键测试结果）的实际通信以无缝，实时的方式发生。
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公开(公告)号：US11137310B2
公开(公告)日：2021-10-05
申请号：US16161260
申请日：2018-10-16
摘要： GaN/Al0.20Ga0.80N/GaN heterostructures Micro-Hall effect sensors providing simultaneous current and temperature detection over at least a best performance temperature range of −183° C. and 252° C.
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