-
1.发明申请Method, system, and computer program product for on-demand creation and distribution of customized dynamic contracts 有权方法，系统和计算机程序产品，用于按需创建和分发定制的动态合同公开(公告)号：US20070124234A1
公开(公告)日：2007-05-31
申请号：US11266610
申请日：2005-11-03
申请人： Daniel Finley , Louis Guglielmo , William Houston , Martina Kim , Randy Klipstein , Joseph Simons , Christian Toft-Nielsen
发明人： Daniel Finley , Louis Guglielmo , William Houston , Martina Kim , Randy Klipstein , Joseph Simons , Christian Toft-Nielsen
IPC分类号： G06Q40/00
CPC分类号： G06Q40/02 , G06Q40/00 , G06Q40/025
摘要： The present invention provides a method, system, and computer program product for the on-demand creation and distribution of customized dynamic contracts. At least one business opportunity is extracted from an opportunity database. For each extracted business opportunity, a credit score for a customer associated with the extracted business opportunity is obtained and a dynamically modifiable contract for the extracted business opportunity is generated. The dynamically modifiable contract is distributed to a contact associated with the extracted business opportunity, who presents the dynamically modifiable contract to the customer associated with the extracted business opportunity. The contact can modify the dynamically modifiable contract, if necessary, during negotiations with the customer, to provide a contract that is acceptable to the contact and the customer.
摘要翻译： 本发明提供了一种用于按需创建和分发定制动态合同的方法，系统和计算机程序产品。 从机会数据库中提取至少一个商业机会。 对于每个提取的商业机会，获得与提取的商业机会相关联的客户的信用分数，并且生成针对所提取的商业机会的动态可修改的合同。 可动态修改的合同分配给与提取的商业机会相关联的联系人，该商业机会向与提取的商业机会相关联的客户呈现动态可修改的合同。 如果需要，联系人可以在与客户谈判期间修改动态可修改的合同，以提供联系人和客户可以接受的合同。
-
公开(公告)号：US5496721A
公开(公告)日：1996-03-05
申请号：US239800
申请日：1994-05-09
IPC分类号： C07K1/107 , C07K14/00 , C12N9/06 , C12N9/38 , C12N9/60 , C12N9/64 , C12N15/11 , C12N15/62 , C12N15/67 , C12P21/02 , C12P21/04 , C12N1/21 , C07K19/00 , C12N5/10
CPC分类号： C12N9/0028 , C07K1/107 , C07K1/1075 , C07K14/00 , C12N15/11 , C12N15/62 , C12N15/67 , C12N9/2471 , C12N9/60 , C12N9/6421 , C12P21/02 , C12Y302/01023 , C07K2319/00 , C07K2319/50 , C07K2319/61 , C07K2319/95
摘要： Methods of designing or modifying protein structure at the protein or genetic level to produce specified amino-termini in vivo or in vitro are described. The methods can be used to alter the metabolic stability and other properties of the protein or, alternatively, to artificially generate authentic amino-termini in proteins produced through artificial means. The methods are based upon the introduction of the use of artificial ubiquitin-protein fusions, and the discovery that the in vivo half-life of a protein is a function of the amino-terminal amino acid of the protein.
摘要翻译： 描述了在蛋白质或遗传水平上设计或修饰蛋白质结构以在体内或体外产生特定氨基末端的方法。 该方法可用于改变蛋白质的代谢稳定性和其它性质，或者替代地，通过人工方式人造产生的蛋白质中的正确的氨基末端。 该方法基于引入人造泛素 - 蛋白质融合物的使用，并且发现蛋白质的体内半衰期是蛋白质的氨基末端氨基酸的函数。
-
公开(公告)号：US20100292129A1
公开(公告)日：2010-11-18
申请号：US12601551
申请日：2008-05-23
申请人： Daniel Finley
发明人： Daniel Finley
CPC分类号： G01N33/573 , A61K31/00 , C12Q1/37 , G01N2500/02
摘要： This invention relates to methods and compositions for enhancing proteasome activity in a cell. The methods and compositions for enhancing the activity of the proteasome in cells modulate the activity of Ubp6 (yeast) or Usp14 (human), an endogenous inhibitor of the proteasome. The methods and compositions partially or completely reduce the inhibitory activity of Usp14 on a proteasome, thereby specifically enhancing the protein-degradation activity of the proteasome. The invention also provides methods of screening to identify inhibitors of Ubp6, Usp14, and/or both Ubp6 and Usp14.
摘要翻译： 本发明涉及用于增强细胞中蛋白酶体活性的方法和组合物。 用于增强细胞中蛋白酶体活性的方法和组合物调节Ubp6（酵母）或Usp14（人）的活性，这是蛋白酶体的内源性抑制剂。 该方法和组合物部分或完全降低了Usp14对蛋白酶体的抑制活性，从而特异性地提高了蛋白酶体的蛋白质降解活性。 本发明还提供筛选以鉴定Ubp6，Usp14和/或Ubp6和Usp14两者的抑制剂的方法。
-
公开(公告)号：US5132213A
公开(公告)日：1992-07-21
申请号：US178924
申请日：1988-04-07
IPC分类号： C12N15/09 , C07K1/107 , C07K1/22 , C07K14/00 , C07K19/00 , C12N1/21 , C12N9/06 , C12N9/38 , C12N9/60 , C12N9/64 , C12N15/11 , C12N15/62 , C12N15/67 , C12P21/00 , C12P21/02 , C12P21/06 , C12R1/19 , C12R1/91
CPC分类号： C12N9/0028 , C07K1/107 , C07K1/1075 , C07K14/00 , C12N15/11 , C12N15/62 , C12N15/67 , C12N9/60 , C12N9/6421 , C12P21/02 , C07K2319/00 , C07K2319/50 , C07K2319/61 , C07K2319/95 , Y10S435/911 , Y10S435/94
摘要： A method of designing or modifying protein structure at the protein or genetic level to produce specified amino-termini in vivo is described. The method is used to alter the metabolic stability and other properties of the protein or, alternatively, to artificially generate authentic amino-termini in proteins produced through artificial means. The method is based upon the introduction of the use of artificial ubiquitin-protein fusions, and the discovery that the in vivo half-life of a protein is a function of the amino-terminal amino acid of the protein.
摘要翻译： 描述了在蛋白质或遗传水平上设计或修饰蛋白质结构以在体内产生特定氨基末端的方法。 该方法用于改变蛋白质的代谢稳定性和其他性质，或者替代地，通过人工方法人造产生的蛋白质中的正确的氨基末端。 该方法基于引入人造泛素蛋白融合物的使用，并且发现蛋白质的体内半衰期是蛋白质的氨基末端氨基酸的函数。
-
公开(公告)号：US5093242A
公开(公告)日：1992-03-03
申请号：US356378
申请日：1989-05-24
IPC分类号： C07K1/107 , C07K14/00 , C12N1/15 , C12N9/06 , C12N9/38 , C12N9/60 , C12N9/64 , C12N15/11 , C12N15/62 , C12N15/67 , C12P21/02
CPC分类号： C12N9/0028 , C07K1/107 , C07K1/1075 , C07K14/00 , C12N15/11 , C12N15/62 , C12N15/67 , C12N9/003 , C12N9/2468 , C12N9/485 , C12N9/60 , C12N9/6421 , C12P21/02 , C12Y105/01003 , C12Y304/19012 , C07K2319/00 , C07K2319/50 , C07K2319/61 , C07K2319/95 , Y10S435/911 , Y10S435/94
摘要： A method of designing or modifying protein structure at the protein or genetic level to produce specified amino-termini in vivo are described. The method can be used to alter the metabolic stability and other properties of the protein or, alternatively, to artificially generate authentic amino-termini in proteins produced through artificial means. The method is based upon the introduction of the use of artificial ubiquitin-protein fusions, and the discovery that the in vivo half-life of a protein is a function of the amino-terminal amino acid of the protein.
摘要翻译： 描述了在蛋白质或遗传水平上设计或修饰蛋白质结构以在体内产生特定氨基末端的方法。 该方法可用于改变蛋白质的代谢稳定性和其它性质，或者替代地，通过人工方式人造产生的蛋白质中产生正确的氨基末端。 该方法基于引入人造泛素蛋白融合物的使用，并且发现蛋白质的体内半衰期是蛋白质的氨基末端氨基酸的函数。
-
公开(公告)号：US5847097A
公开(公告)日：1998-12-08
申请号：US572829
申请日：1995-12-14
IPC分类号： C07K1/107 , C07K14/00 , C12N9/06 , C12N9/38 , C12N9/60 , C12N9/64 , C12N15/11 , C12N15/62 , C12N15/67 , C12P21/02 , C12P21/04 , C07H21/04 , C12N1/20 , C12N5/10
CPC分类号： C12N9/0028 , C07K1/107 , C07K1/1075 , C07K14/00 , C12N15/11 , C12N15/62 , C12N15/67 , C12N9/2471 , C12N9/60 , C12N9/6421 , C12P21/02 , C12Y302/01023 , C07K2319/00 , C07K2319/50 , C07K2319/61 , C07K2319/95
摘要： Methods of designing or modifying protein structure at the protein or genetic level to produce specified amino-termini in vivo or in vitro are described. The methods can be used to alter the metabolic stability and other properties of the protein or, alternatively, to artificially generate authentic amino-termini in proteins produced through artificial means. The methods are based upon the introduction of the use of artificial ubiquitin-protein fusions, and the discovery that the in vivo half-life of a protein is a function of the amino-terminal amino acid of the protein.
摘要翻译： 描述了在蛋白质或遗传水平上设计或修饰蛋白质结构以在体内或体外产生特定氨基末端的方法。 该方法可用于改变蛋白质的代谢稳定性和其它性质，或者替代地，通过人工方式人造产生的蛋白质中的正确的氨基末端。 该方法基于引入人造泛素 - 蛋白质融合物的使用，并且发现蛋白质的体内半衰期是蛋白质的氨基末端氨基酸的函数。
-
公开(公告)号：US5646017A
公开(公告)日：1997-07-08
申请号：US473180
申请日：1995-06-07
IPC分类号： C07K1/107 , C07K14/00 , C12N9/06 , C12N9/38 , C12N9/60 , C12N9/64 , C12N15/11 , C12N15/62 , C12N15/67 , C12P21/02 , C12P21/04 , C07K14/435 , C12N15/63
CPC分类号： C12N9/0028 , C07K1/107 , C07K1/1075 , C07K14/00 , C12N15/11 , C12N15/62 , C12N15/67 , C12N9/2471 , C12N9/60 , C12N9/6421 , C12P21/02 , C12Y302/01023 , C07K2319/00 , C07K2319/50 , C07K2319/61 , C07K2319/95
摘要： Methods of designing or modifying protein structure at the protein or genetic level to produce specified amino-termini in vivo or in vitro are described. The methods can be used to alter the metabolic stability and other properties of the protein or, alternatively, to artificially generate authentic amino-termini in proteins produced through artificial means. The methods are based upon the introduction of the use of artificial ubiquitin-protein fusions, and the discovery that the in vivo half-life of a protein is a function of the amino-terminal amino acid of the protein.
摘要翻译： 描述了在蛋白质或遗传水平上设计或修饰蛋白质结构以在体内或体外产生特定氨基末端的方法。 该方法可用于改变蛋白质的代谢稳定性和其它性质，或者替代地，通过人工方式人造产生的蛋白质中的正确的氨基末端。 该方法基于引入人造泛素 - 蛋白质融合物的使用，并且发现蛋白质的体内半衰期是蛋白质的氨基末端氨基酸的函数。
-
公开(公告)号：US20060236876A1
公开(公告)日：2006-10-26
申请号：US11388556
申请日：2006-03-24
申请人： Daniel Finley
发明人： Daniel Finley
IPC分类号： A23N1/00
CPC分类号： B01D46/10 , B01D46/0002 , B01D46/0016 , F24F3/1603 , F24F2221/12 , Y02A50/2355
摘要： There is provided a panel filter assembly for particular use in commercial and industrial applications, as well as for residential use, that filter, reduce, or eliminate dust, odor, gas and particles from contaminated environments. The panel filter can be installed in portable or stationary air purification systems. It is designed to be lightweight, recyclable, and easily assembled. Certain components of the filter are adapted to be collapsed during shipping (and before complete assembly) to reduce space.
摘要翻译： 提供了用于商业和工业应用以及住宅用途的面板过滤器组件，其过滤，减少或消除了污染环境中的灰尘，气味，气体和颗粒。 面板式过滤器可安装在便携式或固定式空气净化系统中。 它的设计是轻便，可回收和易于组装。 过滤器的某些组件适于在运输期间（和完全组装之前）折叠以减少空间。
-
公开(公告)号：US5196321A
公开(公告)日：1993-03-23
申请号：US821720
申请日：1992-01-15
IPC分类号： C07K1/107 , C07K14/00 , C12N9/06 , C12N9/38 , C12N9/60 , C12N9/64 , C12N15/11 , C12N15/62 , C12N15/67 , C12P21/02 , C12P21/04
CPC分类号： C12N9/0028 , C07K1/107 , C07K1/1075 , C07K14/00 , C12N15/11 , C12N15/62 , C12N15/67 , C12N9/2471 , C12N9/60 , C12N9/6421 , C12P21/02 , C12Y302/01023 , C07K2319/00 , C07K2319/50 , C07K2319/61 , C07K2319/95
摘要： Methods of designing or modifying protein structure at the protein or genetic level to produce specified amino-termini in vivo or in vitro are described. The methods can be used to alter the metabolic stability and other properties of the protein or, alternatively, to artificially generate authentic amino-termini in proteins produced through artificial means. The methods are based upon the introduction of the use of artificial ubiquitin-protein fusions, and the discovery that the in vivo half-life of a protein is a function of the amino-terminal amino acid of the protein.
摘要翻译： 描述了在蛋白质或遗传水平上设计或修饰蛋白质结构以在体内或体外产生特定氨基末端的方法。 该方法可用于改变蛋白质的代谢稳定性和其它性质，或者替代地，通过人工方式人造产生的蛋白质中的正确的氨基末端。 该方法基于引入人造泛素 - 蛋白质融合物的使用，并且发现蛋白质的体内半衰期是蛋白质的氨基末端氨基酸的函数。
-
-
-
-
-
-
-
-
搜索结果
9 条记录 (耗时 0.033 秒)
