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公开(公告)号：US20080286255A1
公开(公告)日：2008-11-20
申请号：US12126100
申请日：2008-05-23
CPC分类号： A61K49/0056 , A61K38/482 , A61K41/00 , A61K49/0017
摘要： The present invention relates to altering the physical and/or chemical properties of at least part of at least one tissue in the eye. In a specific embodiment, it relates to the treatment of any eye disorder, although in particular embodiments the individual has a thickened Bruch's membrane. An activating energy source is utilized to effect a controlled diffusion enhancement and/or degradation of Bruch's membrane that enables improved diffusional transport between the choroid and retina. The individual is administered an inactivated diffusion-enhancing molecule that becomes associated with the membrane, which is then precisely exposed to an activating energy source, such as light or ultrasound.
摘要翻译： 本发明涉及改变眼睛中至少一个组织的至少一部分的物理和/或化学性质。 在具体实施方案中，它涉及任何眼睛疾病的治疗，尽管在具体实施方案中个体具有增厚的布鲁赫氏膜。 使用活化能源来实现Bruch膜的受控扩散增强和/或降解，其能够改善脉络膜和视网膜之间的扩散转运。 给个体施用与膜相关的失活的扩散增强分子，然后将其精确地暴露于诸如光或超声的活化能源。
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公开(公告)号：US08298521B2
公开(公告)日：2012-10-30
申请号：US12126100
申请日：2008-05-23
IPC分类号： A61K31/74
CPC分类号： A61K49/0056 , A61K38/482 , A61K41/00 , A61K49/0017
摘要： The present invention relates to altering the physical and/or chemical properties of at least part of at least one tissue in the eye. In a specific embodiment, it relates to the treatment of any eye disorder, although in particular embodiments the individual has a thickened Bruch's membrane. An activating energy source is utilized to effect a controlled diffusion enhancement and/or degradation of Bruch's membrane that enables improved diffusional transport between the choroid and retina. The individual is administered an inactivated diffusion-enhancing molecule that becomes associated with the membrane, which is then precisely exposed to an activating energy source, such as light or ultrasound.
摘要翻译： 本发明涉及改变眼睛中至少一个组织的至少一部分的物理和/或化学性质。 在具体实施方案中，它涉及任何眼睛疾病的治疗，尽管在具体实施方案中个体具有增厚的布鲁赫氏膜。 使用活化能源来实现Bruch膜的受控扩散增强和/或降解，其能够改善脉络膜和视网膜之间的扩散转运。 给个体施用与膜相关的失活的扩散增强分子，然后将其精确地暴露于诸如光或超声的活化能源。
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公开(公告)号：US07381404B2
公开(公告)日：2008-06-03
申请号：US10611013
申请日：2003-07-01
IPC分类号： A61K31/74
CPC分类号： A61K49/0056 , A61K38/482 , A61K41/00 , A61K49/0017
摘要： The present invention relates to altering the physical and/or chemical properties of at least part of at least one tissue in the eye. In a specific embodiment, it relates to the treatment of any eye disorder, although in particular embodiments the individual has a thickened Bruch's membrane. An activating energy source is utilized to effect a controlled diffusion enhancement and/or degradation of Bruch's membrane that enables improved diffusional transport between the choroid and retina. The individual is administered an inactivated diffusion-enhancing molecule that becomes associated with the membrane, which is then precisely exposed to an activating energy source, such as light or ultrasound.
摘要翻译： 本发明涉及改变眼睛中至少一个组织的至少一部分的物理和/或化学性质。 在具体实施方案中，它涉及任何眼睛疾病的治疗，尽管在具体实施方案中个体具有增厚的布鲁赫氏膜。 使用活化能源来实现Bruch膜的受控扩散增强和/或降解，其能够改善脉络膜和视网膜之间的扩散转运。 给个体施用与膜相关的失活的扩散增强分子，然后将其精确地暴露于诸如光或超声的活化能源。
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4.发明申请公开(公告)号：US20050163713A1
公开(公告)日：2005-07-28
申请号：US11009901
申请日：2004-12-10
申请人： Julian Tyszka , Changjun Yu , Daniel Schwartz , Ilene Sugino , Scott Fraser
发明人： Julian Tyszka , Changjun Yu , Daniel Schwartz , Ilene Sugino , Scott Fraser
IPC分类号： A61K49/00 , G01R33/563
CPC分类号： G01R33/56341
摘要： The present invention relates generally to the field of magnetic resonance imaging and, more particularly, to devices and methods used in the observation of the diffusion of molecules across a permeable membrane using magnetic resonance techniques. A typical embodiment of the invention is a method of observing the diffusion of a molecule in a container having a permeable membrane that is disposed between a first solution and a second solution in the container, by using magnetic resonance imaging to obtain an image of the diffusion of the molecule in the first solution across the membrane in to the second solution.
摘要翻译： 本发明一般涉及磁共振成像领域，更具体地，涉及用于使用磁共振技术观察分子穿过可渗透膜扩散的装置和方法。 本发明的典型实施例是通过使用磁共振成像来观察分子在具有设置在容器中的第一溶液和第二溶液之间的渗透膜的容器中的扩散的方法，以获得扩散图像 的第一溶液中的分子穿过膜进入第二溶液。
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公开(公告)号：US08658702B2
公开(公告)日：2014-02-25
申请号：US12972423
申请日：2010-12-17
申请人： Mamadou Diallo , Changjun Yu
发明人： Mamadou Diallo , Changjun Yu
IPC分类号： C08F20/52
CPC分类号： C08G73/0206 , B01J41/13 , C02F1/42 , C02F1/444 , C02F1/56 , C02F2001/422 , C02F2101/101 , C02F2101/12 , C02F2101/163 , C07C211/09 , C07C229/16 , C07C237/06 , C08G73/0226 , C08L79/02
摘要： Novel macromolecules for filtering contaminants from water and non-aqueous solutions. Molecules such as polyethyleneimine (PEI) may be functionalized, cross-linked, and/or quaternized to improve their binding capacity or selectivity with particular water contaminants such as bromide, nitrate, and sulfate. The macromolecules may be either recyclable or non-recyclable, and may be recovered or separated from water using means such as ultrafiltration, flocculation, or immobilization on a substrate.
摘要翻译： 用于从水和非水溶液中过滤污染物的新型大分子。 诸如聚乙烯亚胺（PEI）的分子可以被官能化，交联和/或季铵化以改善它们与特定水污染物如溴化物，硝酸盐和硫酸盐的结合能力或选择性。 大分子可以是可回收的或不可回收的，并且可以使用诸如超滤，絮凝或固定在基材上的方法从水中回收或分离。
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6.发明授权公开(公告)号：US08241842B2
公开(公告)日：2012-08-14
申请号：US11009901
申请日：2004-12-10
IPC分类号： C12Q1/00
CPC分类号： G01R33/56341
摘要： The present invention relates generally to the field of magnetic resonance imaging and, more particularly, to devices and methods used in the observation of the diffusion of molecules across a permeable membrane using magnetic resonance techniques. A typical embodiment of the invention is a method of observing the diffusion of a molecule in a container having a permeable membrane that is disposed between a first solution and a second solution in the container, by using magnetic resonance imaging to obtain an image of the diffusion of the molecule in the first solution across the membrane in to the second solution.
摘要翻译： 本发明一般涉及磁共振成像领域，更具体地，涉及用于使用磁共振技术观察分子穿过可渗透膜扩散的装置和方法。 本发明的典型实施例是通过使用磁共振成像来观察分子在具有设置在容器中的第一溶液和第二溶液之间的渗透膜的容器中的扩散的方法，以获得扩散图像 的第一溶液中的分子穿过膜进入第二溶液。
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公开(公告)号：US20050208503A1
公开(公告)日：2005-09-22
申请号：US10803166
申请日：2004-03-16
申请人： Handy Yowanto , Changjun Yu
发明人： Handy Yowanto , Changjun Yu
CPC分类号： B82Y15/00 , B82Y30/00 , C12Q1/6827 , C12Q1/6858 , C12Q2523/109 , C12Q2561/125 , C12Q2563/113
摘要： The invention relates to the field of nucleic acid analysis. More particularly, the invention relates to compositions and methods used for the detection of sequence variations or single nucleotide polymorphisms (SNPs) in a nucleic acid of interest.
摘要翻译： 本发明涉及核酸分析领域。 更具体地，本发明涉及用于检测感兴趣的核酸中的序列变异或单核苷酸多态性（SNP）的组合物和方法。
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公开(公告)号：US06977151B2
公开(公告)日：2005-12-20
申请号：US10081936
申请日：2002-02-20
CPC分类号： C07H21/00 , C12Q1/6825
摘要： The invention relates to nucleic acids covalently coupled to electrodes via conductive oligomers. More particularly, the invention is directed to the site-selective modification of nucleic acids with electron transfer moieties and electrodes to produce a new class of biomaterials, and to methods of making and using them.
摘要翻译： 本发明涉及通过导电低聚物共价偶联到电极上的核酸。 更具体地，本发明涉及具有电子转移部分和电极的核酸的位点选择性修饰以产生新类别的生物材料，以及制备和使用它们的方法。
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公开(公告)号：US06753143B2
公开(公告)日：2004-06-22
申请号：US09847113
申请日：2001-05-01
申请人： Chunlin Tao , Changjun Yu
发明人： Chunlin Tao , Changjun Yu
IPC分类号： C12Q168
CPC分类号： B82Y5/00 , B82Y15/00 , B82Y30/00 , B82Y40/00 , G01N33/5438 , G01N33/553 , G01N2610/00
摘要： The present invention relates to the use asymmetric monolayer forming species and electroconduit forming species to detect target analytes.
摘要翻译： 本发明涉及使用非对称单层形成物质和电导体形成物质来检测目标分析物。
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公开(公告)号：US07935481B1
公开(公告)日：2011-05-03
申请号：US09626096
申请日：2000-07-26
申请人： Robert M. Umek , Gary Blackburn , Bruce D. Irvine , Robert H. Terbrueggen , Changjun Yu , Jost G. Vielmetter
发明人： Robert M. Umek , Gary Blackburn , Bruce D. Irvine , Robert H. Terbrueggen , Changjun Yu , Jost G. Vielmetter
IPC分类号： C12Q1/68
CPC分类号： B82Y15/00 , B82Y30/00 , C12Q1/6825 , C12Q2600/156 , C12Q2563/113 , C12Q2537/143
摘要： The present invention is directed to methods and compositions for the use of self-assembled monolayers to electronically detect nucleic acids, particularly alterations such as nucleotide substitutions (mismatches) and single nucleotide polymorphisms (SNPs).
摘要翻译： 本发明涉及使用自组装单层电子检测核酸，特别是诸如核苷酸取代（错配）和单核苷酸多态性（SNP）的改变的方法和组合物。
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