公开(公告)号：US20240384220A1

公开(公告)日：2024-11-21

申请号：US18320315

申请日：2023-05-19

Applicant: DEKA Products Limited Partnership

Inventor： Richard E. Andrews ,  Stephanie M. Miskell ,  Zachary T. Kops ,  Justin M. Ferrentino ,  Michael C. Tilley ,  Andrew K. Capulli ,  Keira L. McGrath ,  Stuart A. Jacobson

IPC: C12M1/36 ,  B01L3/00 ,  B01L9/06 ,  C12M1/00 ,  C12M1/02 ,  C12M1/12 ,  C12M1/26 ,  C12M1/34 ,  C12M3/06 ,  G01N35/00 ,  G01N35/10

Abstract: Manufacturing system and method for creating multiple tissue constructs from cells. System can include a thaw subsystem (if the cells are provided in a frozen state), an expansion subsystem, a concentration subsystem, and a tissue maturation subsystem. Each of these subsystems is modular and can be reconfigured, and the process can be repeated depending on the specific tissue process being implemented. Multiple tissue types can be combined in multiple bioreactors. The activities of multiple bioreactors can be coordinated and controlled in an automated manner by a supervisor controller. The supervisor controller can receive user input at the start of the process, and can manage the process henceforth, alerting the user if user actions are required.

公开(公告)号：US20240254427A1

公开(公告)日：2024-08-01

申请号：US18443395

申请日：2024-02-16

Applicant: DEKA Products Limited Partnership

Inventor： Christopher C. Langenfeld ,  David D.B Cannan ,  Dirk A. Van Der Merwe ,  Dean Kamen ,  Jason A. Demers ,  Frederick Morgan ,  Timothy D. Moreau ,  Brian D. Tracey ,  Matthew Ware ,  Richard J. Lanigan ,  Michael A. Baker ,  David Blumberg, JR. ,  Richard E. Andrews ,  Derek G. Kane ,  Dane C. Fawkes ,  Thomas J. Bollenbach ,  Michael C. Tilley ,  Stuart A. Jacobson ,  John F. Mannisto

IPC: C12M1/36 ,  A01N1/02 ,  A61L27/38 ,  B33Y10/00 ,  B33Y30/00 ,  B33Y70/00 ,  C12M1/00 ,  C12M1/12 ,  C12M1/26 ,  C12M1/34 ,  C12M3/00 ,  C12N5/00

CPC classification number: C12M41/48 ,  A01N1/0247 ,  A61L27/3895 ,  B33Y10/00 ,  B33Y30/00 ,  B33Y70/00 ,  C12M21/08 ,  C12M23/22 ,  C12M23/38 ,  C12M25/02 ,  C12M27/18 ,  C12M29/00 ,  C12M33/00 ,  C12M37/02 ,  C12M41/12 ,  C12M41/40 ,  C12M41/46 ,  C12N5/0018 ,  C12N5/0062 ,  C12N2533/00 ,  C12N2533/50 ,  C12N2533/90

Abstract: A system and method for growing and maintaining biological material including producing a protein associated with the tissue, selecting cells associated with the tissue, expanding the cells, creating at least one tissue bio-ink including the expanded cells, printing the at least one tissue bio-ink in at least one tissue growth medium mixture, growing the tissue from the printed at least one tissue bio-ink, and maintaining viability of the tissue.

公开(公告)号：US11299705B2

公开(公告)日：2022-04-12

申请号：US15805790

申请日：2017-11-07

Applicant: DEKA Products Limited Partnership

Inventor： Christopher C. Langenfeld ,  David D. B. Cannan ,  Dirk A. van der Merwe ,  Dean Kamen ,  Jason A. Demers ,  Frederick Morgan ,  Timothy D. Moreau ,  Brian D. Tracey ,  Matthew Ware ,  Richard J. Lanigan ,  Michael A. Baker ,  David Blumberg, Jr. ,  Richard E. Gautney ,  Derek G. Kane ,  Dane Fawkes ,  Thomas J. Bollenbach ,  Michael C. Tilley ,  Stuart A. Jacobson ,  John F. Mannisto

IPC: C12M3/00 ,  C12M1/00 ,  C12M1/36 ,  C12M1/34 ,  C12M1/12 ,  C12N5/00 ,  C12M1/26 ,  A61L27/38 ,  B33Y10/00 ,  B33Y30/00 ,  B33Y70/00 ,  A01N1/02

Abstract: A system and method for growing and maintaining biological material including producing a protein associated with the tissue, selecting cells associated with the tissue, expanding the cells, creating at least one tissue bio-ink including the expanded cells, printing the at least one tissue bio-ink in at least one tissue growth medium mixture, growing the tissue from the printed at least one tissue bio-ink, and maintaining viability of the tissue.

公开(公告)号：US20180127705A1

公开(公告)日：2018-05-10

申请号：US15805790

申请日：2017-11-07

Applicant: DEKA Products Limited Partnership

Inventor： Christopher C. Langenfeld ,  David D. B. Cannan ,  Dirk A. van der Merwe ,  Dean Kamen ,  Jason A. Demers ,  Frederick Morgan ,  Timothy D. Moreau ,  Brian D. Tracey ,  Matthew Ware ,  Richard J. Lanigan ,  Michael A. Baker ,  David Blumberg ,  Richard E. Gautney ,  Derek G. Kane ,  Dane Fawkes ,  Thomas J. Bollenbach ,  Michael C. Tilley ,  Stuart A. Jacobson ,  John F. Mannisto

IPC: C12M1/36 ,  C12N5/00 ,  C12M1/34 ,  C12M1/00 ,  C12M1/12 ,  C12M1/26 ,  A61L27/38 ,  B33Y10/00 ,  B33Y30/00 ,  B33Y70/00 ,  A01N1/02 ,  C12M3/00

CPC classification number: C12M41/48 ,  A01N1/0247 ,  A61L27/3895 ,  B33Y10/00 ,  B33Y30/00 ,  B33Y70/00 ,  C12M21/08 ,  C12M23/22 ,  C12M23/38 ,  C12M25/02 ,  C12M27/18 ,  C12M29/00 ,  C12M33/00 ,  C12M37/02 ,  C12M41/12 ,  C12M41/40 ,  C12M41/46 ,  C12N5/0018 ,  C12N5/0062 ,  C12N2533/00 ,  C12N2533/50 ,  C12N2533/90

Abstract: A system and method for growing and maintaining biological material including producing a protein associated with the tissue, selecting cells associated with the tissue, expanding the cells, creating at least one tissue bio-ink including the expanded cells, printing the at least one tissue bio-ink in at least one tissue growth medium mixture, growing the tissue from the printed at least one tissue bio-ink, and maintaining viability of the tissue.

公开(公告)号：US12024701B2

公开(公告)日：2024-07-02

申请号：US17465133

申请日：2021-09-02

Applicant: DEKA Products Limited Partnership

Inventor： Christopher C. Langenfeld ,  David D. B. Cannan ,  Dirk A. van der Merwe ,  Dean Kamen ,  Jason A. Demers ,  Frederick Morgan ,  Timothy D. Moreau ,  Brian D. Tracey ,  Matthew Ware ,  Richard J. Lanigan ,  Michael A. Baker ,  David Blumberg, Jr. ,  Richard E. Gautney ,  Derek G. Kane ,  Dane Fawkes ,  Thomas J. Bollenbach ,  Michael C. Tilley ,  Stuart A. Jacobson ,  John F. Mannisto

IPC: C12M3/00 ,  A01N1/02 ,  A61L27/38 ,  B33Y10/00 ,  B33Y30/00 ,  B33Y70/00 ,  C12M1/00 ,  C12M1/12 ,  C12M1/26 ,  C12M1/34 ,  C12M1/36 ,  C12N1/00 ,  C12N5/00

CPC classification number: C12M41/48 ,  A01N1/0247 ,  A61L27/3895 ,  B33Y10/00 ,  B33Y30/00 ,  B33Y70/00 ,  C12M21/08 ,  C12M23/22 ,  C12M23/38 ,  C12M25/02 ,  C12M27/18 ,  C12M29/00 ,  C12M33/00 ,  C12M37/02 ,  C12M41/12 ,  C12M41/40 ,  C12M41/46 ,  C12N5/0018 ,  C12N5/0062 ,  C12N2533/00 ,  C12N2533/50 ,  C12N2533/90

Abstract: A system and method for growing and maintaining biological material including producing a protein associated with the tissue, selecting cells associated with the tissue, expanding the cells, creating at least one tissue bio-ink including the expanded cells, printing the at least one tissue bio-ink in at least one tissue growth medium mixture, growing the tissue from the printed at least one tissue bio-ink, and maintaining viability of the tissue.

公开(公告)号：US20210259240A1

公开(公告)日：2021-08-26

申请号：US17180506

申请日：2021-02-19

Applicant: DEKA Products Limited Partnership

Inventor： Joshua Filgate ,  Timothy D. Moreau ,  Scott A. Coull ,  Piper L. Curtis ,  Justin M. Ferrentino ,  Steve L. Henning ,  Bradley Hovan ,  Stuart A. Jacobson ,  Katie E. Leon ,  Katelyn Mosle

IPC: A01N1/02

Abstract: System and method for maintaining an organ and transporting the organ from a donor to a recipient, maintaining normothermic temperature of the organ. The system includes a circulation system providing oxygenated perfusate to the organ and enabling continuous monitoring of the perfusate moving through the organ. The tank can provide an inlet that can accept selected infusible materials, and an outlet that can enable sampling and waste removal. The system can continually monitor the solution bath in which the organ is bathed, and the system can manage the composition of the gas in the tank.

公开(公告)号：US20240400969A1

公开(公告)日：2024-12-05

申请号：US18656660

申请日：2024-05-07

Applicant: DEKA Products Limited Partnership

Inventor： Stuart A. Jacobson ,  Katie E. Leon ,  Hunter A. Higby ,  Richard J. Lanigan ,  Andrew K. Capulli

IPC: C12M1/36 ,  C12M1/00 ,  C12M1/12 ,  C12M1/34 ,  C12N5/079 ,  G01N35/10

Abstract: A system and method for automated production of a viable cell culture on a mesh supported membrane lattice that is suitable for therapeutic implantation in connection with regenerative cell therapy. At least one bioreactor vial is configured to be supported and received by an automated handling and processing system. The bioreactor vial has a reactor well therein into which a mesh-supported submicron parylene-C membrane (MSPM) scaffold is received. Various support fluids are added and subsequently RPE cells are seeded onto the MSPM. The RPE cells form a culture of monolayer of hexagonally shaped RPE cells that is adhered to the MSPM which is suitable for subsequent transplantation into an eye in order to develop in a manner that supports and maintains the photoreceptors of the retina. The system is preferably automated and configured to process multiple bioreactors simultaneously.

公开(公告)号：US20240344016A1

公开(公告)日：2024-10-17

申请号：US18749741

申请日：2024-06-21

Applicant: DEKA Products Limited Partnership

Inventor： Christopher C. Langenfeld ,  David D. B. Cannan ,  Dirk A. Van Der Merwe ,  Dean Kamen ,  Jason A. Demers ,  Frederick Morgan ,  Timothy D. Moreau ,  Brian D. Tracey ,  Matthew Ware ,  Richard J. Lanigan ,  Michael A. Baker ,  David Blumberg, JR. ,  Richard E. Andrews ,  Derek G. Kane ,  Dane C. Fawkes ,  Thomas J. Bollenbach ,  Michael C. Tilley ,  Stuart A. Jacobson ,  John F. Mannisto

IPC: C12M1/36 ,  A01N1/02 ,  A61L27/38 ,  B33Y10/00 ,  B33Y30/00 ,  B33Y70/00 ,  C12M1/00 ,  C12M1/12 ,  C12M1/26 ,  C12M1/34 ,  C12M3/00 ,  C12N5/00

CPC classification number: C12M41/48 ,  A01N1/0247 ,  A61L27/3895 ,  B33Y10/00 ,  B33Y30/00 ,  B33Y70/00 ,  C12M21/08 ,  C12M23/22 ,  C12M23/38 ,  C12M25/02 ,  C12M27/18 ,  C12M29/00 ,  C12M33/00 ,  C12M37/02 ,  C12M41/12 ,  C12M41/40 ,  C12M41/46 ,  C12N5/0018 ,  C12N5/0062 ,  C12N2533/00 ,  C12N2533/50 ,  C12N2533/90

Abstract: A system and method for growing and maintaining biological material including producing a protein associated with the tissue, selecting cells associated with the tissue, expanding the cells, creating at least one tissue bio-ink including the expanded cells, printing the at least one tissue bio-ink in at least one tissue growth medium mixture, growing the tissue from the printed at least one tissue bio-ink, and maintaining viability of the tissue.

公开(公告)号：US11939566B2

公开(公告)日：2024-03-26

申请号：US17465153

申请日：2021-09-02

Applicant: DEKA Products Limited Partnership

Inventor： Christopher C. Langenfeld ,  David D. B. Cannan ,  Dirk A. van der Merwe ,  Dean Kamen ,  Jason A. Demers ,  Frederick Morgan ,  Timothy D. Moreau ,  Brian D. Tracey ,  Matthew Ware ,  Richard J. Lanigan ,  Michael A. Baker ,  David Blumberg, Jr. ,  Richard E. Gautney ,  Derek G. Kane ,  Dane Fawkes ,  Thomas J. Bollenbach ,  Michael C. Tilley ,  Stuart A. Jacobson ,  John F. Mannisto

IPC: C12M3/00 ,  A01N1/02 ,  A61L27/38 ,  B01L3/00 ,  B33Y10/00 ,  B33Y30/00 ,  B33Y70/00 ,  C12M1/00 ,  C12M1/12 ,  C12M1/26 ,  C12M1/34 ,  C12M1/36 ,  C12N5/00

CPC classification number: C12M41/48 ,  A01N1/0247 ,  A61L27/3895 ,  B33Y10/00 ,  B33Y30/00 ,  B33Y70/00 ,  C12M21/08 ,  C12M23/22 ,  C12M23/38 ,  C12M25/02 ,  C12M27/18 ,  C12M29/00 ,  C12M33/00 ,  C12M37/02 ,  C12M41/12 ,  C12M41/40 ,  C12M41/46 ,  C12N5/0018 ,  C12N5/0062 ,  C12N2533/00 ,  C12N2533/50 ,  C12N2533/90

Abstract: A system and method for growing and maintaining biological material including producing a protein associated with the tissue, selecting cells associated with the tissue, expanding the cells, creating at least one tissue bio-ink including the expanded cells, printing the at least one tissue bio-ink in at least one tissue growth medium mixture, growing the tissue from the printed at least one tissue bio-ink, and maintaining viability of the tissue.

公开(公告)号：US11713442B2

公开(公告)日：2023-08-01

申请号：US16904198

申请日：2020-06-17

Applicant: DEKA Products Limited Partnership

Inventor： Richard E. Andrews ,  Stephanie M. Miskell ,  Zachary T. Kops ,  Justin M. Ferrentino ,  Michael C. Tilley ,  Andrew K. Capulli ,  Keira L McGrath ,  Stuart A. Jacobson

IPC: C12M1/36 ,  B01L3/00 ,  B01L9/06 ,  C12M3/06 ,  C12M1/00 ,  C12M1/26 ,  C12M1/12 ,  C12M1/02 ,  C12M1/34 ,  G01N35/00 ,  G01N35/10

CPC classification number: C12M41/48 ,  B01L3/50273 ,  B01L9/06 ,  C12M23/16 ,  C12M29/00 ,  C12M33/10 ,  C12M37/00 ,  C12M41/18 ,  C12M41/36 ,  C12M41/44 ,  C12M45/20 ,  G01N35/00732 ,  G01N35/1004 ,  G01N35/1079 ,  B01L2300/021 ,  B01L2300/041 ,  B01L2300/0609 ,  B01L2300/1805 ,  B01L2400/0475 ,  B01L2400/06

Abstract: Manufacturing system and method for creating multiple tissue constructs from cells. System can include a thaw subsystem (if the cells are provided in a frozen state), an expansion subsystem, a concentration subsystem, and a tissue maturation subsystem. Each of these subsystems is modular and can be reconfigured, and the process can be repeated depending on the specific tissue process being implemented. Multiple tissue types can be combined in multiple bioreactors. The activities of multiple bioreactors can be coordinated and controlled in an automated manner by a supervisor controller. The supervisor controller can receive user input at the start of the process, and can manage the process henceforth, alerting the user if user actions are required.