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18 条记录 (耗时 0.025 秒)

    Method and apparatus for sorting cells
    1.
    发明授权
    Method and apparatus for sorting cells 有权
    用于分选细胞的方法和装置

    公开(公告)号：US07545491B2

    公开(公告)日：2009-06-09

    申请号：US12071020

    申请日：2008-02-14

    申请人： Daniel Mueth ,  Amy Anderson ,  Christopher Knutson ,  Joseph Plewa

    发明人： Daniel Mueth ,  Amy Anderson ,  Christopher Knutson ,  Joseph Plewa

    IPC分类号： G01N21/47 ,  G01N21/01

    CPC分类号： G01N21/6428 ,  C12M47/04 ,  G01N15/1404 ,  G01N15/1459 ,  G01N2015/1409 ,  G01N2015/1411 ,  G01N2015/149

    摘要： Apparatus for sorting and orienting sperm cells has a pair or walls in confronting relationship forming a flow chamber having inlet, a downstream outlet, and intermediate detector region. The inlet receives first and second spaced apart streams of input fluid and a third stream of sample fluid containing the cells to be sorted. The first and second streams have respective flow rates relative to third stream, such that the third stream is constricted forming a relatively narrow sample stream, so that the cells are oriented parallel to the walls. A detector detects desired cells and a sorter downstream of the detector for sorting the desired cells from the stream.

    摘要翻译： 用于分选和定向精子细胞的装置具有一对或多个相对关系的壁，形成具有入口，下游出口和中间检测器区域的流动室。 入口接收第一和第二间隔开的输入流体流和含有待分选细胞的第三流样品流体。 第一和第二流相对于第三流具有相应的流速，使得第三流收缩形成相对窄的样品流，使得电池平行于壁取向。 检测器检测期望的细胞和检测器下游的分选器，用于从流中分选所需的细胞。

    Method and apparatus for sorting cells
    2.
    发明申请
    Method and apparatus for sorting cells 有权
    用于分选细胞的方法和装置

    公开(公告)号：US20060170912A1

    公开(公告)日：2006-08-03

    申请号：US11046896

    申请日：2005-02-01

    申请人： Daniel Mueth ,  Amy Anderson ,  Christopher Knutson ,  Joseph Plewa

    发明人： Daniel Mueth ,  Amy Anderson ,  Christopher Knutson ,  Joseph Plewa

    IPC分类号： G01N21/01

    CPC分类号： G01N21/6428 ,  C12M47/04 ,  G01N15/1404 ,  G01N15/1459 ,  G01N2015/1409 ,  G01N2015/1411 ,  G01N2015/149

    摘要： Apparatus for sorting and orienting sperm cells has a pair or walls in confronting relationship forming a flow chamber having inlet, a downstream outlet, and intermediate detector region. The inlet receives first and second spaced apart streams of input fluid and a third stream of sample fluid containing the cells to be sorted. The first and second streams have respective flow rates relative to third stream, such that the third stream is constricted forming a relatively narrow sample stream, so that the cells are oriented parallel to the walls. A detector detect desired cells and a sorter downstream of the detector for sorting the desired cells from the stream.

    摘要翻译： 用于分选和定向精子细胞的装置具有一对或多个相对关系的壁，形成具有入口，下游出口和中间检测器区域的流动室。 入口接收第一和第二间隔开的输入流体流和含有待分选细胞的第三流样品流体。 第一和第二流相对于第三流具有相应的流速，使得第三流收缩形成相对窄的样品流，使得电池平行于壁取向。 检测器检测期望的细胞和检测器下游的分选器，用于从流中分选所需的细胞。

    Multiple laminar flow-based particle and cellular separation with laser steering
    4.
    发明申请
    Multiple laminar flow-based particle and cellular separation with laser steering 有权
    多层次流动粒子与细胞分离与激光转向

    公开(公告)号：US20050121604A1

    公开(公告)日：2005-06-09

    申请号：US10934597

    申请日：2004-09-03

    申请人： Daniel Mueth ,  Joseph Plewa ,  Jessica Shireman ,  Amy Anderson ,  Lewis Gruber ,  Neil Rosenbaum

    发明人： Daniel Mueth ,  Joseph Plewa ,  Jessica Shireman ,  Amy Anderson ,  Lewis Gruber ,  Neil Rosenbaum

    IPC分类号： A61M1/36 ,  A61M1/38 ,  G01N33/483 ,  G21K1/00 ,  H05H3/04

    CPC分类号： A61M1/3681 ,  A61M1/36 ,  A61M1/3693 ,  A61M1/38 ,  A61M2206/11 ,  B01L3/502761 ,  B03C1/28 ,  B03C5/005 ,  B03C2201/02 ,  B03C2201/18 ,  G01N30/0005 ,  G03H1/08 ,  G03H1/2294 ,  G03H2001/0077 ,  G03H2001/085 ,  Y10T436/25375

    摘要： The invention provides a method, apparatus and system for separating blood and other types of cellular components, and can be combined with holographic optical trapping manipulation or other forms of optical tweezing. One of the exemplary methods includes providing a first flow having a plurality of blood components; providing a second flow; contacting the first flow with the second flow to provide a first separation region; and differentially sedimenting a first blood cellular component of the plurality of blood components into the second flow while concurrently maintaining a second blood cellular component of the plurality of blood components in the first flow. The second flow having the first blood cellular component is then differentially removed from the first flow having the second blood cellular component. Holographic optical traps may also be utilized in conjunction with the various flows to move selected components from one flow to another, as part of or in addition to a separation stage.

    摘要翻译： 本发明提供了一种用于分离血液和其他类型的细胞组分的方法，装置和系统，并且可以与全息光学捕获操作或其他形式的光学镊子组合。 示例性方法之一包括提供具有多个血液成分的第一流; 提供第二流; 使第一流与第二流接触以提供第一分离区; 以及将所述多个血液成分的第一血细胞成分差异沉积到所述第二流中，同时在所述第一流中同时维持所述多个血液成分的第二血细胞成分。 然后，具有第一血细胞成分的第二流与具有第二血细胞成分的第一流有差别地移除。 全息光学捕集器也可以与各种流动结合使用，以将选定的组分从一个流移动到另一个流，作为分离阶段的一部分或除了分离阶段之外。

    Multiple laminar flow-based particle and cellular separation with laser steering
    6.
    发明申请
    Multiple laminar flow-based particle and cellular separation with laser steering 有权
    多层次流动粒子与细胞分离与激光转向

    公开(公告)号：US20070029257A1

    公开(公告)日：2007-02-08

    申请号：US11543773

    申请日：2006-10-06

    申请人： Daniel Mueth ,  Joseph Plewa ,  Jessica Shireman ,  Amy Anderson ,  Lewis Gruber ,  Neil Rosenbaum

    发明人： Daniel Mueth ,  Joseph Plewa ,  Jessica Shireman ,  Amy Anderson ,  Lewis Gruber ,  Neil Rosenbaum

    IPC分类号： B01D61/00

    CPC分类号： A61M1/3681 ,  A61M1/36 ,  A61M1/3693 ,  A61M1/38 ,  A61M2206/11 ,  B01L3/502761 ,  B03C1/28 ,  B03C5/005 ,  B03C2201/02 ,  B03C2201/18 ,  G01N30/0005 ,  G03H1/08 ,  G03H1/2294 ,  G03H2001/0077 ,  G03H2001/085 ,  Y10T436/25375

    摘要： The invention provides a method, apparatus and system for separating blood and other types of cellular components, and can be combined with holographic optical trapping manipulation or other forms of optical tweezing. One of the exemplary methods includes providing a first flow having a plurality of blood components; providing a second flow; contacting the first flow with the second flow to provide a first separation region; and differentially sedimenting a first blood cellular component of the plurality of blood components into the second flow while concurrently maintaining a second blood cellular component of the plurality of blood components in the first flow. The second flow having the first blood cellular component is then differentially removed from the first flow having the second blood cellular component. Holographic optical traps may also be utilized in conjunction with the various flows to move selected components from one flow to another, as part of or in addition to a separation stage.

    摘要翻译： 本发明提供了一种用于分离血液和其他类型的细胞组分的方法，装置和系统，并且可以与全息光学捕获操作或其他形式的光学镊子组合。 示例性方法之一包括提供具有多个血液成分的第一流; 提供第二流; 使第一流与第二流接触以提供第一分离区; 以及将所述多个血液成分的第一血细胞成分差异沉积到所述第二流中，同时在所述第一流中同时维持所述多个血液成分的第二血细胞成分。 然后，具有第一血细胞成分的第二流与具有第二血细胞成分的第一流有差别地移除。 全息光学捕集器也可以与各种流动结合使用，以将选定的组分从一个流移动到另一个流，作为分离阶段的一部分或除了分离阶段之外。