公开(公告)号：US12146173B2

公开(公告)日：2024-11-19

申请号：US17854595

申请日：2022-06-30

Applicant: DANISCO US INC

Inventor： Marc Kolkman ,  Anja Hemmingsen Kellett-Smith ,  Rie Mejldal ,  Lilia Maria Babe

IPC: C12N9/54 ,  C11D3/386

Abstract: The present disclosure relates to serine proteases and variants thereof. Compositions containing the serine proteases are suitable for use in cleaning fabrics and hard surfaces, as well as in a variety of industrial applications.

公开(公告)号：US11447782B2

公开(公告)日：2022-09-20

申请号：US16081082

申请日：2017-03-06

Applicant: DANISCO US INC.

Inventor： Cristina Bongiorni ,  Marc Kolkman ,  Chris Leeflang ,  Virgil Arthur Rhodius ,  Anita Van Kimmenade

IPC: C07H21/04 ,  C12N15/75 ,  C12N9/28 ,  C07K14/32 ,  C12N9/54

Abstract: The instant disclosure is generally related to novel engineered (hybrid) promoters. In certain embodiments, the instant disclosure is directed to one or more nucleic acid compositions comprising engineered promoters operably linked to nucleic acids encoding proteins of interest. Thus, the disclosure set forth herein described methods and compositions for the production of proteins of interest using one or more novel engineered (hybrid) promoters of the disclosure.

公开(公告)号：US11384348B2

公开(公告)日：2022-07-12

申请号：US16703053

申请日：2019-12-04

Applicant: DANISCO US INC

Inventor： Marc Kolkman ,  Frits Goedegebuur ,  Lilia Maria Babe ,  Rie Mejldal ,  Harm Mulder ,  Anja Hemmingsen Kellett-Smith ,  Richard R Bott ,  Miles Christopher Scotcher

IPC: C12N9/54 ,  A47L15/00 ,  C11D3/386

Abstract: The present disclosure relates to serine proteases cloned from Bacillus gibsonii, and variants thereof. Compositions containing the serine proteases are suitable for use in cleaning fabrics and hard surfaces, as well as in a variety of industrial applications.

公开(公告)号：US20220002685A1

公开(公告)日：2022-01-06

申请号：US17024340

申请日：2020-09-17

Applicant: DANISCO US INC

Inventor： Slavko KRALJ ,  Marc Kolkman ,  Chris Leeflang ,  Johannes G. De Nobel ,  Arjen Hoekstra ,  Veli Alkan

IPC: C12N9/10 ,  C12P19/18 ,  A61K35/742 ,  A61K38/45

Abstract: Bacillus agaradhaerens strain WDG185 expresses an inulosucrase that efficiently synthesizes a broad range of IOS with a GF range of GF3-GF30. The isolated and/or purified inulosucrase, recombinantly engineered variants thereof, active fragments thereof, synthetic nucleic acids encoding the inulosucrase, its variants, or its active fragments, host cells comprising the synthetic nucleic acids, and compositions comprising the inulosucrase are provided. Methods of using the compositions include the manufacture of inulooligosaccharides.

公开(公告)号：US20200277590A1

公开(公告)日：2020-09-03

申请号：US16577096

申请日：2019-09-20

Applicant: DANISCO US INC

Inventor： Christian D. Adams ,  Roopa Santosh Ghirnikar ,  Victoria Huang ,  Marc Kolkman ,  Zhen Qian ,  Liling Jin

IPC: C12N9/24 ,  A23L29/00 ,  A23K20/189 ,  C11D3/386 ,  C12C5/00

Abstract: The present disclosure relates to endo-beta-mannanases from Paenibacillus and Bacillus spp., polynucleotides encoding such endo-beta-mannanases, compositions containing such mannanases, and methods of use thereof. Compositions containing such endo-beta-mannanases are suitable for use as detergents and cleaning fabrics and hard surfaces, as well as a variety of other industrial applications.

公开(公告)号：US20190085341A1

公开(公告)日：2019-03-21

申请号：US16081082

申请日：2017-03-06

Applicant: DANISCO US INC.

Inventor： Cristina Bongiorni ,  Marc Kolkman ,  Chris Leeflang ,  Virgil Arthur Rhodius ,  Anita Van Kimmenade

IPC: C12N15/75 ,  C12N9/54 ,  C12N9/28

Abstract: The instant disclosure is generally related to novel engineered (hybrid) promoters. In certain embodiments, the instant disclosure is directed to one or more nucleic acid compositions comprising engineered promoters operably linked to nucleic acids encoding proteins of interest. Thus, the disclosure set forth herein described methods and compositions for the production of proteins of interest using one or more novel engineered (hybrid) promoters of the disclosure.

公开(公告)号：US20180112204A1

公开(公告)日：2018-04-26

申请号：US15572882

申请日：2016-05-13

Applicant: DANISCO US INC.

Inventor： David A. Estell ,  Frits Goedegebuur ,  Marc Kolkman ,  Rie Mejldal ,  Katherine Augustyn ,  Lilia Maria Babe ,  Richard R. Bott ,  Jian Yao ,  Roopa Ghirnikar

IPC: C12N9/54 ,  C11D3/386

CPC classification number: C12N9/54 ,  C11D3/386 ,  C11D3/38681 ,  C12Y304/21062

Abstract: The present disclosure provides AprL-clade protease enzymes, including variant AprL-clade protease enzymes, nucleic acids encoding same, and compositions and methods related to the production and use thereof, including an AprL-clade variant subtilisin enzyme that has improved stability and/or soil removal compared to a parent AprL-clade subtilisin enzyme.

公开(公告)号：US20150152401A1

公开(公告)日：2015-06-04

申请号：US14406494

申请日：2013-06-03

Applicant: Danisco US Inc.

Inventor： Luis G. Cascao-Pereira ,  David A. Estell ,  Marc Kolkman

IPC: C12N9/28 ,  C11D3/386

CPC classification number: C12N9/2414 ,  A23L2/382 ,  A23V2002/00 ,  C11D3/386 ,  C11D11/0017 ,  C11D11/0023 ,  C12N9/2417 ,  C12N9/242 ,  C12P19/02 ,  C12P19/14 ,  C12Y302/01001

Abstract: Disclosed are compositions and methods relating to variant alpha-amylases. The variant alpha-amylases are useful, for example, for starch liquefaction and saccharification, for cleaning starchy stains in laundry, dishwashing, and other applications, for textile processing (e.g., desizing), in animal feed for improving digestibility, and for baking and brewing.

Abstract translation: 公开了与变体α-淀粉酶相关的组合物和方法。 变体α-淀粉酶可用于例如淀粉液化和糖化，用于清洁衣物，餐具洗涤和其它应用中的淀粉污渍，用于织物加工（例如脱浆），用于改善消化率的动物饲料中，以及烘烤和 酿造。

公开(公告)号：US20130344542A1

公开(公告)日：2013-12-26

申请号：US13899057

申请日：2013-05-21

Applicant: DANISCO US INC.

Inventor： Luis G. Cascao-Pereira ,  Claudine Chang ,  Clement Choy ,  James T. Kellis, JR. ,  Brian E. Jones ,  Melodie Estabrook ,  Marc Kolkman ,  Chris Leeflang ,  Casper Vroemen ,  Walter Weyler

IPC: C12N9/28

CPC classification number: C12N9/2417 ,  A21D8/042 ,  A23K20/189 ,  A23K50/75 ,  A23L29/06

Abstract: Described are variants (mutants) of a parent alpha-amylase having alpha-amylase activity and exhibiting altered properties relative to the parent alpha-amylase, and methods of use, thereof.

Abstract translation: 描述了具有α-淀粉酶活性并且相对于母体α-淀粉酶具有改变的性质的亲本α-淀粉酶的变体（突变体）及其使用方法。

公开(公告)号：US20250163398A1

公开(公告)日：2025-05-22

申请号：US18912966

申请日：2024-10-11

Applicant: Danisco US Inc.

Inventor： Marc Kolkman ,  Anja Hemmingsen Kellett-Smith ,  Rie Mejldal ,  Lilia Maria Babe

IPC: C12N9/54 ,  C11D3/386

Abstract: The present disclosure relates to serine proteases and variants thereof. Compositions containing the serine proteases are suitable for use in cleaning fabrics and hard surfaces, as well as in a variety of industrial applications.