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    Inhibition of endosomal toll-like receptor activation
    1.
    发明授权
    Inhibition of endosomal toll-like receptor activation 有权

    公开(公告)号：US11617779B2

    公开(公告)日：2023-04-04

    申请号：US15291849

    申请日：2016-10-12

    Applicant: DUKE UNIVERSITY

    Inventor： Bruce A. Sullenger ,  Jaewoo Lee

    IPC: A61K38/16 ,  A61K38/17 ,  A61K31/70 ,  A61K31/13 ,  A61K31/722 ,  A61K31/785

    Abstract: The present invention relates, in general, to pattern-recognition receptors (PRRs), including toll-like receptors (TLRs), and, in particular, to a method of inhibiting nucleic acid-induced activation of, for example, endosomal TLRs using an agent that binds to the nucleic acid (“nucleic acid binding agent”), preferably, in a manner that is independent of the nucleotide sequence, the chemistry (e.g., DNA or RNA, with or without base or sugar modifications) and/or the structure (e.g., double-stranded or single-stranded, complexed or uncomplexed with, for example protein) of the nucleic acid(s) responsible for inducing TLR activation. The invention also relates to methods of identifying nucleic acid binding agents suitable for use in such methods.

    2′ fluoro-modified RNAs as immunostimulators
    3.
    发明授权
    2′ fluoro-modified RNAs as immunostimulators 有权

    公开(公告)号：US10350158B2

    公开(公告)日：2019-07-16

    申请号：US15860248

    申请日：2018-01-02

    Applicant: DUKE UNIVERSITY

    Inventor： Jaewoo Lee ,  Johannes Urban ,  Bruce A. Sullenger

    IPC: C12N15/113 ,  C12N15/117 ,  A61K9/00 ,  C12N15/115 ,  A61K31/7115 ,  A61K9/127 ,  A61K39/00

    Abstract: Methods of inhibiting the growth of cells or inducing cell death by contacting the cells with or introducing into the cells a composition including a 5′ triphosphate, 2′ fluoro-modified pyrimidine non-linear single stranded RNA at least 17 nucleotides long with a least 3 base pairings or a 5′ triphosphate, 2′ fluoro-modified double stranded RNA at least 17 base pairs long in an amount effective to inhibit cell growth, induce cell death or induce cytokine production by the cells. The methods also include administration of the compositions to a subject. The subject may have a proliferative disorder or infectious disease and administration of the compositions provided herein may treat the disorder or disease.

    Compositions and methods for differential induction of cell death and interferon expression
    5.
    发明授权
    Compositions and methods for differential induction of cell death and interferon expression 有权

    公开(公告)号：US11613756B2

    公开(公告)日：2023-03-28

    申请号：US16499991

    申请日：2018-04-03

    Applicant: Duke University

    Inventor： Jaewoo Lee ,  Bruce A. Sullenger ,  Youngju Lee

    IPC: C12N15/117

    Abstract: Disclosed herein are compositions and methods for inhibiting the growth of cells or inducing cell death. The composition capable of inhibiting the growth of cells or inducing cell death comprises a 5′-triphosphate non-linear RNA. The RNA comprises a first stem-loop formed from the complete or partial hybridization of at least 8 nucleotide pairings and may optionally comprise a second stem-loop formed from the complete or partial hybridization of at least 8 nucleotide pairings and a spacer between the first stem-loop and the second stem loop. Methods for inhibiting the growth of cells or inducing cell death comprise contacting cells with the composition or administering the composition to a subject in an amount effective to inhibit the growth of the cells or induce death of the cells.

    INHIBITION OF ENDOSOMAL TOLL-LIKE RECEPTOR ACTIVATION
    9.
    发明公开
    INHIBITION OF ENDOSOMAL TOLL-LIKE RECEPTOR ACTIVATION 审中-公开

    公开(公告)号：US20230248805A1

    公开(公告)日：2023-08-10

    申请号：US18128957

    申请日：2023-03-30

    Applicant: DUKE UNIVERSITY

    Inventor： Bruce A. Sullenger ,  Jaewoo Lee

    IPC: A61K38/16 ,  A61K38/17 ,  A61K31/70 ,  A61K31/13 ,  A61K31/722 ,  A61K31/785

    CPC classification number: A61K38/16 ,  A61K38/1709 ,  A61K31/70 ,  A61K31/13 ,  A61K31/722 ,  A61K31/785

    Abstract: The present invention relates, in general, to pattern-recognition receptors (PRRs), including toll-like receptors (TLRs), and, in particular, to a method of inhibiting nucleic acid-induced activation of, for example, endosomal TLRs using an agent that binds to the nucleic acid (“nucleic acid binding agent”), preferably, in a manner that is independent of the nucleotide sequence, the chemistry (e.g., DNA or RNA, with or without base or sugar modifications) and/or the structure (e.g., double-stranded or single-stranded, complexed or uncomplexed with, for example protein) of the nucleic acid(s) responsible for inducing TLR activation. The invention also relates to methods of identifying nucleic acid binding agents suitable for use in such methods.

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