公开(公告)号：US6066848A

公开(公告)日：2000-05-23

申请号：US185450

申请日：1998-11-03

申请人： Daniel B. Kassel ,  Tao Wang ,  Lu Zeng

发明人： Daniel B. Kassel ,  Tao Wang ,  Lu Zeng

IPC分类号： G01N30/46 ,  G01N30/62 ,  G01N30/72 ,  H01J49/04 ,  H01J49/10

CPC分类号： H01J49/165 ,  G01N2030/628 ,  G01N30/466 ,  G01N30/7266

摘要： A method of analyzing each of a plurality of fluid samples (11-16), comprising, simultaneously spraying a plurality fluid samples (11-16) from electrospray needle array (20) towards mass spectrometer (50); positioning blocking device (40) to block all but one (32-34) of fluid samples (31-34) from reaching mass spectrometer (50); moving electrospray needle array (20) and blocking device (40) relative to one another to permit at least two of the plurality of fluid samples (31, 32) to reach mass spectrometer (50) one at a time; and analyzing the mass spectrum of fluid samples (31, 32, 33, 34) sequentially reaching mass spectrometer (50). A system for analyzing the composition of each of a plurality of fluid samples (31-34), comprising, mass spectrometer (50); multi-head electrospray needle array (20) for spraying fluid samples (31-34) towards mass spectrometer (50); and blocking device (40) positioned between electrospray needle array (20) and mass spectrometer (50), blocking device (40) dimensioned to block all but one (32-34) of fluid sample electrosprays (31-34) from reaching mass spectrometer (50).

摘要翻译： 一种分析多个流体样品（11-16）中的每一个的方法，包括：从电喷枪针阵列（20）向质谱仪（50）同时喷射多个流体样品（11-16）; 定位阻挡装置（40）阻挡除了一个（32-34）的流体样品（31-34）之外的所有物质到达质谱仪（50）; 相对于彼此移动的电喷枪针阵列（20）和阻挡装置（40），以允许多个流体样品（31,32）中的至少两个一次到达质谱仪（50）; 并分析顺序到达质谱仪（50）的流体样品（31,32,33,34）的质谱。 一种用于分析多个流体样品（31-34）中的每一个的组成的系统，包括质谱仪（50）; 用于向质谱仪（50）喷射流体样品（31-34）的多头电喷枪针阵列（20）; 以及位于电喷枪针阵列（20）和质谱仪（50）之间的阻挡装置（40），阻挡装置（40）的尺寸被设计成阻挡除了一个（32-34）的流体样品电喷雾器（31-34）之外的所有物质到达质谱仪 （50）。

公开(公告)号：US20210138086A1

公开(公告)日：2021-05-13

申请号：US17145006

申请日：2021-01-08

申请人： Rongliang Chen ,  Padma Manam ,  Lu Zeng ,  Takeda Pharmaceutical Company Limited

发明人： Rongliang Chen ,  Padma Manam ,  Lu Zeng

IPC分类号： A61K47/69 ,  C08B37/16 ,  C07D401/14 ,  A61K31/4725 ,  A61K31/519

摘要： Disclosed is a complex of a compound of Formula 1, a stereoisomer thereof, or a tautomer of the compound of Formula 1 or stereoisomer thereof, and a cyclodextrin, in which the complex is an amorphous solid. This disclosure also relates to materials and methods for preparing the complex, to pharmaceutical compositions which contain the complex, and to the use of the complex to treat Type I hypersensitivity reactions, autoimmune diseases, inflammatory disorders, cancer, non-malignant proliferative disorders, and other conditions associated with BTK.

公开(公告)号：US11786608B2

公开(公告)日：2023-10-17

申请号：US17145006

申请日：2021-01-08

申请人： Takeda Pharmaceutical Company Limited ,  Rongliang Chen ,  Padma Manam ,  Lu Zeng

发明人： Rongliang Chen ,  Padma Manam ,  Lu Zeng

IPC分类号： A61K47/69 ,  C07D401/14 ,  A61K31/4725 ,  A61K31/519 ,  C08B37/16

CPC分类号： A61K47/6951 ,  A61K31/4725 ,  A61K31/519 ,  C07D401/14 ,  C08B37/0015

摘要： Disclosed is a complex of a compound of Formula 1,




a stereoisomer thereof, or a tautomer of the compound of Formula 1 or stereoisomer thereof, and a cyclodextrin, in which the complex is an amorphous solid. This disclosure also relates to materials and methods for preparing the complex, to pharmaceutical compositions which contain the complex, and to the use of the complex to treat Type I hypersensitivity reactions, autoimmune diseases, inflammatory disorders, cancer, non-malignant proliferative disorders, and other conditions associated with BTK.

公开(公告)号：US20080255001A1

公开(公告)日：2008-10-16

申请号：US12077256

申请日：2008-03-18

申请人： Gary Eldridge ,  Lu Zeng ,  Peader Cremin ,  Chris Lee ,  Helene C. Vervoort ,  Marilyn Ghanem

发明人： Gary Eldridge ,  Lu Zeng ,  Peader Cremin ,  Chris Lee ,  Helene C. Vervoort ,  Marilyn Ghanem

IPC分类号： C40B30/00 ,  C40B50/00

CPC分类号： C40B40/04 ,  B01J2219/00315 ,  B01J2219/00707 ,  B01J2219/0072 ,  B01J2219/00759 ,  C40B40/00 ,  C40B50/08 ,  G01N2500/04

摘要： A method of producing a chemical compound library comprises extracting at least one extract from at least one species of plant; processing at least one of the extract(s) to remove at least one type of chemical interference to produce a processed extract; chromatographically separating the processed extract into a plurality of chromatographic fractions, each containing an amount of chemical compounds; determining the amount of chemical compounds in at least one of the chromatographic fractions; and normalizing the chromatographic fractions in which the amounts were determined to produce normalized chromatographic fractions, each such fraction comprising from about 1 microgram to about 500 micrograms of each of from one to seven chemical compounds that were present in lower concentrations in the extract and that each have a log P of from about −1 to about 5 and a molecular weight less than about 1000 Daltons; thereby to produce a chemical compound library from at least one species of plant.

摘要翻译： 制备化学化合物文库的方法包括从至少一种植物提取至少一种提取物; 处理至少一种提取物以除去至少一种类型的化学干扰以产生经处理的提取物; 将经处理的提取物色谱分离成多个色谱级分，每一层含有一定数量的化合物; 确定至少一个色谱级分中的化合物的量; 并归一化其中确定量的色谱级分以产生归一化色谱级分，每个这样的级分包含从提取物中以较低浓度存在的1至7种化合物中的约1微克至约500微克， 具有约-1至约5的对数P和小于约1000道尔顿的分子量; 从而从至少一种植物产生化学化合物文库。

公开(公告)号：US20080280770A1

公开(公告)日：2008-11-13

申请号：US12166428

申请日：2008-07-02

申请人： Gary Eldridge ,  Lu Zeng ,  Peader Cremin ,  Chris Lee ,  Helene C. Vervoort ,  Marilyn Ghanem

发明人： Gary Eldridge ,  Lu Zeng ,  Peader Cremin ,  Chris Lee ,  Helene C. Vervoort ,  Marilyn Ghanem

IPC分类号： C40B30/00 ,  C40B99/00

CPC分类号： C40B40/04 ,  B01J2219/00315 ,  B01J2219/00707 ,  B01J2219/0072 ,  B01J2219/00759 ,  C40B40/00 ,  C40B50/08 ,  G01N2500/04

摘要： A method of producing a chemical compound library comprises extracting at least one extract from at least one species of plant; processing at least one of the extract(s) to remove at least one type of chemical interference to produce a processed extract; chromatographically separating the processed extract into a plurality of chromatographic fractions, each containing an amount of chemical compounds; determining the amount of chemical compounds in at least one of the chromatographic fractions; and normalizing the chromatographic fractions in which the amounts were determined to produce normalized chromatographic fractions, each such fraction comprising from about 1 microgram to about 500 micrograms of each of from one to seven chemical compounds that were present in lower concentrations in the extract and that each have a log P of from about −1 to about 5 and a molecular weight less than about 1000 Daltons; thereby to produce a chemical compound library from at least one species of plant.

摘要翻译： 制备化学化合物文库的方法包括从至少一种植物提取至少一种提取物; 处理至少一种提取物以除去至少一种类型的化学干扰以产生经处理的提取物; 将经处理的提取物色谱分离成多个色谱级分，每一层含有一定数量的化合物; 确定至少一个色谱级分中的化合物的量; 并归一化其中确定量的色谱级分以产生归一化色谱级分，每个这样的级分包含从提取物中以较低浓度存在的1至7种化合物中的约1微克至约500微克， 具有约-1至约5的对数P和小于约1000道尔顿的分子量; 从而从至少一种植物产生化学化合物文库。

公开(公告)号：US07367933B2

公开(公告)日：2008-05-06

申请号：US11358815

申请日：2006-02-21

申请人： Gary Eldridge ,  Lu Zeng ,  Peader Cremin ,  Chris Lee ,  Helene C. Vervoort ,  Marilyn Ghanem

发明人： Gary Eldridge ,  Lu Zeng ,  Peader Cremin ,  Chris Lee ,  Helene C. Vervoort ,  Marilyn Ghanem

IPC分类号： C40B50/00 ,  G01N33/53

CPC分类号： C40B40/04 ,  B01J2219/00315 ,  B01J2219/00707 ,  B01J2219/0072 ,  B01J2219/00759 ,  C40B40/00 ,  C40B50/08 ,  G01N2500/04

摘要： A method of producing a chemical compound library comprises extracting at least one extract from at least one species of plant; processing at least one of the extract(s) to remove at least one type of chemical interference to produce a processed extract; chromatographically separating the processed extract into a plurality of chromatographic fractions, each containing an amount of chemical compounds; determining the amount of chemical compounds in at least one of the chromatographic fractions; and normalizing the chromatographic fractions in which the amounts were determined to produce normalized chromatographic fractions, each such fraction comprising from about 1 microgram to about 500 micrograms of each of from one to seven chemical compounds that were present in lower concentrations in the extract and that each have a log P of from about −1 to about 5 and a molecular weight less than about 1000 Daltons; thereby to produce a chemical compound library from at least one species of plant.

公开(公告)号：US20060223118A1

公开(公告)日：2006-10-05

申请号：US11358815

申请日：2006-02-21

申请人： Gary Eldridge ,  Lu Zeng ,  Peader Cremin ,  Chris Lee ,  Helene Vervoort ,  Marilyn Ghanem

发明人： Gary Eldridge ,  Lu Zeng ,  Peader Cremin ,  Chris Lee ,  Helene Vervoort ,  Marilyn Ghanem

IPC分类号： C40B30/10

CPC分类号： C40B40/04 ,  B01J2219/00315 ,  B01J2219/00707 ,  B01J2219/0072 ,  B01J2219/00759 ,  C40B40/00 ,  C40B50/08 ,  G01N2500/04

摘要： A method of producing a chemical compound library comprises extracting at least one extract from at least one species of plant; processing at least one of the extract(s) to remove at least one type of chemical interference to produce a processed extract; chromatographically separating the processed extract into a plurality of chromatographic fractions, each containing an amount of chemical compounds; determining the amount of chemical compounds in at least one of the chromatographic fractions; and normalizing the chromatographic fractions in which the amounts were determined to produce normalized chromatographic fractions, each such fraction comprising from about 1 microgram to about 500 micrograms of each of from one to seven chemical compounds that were present in lower concentrations in the extract and that each have a log P of from about −1 to about 5 and a molecular weight less than about 1000 Daltons; thereby to produce a chemical compound library from at least one species of plant.

摘要翻译： 制备化学化合物文库的方法包括从至少一种植物提取至少一种提取物; 处理至少一种提取物以除去至少一种类型的化学干扰以产生经处理的提取物; 将经处理的提取物色谱分离成多个色谱级分，每一层含有一定数量的化合物; 确定至少一个色谱级分中的化合物的量; 并归一化其中确定量的色谱级分以产生归一化色谱级分，每个这样的级分包含从提取物中以较低浓度存在的1至7种化合物中的约1微克至约500微克， 具有约-1至约5的对数P和小于约1000道尔顿的分子量; 从而从至少一种植物产生化学化合物文库。