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公开(公告)号：US20080286255A1
公开(公告)日：2008-11-20
申请号：US12126100
申请日：2008-05-23
CPC分类号： A61K49/0056 , A61K38/482 , A61K41/00 , A61K49/0017
摘要： The present invention relates to altering the physical and/or chemical properties of at least part of at least one tissue in the eye. In a specific embodiment, it relates to the treatment of any eye disorder, although in particular embodiments the individual has a thickened Bruch's membrane. An activating energy source is utilized to effect a controlled diffusion enhancement and/or degradation of Bruch's membrane that enables improved diffusional transport between the choroid and retina. The individual is administered an inactivated diffusion-enhancing molecule that becomes associated with the membrane, which is then precisely exposed to an activating energy source, such as light or ultrasound.
摘要翻译： 本发明涉及改变眼睛中至少一个组织的至少一部分的物理和/或化学性质。 在具体实施方案中，它涉及任何眼睛疾病的治疗，尽管在具体实施方案中个体具有增厚的布鲁赫氏膜。 使用活化能源来实现Bruch膜的受控扩散增强和/或降解，其能够改善脉络膜和视网膜之间的扩散转运。 给个体施用与膜相关的失活的扩散增强分子，然后将其精确地暴露于诸如光或超声的活化能源。
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公开(公告)号：US08298521B2
公开(公告)日：2012-10-30
申请号：US12126100
申请日：2008-05-23
IPC分类号： A61K31/74
CPC分类号： A61K49/0056 , A61K38/482 , A61K41/00 , A61K49/0017
摘要： The present invention relates to altering the physical and/or chemical properties of at least part of at least one tissue in the eye. In a specific embodiment, it relates to the treatment of any eye disorder, although in particular embodiments the individual has a thickened Bruch's membrane. An activating energy source is utilized to effect a controlled diffusion enhancement and/or degradation of Bruch's membrane that enables improved diffusional transport between the choroid and retina. The individual is administered an inactivated diffusion-enhancing molecule that becomes associated with the membrane, which is then precisely exposed to an activating energy source, such as light or ultrasound.
摘要翻译： 本发明涉及改变眼睛中至少一个组织的至少一部分的物理和/或化学性质。 在具体实施方案中，它涉及任何眼睛疾病的治疗，尽管在具体实施方案中个体具有增厚的布鲁赫氏膜。 使用活化能源来实现Bruch膜的受控扩散增强和/或降解，其能够改善脉络膜和视网膜之间的扩散转运。 给个体施用与膜相关的失活的扩散增强分子，然后将其精确地暴露于诸如光或超声的活化能源。
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公开(公告)号：US07381404B2
公开(公告)日：2008-06-03
申请号：US10611013
申请日：2003-07-01
IPC分类号： A61K31/74
CPC分类号： A61K49/0056 , A61K38/482 , A61K41/00 , A61K49/0017
摘要： The present invention relates to altering the physical and/or chemical properties of at least part of at least one tissue in the eye. In a specific embodiment, it relates to the treatment of any eye disorder, although in particular embodiments the individual has a thickened Bruch's membrane. An activating energy source is utilized to effect a controlled diffusion enhancement and/or degradation of Bruch's membrane that enables improved diffusional transport between the choroid and retina. The individual is administered an inactivated diffusion-enhancing molecule that becomes associated with the membrane, which is then precisely exposed to an activating energy source, such as light or ultrasound.
摘要翻译： 本发明涉及改变眼睛中至少一个组织的至少一部分的物理和/或化学性质。 在具体实施方案中，它涉及任何眼睛疾病的治疗，尽管在具体实施方案中个体具有增厚的布鲁赫氏膜。 使用活化能源来实现Bruch膜的受控扩散增强和/或降解，其能够改善脉络膜和视网膜之间的扩散转运。 给个体施用与膜相关的失活的扩散增强分子，然后将其精确地暴露于诸如光或超声的活化能源。
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4.发明申请公开(公告)号：US20050163713A1
公开(公告)日：2005-07-28
申请号：US11009901
申请日：2004-12-10
申请人： Julian Tyszka , Changjun Yu , Daniel Schwartz , Ilene Sugino , Scott Fraser
发明人： Julian Tyszka , Changjun Yu , Daniel Schwartz , Ilene Sugino , Scott Fraser
IPC分类号： A61K49/00 , G01R33/563
CPC分类号： G01R33/56341
摘要： The present invention relates generally to the field of magnetic resonance imaging and, more particularly, to devices and methods used in the observation of the diffusion of molecules across a permeable membrane using magnetic resonance techniques. A typical embodiment of the invention is a method of observing the diffusion of a molecule in a container having a permeable membrane that is disposed between a first solution and a second solution in the container, by using magnetic resonance imaging to obtain an image of the diffusion of the molecule in the first solution across the membrane in to the second solution.
摘要翻译： 本发明一般涉及磁共振成像领域，更具体地，涉及用于使用磁共振技术观察分子穿过可渗透膜扩散的装置和方法。 本发明的典型实施例是通过使用磁共振成像来观察分子在具有设置在容器中的第一溶液和第二溶液之间的渗透膜的容器中的扩散的方法，以获得扩散图像 的第一溶液中的分子穿过膜进入第二溶液。
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公开(公告)号：US20060238756A1
公开(公告)日：2006-10-26
申请号：US11351558
申请日：2006-02-10
申请人： Gregory Bearman , Daniel Wilson , Scott Fraser
发明人： Gregory Bearman , Daniel Wilson , Scott Fraser
CPC分类号： G01J3/2823 , G01J3/18 , G01J3/4406 , G01N21/6458 , G01N2021/6423 , G02B21/0064 , G02B21/0076
摘要： Fast confocal spectral imagers are provided. A fast confocal spectral imager according to the invention includes a spectral imager coupled to a fast confocal microscope. A laser is provided for generating laser light, which passes through scanning optics which are configured to scan a line- or slit-shaped region of a specimen at a given time. The light then passes through an objective lens and excites fluorescent dyes applied to the specimen, causing the dyes to fluoresce at respective emission spectra. The fluorescence radiated by the excited dyes then passes back through the scanning optics and is directed to a fixed slit that functions as an entrance slit for a spectral imager. The spectral imager receives the fluorescence and separates it into wavelength bands. The wavelength and position across the slit-shaped region of the specimen for each wavelength band are then recorded.
摘要翻译： 提供快速共聚焦光谱成像仪。 根据本发明的快速共焦光谱成像仪包括耦合到快速共聚焦显微镜的光谱成像仪。 提供了用于产生激光的激光，其通过扫描光学器件，扫描光学器件被配置为在给定时间扫描样品的线或狭缝形区域。 然后光通过物镜并激发施加到样品上的荧光染料，导致染料在各自的发射光谱下发荧光。 由激发的染料辐射的荧光然后通过扫描光学器件返回，并被引导到用作光谱成像器的入口狭缝的固定狭缝。 光谱成像仪接收荧光并将其分离成波段。 然后记录每个波长带的样品的狭缝状区域的波长和位置。
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公开(公告)号：US20050003399A1
公开(公告)日：2005-01-06
申请号：US10823503
申请日：2004-04-12
申请人： Gary Blackburn , Stephen Creager , Scott Fraser , Bruce Irvine , Thomas Meade , Stephen O'Connor , Robert Terbrueggen , Jost Vielmetter , Thomas Welch
发明人： Gary Blackburn , Stephen Creager , Scott Fraser , Bruce Irvine , Thomas Meade , Stephen O'Connor , Robert Terbrueggen , Jost Vielmetter , Thomas Welch
CPC分类号： B82Y30/00 , B82Y15/00 , C12Q1/6825 , C12Q2565/629
摘要： The invention relates to compositions and methods useful in the acceleration of binding of target analytes to capture ligands on surfaces. Detection proceeds through the use of an electron transfer moiety (ETM) that is associated with the target analyte, either directly or indirectly, to allow electronic detection of the ETM.
摘要翻译： 本发明涉及用于加速目标分析物与表面捕获配体结合的组合物和方法。 检测通过直接或间接使用与目标分析物相关的电子转移部分（ETM）进行，以允许电子检测ETM。
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公开(公告)号：US08793910B2
公开(公告)日：2014-08-05
申请号：US12898247
申请日：2010-10-05
IPC分类号： G09F7/02
CPC分类号： G09F15/00
摘要： A frame for a sign. The frame comprises a plurality of struts and corner brackets. The struts have an exposed front surface including a gripping means. Each corner bracket slidably engages with two of the struts at an angle. The corner brackets also have an exposed front surface including a gripping means. The gripping means of the struts is substantially continuous with the gripping means of the corner brackets so that when the corner brackets and struts are engaged to form a polygon, the polygon includes a substantially continuous gripping means that is engageable with a sign to mount the sign on the frame.
摘要翻译： 一个符号的框架。 框架包括多个支柱和角落托架。 支柱具有包括夹持装置的暴露的前表面。 每个角支架以一定角度与两个支柱滑动接合。 角落托架还具有包括夹持装置的暴露的前表面。 支柱的夹持装置与角托的夹持装置基本上连续，使得当角落支架和支柱接合以形成多边形时，多边形包括基本上连续的夹持装置，其可与符号接合以安装标志 在框架上。
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公开(公告)号：US07655129B2
公开(公告)日：2010-02-02
申请号：US10823503
申请日：2004-04-12
申请人： Gary Blackburn , Stephen E. Creager , Scott Fraser , Bruce D. Irvine , Thomas J. Meade , Stephen J. O'Connor , Robert H. Terbrueggen , Jost G. Vielmetter , Thomas W. Welch
发明人： Gary Blackburn , Stephen E. Creager , Scott Fraser , Bruce D. Irvine , Thomas J. Meade , Stephen J. O'Connor , Robert H. Terbrueggen , Jost G. Vielmetter , Thomas W. Welch
IPC分类号： G01N27/327
CPC分类号： B82Y30/00 , B82Y15/00 , C12Q1/6825 , C12Q2565/629
摘要： The invention relates to compositions and methods useful in the acceleration of binding of target analytes to capture ligands on surfaces. Detection proceeds through the use of an electron transfer moiety (ETM) that is associated with the target analyte, either directly or indirectly, to allow electronic detection of the ETM.
摘要翻译： 本发明涉及用于加速目标分析物与表面捕获配体结合的组合物和方法。 检测通过直接或间接使用与目标分析物相关的电子转移部分（ETM）进行，以允许电子检测ETM。
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9.发明授权公开(公告)号：US07354568B1
公开(公告)日：2008-04-08
申请号：US09405046
申请日：1999-09-27
申请人： Thomas Meade , Scott Fraser , Russell Jacobs
发明人： Thomas Meade , Scott Fraser , Russell Jacobs
IPC分类号： A61B5/055
CPC分类号： A61K49/10 , A61K49/085
摘要： The invention relates to novel magnetic resonance imaging contrast agents and methods of detecting physiological signals or substances.
摘要翻译： 本发明涉及新型磁共振成像造影剂和检测生理信号或物质的方法。
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10.发明申请Method and apparatus for providing signal analysis of a bionems resonator or transducer 有权用于提供二元共振器或换能器的信号分析的方法和装置公开(公告)号：US20060155478A1
公开(公告)日：2006-07-13
申请号：US10502466
申请日：2003-05-07
申请人： Michael Roukes , Scott Fraser , Jerry Solomon
发明人： Michael Roukes , Scott Fraser , Jerry Solomon
IPC分类号： G01N33/48
CPC分类号： G01N33/54373
摘要： An outputs signal, v(t), is generated from a bioNEMs transducer and mixed with a reference signal and then filtered to generate a correlator output, r(t). The correlator output is detected to generate a signal u(t) and then determined whether the signal u(t) satisfies a predetermined threshold. If qualified, it is then decided whether the signal u(t) represents a predetermined type of interaction between a free ligand in a fluid in which the NEMS device is immersed and a receptor attached to the transducer. The threshold is the Neyman-Pearson criterion based on a predetermined probability of false detection, Pfa. The interaction may be binding of a free ligand to the receptor or releasing a bound ligand from the receptor by competitive binding with the free ligand. The step of detecting comprises detecting the envelope of the signal, r(t).
摘要翻译： 输出信号v（t）由bioNEMs传感器产生并与参考信号混合，然后被滤波以产生相关器输出r（t）。 检测相关器输出以产生信号u（t），然后确定信号u（t）是否满足预定阈值。 如果合格，则判定信号u（t）是否表示在其中浸入NEMS装置的流体中的游离配体与附接到换能器的受体之间的预定类型的相互作用。 阈值是基于预先确定的错误检测概率的Neyman-Pearson标准Pfa。 相互作用可以是游离配体与受体的结合或通过与游离配体的竞争性结合从受体释放结合的配体。 检测步骤包括检测信号的包络r（t）。
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