公开(公告)号：US20070185015A1

公开(公告)日：2007-08-09

申请号：US11361682

申请日：2006-02-24

申请人： Daniel Chu ,  Yaohui Lei ,  Yu Bai ,  Zhi-Jie Ni ,  John Wang

发明人： Daniel Chu ,  Yaohui Lei ,  Yu Bai ,  Zhi-Jie Ni ,  John Wang

IPC分类号： A61K38/14 ,  C07K9/00

CPC分类号： C07K9/008 ,  A61K38/00

摘要： Semi-synthetic glycopeptides that have antibacterial activity are based on modifications of the desmethyl-vancomycin scaffold, in particular, acylation of the amino substituent on the amino-substituted sugar moiety on this scaffold with certain acyl groups; and/or conversion of the acid moiety on the macrocyclic ring of this scaffolds to certain substituted amides. In addition, compounds of the invention include desmethyl-vancomycin scaffolds on which the acid moiety on the macrocyclic ring is converted to certain substituted amides and the amino substituent on the amino-substituted sugar moiety is alkylated with certain alkyl groups. Also provided are methods for synthesis of the compounds, pharmaceutical compositions containing the compounds, and methods of use of the compounds for the treatment and/or prophylaxis of diseases, especially bacterial infections.

摘要翻译： 具有抗菌活性的半合成糖肽基于脱甲基万古霉素支架的修饰，特别是在该支架上具有某些酰基的氨基取代的糖部分上的氨基取代基的酰化; 和/或将该支架的大环上的酸部分转化为某些取代的酰胺。 此外，本发明的化合物包括去甲基 - 万古霉素支架，大环上的酸部分转化为某些取代的酰胺，氨基取代的糖部分上的氨基取代基被某些烷基烷基化。 还提供了合成化合物的方法，含有化合物的药物组合物，以及用于治疗和/或预防疾病，特别是细菌感染的化合物的使用方法。

公开(公告)号：US20070021328A1

公开(公告)日：2007-01-25

申请号：US11361311

申请日：2006-02-24

申请人： Yaohui Lei ,  Yu Bai ,  Daniel Chu ,  Zhi-Jie Ni ,  John Wang

发明人： Yaohui Lei ,  Yu Bai ,  Daniel Chu ,  Zhi-Jie Ni ,  John Wang

IPC分类号： C07K9/00 ,  A61K38/14

CPC分类号： C07K9/008

摘要： Semi-synthetic glycopeptides that have antibacterial activity are based on modifications of a rearranged vancomycin or desmethyl-vancomycin scaffold, in particular, alkylation or acylation of the amino substituent on the amino-substituted sugar moiety on this scaffold with certain acyl groups; and/or conversion of the acid moiety on the macrocyclic ring of this scaffolds to certain substituted amides. Also provided are methods for synthesis of the compounds, pharmaceutical compositions containing the compounds, and methods of use of the compounds for the treatment and/or prophylaxis of diseases, especially bacterial infections.

摘要翻译： 具有抗菌活性的半合成糖肽基于重排的万古霉素或去甲基 - 万古霉素支架的修饰，特别是在该支架上的具有某些酰基的氨基取代的糖部分上的氨基取代基的烷基化或酰化; 和/或将该支架的大环上的酸部分转化为某些取代的酰胺。 还提供了合成化合物的方法，含有化合物的药物组合物，以及用于治疗和/或预防疾病，特别是细菌感染的化合物的使用方法。

公开(公告)号：US20130008157A1

公开(公告)日：2013-01-10

申请号：US13447908

申请日：2012-04-16

申请人： Lei ZUO ,  Gopinath Reddy Penamalli ,  John Wang ,  Rui He Zheng ,  Xiao Hui Lei ,  Jorge F. Lam-Ki ,  Zhongjie Li ,  Teng Lin

发明人： Lei ZUO ,  Gopinath Reddy Penamalli ,  John Wang ,  Rui He Zheng ,  Xiao Hui Lei ,  Jorge F. Lam-Ki ,  Zhongjie Li ,  Teng Lin

IPC分类号： F03B13/18

CPC分类号： F03B13/18 ,  Y02E10/38

摘要： An energy generating device utilizing mechanical vibration power is provided. The energy generating device includes a first body for reciprocating according to vibration motions; an anchored second body; a rack coupled to one of the first body and the anchored second body; a gear assembly engaged with the rack and coupled to the other one of the first body and the anchored second body such that the gear assembly drives a generator via a rotational movement in a single direction according to each of upward and downward movement of the rack relative to the gear assembly; and the generator engaged with the gear assembly for receiving the rotational movement output from the gear assembly and outputting a direct current according to the rotational input from the gear assembly.

公开(公告)号：US20120026644A1

公开(公告)日：2012-02-02

申请号：US13177401

申请日：2011-07-06

申请人： Bruce S. Dunn ,  Sarah H. Tolbert ,  John Wang ,  Torsten Brezesinski

发明人： Bruce S. Dunn ,  Sarah H. Tolbert ,  John Wang ,  Torsten Brezesinski

IPC分类号： H01G9/155

CPC分类号： H01G11/84 ,  B82Y99/00 ,  H01G11/24 ,  H01G11/26 ,  H01G11/36 ,  H01G11/46 ,  Y02E60/13 ,  Y10S977/948

摘要： A mesoporous, nanocrystalline, metal oxide construct particularly suited for capacitive energy storage that has an architecture with short diffusion path lengths and large surface areas and a method for production are provided. Energy density is substantially increased without compromising the capacitive charge storage kinetics and electrode demonstrates long term cycling stability. Charge storage devices with electrodes using the construct can use three different charge storage mechanisms immersed in an electrolyte: (1) cations can be stored in a thin double layer at the electrode/electrolyte interface (non-faradaic mechanism); (2) cations can interact with the bulk of an electroactive material which then undergoes a redox reaction or phase change, as in conventional batteries (faradaic mechanism); or (3) cations can electrochemically adsorb onto the surface of a material through charge transfer processes (faradaic mechanism).

摘要翻译： 提供了特别适用于具有短扩散路径长度和大表面积的结构的电容性能量存储的介孔纳米晶体金属氧化物构造以及生产方法。 能量密度大大增加，而不损害电容性电荷存储动力学，电极表现出长期的循环稳定性。 带电极的电荷存储装置可以使用浸入电解质中的三种不同的电荷存储机构：（1）阳离子可以存储在电极/电解质界面（非法拉第机制）的薄双层中; （2）如常规电池（法拉第机制），阳离子可与电活性材料的主体相互作用，然后电活性材料经历氧化还原反应或相变。 或（3）阳离子可以通过电荷转移过程（法拉第机制）电化学吸附在材料的表面上。

公开(公告)号：US20100058558A1

公开(公告)日：2010-03-11

申请号：US12204833

申请日：2008-09-05

申请人： John Wang

发明人： John Wang

IPC分类号： B25G1/10

CPC分类号： B62K21/26 ,  Y10T16/466 ,  Y10T16/498 ,  Y10T74/2078 ,  Y10T74/20822

摘要： A handlebar grip capable of combining with or without an auxiliary handle is disclosed. Four first tongue plates in an annular arrangement extend from a main grip. There is a gap between two adjacent first tongue plates. Each first tongue plate has a first rib extending therefrom. A cap having second tongue plates corresponding to the first tongue plates is fixed on the outer end of the main grip by interlacing the tongue plates. A hitching ring is sandwiched between the cap and main grip to form an extended portion of the main grip. Each the second tongue plate has a second rib, which connects the first ribs to form an annular rib with the first ribs. The ring has an annular groove to receiving the annular rib and to engage the main grip and cap. The ring may be changed into a horn shape as an auxiliary handle.

摘要翻译： 公开了能够与辅助手柄结合使用的把手把手。 环形布置的四个第一舌板从主把手延伸。 两个相邻的第一舌板之间有间隙。 每个第一舌板具有从其延伸的第一肋。 具有对应于第一舌板的第二舌板的帽通过交错舌板而固定在主把手的外端上。 夹紧环被夹在盖和主把手之间以形成主把手的延伸部分。 每个第二舌板具有第二肋，其连接第一肋以形成具有第一肋的环形肋。 环具有环形槽以容纳环形肋并与主把手和帽接合。 环可以变成喇叭形作为辅助把手。

公开(公告)号：US20100021763A1

公开(公告)日：2010-01-28

申请号：US12179562

申请日：2008-07-24

申请人： Alan Huang ,  Connie Chunling Liu ,  John Wang ,  Romulo Canilon Ata ,  Shanghsien Alex Rou

发明人： Alan Huang ,  Connie Chunling Liu ,  John Wang ,  Romulo Canilon Ata ,  Shanghsien Alex Rou

IPC分类号： C23C14/34 ,  G11B5/33

CPC分类号： G11B5/82 ,  C03C17/36 ,  C03C17/40 ,  C23C14/025 ,  C23C14/185 ,  C23C14/584 ,  G11B5/656 ,  G11B5/66 ,  G11B5/851

摘要： A magnetic recording medium is presented, characterized by having a nonmonotonicity in the DCD curve, resulting in low dynamic coercivity when writing information to the medium, with high static coercivity and thermal stability during storage. A method is also presented for producing the magnetic recording medium of the present invention.

摘要翻译： 提出了一种磁记录介质，其特征在于在DCD曲线中具有非单调性，当将信息写入介质时具有低的动态矫顽力，具有高的静电矫顽力和储存期间的热稳定性。 还提出了用于制造本发明的磁记录介质的方法。

公开(公告)号：US20070288221A1

公开(公告)日：2007-12-13

申请号：US11841479

申请日：2007-08-20

申请人： John Wang ,  Mu-Yi Chen ,  Yung-Chieh Lin

发明人： John Wang ,  Mu-Yi Chen ,  Yung-Chieh Lin

IPC分类号： G06F17/50

CPC分类号： G06F17/5031 ,  G06F2217/84

摘要： A timing-control method of a hardware-simulating program can be applied to a software platform for facilitating control program development. The hardware-simulating program can be recorded in any suitable recording medium and defines therein a plurality of simulating elements which are automatically synchronized at intervals by setting specified time points as aligning points. The specified time points are set with adjustable intervals. By adjusting an interval between adjacent specified time points, the simulating speed between the adjacent specified time points can be changed to comply with practical requirements.

摘要翻译： 硬件仿真程序的时序控制方法可以应用于软件平台，以便于控制程序开发。 硬件模拟程序可以记录在任何合适的记录介质中，并且在其中定义多个模拟元件，它们通过将指定的时间点设置为对齐点而以间隔自动同步。 指定的时间点以可调节的间隔设置。 通过调整相邻指定时间点之间的间隔，可以改变相邻指定时间点之间的模拟速度，以符合实际要求。

公开(公告)号：US20070190363A1

公开(公告)日：2007-08-16

申请号：US11739026

申请日：2007-04-23

申请人： John Wang ,  Anthony Zhou ,  Junmin Xue

发明人： John Wang ,  Anthony Zhou ,  Junmin Xue

IPC分类号： G11B5/33 ,  B32B15/04 ,  B32B9/00

CPC分类号： H01L41/318 ,  C23C18/1216 ,  C23C18/1225 ,  C23C18/1254 ,  C23C18/1283 ,  H01L41/1876 ,  Y10T428/32 ,  Y10T428/325

摘要： Heterolayered thin films having ferroelectric/piezoelectric layers of alternating crystal structures and methods of their preparation are provided. In the ferroelectric/piezoelectric thin film, a first layer has a rhombohedral crystal structure and a second layer adjacent the first layer has a tetragonal crystal structure. The layers have a (100) preferred orientation with a-axis normal to the surface of the film. The first layer can be a Zr-rich lead ziroconate titanate layer (e.g. PbZr0.8Ti0.2O3) and the second layer can be a Ti-rich PZT layer (e.g., PbZr0.2Ti0.8O3). Heterolayered ferroelectric/piezoelectric thin film comprising a plurality of such first and second layers in alternating sequence exhibits particularly improved electrical properties.

摘要翻译： 提供了具有交替晶体结构的铁电/压电层的非均相薄膜及其制备方法。 在铁电/压电薄膜中，第一层具有菱形晶体结构，与第一层相邻的第二层具有四方晶体结构。 这些层具有（100）优选的取向，其中a轴垂直于膜的表面。 第一层可以是富锆的半挥发酸铅钛酸盐层（例如PbZr 0SiO 2 0.2 O 3 O 3），第二层可以是 富Ti的PZT层（例如，PbZr 0.2Ni 0.8 O 3 O 3）。 包含多个这样的第一和第二层的交替层叠的非均相铁电/压电薄膜表现出特别改善的电性能。

公开(公告)号：US20060200076A1

公开(公告)日：2006-09-07

申请号：US11417738

申请日：2006-05-03

申请人： Hugo Gonzalez ,  Steven Springmeyer ,  Richard Shea ,  John Wang ,  Lauri DeVore

发明人： Hugo Gonzalez ,  Steven Springmeyer ,  Richard Shea ,  John Wang ,  Lauri DeVore

IPC分类号： A61M29/00

CPC分类号： A61M31/002 ,  A61B17/12022 ,  A61B17/12036 ,  A61B17/1204 ,  A61B17/12104 ,  A61B17/12159 ,  A61B17/12172 ,  A61B2017/1205 ,  A61B2017/22051 ,  A61B2017/22067 ,  A61B2017/242 ,  A61B2217/005 ,  A61F2002/043 ,  A61M1/0023 ,  A61M25/04 ,  A61M31/00 ,  A61M2025/0076 ,  A61M2210/1035 ,  A61N5/1027 ,  A61N2005/1021

摘要： The present invention includes an intra-bronchial device, system, and method for providing a therapeutic agent to a patient. A device includes a flow control member for placement in an air passageway communicating with a lung portion, and when deployed in the air passageway inhibits a therapeutic agent distal of the control member from moving proximal of the control member, and includes the therapeutic agent associated with the flow control member. The control member may inhibit movement of the therapeutic agent by limiting airflow, and may include a one-way valve limiting exhalation of air from the lung portion. The control member may include a flexible membrane impervious to air flow, or a separator arranged to inhibit the movement of the therapeutic agent. The control member may include at least one anchor, and the anchor may be releasable from the air passageway for removal of the intra-bronchial device.

公开(公告)号：US20060139325A1

公开(公告)日：2006-06-29

申请号：US11285307

申请日：2005-11-23

申请人： John Wang

发明人： John Wang

IPC分类号： G09G5/08

CPC分类号： G06F3/0317 ,  G06F1/1626 ,  G06F1/1684 ,  G06F1/1686 ,  G06F1/169 ,  G06F2200/1637

摘要： A handheld device is disclosed. A processor thereof changes a page shown on a display thereof according to the displacement of the handheld device on a reference plane detected by a sensor.

摘要翻译： 公开了一种手持设备。 其处理器根据由传感器检测到的参考平面上的手持设备的位移来改变显示在其显示器上的页面。