PC5 as a factor IX propeptide processing enzyme
    1.
    发明申请
    PC5 as a factor IX propeptide processing enzyme 有权
    PC5作为因子IX前肽加工酶

    公开(公告)号:US20070259402A1

    公开(公告)日:2007-11-08

    申请号:US11728045

    申请日:2007-03-23

    IPC分类号: C12P21/04 C12N15/00 C12N5/06

    摘要: Compositions and methods for preparing Factor IX, Factor IX-containing fusion proteins, and Factor IX-containing conjugates with processing of Factor IX propeptide by PC5, are provided. In one embodiment PC5 is used to process a precursor polypeptide for a Factor IX-Fc monomer-dimer hybrid.

    摘要翻译: 提供了通过PC5处理因子IX前体肽制备因子IX,含因子IX的融合蛋白和含有因子IX的缀合物的组合物和方法。 在一个实施方案中,PC5用于处理因子IX-Fc单体 - 二聚体杂交体的前体多肽。

    Clotting factor-Fc chimeric proteins to treat hemophilia
    3.
    发明申请
    Clotting factor-Fc chimeric proteins to treat hemophilia 审中-公开
    凝血因子-Fc嵌合蛋白治疗血友病

    公开(公告)号:US20050147618A1

    公开(公告)日:2005-07-07

    申请号:US10841819

    申请日:2004-05-06

    摘要: The invention relates to a chimeric protein comprising at least one clotting factor and at least a portion of an immunoglobulin constant region. The invention relates to a method of treating a hemostatic disorder comprising administering a therapeutically effective amount of a chimeric protein wherein the chimeric protein comprises at least one clotting factor and at least a portion of an immunoglobulin constant region.

    摘要翻译: 本发明涉及包含至少一种凝血因子和至少一部分免疫球蛋白恒定区的嵌合蛋白。 本发明涉及一种治疗止血障碍的方法,包括施用治疗有效量的嵌合蛋白,其中所述嵌合蛋白包含至少一种凝血因子和至少一部分免疫球蛋白恒定区。

    INHIBITION OF DRUG BINDING TO SERUM ALBUMIN
    7.
    发明申请
    INHIBITION OF DRUG BINDING TO SERUM ALBUMIN 审中-公开
    药物结合抑制血清ALBUMIN

    公开(公告)号:US20050037947A1

    公开(公告)日:2005-02-17

    申请号:US10841949

    申请日:2004-05-06

    IPC分类号: A61K20060101 A61K31/00

    CPC分类号: C07K14/765 C07K2319/30

    摘要: The invention relates to improved therapeutics for treating diseases or conditions that provide greater bioavailabilty and more predictable dosing. The invention relates to a chimeric protein comprised of a biologically active molecule linked to an Fc fragment of an immunoglobulin, wherein the chimeric protein binds less serum albumin compared to the same biologically active molecule of the chimeric protein not linked to an Fc fragment of an immunoglobulin. The invention also relates to a method of treating a disease or condition said method comprising administering a chimeric protein comprising a biologically active molecule linked to an Fc fragment of an immunoglobulin, wherein the chimeric protein binds less serum albumin compared to the same biologically active molecule of the chimeric protein not linked to an Fc fragment of an immunoglobulin

    摘要翻译: 本发明涉及用于治疗提供更大生物利用度和更可预测剂量的疾病或病症的改进治疗剂。 本发明涉及由连接于免疫球蛋白Fc片段的生物活性分子组成的嵌合蛋白质,其中嵌合蛋白质与不与免疫球蛋白Fc片段连接的嵌合蛋白质的相同生物活性分子相比结合较少的血清白蛋白 。 本发明还涉及一种治疗疾病或病症的方法,所述方法包括给予包含与免疫球蛋白Fc片段连接的生物活性分子的嵌合蛋白,其中所述嵌合蛋白与相同的生物活性分子 未与免疫球蛋白的Fc片段连接的嵌合蛋白

    Systems and methods for package sortation and delivery using radio frequency identification technology
    9.
    发明授权
    Systems and methods for package sortation and delivery using radio frequency identification technology 有权
    使用射频识别技术进行封装分拣和交付的系统和方法

    公开(公告)号:US07306147B2

    公开(公告)日:2007-12-11

    申请号:US11465216

    申请日:2006-08-17

    IPC分类号: G07B15/02

    摘要: A disclosed method comprises scanning a radio-frequency identification (RFID) tag on a package to generate scanned data, and generating a handling instruction for the package based on the scanned data. The handling instruction can be executed to route the package to a tip position within a hub facility for directing the package to the next location along its route, and/or to pre-load the package in a vehicle for delivery to the package's final destination. Related systems and computer-readable media are also disclosed.

    摘要翻译: 所公开的方法包括扫描包装上的射频识别(RFID)标签以产生扫描数据,以及基于扫描数据生成针对包的处理指令。 可以执行处理指令以将包裹路由到集线器设备内的尖端位置,以将包装沿着其路线引导到下一个位置,和/或将包装预先装载在车辆中以便传送到包裹的最终目的地。 还公开了相关系统和计算机可读介质。

    METHOD AND APPARATUS FOR FAST SPIN ECHO (FSE) PRESCAN PHASE CORRECTION
    10.
    发明申请
    METHOD AND APPARATUS FOR FAST SPIN ECHO (FSE) PRESCAN PHASE CORRECTION 有权
    用于快速旋转(FSE)预相位校正的方法和装置

    公开(公告)号:US20070063704A1

    公开(公告)日:2007-03-22

    申请号:US11162704

    申请日:2005-09-20

    申请人: Robert Peters

    发明人: Robert Peters

    IPC分类号: G01V3/00

    CPC分类号: G01R33/5617 G01R33/56554

    摘要: A method and apparatus for prescan phase correction analyzes the phase profile of the first echo sampled in a prescan and the phase profile corresponding to the lope echo of an impending FSE acquisition to determine appropriate phase correction settings of the FSE scan.

    摘要翻译: 用于预扫描相位校正的方法和装置分析在预扫描中采样的第一回波的相位分布和对应于即将到来的FSE采集的波形回波的相位曲线,以确定FSE扫描的适当的相位校正设置。