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1.发明授权Semi-synthetic rearranged vancomycin/desmethyl-vancomycin-based glycopeptides with antibiotic activity 失效半合成重组万古霉素/脱甲基万古霉素类糖肽具有抗菌活性公开(公告)号：US07368422B2
公开(公告)日：2008-05-06
申请号：US11361311
申请日：2006-02-24
申请人： Yaohui Lei , Yu Bai , Daniel Chu , Zhi-Jie Ni , John Jian-Xin Wang
发明人： Yaohui Lei , Yu Bai , Daniel Chu , Zhi-Jie Ni , John Jian-Xin Wang
CPC分类号： C07K9/008
摘要： Semi-synthetic glycopeptides that have antibacterial activity are based on modifications of a rearranged vancomycin or desmethyl-vancomycin scaffold, in particular, alkylation or acylation of the amino substituent on the amino-substituted sugar moiety on this scaffold with certain acyl groups; and/or conversion of the acid moiety on the macrocyclic ring of this scaffolds to certain substituted amides. Also provided are methods for synthesis of the compounds, pharmaceutical compositions containing the compounds, and methods of use of the compounds for the treatment and/or prophylaxis of diseases, especially bacterial infections.
摘要翻译： 具有抗菌活性的半合成糖肽基于重排的万古霉素或去甲基 - 万古霉素支架的修饰，特别是在该支架上的具有某些酰基的氨基取代的糖部分上的氨基取代基的烷基化或酰化; 和/或将该支架的大环上的酸部分转化为某些取代的酰胺。 还提供了合成化合物的方法，含有化合物的药物组合物，以及用于治疗和/或预防疾病，特别是细菌感染的化合物的使用方法。
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2.发明申请SEMI-SYNTHETIC REARRANGED VANCOMYCIN/DESMETHYL-VANCOMYCIN-BASED GLYCOPEPTIDES WITH ANTIBIOTIC ACTIVITY 审中-公开具有抗生素活性的半合成重组型VANCOMYCIN / DESMETHYL-VANCOMYCIN型糖尿病公开(公告)号：US20080214444A1
公开(公告)日：2008-09-04
申请号：US12043076
申请日：2008-03-05
申请人： Yaohui Lei , Yu Bai , Daniel Chu , Zhi-Jie Ni , John Jian-Xin Wang
发明人： Yaohui Lei , Yu Bai , Daniel Chu , Zhi-Jie Ni , John Jian-Xin Wang
CPC分类号： C07K9/008
摘要： Semi-synthetic glycopeptides that have antibacterial activity are based on modifications of a rearranged vancomycin or desmethyl-vancomycin scaffold, in particular, alkylation or acylation of the amino substituent on the amino-substituted sugar moiety on this scaffold with certain acyl groups; and/or conversion of the acid moiety on the macrocyclic ring of this scaffolds to certain substituted amides. Also provided are methods for synthesis of the compounds, pharmaceutical compositions containing the compounds, and methods of use of the compounds for the treatment and/or prophylaxis of diseases, especially bacterial infections.
摘要翻译： 具有抗菌活性的半合成糖肽基于重排的万古霉素或去甲基 - 万古霉素支架的修饰，特别是在该支架上的具有某些酰基的氨基取代的糖部分上的氨基取代基的烷基化或酰化; 和/或将该支架的大环上的酸部分转化为某些取代的酰胺。 还提供了合成化合物的方法，含有化合物的药物组合物，以及用于治疗和/或预防疾病，特别是细菌感染的化合物的使用方法。
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3.发明申请Semi-Synthetic Desmethyl-Vancomycin-Based Glycopeptides With Antibiotic Activity 审中-公开具有抗生素活性的半合成去甲基 - 万古霉素基糖肽公开(公告)号：US20090131304A1
公开(公告)日：2009-05-21
申请号：US12268364
申请日：2008-11-10
申请人： Daniel Chu , Yaohui Lei , Yu Bai , Zhi-Jie Ni , John Jian-Xin Wang
发明人： Daniel Chu , Yaohui Lei , Yu Bai , Zhi-Jie Ni , John Jian-Xin Wang
摘要： Semi-synthetic glycopeptides that have antibacterial activity are based on modifications of the desmethyl-vancomycin scaffold, in particular, acylation of the amino substituent on the amino-substituted sugar moiety on this scaffold with certain acyl groups; and/or conversion of the acid moiety on the macrocyclic ring of this scaffolds to certain substituted amides. In addition, compounds of the invention include desmethyl-vancomycin scaffolds on which the acid moiety on the macrocyclic ring is converted to certain substituted amides and the amino substituent on the amino-substituted sugar moiety is alkylated with certain alkyl groups. Also provided are methods for synthesis of the compounds, pharmaceutical compositions containing the compounds, and methods of use of the compounds for the treatment and/or prophylaxis of diseases, especially bacterial infections.
摘要翻译： 具有抗菌活性的半合成糖肽基于脱甲基万古霉素支架的修饰，特别是在该支架上具有某些酰基的氨基取代的糖部分上的氨基取代基的酰化; 和/或将该支架的大环上的酸部分转化为某些取代的酰胺。 此外，本发明的化合物包括去甲基 - 万古霉素支架，大环上的酸部分转化为某些取代的酰胺，氨基取代的糖部分上的氨基取代基被某些烷基烷基化。 还提供了合成化合物的方法，含有化合物的药物组合物，以及用于治疗和/或预防疾病，特别是细菌感染的化合物的使用方法。
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4.发明申请Semi-synthetic desmethyl-vancomycin-based glycopeptides with antibiotic activity 审中-公开具有抗菌活性的半合成脱甲基万古霉素基糖肽公开(公告)号：US20070185015A1
公开(公告)日：2007-08-09
申请号：US11361682
申请日：2006-02-24
申请人： Daniel Chu , Yaohui Lei , Yu Bai , Zhi-Jie Ni , John Wang
发明人： Daniel Chu , Yaohui Lei , Yu Bai , Zhi-Jie Ni , John Wang
摘要： Semi-synthetic glycopeptides that have antibacterial activity are based on modifications of the desmethyl-vancomycin scaffold, in particular, acylation of the amino substituent on the amino-substituted sugar moiety on this scaffold with certain acyl groups; and/or conversion of the acid moiety on the macrocyclic ring of this scaffolds to certain substituted amides. In addition, compounds of the invention include desmethyl-vancomycin scaffolds on which the acid moiety on the macrocyclic ring is converted to certain substituted amides and the amino substituent on the amino-substituted sugar moiety is alkylated with certain alkyl groups. Also provided are methods for synthesis of the compounds, pharmaceutical compositions containing the compounds, and methods of use of the compounds for the treatment and/or prophylaxis of diseases, especially bacterial infections.
摘要翻译： 具有抗菌活性的半合成糖肽基于脱甲基万古霉素支架的修饰，特别是在该支架上具有某些酰基的氨基取代的糖部分上的氨基取代基的酰化; 和/或将该支架的大环上的酸部分转化为某些取代的酰胺。 此外，本发明的化合物包括去甲基 - 万古霉素支架，大环上的酸部分转化为某些取代的酰胺，氨基取代的糖部分上的氨基取代基被某些烷基烷基化。 还提供了合成化合物的方法，含有化合物的药物组合物，以及用于治疗和/或预防疾病，特别是细菌感染的化合物的使用方法。
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5.发明申请Semi-synthetic rearranged vancomycin/desmethyl-vancomycin-based glycopeptides with antibiotic activity 失效半合成重组万古霉素/脱甲基万古霉素类糖肽具有抗菌活性公开(公告)号：US20070021328A1
公开(公告)日：2007-01-25
申请号：US11361311
申请日：2006-02-24
申请人： Yaohui Lei , Yu Bai , Daniel Chu , Zhi-Jie Ni , John Wang
发明人： Yaohui Lei , Yu Bai , Daniel Chu , Zhi-Jie Ni , John Wang
CPC分类号： C07K9/008
摘要： Semi-synthetic glycopeptides that have antibacterial activity are based on modifications of a rearranged vancomycin or desmethyl-vancomycin scaffold, in particular, alkylation or acylation of the amino substituent on the amino-substituted sugar moiety on this scaffold with certain acyl groups; and/or conversion of the acid moiety on the macrocyclic ring of this scaffolds to certain substituted amides. Also provided are methods for synthesis of the compounds, pharmaceutical compositions containing the compounds, and methods of use of the compounds for the treatment and/or prophylaxis of diseases, especially bacterial infections.
摘要翻译： 具有抗菌活性的半合成糖肽基于重排的万古霉素或去甲基 - 万古霉素支架的修饰，特别是在该支架上的具有某些酰基的氨基取代的糖部分上的氨基取代基的烷基化或酰化; 和/或将该支架的大环上的酸部分转化为某些取代的酰胺。 还提供了合成化合物的方法，含有化合物的药物组合物，以及用于治疗和/或预防疾病，特别是细菌感染的化合物的使用方法。
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公开(公告)号：US08063413B2
公开(公告)日：2011-11-22
申请号：US12265976
申请日：2008-11-06
申请人： Yu Bai , Minjoo L. Lee , Eugene A. Fitzgerald
发明人： Yu Bai , Minjoo L. Lee , Eugene A. Fitzgerald
IPC分类号： H01L29/15
CPC分类号： H01L21/0251 , B82Y10/00 , H01L21/02395 , H01L21/0245 , H01L21/02452 , H01L21/02463 , H01L21/02532 , H01L21/02535 , H01L29/1054 , Y10S438/933 , Y10S438/938
摘要： A semiconductor structure is provided. The semiconductor structure includes one or more III-IV material-based semiconductor layers. A tensile-strained Ge layer is formed on the one or more a III-IV material-based semiconductor layers. The tensile-strained Ge layer is produced through lattice-mismatched heteroepitaxy on the one or more a III-IV material-based semiconductor layers.
摘要翻译： 提供半导体结构。 半导体结构包括一个或多个III-IV材料基半导体层。 在一个或多个III-IV材料基半导体层上形成拉伸应变Ge层。 拉伸应变Ge层通过在一个或多个III-IV材料基半导体层上的晶格失配的异质外延产生。
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7.发明申请公开(公告)号：US20070274713A1
公开(公告)日：2007-11-29
申请号：US11833956
申请日：2007-08-03
申请人： Yu Bai
发明人： Yu Bai
IPC分类号： H04B10/08
CPC分类号： H04B10/00 , H04B2210/078
摘要： An apparatus and method for processing a supervisory signal for optical network applications. The apparatus includes a subcarrier transmission system configured to receive a first supervisory signal and output a second supervisory signal, and an electrical-to-optical conversion system configured to receive the second supervisory signal and a first data signal and output a first optical signal. Additionally, the apparatus includes an optical-to-electrical conversion system configured to receive the first optical signal and output a first electrical signal and a second data signal, and a subcarrier reception system configured to receive the first electrical signal and output a third supervisory signal. The second supervisory signal is associated with a first subcarrier frequency. The first data signal is associated with a first data bandwidth, and the first data bandwidth includes a first data frequency. A ratio of the first subcarrier frequency to the first data frequency ranges from 0.8 to 1.
摘要翻译： 一种用于处理光网络应用的监控信号的装置和方法。 该装置包括配置成接收第一监控信号并输出第二监控信号的副载波传输系统，以及被配置为接收第二监控信号和第一数据信号并输出第一光信号的电 - 光转换系统。 另外，该装置包括被配置为接收第一光信号并输出第一电信号和第二数据信号的光电转换系统，以及被配置为接收第一电信号并输出第三监控信号的副载波接收系统 。 第二监控信号与第一副载波频率相关联。 第一数据信号与第一数据带宽相关联，并且第一数据带宽包括第一数据频率。 第一副载波频率与第一数据频率的比率范围为0.8至1。
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公开(公告)号：US20060263099A1
公开(公告)日：2006-11-23
申请号：US11347558
申请日：2006-02-02
IPC分类号： H04B10/12
CPC分类号： H04B10/508 , H04B10/505 , H04B2210/254
摘要： A system and method for providing chirped light for an optical network. The system includes a light source configured to provide a light. The system additionally includes a driving signal source configured to provide a first driving signal. The system also includes an amplifier configured to receive the first driving signal, amplify the first driving signal, and provide a second driving signal at a predetermined amplification level, the second driving signal being the amplified first signal. Additionally, the system includes a splitter configured to receive the second driving signal and split the second driving signal into a third driving signal and a fourth driving signal. The system also includes a first attenuator configured to receive the third driving signal, attenuate the third driving signal at a first attenuation level, and provide a fifth driving signal, the fifth driving signal being the third driving signal attenuated by the first attenuator.
摘要翻译： 一种用于为光网络提供啁啾光的系统和方法。 该系统包括被配置为提供光的光源。 该系统还包括被配置为提供第一驱动信号的驱动信号源。 该系统还包括放大器，其被配置为接收第一驱动信号，放大第一驱动信号，并以预定的放大电平提供第二驱动信号，第二驱动信号是放大的第一信号。 另外，该系统包括分配器，其被配置为接收第二驱动信号并将第二驱动信号分成第三驱动信号和第四驱动信号。 该系统还包括被配置为接收第三驱动信号的第一衰减器，以第一衰减电平衰减第三驱动信号，并提供第五驱动信号，第五驱动信号是由第一衰减器衰减的第三驱动信号。
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10.发明申请System and method for generating optical return-to-zero signals with differential bi-phase shift and frequency chirp 有权用于产生具有差分双相位移和频率啁啾的光回归信号的系统和方法公开(公告)号：US20070042735A1
公开(公告)日：2007-02-22
申请号：US11373845
申请日：2006-03-10
申请人： Yu Bai
发明人： Yu Bai
IPC分类号： H04B1/16
CPC分类号： H04B10/5561 , H04B10/505 , H04B10/5051 , H04B10/5055 , H04B10/5162 , H04L25/4904
摘要： A system and method for generating an optical return-to-zero signal. The system includes an electro-optical conversion system. The electro-optical conversion system is configured to receive an input electrical non-return-to-zero signal, process information associated with the input electrical non-return-to-zero signal, and generate an output optical return-to-zero signal based on at least information associated with the input electrical non-return-to-zero signal. The output optical return-to-zero signal is an optical differential return-to-zero signal, and the optical differential return-to-zero signal is associated with a frequency chirp.
摘要翻译： 一种用于产生光返回信号的系统和方法。 该系统包括电光转换系统。 电光转换系统被配置为接收输入的电不归零信号，与输入的电不归零信号相关联的处理信息，并且基于输出光回归至零信号生成 至少与输入的电气不归零信号相关联的信息。 输出光回归信号是光差分归零信号，光差分归零信号与频率啁啾相关联。
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