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公开(公告)号：US06258123B1
公开(公告)日：2001-07-10
申请号：US08844428
申请日：1997-04-18
IPC分类号： A61F216
CPC分类号： A61F2/16 , A61F2/1613 , A61F2002/009 , A61F2002/1683 , A61F2002/1699
摘要： An IOL implantable in an eye comprising an optic having an optical portion for directing light toward the retina of the eye and a cell barrier portion for inhibiting cell growth from the eye in front of or in back of the optical portion. The cell barrier portion circumscribes the optical portion, is incapable of focusing light on the retina and includes an irregularly configured structure, for example, irregular grooves. At least one elongated fixation member is coupled to the optic for use in fixing the optic in the eye.
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公开(公告)号：US06656222B2
公开(公告)日：2003-12-02
申请号：US09859658
申请日：2001-05-17
IPC分类号： A61F216
CPC分类号： A61F2/16 , A61F2/1613 , A61F2002/009 , A61F2002/1683 , A61F2002/1699
摘要： An IOL implantable in an eye comprising an optic having an optical portion for directing light toward the retina of the eye and a cell barrier portion for inhibiting cell growth from the eye in front of or in back of the optical portion. The cell barrier portion circumscribes the optical portion, is incapable of focusing light on the retina and includes an irregularly configured structure, for example, irregular grooves. At least one elongated fixation member is coupled to the optic for use in fixing the optic in the eye.
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公开(公告)号：US5549670A
公开(公告)日：1996-08-27
申请号：US437656
申请日：1995-05-09
CPC分类号： A61F2/16 , A61F2/1613 , A61F2002/009 , A61F2002/1699
摘要： An IOL implantable in an eye including an optic having an optical portion for directing light toward the retina of the eye and a cell barrier portion for inhibiting cell growth from the eye in front of or in back of the optical portion. The cell barrier portion circumscribes the optical portion, is incapable of focusing light on the retina and includes an irregularly configured structure, for example, irregular grooves. At least one elongated fixation member is coupled to the optic for use in fixing the optic in the eye.
摘要翻译： 可植入眼睛中的IOL，包括具有用于将光引导到眼睛的视网膜的光学部分的光学元件，以及用于在光学部分的前方或后面抑制细胞从眼睛生长的细胞屏障部分。 细胞屏障部分围绕光学部分，不能将光聚焦在视网膜上并且包括不规则构造的结构，例如不规则凹槽。 至少一个细长的固定构件联接到光学元件以用于将光学元件固定在眼睛中。
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公开(公告)号：US5693094A
公开(公告)日：1997-12-02
申请号：US627723
申请日：1996-04-02
CPC分类号： A61F2/16 , A61F2/1613 , A61F2002/009 , A61F2002/1683 , A61F2002/1699
摘要： An IOL implantable in an eye including an optic having an optical portion for directing light toward the retina of the eye and a cell barrier portion for inhibiting cell growth from the eye in front of or in back of the optical portion. The cell barrier portion circumscribes the optical portion, is incapable of focusing light on the retina and includes an irregularly configured structure, for example, irregular grooves. At least one elongated fixation member is coupled to the optic for use in fixing the optic in the eye.
摘要翻译： 可植入眼睛中的IOL，包括具有用于将光引导到眼睛的视网膜的光学部分的光学元件，以及用于在光学部分的前方或后面抑制细胞从眼睛生长的细胞屏障部分。 细胞屏障部分围绕光学部分，不能将光聚焦在视网膜上并且包括不规则构造的结构，例如不规则凹槽。 至少一个细长的固定构件联接到光学元件以用于将光学元件固定在眼睛中。
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公开(公告)号：US06214054B1
公开(公告)日：2001-04-10
申请号：US09157546
申请日：1998-09-21
申请人： Crystal M. Cunanan , Lillian Quintero , Michael N. Helmus , Christine Loshbaugh , H. Chris Sarner
发明人： Crystal M. Cunanan , Lillian Quintero , Michael N. Helmus , Christine Loshbaugh , H. Chris Sarner
IPC分类号： A61F224
CPC分类号： A61L27/3691 , A61L2/0088 , A61L27/3604 , A61L27/3641 , A61L27/3645 , A61L27/3683 , A61L27/3687 , A61L33/12 , A61L2400/02 , A61L2430/40 , Y10S623/901 , Y10S623/915 , Y10S623/917 , Y10S623/92
摘要： A method for fixation of biological tissues, and bioprosthetic devices prepared by such method. The method generally comprises the steps of A) fixing the tissue, B) treating the tissue with a mixture of i) a denaturant, ii) a surfactant and iii) a crosslinking agent, C) fabricating or forming the bioprosthesis (e.g., forming the tissue and attaching any non-biological components thereto) and D) subjecting the bioprosthesis to terminal sterilization.
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6.发明授权公开(公告)号：US06648922B2
公开(公告)日：2003-11-18
申请号：US09790395
申请日：2001-02-21
IPC分类号： A61F236
CPC分类号： A61L33/0041 , A61L27/34 , A61L29/085 , A61L31/10 , A61L33/0011 , A61M1/3679 , A61M2202/0439 , B01D39/1623 , B01D39/1692 , C08L89/00 , C08L71/02 , A61M2202/0057
摘要： Medical devices and methods of producing same are provided. The medical device comprising a body member and a coating on at least a portion of the body member comprising an insitu condensation product of a first electrophilically active, high molecular weight polyalkylene oxide and a second high molecular weight polyoxyalkylene derivative.
摘要翻译： 提供医疗装置及其制造方法。 所述医疗装置包括主体构件和在所述主体构件的至少一部分上的涂层，其包含第一亲电活性的高分子量聚环氧烷和第二高分子量聚氧化烯衍生物的原位缩合产物。
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公开(公告)号：US5632773A
公开(公告)日：1997-05-27
申请号：US616786
申请日：1996-03-15
CPC分类号： A61F2/14 , A61L27/24 , A61F2310/00365
摘要： Corneal implants and methods for producing such implants are disclosed. The present corneal implants comprise a lens body which is optically clear and is structured to be surgically attached in or on the cornea of a mammalian eye, the lens body including a hydrogel composition containing water, a collagen component and a polymeric material covalently bonded to the collagen component. The hydrogel composition has enhanced biostability relative to an identical hydrogel composition without the polymeric material.
摘要翻译： 公开了角膜植入物和用于生产这种植入物的方法。 本发明的角膜植入物包括光学透明的透镜体，其被构造成手术附着在哺乳动物眼睛的角膜中或上面，所述透镜体包括水凝胶组合物，所述水凝胶组合物含有水，胶原组分和共价键合到 胶原成分。 相对于没有聚合物材料的相同的水凝胶组合物，水凝胶组合物具有增强的生物稳定性。
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公开(公告)号：US5433745A
公开(公告)日：1995-07-18
申请号：US135875
申请日：1993-10-13
摘要： New corneal implants and methods for producing such implants are disclosed. The present corneal implants comprise a lens body which is optically clear and is structured to be surgically attached in or on the cornea of a mammalian eye, the lens body including a core having an outer surface and made of a hydrogel composition containing water and a hydrophilic polymeric material, and a coating comprising a synthetic polymeric component located on the outer surface, covalently bonded to the hydrogel composition and having enhanced ability to support epithelial cell growth and/or adhesion relative to the hydrogel composition.
摘要翻译： 公开了新的角膜植入物和用于生产这种植入物的方法。 本发明的角膜植入物包括光学透明的透镜体，其被构造成手术附着在哺乳动物眼睛的角膜中或上面，所述透镜体包括具有外表面并且由含有水和亲水性的水凝胶组合物制成的芯 聚合物材料和包含位于外表面上的合成聚合物组分的涂层，共价键合到水凝胶组合物上，并具有增强的相对于水凝胶组合物支持上皮细胞生长和/或粘附的能力。
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9.发明授权公开(公告)号：US07989157B2
公开(公告)日：2011-08-02
申请号：US11032923
申请日：2005-01-11
CPC分类号： A01N1/02 , A01N1/0226
摘要： A method for processing biological tissue used in biological prostheses includes providing a tissue procurement solution formed from a phosphate buffered saline (PBS) solution and a chelating agent. The tissue is transferred from the tissue procurement solution and undergoes chemical fixation. The fixed tissue is then immersed in a series of fresh bioburden reduction process (BRP) solutions to extract phospholipids. The tissue procurement solution reduces the bioburden on the stored tissue and preserves tissue architecture by minimizing tissue swelling. The tissue procurement solution further reduces calcium from the incoming water and/or tissue, and inhibits enzymes that digest the collagen matrix. The serial immersion of the tissue in the fresh bioburden solutions ensures optimal extraction of phospholipids thereby mitigating subsequent calcification of the tissue.
摘要翻译： 用于处理生物假体中使用的生物组织的方法包括提供由磷酸盐缓冲盐水（PBS）溶液和螯合剂形成的组织采购溶液。 组织从组织采购溶液转移并进行化学固定。 然后将固定的组织浸入一系列新鲜的生物负载降低过程（BRP）溶液中以提取磷脂。 组织采购解决方案减少存储组织的生物负载，并通过最小化组织肿胀来保持组织结构。 组织采购解决方案进一步减少来自进入的水和/或组织的钙，并且抑制消化胶原蛋白基质的酶。 将组织连续浸入新鲜的生物负载溶液中确保磷脂的最佳提取，从而减轻随后的组织钙化。
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公开(公告)号：US07422606B2
公开(公告)日：2008-09-09
申请号：US10678875
申请日：2003-10-03
IPC分类号： A61F2/02
CPC分类号： A61L33/0041 , A61L27/34 , A61L29/085 , A61L31/10 , A61L33/0011 , A61M1/3679 , A61M2202/0439 , B01D39/1623 , B01D39/1692 , C08L89/00 , C08L71/02 , A61M2202/0057
摘要： Medical devices and methods of producing same are provided. The medical device comprising a body member and a coating on at least a portion of the body member comprising an insitu condensation product of a first electrophilically active, high molecular weight polyalkylene oxide and a second high molecular weight polyoxyalkylene derivative.
摘要翻译： 提供医疗装置及其制造方法。 所述医疗装置包括主体构件和在所述主体构件的至少一部分上的涂层，其包含第一亲电活性的高分子量聚环氧烷和第二高分子量聚氧化烯衍生物的原位缩合产物。
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