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1.发明授权公开(公告)号：US11826724B2
公开(公告)日：2023-11-28
申请号：US17372985
申请日：2021-07-12
发明人： Tamaz Guliashvili , Thomas Golobish , Maryann Gruda , Pamela O'Sullivan , Andrew Scheirer , Vincent Capponi , Phillip Chan , Wei-Tai Young
IPC分类号： A61K38/00 , B01J20/26 , B01D15/34 , B01J20/28 , B01J20/32 , A61K9/00 , A61K31/745 , A61M1/36 , B01D15/12
CPC分类号： B01J20/261 , A61K9/0031 , A61K9/0053 , A61K31/745 , A61M1/3679 , B01D15/34 , B01J20/262 , B01J20/267 , B01J20/2808 , B01J20/28069 , B01J20/28078 , B01J20/28083 , B01J20/28085 , B01J20/327 , B01J20/3208 , B01J20/3231 , B01J20/3272 , B01J20/3274 , B01J20/3289 , B01D15/125
摘要： The invention concerns biocompatible polymer systems comprising at least one polymer with a plurality of pores, said polymer comprising either polyol or zwitterionic groups designed to adsorb endotoxins and other inflammatory mediator molecules. The inventions are in the field of porous polymeric sorbents, also in the field of broadly reducing endotoxins in blood and blood products that can cause endotoxemia, additionally, in the field of broadly removing endotoxins by perfusion or hemoperfusion.
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2.发明公开公开(公告)号：US20240082817A1
公开(公告)日：2024-03-14
申请号：US18502809
申请日：2023-11-06
发明人： Tamaz Guliashvili , Thomas Golobish , Maryann Gruda , Pamela O'Sullivan , Andrew Scheirer , Vincent Capponi , Phillip Chan , Wei-Tai Young
CPC分类号： B01J20/261 , A61K9/0031 , A61K9/0053 , A61K31/745 , A61M1/3679 , B01D15/34 , B01J20/262 , B01J20/267 , B01J20/28069 , B01J20/28078 , B01J20/2808 , B01J20/28083 , B01J20/28085 , B01J20/3208 , B01J20/3231 , B01J20/327 , B01J20/3272 , B01J20/3274 , B01J20/3289 , B01D15/125
摘要： The invention concerns biocompatible polymer systems comprising at least one polymer with a plurality of pores, said polymer comprising either polyol or zwitterionic groups designed to adsorb endotoxins and other inflammatory mediator molecules.
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3.发明申请公开(公告)号：US20220032267A1
公开(公告)日：2022-02-03
申请号：US17372985
申请日：2021-07-12
发明人： Tamaz Guliashvili , Thomas Golobish , Maryann Gruda , Pamela O'Sullivan , Andrew Scheirer , Vincent Capponi , Phillip Chan , Wei-Tai Young
摘要： The invention concerns biocompatible polymer systems comprising at least one polymer with a plurality of pores, said polymer comprising either polyol or zwitterionic groups designed to adsorb endotoxins and other inflammatory mediator molecules. The inventions are in the field of porous polymeric sorbents, also in the field of broadly reducing endotoxins in blood and blood products that can cause endotoxemia, additionally, in the field of broadly removing endotoxins by perfusion or hemoperfusion.
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公开(公告)号：US20210401874A1
公开(公告)日：2021-12-30
申请号：US17341912
申请日：2021-06-08
发明人： Thomas Golobish , Maryann Gruda , Tamaz Guliashvili , Pamela O'Sullivan , Andrew Scheirer , Vi Dan , Wei-Tai Young , Vincent Capponi , Phillip Chan
摘要： The invention concerns biocompatible polymer systems comprising at least one polymer with a plurality of pores, said polymer comprising a sulfonic acid salt functionality designed to adsorb a broad range of protein based toxins from less than 0.5 kDa to 1,000 kDa and positively charged ions including but not limited to potassium.
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5.发明授权公开(公告)号：US11065600B2
公开(公告)日：2021-07-20
申请号：US16303232
申请日：2017-05-18
发明人： Tamaz Guliashvili , Thomas Golobish , Maryann Gruda , Pamela O'Sullivan , Andrew Scheirer , Vincent Capponi , Phillip Chan , Wei-Tai Young
IPC分类号： A61K31/745 , B01J20/00 , B01J20/26 , B01D15/34 , B01J20/28 , B01J20/32 , A61K9/00 , A61M1/36 , B01D15/12
摘要： The invention concerns biocompatible polymer systems comprising at least one polymer with a plurality of pores, said polymer comprising either polyol or zwitterionic groups designed to adsorb endotoxins and other inflammatory mediator molecules. The inventions are in the field of porous polymeric sorbents, also in the field of broadly reducing endotoxins in blood and blood products that can cause endotoxemia, additionally, in the field of broadly removing endotoxins by perfusion or hemoperfusion.
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公开(公告)号：US11723916B2
公开(公告)日：2023-08-15
申请号：US17341912
申请日：2021-06-08
发明人： Thomas Golobish , Maryann Gruda , Tamaz Guliashvili , Pamela O'Sullivan , Andrew Scheirer , Vi Dan , Wei-Tai Young , Vincent Capponi , Phillip Chan
IPC分类号： A61K31/795 , A61M5/165 , B01J20/26 , B01J39/20 , B01J20/28 , A61K47/20 , A61K47/26 , A61M1/36 , A61M5/14
CPC分类号： A61K31/795 , A61K47/20 , A61K47/26 , A61M5/165 , B01J20/264 , B01J20/267 , B01J20/28069 , B01J39/20 , A61M1/3679 , A61M5/14
摘要： The invention concerns biocompatible polymer systems comprising at least one polymer with a plurality of pores, said polymer comprising a sulfonic acid salt functionality designed to adsorb a broad range of protein based toxins from less than 0.5 kDa to 1,000 kDa and positively charged ions including but not limited to potassium.
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公开(公告)号：US11202855B2
公开(公告)日：2021-12-21
申请号：US16497982
申请日：2018-03-22
发明人： Wei-Tai Young , Tamaz Guliashvili , Andrew Scheirer , Josh Vichare , Timothy Kovacs , Maryann Gruda , Thomas Golobish , Vincent Capponi , Phillip Chan
摘要： This invention discloses methods for reducing physiologic molecules in abnormal levels and/or exogenous toxins in blood from blood by way of an extracorporeal circuit comprising a hollow-fiber filter module and polymer sorbent in combination.
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公开(公告)号：US11040061B2
公开(公告)日：2021-06-22
申请号：US15769361
申请日：2016-10-21
发明人： Thomas Golobish , Maryann Gruda , Tamaz Guliashvili , Pamela O'Sullivan , Andrew Scheirer , Vi Dan , Wei-Tai Young , Vincent Capponi , Phillip Chan
IPC分类号： A61K31/795 , A61K47/20 , A61K47/26 , A61M5/165 , B01J20/26 , B01J39/20 , B01J20/28 , A61M1/36 , A61M5/14
摘要： The invention concerns biocompatible polymer systems comprising at least one polymer with a plurality of pores, said polymer comprising a sulfonic acid salt functionality designed to adsorb a broad range of protein based toxins from less than 0.5 kDa to 1,000 kDa and positively charged ions including but not limited to potassium.
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