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公开(公告)号：US20070172928A1
公开(公告)日：2007-07-26
申请号：US11588431
申请日：2006-10-27
申请人： Robert Peters , Adam Mezo , Daniel Rivera , Alan Bitonti , Susan Low
发明人： Robert Peters , Adam Mezo , Daniel Rivera , Alan Bitonti , Susan Low
CPC分类号： C07K14/755 , A61K38/00 , A61K47/60 , A61K47/642 , A61K47/68 , A61K47/6803 , A61K47/6811 , A61K47/6813 , A61K47/6835 , C07K14/475 , C07K14/505 , C07K14/555 , C07K14/56 , C07K14/565 , C07K14/59 , C07K14/61 , C07K14/70503 , C07K14/745 , C07K16/00 , C07K2317/52 , C07K2319/00 , C07K2319/30 , C12N9/6437 , C12N9/644 , C12N9/647 , C12N9/96 , C12Y304/21021 , C12Y304/21022
摘要： The invention relates to a chimeric monomer-dimer hybrid protein wherein said protein comprises a first and a second polypeptide chain, said first polypeptide chain comprising at least a portion of an immunoglobulin constant region and a biologically active molecule, and said second polypeptide chain comprising at least a portion of an immunoglobulin constant region without the biologically active molecule of the first chain. The invention also relates to methods of using and methods of making the chimeric monomer-dimer hybrid protein of the invention.
摘要翻译： 本发明涉及嵌合单体 - 二聚体杂合蛋白，其中所述蛋白质包含第一和第二多肽链，所述第一多肽链包含至少一部分免疫球蛋白恒定区和生物活性分子，所述第二多肽链包含 至少一部分没有第一链的生物活性分子的免疫球蛋白恒定区。 本发明还涉及制备本发明的嵌合单体 - 二聚体杂交蛋白质的方法和方法。
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公开(公告)号：US20050260194A1
公开(公告)日：2005-11-24
申请号：US11029003
申请日：2005-01-05
申请人： Robert Peters , Adam Mezo , Daniel Rivera , Alan Bitonti , Susan Low , James Stattel
发明人： Robert Peters , Adam Mezo , Daniel Rivera , Alan Bitonti , Susan Low , James Stattel
IPC分类号： A61K39/395 , C07H21/04 , C07K14/475 , C07K14/505 , C07K14/555 , C07K14/56 , C07K14/565 , C07K14/745 , C07K16/44 , C07K16/46 , C12N5/06 , C12N9/64 , C12P21/04
CPC分类号： C07K14/505 , A61K38/00 , C07K5/0806 , C07K5/1013 , C07K7/06 , C07K7/08 , C07K14/475 , C07K14/555 , C07K14/56 , C07K14/565 , C07K14/57 , C07K14/745 , C07K2319/00 , C07K2319/30 , C07K2319/43 , C07K2319/73 , C12N9/6437 , C12N9/644 , C12N9/647 , C12Y304/21021 , C12Y304/21022
摘要： The invention relates to a chimeric monomer-dimer hybrid protein wherein said protein comprises a first and a second polypeptide chain, said first polypeptide chain comprising at least a portion of an immunoglobulin constant region and a biologically active molecule, and said second polypeptide chain comprising at least a portion of an immunoglobulin constant region without the biologically active molecule of the first chain. The invention also relates to methods of using and methods of making the chimeric monomer-dimer hybrid protein of the invention.
摘要翻译： 本发明涉及嵌合单体 - 二聚体杂合蛋白，其中所述蛋白质包含第一和第二多肽链，所述第一多肽链包含至少一部分免疫球蛋白恒定区和生物活性分子，所述第二多肽链包含 至少一部分没有第一链的生物活性分子的免疫球蛋白恒定区。 本发明还涉及制备本发明的嵌合单体 - 二聚体杂交蛋白质的方法和方法。
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公开(公告)号：US20050147618A1
公开(公告)日：2005-07-07
申请号：US10841819
申请日：2004-05-06
申请人： Daniel Rivera , Robert Peters , Alan Bitonti
发明人： Daniel Rivera , Robert Peters , Alan Bitonti
IPC分类号： A61K39/395 , A61K47/48 , C07K16/46 , C12N20060101 , C12N9/64 , C12P21/08
摘要： The invention relates to a chimeric protein comprising at least one clotting factor and at least a portion of an immunoglobulin constant region. The invention relates to a method of treating a hemostatic disorder comprising administering a therapeutically effective amount of a chimeric protein wherein the chimeric protein comprises at least one clotting factor and at least a portion of an immunoglobulin constant region.
摘要翻译： 本发明涉及包含至少一种凝血因子和至少一部分免疫球蛋白恒定区的嵌合蛋白。 本发明涉及一种治疗止血障碍的方法，包括施用治疗有效量的嵌合蛋白，其中所述嵌合蛋白包含至少一种凝血因子和至少一部分免疫球蛋白恒定区。
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公开(公告)号：US20050032174A1
公开(公告)日：2005-02-10
申请号：US10841250
申请日：2004-05-06
申请人： Robert Peters , Adam Mezo , Daniel Rivera , Alan Bitonti , James Stattel , Susan Low
发明人： Robert Peters , Adam Mezo , Daniel Rivera , Alan Bitonti , James Stattel , Susan Low
IPC分类号： A61K39/395 , C07H21/04 , C07K1/02 , C07K1/06 , C07K1/10 , C07K1/107 , C07K14/475 , C07K14/505 , C07K14/555 , C07K14/56 , C07K14/565 , C07K14/745 , C07K16/00 , C07K16/44 , C07K16/46 , C12N20060101 , C12N5/06 , C12N9/64 , C12P21/00 , C12P21/04
CPC分类号： C07K14/755 , A61K38/00 , A61K47/60 , A61K47/642 , A61K47/68 , A61K47/6803 , A61K47/6811 , A61K47/6813 , A61K47/6835 , C07K14/475 , C07K14/505 , C07K14/555 , C07K14/56 , C07K14/565 , C07K14/59 , C07K14/61 , C07K14/70503 , C07K14/745 , C07K16/00 , C07K2317/52 , C07K2319/00 , C07K2319/30 , C12N9/6437 , C12N9/644 , C12N9/647 , C12N9/96 , C12Y304/21021 , C12Y304/21022
摘要： The invention relates to a chimeric monomer-dimer hybrid protein wherein said protein comprises a first and a second polypeptide chain, said first polypeptide chain comprising at least a portion of an immunoglobulin constant region and a biologically active molecule, and said second polypeptide chain comprising at least a portion of an immunoglobulin constant region without the biologically active molecule of the first chain. The invention also relates to methods of using and methods of making the chimeric monomer-dimer hybrid protein of the invention.
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公开(公告)号：US20070259402A1
公开(公告)日：2007-11-08
申请号：US11728045
申请日：2007-03-23
申请人： Robert Peters , Alan Bitonti
发明人： Robert Peters , Alan Bitonti
CPC分类号： C12N9/644 , C07K2319/30 , C12N9/6454 , C12Y304/21022
摘要： Compositions and methods for preparing Factor IX, Factor IX-containing fusion proteins, and Factor IX-containing conjugates with processing of Factor IX propeptide by PC5, are provided. In one embodiment PC5 is used to process a precursor polypeptide for a Factor IX-Fc monomer-dimer hybrid.
摘要翻译： 提供了通过PC5处理因子IX前体肽制备因子IX，含因子IX的融合蛋白和含有因子IX的缀合物的组合物和方法。 在一个实施方案中，PC5用于处理因子IX-Fc单体 - 二聚体杂交体的前体多肽。
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公开(公告)号：US20050281829A1
公开(公告)日：2005-12-22
申请号：US10841956
申请日：2004-05-06
申请人： Cristina Hehir , Adam Mezo , Robert Peters , James Stattel , Vito Palombella , Alan Bitonti
发明人： Cristina Hehir , Adam Mezo , Robert Peters , James Stattel , Vito Palombella , Alan Bitonti
IPC分类号： A61K38/16 , A61K39/42 , C07K14/16 , C07K16/10 , C12N20060101
CPC分类号： C07K14/005 , A61K38/162 , C07K2319/00 , C07K2319/30 , C12N2740/16122
摘要： The invention relates to anti viral agents comprised of viral fusion inhibitors and at least a portion of an immunoglobulin constant region. The invention further relates to anti viral agents comprised HIV viral fusion inhibitors and an Fc fragment of an immunoglobulin. The invention also relates to methods of treating a viral infection, including HIV infection.
摘要翻译： 本发明涉及由病毒融合抑制剂和至少一部分免疫球蛋白恒定区组成的抗病毒剂。 本发明还涉及包含HIV病毒融合抑制剂和免疫球蛋白的Fc片段的抗病毒剂。 本发明还涉及治疗包括HIV感染在内的病毒感染的方法。
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公开(公告)号：US20130216513A1
公开(公告)日：2013-08-22
申请号：US13809289
申请日：2011-07-11
申请人： Joe Salas , Robert Peters , Alan Bitonti
发明人： Joe Salas , Robert Peters , Alan Bitonti
IPC分类号： C12N9/96
CPC分类号： C12N9/644 , A61K38/00 , A61K2039/505 , C07K14/745 , C07K14/755 , C07K16/18 , C07K16/28 , C07K16/2848 , C07K2317/622 , C07K2319/00 , C07K2319/30 , C07K2319/33 , C12N9/6432 , C12N9/6437 , C12N9/647 , C12N9/96 , C12Y304/21021 , C12Y304/21022
摘要： Chimeric clotting factors which localize the therapeutic to sites of coagulation (e.g., by being targeted to platelets or being activatable at sites of coagulation), have reduced clearance rates, have improved manufacturability, have reduced thrombogenicity, have enhanced activity, or have more than one of these characteristics are described as are methods for making chimeric clotting factors and methods for improving hemostasia using these clotting factors.
摘要翻译： 将治疗剂局部化为凝血部位（例如通过靶向血小板或在凝血部位可激活）的嵌合凝血因子具有降低的清除率，具有改善的可制造性，具有降低的血栓形成，具有增强的活性或具有多于一种 这些特征描述为制备嵌合凝血因子的方法和使用这些凝血因子改善止血的方法。
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公开(公告)号：US20050037947A1
公开(公告)日：2005-02-17
申请号：US10841949
申请日：2004-05-06
申请人： Alan Bitonti , Vito Palombella , James Stattel , Robert Peters
发明人： Alan Bitonti , Vito Palombella , James Stattel , Robert Peters
IPC分类号： A61K20060101 , A61K31/00
CPC分类号： C07K14/765 , C07K2319/30
摘要： The invention relates to improved therapeutics for treating diseases or conditions that provide greater bioavailabilty and more predictable dosing. The invention relates to a chimeric protein comprised of a biologically active molecule linked to an Fc fragment of an immunoglobulin, wherein the chimeric protein binds less serum albumin compared to the same biologically active molecule of the chimeric protein not linked to an Fc fragment of an immunoglobulin. The invention also relates to a method of treating a disease or condition said method comprising administering a chimeric protein comprising a biologically active molecule linked to an Fc fragment of an immunoglobulin, wherein the chimeric protein binds less serum albumin compared to the same biologically active molecule of the chimeric protein not linked to an Fc fragment of an immunoglobulin
摘要翻译： 本发明涉及用于治疗提供更大生物利用度和更可预测剂量的疾病或病症的改进治疗剂。 本发明涉及由连接于免疫球蛋白Fc片段的生物活性分子组成的嵌合蛋白质，其中嵌合蛋白质与不与免疫球蛋白Fc片段连接的嵌合蛋白质的相同生物活性分子相比结合较少的血清白蛋白 。 本发明还涉及一种治疗疾病或病症的方法，所述方法包括给予包含与免疫球蛋白Fc片段连接的生物活性分子的嵌合蛋白，其中所述嵌合蛋白与相同的生物活性分子 未与免疫球蛋白的Fc片段连接的嵌合蛋白
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公开(公告)号：US20060140907A1
公开(公告)日：2006-06-29
申请号：US11336581
申请日：2006-01-20
申请人： Richard Blumberg , Wayne Lencer , Neil Simister , Alan Bitonti
发明人： Richard Blumberg , Wayne Lencer , Neil Simister , Alan Bitonti
CPC分类号： A61K9/0073 , A61K9/0078 , A61K47/6849
摘要： The present invention relates to methods and products for the transepithelial systemic delivery of therapeutics. In particular, the invention relates to methods and compositions for the systemic delivery of therapeutics by administering an aerosol containing antibodies or conjugates of a therapeutic agent with an FcRn binding partner to epithelium of central airways of the lung. The methods and products are adaptable to a wide range of therapeutic agents, including proteins and polypeptides, nucleic acids, drugs, and others. The methods and products have the advantage of not requiring administration to the deep lung in order to effect systemic delivery.
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