公开(公告)号：US5643328A

公开(公告)日：1997-07-01

申请号：US684429

申请日：1996-07-19

申请人： Daniel J. Cooke ,  David Prutchi ,  Patrick J. Paul

发明人： Daniel J. Cooke ,  David Prutchi ,  Patrick J. Paul

IPC分类号： A61N1/05 ,  A61N1/362 ,  A61N1/37 ,  A61N1/375

CPC分类号： A61N1/3708 ,  A61N1/05 ,  A61N1/375

摘要： An implantable cardiac stimulation system having a patient warning system and an elongated electrode mounted near the can of the system for providing reliable stimulation for warning. The electrode has an extended length and a short width. The length is preferably at least double the width and more preferably at least four times the width. This extended length increases the probability that contact with the surrounding tissue will be achieved. The short width and rounded profile of the width, forming an "edge", on the other hand, increases the probability that a high enough current density will be achieved, causing stimulation to occur. The electrode may also be curved along its length, which tends to promote a "point" or small area contact between the electrode and the patient's tissue. The electrode may be mounted directly on the can or header of the cardiac stimulator or may be part of a separate pin electrode. If a pin electrode is used, a hood configuration can be used to surround at least part of the header, reducing rotation of the pin electrode. By making only a portion of the surface of the pin electrode conductive, and particularly edges or corners, an elongated electrode, as described herein, is formed which produces a higher electric current density and more efficient stimulation.

摘要翻译： 一种植入式心脏刺激系统，其具有患者警告系统和安装在该系统的罐附近的细长电极，用于提供用于警告的可靠刺激。 电极具有延长的长度和短的宽度。 该长度优选为宽度的至少两倍，更优选地为该宽度的至少四倍。 这种延长的长度增加了与周围组织接触的可能性。 另一方面，形成“边缘”的宽度的短宽度和圆形轮廓增加了实现足够高的电流密度，导致刺激发生的可能性。 电极也可以沿其长度弯曲，这倾向于促进电极和患者组织之间的“点”或小面积的接触。 电极可以直接安装在心脏刺激器的容器或头部上，或者可以是单独的针电极的一部分。 如果使用引脚电极，则可以使用发动机罩构造来围绕头部的至少一部分，减少销电极的旋转。 通过仅使引脚电极的表面的一部分导电，特别是边缘或角部，形成如本文所述的细长电极，其产生较高的电流密度和更有效的刺激。

公开(公告)号：US08543207B2

公开(公告)日：2013-09-24

申请号：US13178571

申请日：2011-07-08

申请人： Daniel J. Cooke ,  Jeffrey A. Von Arx

发明人： Daniel J. Cooke ,  Jeffrey A. Von Arx

IPC分类号： A61N1/37

CPC分类号： A61N1/3718 ,  A61N1/02 ,  A61N1/36092 ,  A61N1/3688 ,  A61N1/3931 ,  A61N1/3962 ,  Y10S128/901

摘要： One embodiment of the present invention relates to an implantable medical device (“IMD”) that can be programmed from one operational mode to another operational mode when in the presence of electro-magnetic interference (“EMI”). In accordance with this particular embodiment, the IMD includes a communication interface for receiving communication signals from an external device, such as a command to switch the IMD from a first operation mode to a second operation mode. The IMD further includes a processor in electrical communication with the communication interface, which is operable to switch or reprogram the IMD from the first operation mode to the second operation mode upon receiving a command to do so. In addition, the IMD includes a timer operable to measure a time period from when the processor switches the IMD to the second operation mode. In accordance with this aspect of the invention, the processor is in electrical communication with the timer, and is further operable to switch the IMD from the second operation mode back to the first operation mode when the measured time period reaches a predetermined time period.

摘要翻译： 本发明的一个实施例涉及当存在电磁干扰（“EMI”）时可从一个操作模式编程到另一个操作模式的可植入医疗装置（“IMD”）。 根据该特定实施例，IMD包括用于从外部设备接收通信信号的通信接口，诸如将IMD从第一操作模式切换到第二操作模式的命令。 IMD还包括与通信接口电通信的处理器，其可操作以在接收到这样做的命令时将IMD从第一操作模式切换或重新编程到第二操作模式。 另外，IMD包括一个定时器，可操作以测量从处理器将IMD切换到第二操作模式的时间段。 根据本发明的这个方面，处理器与定时器电通信，并且当测量的时间段达到预定的时间周期时，进一步可操作地将IMD从第二操作模式切换回第一操作模式。

公开(公告)号：US20120052184A1

公开(公告)日：2012-03-01

申请号：US13288487

申请日：2011-11-03

申请人： Harshad M. Borgaonkar ,  Ronald W. Heil, JR. ,  Arienne P. Simon ,  Jeannette C. Polkinghorne ,  Daniel J. Cooke

发明人： Harshad M. Borgaonkar ,  Ronald W. Heil, JR. ,  Arienne P. Simon ,  Jeannette C. Polkinghorne ,  Daniel J. Cooke

IPC分类号： B05D5/00 ,  B05D3/00 ,  B05D7/00

CPC分类号： A61N1/056 ,  A61N1/0568

摘要： A medical electrical lead includes a drug eluting coating provided over at least a portion of the lead body. The drug eluting coating can be provided over at least a portion of the lead body and adjacent to at least one electrode located on the lead body. The drug eluting coating can include at least one matrix polymer layer including a polymer admixed with a therapeutic agent. The therapeutic agent, for example, can be an anti-proliferative agent or an anti-inflammatory agent. The matrix polymer can include a medical adhesive. The rate of elution of the drug from the matrix polymer layer is affected by the drug to polymer ratio of the drug in the matrix polymer layer.

摘要翻译： 医用电引线包括提供在引线主体的至少一部分上的药物洗脱涂层。 药物洗脱涂层可以提供在引线主体的至少一部分上并与位于引线主体上的至少一个电极相邻。 药物洗脱涂层可以包括至少一种包含与治疗剂混合的聚合物的基质聚合物层。 治疗剂例如可以是抗增殖剂或抗炎剂。 基质聚合物可以包括医用粘合剂。 药物从基质聚合物层的洗脱速率受基质聚合物层中药物与聚合物的比例的影响。

公开(公告)号：US20090221885A1

公开(公告)日：2009-09-03

申请号：US12391761

申请日：2009-02-24

申请人： Peter Hall ,  Daniel J. Cooke ,  Michael John Kane

发明人： Peter Hall ,  Daniel J. Cooke ,  Michael John Kane

IPC分类号： A61B5/1473 ,  B23K31/02

CPC分类号： A61B5/14542 ,  A61B5/1473

摘要： Embodiments of the invention are related to optical window assemblies for implantable medical devices, amongst other things. In an embodiment, the invention includes an optical window assembly for a medical device. The assembly can include a ferrule defining an aperture and a spacer ring disposed within the aperture. The assembly can also include an optical window coupled to the metal ferrule and the spacer ring. In an embodiment, the invention includes an implantable medical device including a housing and an optical window assembly coupled to the housing. In an embodiment, the invention can include a method of manufacturing a medical device. The method can include brazing a spacer ring to a metal ferrule, coupling an optical window to the spacer ring and the metal ferrule with a bonding glass material, depositing a chemical sensing element over the optical window, and coupling a porous cover layer to the spacer ring and the ferrule with an adhesive. Other embodiments are also included herein.

摘要翻译： 本发明的实施例涉及用于可植入医疗装置的光学窗组件，其中包括。 在一个实施例中，本发明包括用于医疗装置的光学窗组件。 组件可以包括限定孔的套圈和设置在孔内的间隔环。 组件还可以包括耦合到金属套圈和间隔环的光学窗口。 在一个实施例中，本发明包括可植入医疗装置，其包括壳体和耦合到壳体的光学窗组件。 在一个实施例中，本发明可以包括制造医疗装置的方法。 该方法可以包括将间隔环钎焊到金属套箍上，用光学玻璃材料将光学窗口耦合到间隔环和金属套圈，在光学窗口上沉积化学感测元件，以及将多孔覆盖层耦合到间隔物 环和带有粘合剂的套圈。 本文还包括其它实施例。

公开(公告)号：US20090138058A1

公开(公告)日：2009-05-28

申请号：US11015807

申请日：2004-12-17

申请人： Daniel J. Cooke ,  Jeffrey A. Von Arx

发明人： Daniel J. Cooke ,  Jeffrey A. Von Arx

IPC分类号： A61N1/08 ,  A61N1/362 ,  A61N1/39

CPC分类号： A61N1/3718 ,  A61N1/02 ,  A61N1/36092 ,  A61N1/3688 ,  A61N1/3931 ,  A61N1/3962 ,  Y10S128/901

摘要： One embodiment of the present invention relates to an implantable medical device (“IMD”) that can be programmed from one operational mode to another operational mode when in the presence of electro-magnetic interference (“EMI”). In accordance with this particular embodiment, the IMD includes a communication interface for receiving communication signals from an external device, such as a command to switch the IMD from a first operation mode to a second operation mode. The IMD further includes a processor in electrical communication with the communication interface, which is operable to switch or reprogram the IMD from the first operation mode to the second operation mode upon receiving a command to do so. In addition, the IMD includes a timer operable to measure a time period from when the processor switches the IMD to the second operation mode. In accordance with this aspect of the invention, the processor is in electrical communication with the timer, and is further operable to switch the IMD from the second operation mode back to the first operation mode when the measured time period reaches a predetermined time period.

摘要翻译： 本发明的一个实施例涉及当存在电磁干扰（“EMI”）时可从一个操作模式编程到另一个操作模式的可植入医疗装置（“IMD”）。 根据该特定实施例，IMD包括用于从外部设备接收通信信号的通信接口，诸如将IMD从第一操作模式切换到第二操作模式的命令。 IMD还包括与通信接口电通信的处理器，其可操作以在接收到这样做的命令时将IMD从第一操作模式切换或重新编程到第二操作模式。 另外，IMD包括一个定时器，可操作以测量从处理器将IMD切换到第二操作模式的时间段。 根据本发明的这个方面，处理器与定时器电通信，并且当测量的时间段达到预定的时间周期时，进一步可操作地将IMD从第二操作模式切换回第一操作模式。

公开(公告)号：US08324290B2

公开(公告)日：2012-12-04

申请号：US12492483

申请日：2009-06-26

申请人： Shrojalkumar Desai ,  Marlene C. Schwarz ,  Mark Boden ,  Mohan Krishnan ,  Michael C. Smith ,  Frederick H. Strickler ,  Daniel J. Cooke

发明人： Shrojalkumar Desai ,  Marlene C. Schwarz ,  Mark Boden ,  Mohan Krishnan ,  Michael C. Smith ,  Frederick H. Strickler ,  Daniel J. Cooke

IPC分类号： A61N1/05

CPC分类号： C08G18/6204 ,  A61L27/18 ,  A61L31/06 ,  C08G18/10 ,  C08G18/12 ,  C08G18/4063 ,  C08G18/4854 ,  C08G18/4858 ,  C08G18/6511 ,  C08G18/7657 ,  C08L75/00 ,  C08G18/3206

摘要： The present invention pertains to polyisobutylene urethane, urea and urethane/urea copolymers, to methods of making such copolymers and to medical devices that contain such polymers. According to certain aspects of the invention, polyisobutylene urethane, urea and urethane/urea copolymers are provided, which comprise a polyisobutylene segment, an additional polymeric segment that is not a polyisobutylene segment, and a segment comprising a residue of a diisocyanate. According to other aspects of the invention, polyisobutylene urethane, urea and urethane/urea copolymers are provided, which comprise a polyisobutylene segment and end groups that comprise alkyl-, alkenyl- or alkynyl-chain-containing end groups.

摘要翻译： 本发明涉及聚异丁烯氨基甲酸酯，脲和氨基甲酸酯/尿素共聚物，涉及制备这种共聚物的方法和含有这种聚合物的医疗装置。 根据本发明的某些方面，提供聚异丁烯氨基甲酸酯，脲和氨基甲酸酯/脲共聚物，其包含聚异丁烯链段，不是聚异丁烯链段的另外的聚合链段和包含二异氰酸酯残基的链段。 根据本发明的其它方面，提供聚异丁烯氨基甲酸酯，脲和氨基甲酸酯/脲共聚物，其包含聚异丁烯链段和包含含有烷基，链烯基或炔基链的端基的端基。

公开(公告)号：US20110270338A1

公开(公告)日：2011-11-03

申请号：US13178571

申请日：2011-07-08

申请人： Daniel J. Cooke ,  Jeffrey A. Von Arx

发明人： Daniel J. Cooke ,  Jeffrey A. Von Arx

IPC分类号： A61N1/362 ,  A61N1/39 ,  A61N1/36

CPC分类号： A61N1/3718 ,  A61N1/02 ,  A61N1/36092 ,  A61N1/3688 ,  A61N1/3931 ,  A61N1/3962 ,  Y10S128/901

摘要： One embodiment of the present invention relates to an implantable medical device (“IMD”) that can be programmed from one operational mode to another operational mode when in the presence of electro-magnetic interference (“EMI”). In accordance with this particular embodiment, the IMD includes a communication interface for receiving communication signals from an external device, such as a command to switch the IMD from a first operation mode to a second operation mode. The IMD further includes a processor in electrical communication with the communication interface, which is operable to switch or reprogram the IMD from the first operation mode to the second operation mode upon receiving a command to do so. In addition, the IMD includes a timer operable to measure a time period from when the processor switches the IMD to the second operation mode. In accordance with this aspect of the invention, the processor is in electrical communication with the timer, and is further operable to switch the IMD from the second operation mode back to the first operation mode when the measured time period reaches a predetermined time period.

摘要翻译： 本发明的一个实施例涉及当存在电磁干扰（“EMI”）时可从一个操作模式编程到另一个操作模式的可植入医疗装置（“IMD”）。 根据该特定实施例，IMD包括用于从外部设备接收通信信号的通信接口，诸如将IMD从第一操作模式切换到第二操作模式的命令。 IMD还包括与通信接口电通信的处理器，其可操作以在接收到这样做的命令时将IMD从第一操作模式切换或重新编程到第二操作模式。 另外，IMD包括一个定时器，可操作以测量从处理器将IMD切换到第二操作模式的时间段。 根据本发明的这个方面，处理器与定时器电通信，并且当测量的时间段达到预定的时间周期时，进一步可操作地将IMD从第二操作模式切换回第一操作模式。

公开(公告)号：US20100042195A1

公开(公告)日：2010-02-18

申请号：US12508322

申请日：2009-07-23

申请人： Daniel J. Cooke ,  Leslie L. Carion ,  Shrojalkumar Desai ,  Brendan E. Koop ,  Ronald W. Heil, JR. ,  Harshad M. Borgaonkar ,  Matthew S. Finlay

发明人： Daniel J. Cooke ,  Leslie L. Carion ,  Shrojalkumar Desai ,  Brendan E. Koop ,  Ronald W. Heil, JR. ,  Harshad M. Borgaonkar ,  Matthew S. Finlay

IPC分类号： A61N1/05

CPC分类号： A61N1/057 ,  A61N1/0568

摘要： A medical electrical lead comprises a flexible, elongate lead body extending along a longitudinal axis and having a proximal end and a distal end. A protective distal tip structure is disposed on the distal end of the lead body. The tip structure includes a plurality of compliant projections each extending distally from the distal end of the body in the direction of the longitudinal axis. The projections are configured to contact and bear against cardiac tissue when the lead is implanted, and are deformable under the action of an axially or radially directed force. The projections optionally include a coating over a substrate. The coating can include a hydrogel material and/or a pharmaceutical agent such as a steroid for reducing inflammation at the implantation site.

摘要翻译： 医疗电引线包括沿着纵向轴线延伸并且具有近端和远端的柔性细长引线体。 保护性的顶端结构设置在引线体的远端。 尖端结构包括多个顺从突起，每个突起从纵向轴线的方向远离主体的远端延伸。 突起被配置为当铅被植入时与心脏组织接触并承受，并且在轴向或径向力的作用下可变形。 突起任选地包括在基底上的涂层。 涂层可以包括水凝胶材料和/或药剂，例如类固醇，用于在植入部位减少炎症。

公开(公告)号：US20080046059A1

公开(公告)日：2008-02-21

申请号：US11462479

申请日：2006-08-04

申请人： Paul E. Zarembo ,  Mohan Krishnan ,  David Durand ,  Donna Osterkamp ,  Daniel J. Cooke

发明人： Paul E. Zarembo ,  Mohan Krishnan ,  David Durand ,  Donna Osterkamp ,  Daniel J. Cooke

IPC分类号： A61N1/00

CPC分类号： A61N1/056 ,  A61N1/057

摘要： An implantable lead comprises a lead body extending from a lead proximal end portion to a lead distal end portion. In one example, the lead body may comprise a heat-formed bias portion. In another example, an outer insulator is fused to the lead body. In such an example, a lead body fusable plug may be disposed distal to at least one conductor. In another example, the lead comprises an inner boot and an outer boot fused to one another. In another example, the lead includes an atraumatic tip fused to the lead distal end portion. In another example, the lead body is reducable in size using heat shrink tubing. In yet another example, two or more lead sections may be interconnected using an outer insulator fused to the respective lead bodies. In a further example, a stiffener member is fused to the lead body adjacent a lead component.

摘要翻译： 可植入引线包括从引线近端部分延伸到引线远端部分的引线体。 在一个示例中，引线体可以包括加热成形的偏压部分。 在另一示例中，外绝缘体熔合到引线体。 在这种示例中，引线本体可熔插塞可以设置在至少一个导体的远侧。 在另一个示例中，引线包括彼此融合的内靴和外靴。 在另一示例中，引线包括熔合到引线远端部分的无创尖端。 在另一个例子中，使用热缩管可以使引线体尺寸减小。 在又一示例中，两个或更多个引线部分可以使用融合到相应引线体的外绝缘体互连。 在另一个例子中，加强件与引线部件相邻地被引导体熔合。

公开(公告)号：US08160721B2

公开(公告)日：2012-04-17

申请号：US12508322

申请日：2009-07-23

申请人： Daniel J. Cooke ,  Leslie J. Carion ,  Shrojalkumar Desai ,  Brendan E. Koop ,  Ronald W. Heil, Jr. ,  Harshad M. Borgaonkar ,  Matthew S. Finlay

发明人： Daniel J. Cooke ,  Leslie J. Carion ,  Shrojalkumar Desai ,  Brendan E. Koop ,  Ronald W. Heil, Jr. ,  Harshad M. Borgaonkar ,  Matthew S. Finlay

IPC分类号： A61N1/00

CPC分类号： A61N1/057 ,  A61N1/0568

摘要： A medical electrical lead comprises a flexible, elongate lead body extending along a longitudinal axis and having a proximal end and a distal end. A protective distal tip structure is disposed on the distal end of the lead body. The tip structure includes a plurality of compliant projections each extending distally from the distal end of the body in the direction of the longitudinal axis. The projections are configured to contact and bear against cardiac tissue when the lead is implanted, and are deformable under the action of an axially or radially directed force. The projections optionally include a coating over a substrate. The coating can include a hydrogel material and/or a pharmaceutical agent such as a steroid for reducing inflammation at the implantation site.

摘要翻译： 医疗电引线包括沿着纵向轴线延伸并且具有近端和远端的柔性细长引线体。 保护性的顶端结构设置在引线体的远端。 尖端结构包括多个顺从突起，每个突起从纵向轴线的方向远离主体的远端延伸。 突起被配置为当铅被植入时与心脏组织接触并承受，并且在轴向或径向力的作用下可变形。 突起任选地包括在基底上的涂层。 涂层可以包括水凝胶材料和/或药剂，例如类固醇，用于在植入部位减少炎症。