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公开(公告)号：US20130123707A1
公开(公告)日：2013-05-16
申请号：US13699805
申请日：2011-05-26
CPC分类号： A61K9/0021 , A61K47/10 , A61K47/183 , A61K47/22 , A61K47/26 , A61K47/32 , A61K47/36 , A61K47/38 , A61M37/0015
摘要： Aqueous formulations that include at least one active pharmaceutical ingredient; and at least one excipient, wherein the aqueous formulation has a viscosity of from 500 to 30,000 centipoise when measured at a shear rate of 100 s−1 and a temperature of 25° C.; a surface tension that is not greater than 60 dynes/cm when measured under ambient conditions; or a contact angle on a medical grade polymeric material of 50° or greater when measured under ambient conditions. Methods of coating and coated microneedle arrays using the aqueous formulations are also disclosed herein.
摘要翻译： 包含至少一种活性药物成分的水性制剂; 和至少一种赋形剂，其中当在100s -1的剪切速率和25℃的温度下测量时，所述水性制剂具有500至30,000厘泊的粘度。 当在环境条件下测量时，表面张力不大于60达因/厘米; 或在环境条件下测量时，医疗级聚合物材料的接触角为50°或更大。 本文还公开了使用水性制剂的包衣和包衣微针阵列的方法。
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2.发明授权C-17/21 OH 20-ketosteroid solution aerosol products with enhanced chemical stability 有权C-17/21 OH 20-酮类溶液气溶胶产品具有增强的化学稳定性公开(公告)号：US06315985B1
公开(公告)日：2001-11-13
申请号：US09592885
申请日：2000-06-13
申请人： Zheng Z. Wu , Nayna Govind , Peter R. Johnson
发明人： Zheng Z. Wu , Nayna Govind , Peter R. Johnson
IPC分类号： A61K912
摘要： A medicinal aerosol steroid solution formulation product with enhanced chemical stability. The steroid is a 20-ketosteroid having an OH group at the C-17 or C-21 position and the aerosol container has a non-metal interior surface which has been found to reduce chemical degradation of such steroids.
摘要翻译： 具有增强化学稳定性的药用气溶胶类固醇溶液制剂产品。 类固醇是在C-17或C-21位置具有OH基团的20-酮类固醇，并且气溶胶容器具有非金属内表面，已被发现可减少这类类固醇的化学降解。
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公开(公告)号：US07846488B2
公开(公告)日：2010-12-07
申请号：US11718737
申请日：2005-11-18
申请人： Peter R. Johnson , Marla R. Emery , James T. Wolter , Jennifer E. Raeder-Devens , Daniel C. Duan , Moses M. David , Hye-Ok Choi
发明人： Peter R. Johnson , Marla R. Emery , James T. Wolter , Jennifer E. Raeder-Devens , Daniel C. Duan , Moses M. David , Hye-Ok Choi
IPC分类号： A61L33/00
CPC分类号： A61K9/0021 , A61M37/0015 , A61M2037/0046 , A61M2037/0053
摘要： A method of coating a microneedle array comprising: providing a microneedle array having a substrate and at least one needle; providing a removable masking layer on the microneedle array such that the substrate is at least partially covered by the masking layer and the at least one needle remains at least partially exposed; and applying a coating material to at least a portion of the exposed portion of the microneedle array.
摘要翻译： 一种涂覆微针阵列的方法，包括：提供具有基底和至少一个针的微针阵列; 在所述微针阵列上提供可移除的掩模层，使得所述基底至少部分地被所述掩蔽层覆盖，并且所述至少一个针保持至少部分地暴露; 以及将涂层材料施加到所述微针阵列的暴露部分的至少一部分。
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公开(公告)号：US20080114298A1
公开(公告)日：2008-05-15
申请号：US11718465
申请日：2005-11-18
IPC分类号： A61M5/158
CPC分类号： A61M37/0015 , A61M2037/0023
摘要： An applicator (100) used to apply microneedle arrays (10) to a mammal. In particular, an application device for applying a microneedle device (120) to a skin surface comprising a flexible sheet (110) having a raised central area (115) attached to the microneedle device and a supporting member at or near the periphery of the flexible sheet, wherein the flexible sheet is configured such that it will undergo a stepwise motion in the direction orthogonal to the major plane of the sheet.
摘要翻译： 用于将微针阵列（10）施用于哺乳动物的施加器（100）。 特别地，一种用于将微针装置（120）施加到皮肤表面的施加装置，包括具有附接到微针装置的凸起中心区域（115）的柔性片（110）和位于柔性片 其中所述柔性片被构造成使得其将在与所述片材的主平面正交的方向上进行逐步运动。
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公开(公告)号：US5943300A
公开(公告)日：1999-08-24
申请号：US984218
申请日：1997-12-03
申请人： Peter R. Johnson
发明人： Peter R. Johnson
CPC分类号： G04B19/046
摘要： A timepiece that uses disks having sharp zones of contrast of visual design density to indicate time intervals when the sharp zone of contrast is aligned with time interval indicator markings or traditional time indicator positions on a non-rotatable frame. The disks of the chronograph are continuously graduated in visual design density from an area of greatest density to an area of least density to form a sharp zone or line of contrast. The disks are located so that when the sharp zone or line of contrast is aligned with the time indicator markings or positions on the frame, thus displaying the time in an accurate fashion that is easily and quickly discernable even for individuals that are poor sighted. In addition, the timepiece presents such a strikingly novel design that it makes an aesthetic statement that is desirable for use by individuals with no sight problems.
摘要翻译： 使用具有尖锐视觉设计密度区域的磁盘的时钟表示当对比度的尖锐区域与不可旋转的框架上的时间间隔指示符标记或传统的时间指示器位置对准时的时间间隔。 计时码表的磁盘以视觉设计密度从最大密度的区域连续刻度到最小密度的区域，形成锋利的区域或对比线。 这些盘被定位成使得当锋利区域或对比线与时间指示器标记或框架上的位置对准时，从而以准确的方式显示时间，即使对于看不见的人也容易且快速地辨别。 此外，这款腕表呈现出这样一种惊人的新颖设计，使得美学上的声明对于没有视力问题的个人而言是理想的。
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公开(公告)号：US09693950B2
公开(公告)日：2017-07-04
申请号：US13699805
申请日：2011-05-26
IPC分类号： A61K9/00 , A61K47/32 , A61K47/36 , A61K47/38 , A61M37/00 , A61K47/10 , A61K47/18 , A61K47/22 , A61K47/26
CPC分类号： A61K9/0021 , A61K47/10 , A61K47/183 , A61K47/22 , A61K47/26 , A61K47/32 , A61K47/36 , A61K47/38 , A61M37/0015
摘要： Aqueous formulations that include at least one active pharmaceutical ingredient; and at least one excipient, wherein the aqueous formulation has a viscosity of from 500 to 30,000 centipoise when measured at a shear rate of 100 s−1 and a temperature of 25° C.; a surface tension that is not greater than 60 dynes/cm when measured under ambient conditions; or a contact angle on a medical grade polymeric material of 50° or greater when measured under ambient conditions. Methods of coating and coated microneedle arrays using the aqueous formulations are also disclosed herein.
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公开(公告)号：US20090050143A1
公开(公告)日：2009-02-26
申请号：US12293216
申请日：2007-03-23
申请人： Larry D. Boardman , Peter R. Johnson , Gary A. Korba , Mark E. Mueller , Mark J. Pellerite , Ravi Ravichandran
发明人： Larry D. Boardman , Peter R. Johnson , Gary A. Korba , Mark E. Mueller , Mark J. Pellerite , Ravi Ravichandran
CPC分类号： A61M15/009 , A61M2205/0222 , B65D83/54 , B82Y30/00 , C23C22/03 , C23C30/00
摘要： A container, such as a metered dose inhaler, suitable for use with a propellant-based medicinal formulation, the container comprising one or more treated metal surfaces that come into contact with the medicinal formulation, wherein the one or more treated metal surfaces are characterized by an organic surface treatment compound covalently bonded to the metal surface through a reactive head group selected from either phosphonic acid or carboxylic acid and wherein the organic surface treatment compound is further characterized by an exposed, substantially non-reactive tail group disposed away from the metal surface. Also, metered dose inhaler canisters and valves with treated surfaces.
摘要翻译： 一种容器，例如计量吸入器，适用于基于推进剂的药物制剂，所述容器包括与药物制剂接触的一种或多种经处理的金属表面，其中所述一种或多种经处理的金属表面的特征在于 通过选自膦酸或羧酸的反应性头基团共价结合到金属表面的有机表面处理化合物，其中有机表面处理化合物的进一步特征在于远离金属表面放置的暴露的，基本上不反应的尾基 。 此外，计量吸入器罐和具有处理表面的阀。
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8.发明申请Coatable Compositions, Coatings Derived Therefrom and Microarrays Having Such Coatings 有权可涂覆组合物，衍生自其的涂层和具有这种涂层的微阵列公开(公告)号：US20080294116A1
公开(公告)日：2008-11-27
申请号：US12092733
申请日：2006-11-17
CPC分类号： A61K9/0021 , A61K47/12 , A61K47/26 , A61K47/32 , A61M37/0015 , A61M2037/0023 , A61M2037/0046
摘要： Coatable compositions and coatings derived from the coatable compositions, and microarrays comprising such coatings are described. In one aspect, the invention provides a microarray comprising: a plurality of microneedles extending from a support substrate; a coating deposited on at least one of the plurality of microneedles, the coating comprising an active agent and a biological salt. In another aspect, the invention provides a coatable composition, comprising: active agent; a biological salt; and solvent. In still another aspect, the invention provides a dried coating coated on a microneedle, the coating comprising: an active agent; and a biological salt.
摘要翻译： 描述了可涂覆组合物和衍生自可涂覆组合物的涂层，以及包含这种涂层的微阵列。 一方面，本发明提供了一种微阵列，包括：多个从支撑基板延伸的微针; 沉积在所述多个微针中的至少一个上的涂层，所述涂层包含活性剂和生物盐。 另一方面，本发明提供一种可涂覆组合物，其包含：活性剂; 生物盐; 和溶剂。 另一方面，本发明提供涂覆在微针上的干燥涂层，所述涂层包含：活性剂; 和生物盐。
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公开(公告)号：US20080262416A1
公开(公告)日：2008-10-23
申请号：US12089551
申请日：2006-11-17
申请人： Daniel C. Duan , Peter R. Johnson
发明人： Daniel C. Duan , Peter R. Johnson
CPC分类号： B81C1/0038 , A61K9/0021 , A61K47/26 , A61K47/32 , A61M37/0015 , A61M2037/0023 , A61M2037/0053 , A61M2037/0061 , B81B2201/055
摘要： A microneedle array having a substrate and a plurality of microneedles extending out from the substrate with a multi-phase matrix coating on at least a portion of the microneedle surface of the microneedle array. The multi-phase matrix coating comprises an active substance and has a first solid phase and a liquid phase. The first solid phase comprises a water-soluble polymer. Also, a method of providing an active substance- containing matrix coating on a microneedle array in which a water-soluble polymer is applied to the microneedle surface of the array to form a dried coating of water-soluble polymer. A coating solution comprising an active substance, a liquid capable of phase separating from the water-soluble polymer, and a carrier fluid is prepared and applied to the dried coating of water-soluble polymer. At least a portion of the carrier fluid is removed from the array.
摘要翻译： 一种微针阵列，其具有基底和多个微针，所述微针在所述微针阵列的所述微针表面的至少一部分上以多相基质涂层从所述基底延伸出来。 多相基质涂层包含活性物质并具有第一固相和液相。 第一固相包含水溶性聚合物。 另外，一种在微针阵列上提供含活性物质的基质涂层的方法，其中将水溶性聚合物施加到阵列的微针表面以形成水溶性聚合物的干燥涂层。 制备包含活性物质，能够与水溶性聚合物相分离的液体和载体流体的涂布溶液，并将其涂覆到水溶性聚合物的干燥涂层上。 载体流体的至少一部分从阵列中移除。
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公开(公告)号：US5243823A
公开(公告)日：1993-09-14
申请号：US966220
申请日：1992-10-26
CPC分类号： B60T11/20 , B60T11/16 , Y10T403/7058
摘要： In a master cylinder (20), a cap (30) for guiding a primary piston (50) is located within an end opening (24) of a body (22) of the master cylinder (20). The end cap (30) retains a sleeve (40) and other components within a bore (12) of the master cylinder (20), and is attached to the body (22) of the master cylinder (20) by way of a biasing retention mechanism (45; 145, 150; 260). The mechanism (45; 145, 150; 260) may bias the end cap (30) axially inwardly of the bore (12), bias a gripping ring member (145) radially outwardly into engagement with the body (22) of the master cylinder (20), and retain a first end (32) of the end cap (30) within the bore (12) in accordance with the extent to which the first end (32) is inserted axially into the bore (12).
摘要翻译： 在主缸（20）中，用于引导主活塞（50）的盖（30）位于主缸（20）的主体（22）的端部开口（24）内。 端盖（30）将套筒（40）和其它部件保持在主缸（20）的孔（12）内，并且通过偏置件附接到主缸（20）的主体（22） 保持机构（45; 145,150; 260）。 所述机构（45; 145,150,260）可以轴向地向所述孔（12）的内侧偏压所述端盖（30），从而径向向外偏置夹紧环构件（145），以与所述主缸（12）的主体（22）接合 （20），并且根据所述第一端（32）轴向插入所述孔（12）的程度，将所述端盖（30）的第一端（32）保持在所述孔（12）内。
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