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公开(公告)号：US09261460B2
公开(公告)日：2016-02-16
申请号：US10096076
申请日：2002-03-12
CPC分类号： C12Q1/6818 , C12Q1/6834 , C12Q1/6844 , C12Q1/6853 , C12Q1/686 , G01N21/64 , G01N21/6486 , C12Q2565/101 , C12Q2533/101 , C12Q2561/113
摘要： This invention provides compositions for use in real time nucleic acid detection processes. Such real time nucleic acid detection processes are carried out with energy transfer elements attached to nucleic acid primers, nucleotides, nucleic acid probes or nucleic acid binding agents. Real time nucleic acid detection allows for the qualitative or quantitative detection or determination of single-stranded or double-stranded nucleic acids of interest in a sample. Other processes are provided by this invention including processes for removing a portion of a homopolymeric sequence, e.g., poly A sequence or tail, from an analyte or library of analytes. Compositions useful in carrying out such removal processes are also described and provided.
摘要翻译： 本发明提供用于实时核酸检测过程的组合物。 这种实时核酸检测方法是用连接于核酸引物，核苷酸，核酸探针或核酸结合剂的能量转移元件进行的。 实时核酸检测允许定性或定量检测或测定样品中感兴趣的单链或双链核酸。 本发明提供了其它方法，包括从被分析物或分析物库中除去一部分均聚物序列，例如聚A序列或尾部的方法。 还描述和提供了用于进行这种去除方法的组合物。
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2.发明授权Property effecting and/or property exhibiting compositions for therapeutic and diagnostic uses 失效性能影响和/或性能表现出用于治疗和诊断用途的组合物公开(公告)号：US08742090B2
公开(公告)日：2014-06-03
申请号：US08978632
申请日：1997-11-25
申请人： Elazar Rabbani , Jannis G. Stavrianopoulos , James J. Donegan , Dakai Liu , Norman E. Kelker , Dean L. Engelhardt
发明人： Elazar Rabbani , Jannis G. Stavrianopoulos , James J. Donegan , Dakai Liu , Norman E. Kelker , Dean L. Engelhardt
IPC分类号： C07H21/04
CPC分类号： C12N15/1132 , C07K14/005 , C07K14/62 , C12N9/1247 , C12N15/87 , C12N2740/16322 , C12Q1/6897 , C12Q1/703 , C12Q2525/301 , C12Q2525/307
摘要： The present invention provides an array of compositions useful for effecting and/or exhibiting changes in biological functioning and processing within cells and in biological systems containing such cells. In effect, these compositions combine chemical modifications and/or ligand additions with biological functions. The chemical modifications and/or ligand additions provide additional characteristics to the compositions without interfering substantially with their biological function. Such additional characteristics include nuclease resistance, targeting specific cells or specific cell receptors localizing to specific sites within cells and augmenting interactions between the compositions and target cells of interest as well as decreasing such interactions when desired. Also provided by the present invention are processes and kits.
摘要翻译： 本发明提供了一组组合物，其用于在细胞内和含有这种细胞的生物系统中实现和/或表现出生物功能和加工中的变化。 实际上，这些组合物将化学修饰和/或配体添加与生物学功能相结合。 化学修饰和/或配体添加为组合物提供额外的特征，而不会基本上干扰它们的生物学功能。 这样的附加特征包括核酸酶抗性，靶向特定细胞或定位于细胞内特定位点的特定细胞受体，并且增加组合物和靶细胞之间的相互作用，并且当需要时减少这种相互作用。 本发明还提供了方法和试剂盒。
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3.发明授权Methods for detecting the presence, location or quantity of targets using novel dyes 有权使用新型染料检测靶的存在，位置或数量的方法公开(公告)号：US08389729B2
公开(公告)日：2013-03-05
申请号：US12456503
申请日：2009-06-17
申请人： Yuejun Xiang , Praveen Pande , Rajesh Khazanchi , Elazar Rabbani , Dakai Liu , Wei Cheng
发明人： Yuejun Xiang , Praveen Pande , Rajesh Khazanchi , Elazar Rabbani , Dakai Liu , Wei Cheng
IPC分类号： C07D215/44
CPC分类号： C07D417/14 , C07D209/14 , C07D235/20 , C07D401/14 , C07D405/14 , C07D417/06 , C07H19/10 , C07H21/00 , C07K14/00 , C07K16/00 , C09B23/0091 , C09B23/04 , C09B23/06 , C09B23/083 , C09B23/105 , C09B23/145 , C09B23/146
摘要： The present invention provides dyes, reactive dyes and labeled reagents that may be used in the detection or quantification of desirable target molecules, such as proteins and nucleic acids. Dyes are provided that may be used free in solution where the binding of the dye to the target molecule provides signal generation. Dyes are also provided that comprise reactive groups that may be used to attach the dyes to probes that will bind to desirable target molecules. The novel dyes of the present invention have been modified by the addition of charged and polar groups to provide beneficial properties.
摘要翻译： 本发明提供可用于检测或定量所需靶分子例如蛋白质和核酸的染料，活性染料和标记试剂。 提供可以在染料与靶分子的结合提供信号产生的溶液中游离的染料。 还提供了包含可用于将染料连接到将与所需靶分子结合的探针的反应性基团的染料。 通过加入带电极和极性基团来改进本发明的新型染料以提供有益的性质。
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4.发明授权Dyes linked to target molecules, oligonucleotides or polynucleotides comprising dye molecules, composite dyes and other compositions useful for detecting or quantifying desirable target molecules 有权与靶分子连接的染料，包含染料分子的寡核苷酸或多核苷酸，复合染料和可用于检测或定量所需靶分子的其它组合物公开(公告)号：US08153802B2
公开(公告)日：2012-04-10
申请号：US12456502
申请日：2009-06-17
申请人： Yuejun Xiang , Praveen Pande , Elazar Rabbani , Rajesh Khazanchi , Dakai Liu , Wei Cheng
发明人： Yuejun Xiang , Praveen Pande , Elazar Rabbani , Rajesh Khazanchi , Dakai Liu , Wei Cheng
IPC分类号： C07D215/44 , C07D401/02
CPC分类号： C07D417/14 , C07D209/14 , C07D235/20 , C07D401/14 , C07D405/14 , C07D417/06 , C07H19/10 , C07H21/00 , C07K14/00 , C07K16/00 , C09B23/0091 , C09B23/04 , C09B23/06 , C09B23/083 , C09B23/105 , C09B23/145 , C09B23/146
摘要： The present invention provides dyes, reactive dyes and labeled reagents that may be used in the detection or quantification of desirable target molecules, such as proteins and nucleic acids. Dyes are provided that may be used free in solution where the binding of the dye to the target molecule provides signal generation. Dyes are also provided that comprise reactive groups that may be used to attach the dyes to probes that will bind to desirable target molecules. The novel dyes of the present invention have been modified by the addition of charged and polar groups to provide beneficial properties.
摘要翻译： 本发明提供可用于检测或定量所需靶分子例如蛋白质和核酸的染料，活性染料和标记试剂。 提供可以在染料与靶分子的结合提供信号产生的溶液中游离的染料。 还提供了包含可用于将染料连接到将与所需靶分子结合的探针的反应性基团的染料。 通过加入带电极和极性基团来改进本发明的新型染料以提供有益的性质。
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5.发明申请公开(公告)号：US20110105606A1
公开(公告)日：2011-05-05
申请号：US12221863
申请日：2008-08-07
申请人： Elazar Rabbani , Xiaofeng Li , Dakai Liu , Yazhou Zhang , Richard Jin , Riddhi Bhattacharyya , Wei Cheng , James J. Donegan
发明人： Elazar Rabbani , Xiaofeng Li , Dakai Liu , Yazhou Zhang , Richard Jin , Riddhi Bhattacharyya , Wei Cheng , James J. Donegan
IPC分类号： A61K31/235 , A61P3/06 , A61P29/00 , A61P37/02 , A61P3/08 , A61P17/14 , A61K31/192 , A61K31/185 , C40B30/06 , C40B30/02 , C40B30/04
CPC分类号： A61K31/538 , A61K31/015 , A61K31/185 , A61K31/192 , A61K31/235 , A61K31/395 , A61K31/535 , A61K38/00 , G01N33/5011 , G01N33/5041 , G01N33/564 , G01N33/92 , G01N2333/705 , G01N2800/24
摘要： The present invention relates to the field of therapeutic methods, compositions and uses thereof, that affect, directly or indirectly, the behavior of LRP receptors. These compositions and methods result in the treatment of inflammatory, immunological and metabolic conditions. More particularly, the methods and compositions of the invention are directed to the identification of small molecules, drugs and/or pharmacological agents that affect the Wnt pathway by affecting normal complex formation among various signaling receptors, the LRP5 and LRP6 receptor, and related ligands.
摘要翻译： 本发明涉及直接或间接影响LRP受体的行为的治疗方法，组合物和用途领域。 这些组合物和方法导致治疗炎症，免疫和代谢疾病。 更具体地，本发明的方法和组合物涉及通过影响各种信号传导受体（LRP5和LRP6受体）和相关配体之间的正常复合物形成来鉴定影响Wnt途径的小分子，药物和/或药理学试剂。
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6.发明授权Processes for incorporating nucleic acid sequences into an analyte or library of analytes 有权将核酸序列并入分析物或分析物库中的方法公开(公告)号：US07858302B2
公开(公告)日：2010-12-28
申请号：US11237466
申请日：2005-09-27
CPC分类号： C12Q1/6818 , C12Q1/6834 , C12Q1/6844 , C12Q1/6853 , C12Q1/686 , G01N21/64 , G01N21/6486 , C12Q2565/101 , C12Q2533/101 , C12Q2561/113
摘要： This invention provides for compositions for use in real time nucleic acid detection processes. Such real time nucleic acid detection processes are carried out with energy transfer elements attached to nucleic acid primers, nucleotides, nucleic acid probes or nucleic acid binding agents. Real time nucleic acid detection allows for the qualitative or quantitative detection or determination of single-stranded or double-stranded nucleic acids of interest in a sample. Other processes are provided by this invention including processes for removing a portion of a homopolymeric sequence, e.g., poly A sequence or tail, from an analyte or library of analytes. Compositions useful in carrying out such removal processes are also described and provided.
摘要翻译： 本发明提供用于实时核酸检测过程的组合物。 这种实时核酸检测方法是用连接于核酸引物，核苷酸，核酸探针或核酸结合剂的能量转移元件进行的。 实时核酸检测允许定性或定量检测或测定样品中感兴趣的单链或双链核酸。 本发明提供了其它方法，包括从被分析物或分析物库中除去一部分均聚物序列，例如聚A序列或尾部的方法。 还描述和提供了用于进行这种去除方法的组合物。
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公开(公告)号：US20090263895A1
公开(公告)日：2009-10-22
申请号：US12075482
申请日：2008-03-12
申请人： Dakai Liu , Elazar Rabbani
发明人： Dakai Liu , Elazar Rabbani
IPC分类号： C12N5/08
CPC分类号： C12N15/86 , C12N7/00 , C12N2710/10352 , C12N2740/13043 , C12N2740/16021 , C12N2740/16043 , C12N2750/14122 , C12N2750/14143 , C12N2750/14152
摘要： Provided are novel vectors and viral vectors capable of expressing exogenous gene or exogenous nucleic acid sequences in a target cell of interest, such as T cells, bone marrow cells, epithelial cells, liver cells and the like. The nucleic acid components of the vectors may include one or more native promoter/enhancer regions having modified sequence segments, one or more non-native promoter/enhancer or non-native promoter's gene or gene segment, and a native viral vector terminator or processing signal or segment thereof. The viral vectors comprise a virus or viral portion having on the surfaces or envelopes adsorption components, one for a packaging cell line and the other for delivery to a target cell. Other viral vectors provided by this invention have two components on their surfaces or envelopes, one of which is native to the virus and the other being non-native and capable of adsorbing to the target cell while being incapable of adsorbing to a native cell for the viral vector. Packaging cell lines for propagating the vectors and viral vectors are also provided, as are novel processes for propagating any of the disclosed vectors or viral vectors.
摘要翻译： 提供能够在靶细胞中表达外源基因或外源核酸序列的新载体和病毒载体，例如T细胞，骨髓细胞，上皮细胞，肝细胞等。 载体的核酸组分可以包括一个或多个具有修饰的序列区段的天然启动子/增强子区域，一个或多个非天然启动子/增强子或非天然启动子的基因或基因区段，以及天然病毒载体终止子或处理信号 或其片段。 病毒载体包含在表面或包膜上具有吸附组分的病毒或病毒部分，一个用于包装细胞系，另一个用于递送至靶细胞。 本发明提供的其它病毒载体在其表面或包膜上具有两个组分，其中一个组分是病毒天然的，另一个是非天然的，并且能够吸附到靶细胞，同时不能吸附到天然细胞中 病毒载体。 还提供用于繁殖载体和病毒载体的包装细胞系，以及用于繁殖任何所公开的载体或病毒载体的新方法。
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8.发明授权Chimeric nucleic acid constructs and compositions comprising sets of nucleic acid constructs 有权嵌合核酸构建体和包含一组核酸构建体的组合物公开(公告)号：US07547772B2
公开(公告)日：2009-06-16
申请号：US11236151
申请日：2005-09-27
CPC分类号： C12Q1/6818 , C12Q1/6834 , C12Q1/6844 , C12Q1/6853 , C12Q1/686 , G01N21/64 , G01N21/6486 , C12Q2565/101 , C12Q2533/101 , C12Q2561/113
摘要： This invention provides for compositions for use in real time nucleic acid detection processes. Such real time nucleic acid detection processes are carried out with energy transfer elements attached to nucleic acid primers, nucleotides, nucleic acid probes or nucleic acid binding agents. Real time nucleic acid detection allows for the qualitative or quantitative detection or determination of single-stranded or double-stranded nucleic acids of interest in a sample. Other processes are provided by this invention including processes for removing a portion of a homopolymeric sequence, e.g., poly A sequence or tail, from an analyte or library of analytes. Compositions useful in carrying out such removal processes are also described and provided.
摘要翻译： 本发明提供用于实时核酸检测过程的组合物。 这种实时核酸检测方法是用连接于核酸引物，核苷酸，核酸探针或核酸结合剂的能量转移元件进行的。 实时核酸检测允许定性或定量检测或测定样品中感兴趣的单链或双链核酸。 本发明提供了其它方法，包括从被分析物或分析物库中除去一部分均聚物序列，例如聚A序列或尾部的方法。 还描述和提供了用于进行这种去除方法的组合物。
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9.发明申请NOVEL PROPERTY EFFECTING AND/OR PROPERTY EXHIBITING COMPOSITIONS FOR THERAPEUTIC AND DIAGNOSTIC USES 有权用于治疗和诊断用途的新型物业效果和/或物业展示组合物公开(公告)号：US20080248564A1
公开(公告)日：2008-10-09
申请号：US11929897
申请日：2007-10-30
申请人： Elazar Rabbani , Jannis G. Stavrianopoulos , James J. Donegan , Dakai Liu , Norman E. Kelker , Dean L. Engelhardt
发明人： Elazar Rabbani , Jannis G. Stavrianopoulos , James J. Donegan , Dakai Liu , Norman E. Kelker , Dean L. Engelhardt
IPC分类号： C12N15/00
CPC分类号： C12N15/1132 , C07K14/005 , C07K14/62 , C12N9/1247 , C12N15/87 , C12N2740/16322 , C12Q1/6897 , C12Q1/703 , C12Q2525/301 , C12Q2525/307
摘要： The present invention provides an array of compositions useful for effecting and/or exhibiting changes in biological functioning and processing within cells and in biological systems containing such cells. In effect, these compositions combine chemical modifications and/or ligand additions with biological functions. The chemical modifications and/or ligand additions provide additional characteristics to the compositions without interfering substantially with their biological function. Such additional characteristics include nuclease resistance, targeting specific cells or specific cell receptors localizing to specific sites within cells and augmenting interactions between the compositions and target cells of interest as well as decreasing such interactions when desired. Also provided by the present invention are processes and kits.
摘要翻译： 本发明提供了一组组合物，其用于在细胞内和含有这种细胞的生物系统中实现和/或表现出生物功能和加工中的变化。 实际上，这些组合物将化学修饰和/或配体添加与生物学功能相结合。 化学修饰和/或配体添加为组合物提供额外的特征，而不会基本上干扰它们的生物学功能。 这样的附加特征包括核酸酶抗性，靶向特定细胞或定位于细胞内特定位点的特定细胞受体，并且增加组合物和靶细胞之间的相互作用，并且当需要时减少这种相互作用。 本发明还提供了方法和试剂盒。
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10.发明申请公开(公告)号：US20070037284A1
公开(公告)日：2007-02-15
申请号：US11285757
申请日：2005-11-22
申请人： Dakai Liu , Elazar Rabbani
发明人： Dakai Liu , Elazar Rabbani
CPC分类号： C12N15/86 , C12N2740/13043 , C12N2750/14122 , C12N2800/50 , C12N2830/00
摘要： Provided are novel vectors and viral vectors capable of expressing exogenous gene or exogenous nucleic acid sequences in a target cell of interest, such as T cells, bone marrow cells, epithelial cells, liver cells and the like. The nucleic acid components of the vectors may include one or more native promoter/enhancer regions having modified sequence segments, one or more non-native promoter/enhancer or non-native promoter's gene or gene segment, and a native viral vector terminator or processing signal or segment thereof. The viral vectors comprise a virus or viral portion having on the surfaces or envelopes adsorption components, one for a packaging cell line and the other for delivery to a target cell. Other viral vectors provided by this invention have two components on their surfaces or envelopes, one of which is native to the virus and the other being non-native and capable of adsorbing to the target cell while being incapable of adsorbing to a native cell for the viral vector. Packaging cell lines for propagating the vectors and viral vectors are also provided, as are novel processes for propagating any of the disclosed vectors or viral vectors.
摘要翻译： 提供能够在靶细胞中表达外源基因或外源核酸序列的新载体和病毒载体，例如T细胞，骨髓细胞，上皮细胞，肝细胞等。 载体的核酸组分可以包括一个或多个具有修饰的序列区段的天然启动子/增强子区域，一个或多个非天然启动子/增强子或非天然启动子的基因或基因区段，以及天然病毒载体终止子或处理信号 或其片段。 病毒载体包含在表面或包膜上具有吸附组分的病毒或病毒部分，一个用于包装细胞系，另一个用于递送至靶细胞。 本发明提供的其它病毒载体在其表面或包膜上具有两个组分，其中一个组分是病毒天然的，另一个是非天然的，并且能够吸附到靶细胞，同时不能吸附到天然细胞中 病毒载体。 还提供用于繁殖载体和病毒载体的包装细胞系，以及用于繁殖任何所公开的载体或病毒载体的新方法。
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