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公开(公告)号：US20050059668A1
公开(公告)日：2005-03-17
申请号：US10933072
申请日：2004-09-01
申请人： Daniela Alberati-Giani , Synese Jolidon , Robert Narquizian , Matthias Nettekoven , Roger Norcross , Emmanuel Pinard , Henri Stalder
发明人： Daniela Alberati-Giani , Synese Jolidon , Robert Narquizian , Matthias Nettekoven , Roger Norcross , Emmanuel Pinard , Henri Stalder
IPC分类号： A61K31/495 , A61K31/496 , A61P25/28 , C07D213/56 , C07D213/69 , C07D213/74 , C07D233/54 , C07D239/26 , C07D239/42 , C07D241/12 , C07D251/42 , C07D251/48 , C07D257/04 , C07D263/32 , C07D277/30 , C07D295/16 , C07D295/185 , C07D309/04 , C07D309/20 , C07D333/24 , C07D409/12 , C07D43/02
CPC分类号： C07D295/16 , A61K31/495 , A61K31/496 , C07D213/56 , C07D213/69 , C07D213/74 , C07D233/64 , C07D239/26 , C07D239/42 , C07D241/12 , C07D251/42 , C07D251/48 , C07D257/04 , C07D263/32 , C07D277/30 , C07D295/185 , C07D309/04 , C07D309/20 , C07D333/24 , C07D409/12
摘要： The invention relates to compounds of formula wherein the substituents are as defined in the specification and to pharmaceutically acceptable acid addition salts thereof. The invention further relates to methods for the treatment of psychoses, pain, neurodegenerative disfunction in memory and learning, schizophrenia, dementia and other diseases in which cognitive processes are impaired, such as attention deficit disorders or Alzheimer's disease.
摘要翻译： 本发明涉及下式的化合物，其中取代基如说明书中所定义，及其药学上可接受的酸加成盐。 本发明还涉及用于治疗精神病，疼痛，记忆和学习中的神经变性功能障碍，精神分裂症，痴呆和认知过程受损的其它疾病如注意力缺陷障碍或阿尔茨海默病的方法。
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公开(公告)号：US20050070539A1
公开(公告)日：2005-03-31
申请号：US10933103
申请日：2004-09-02
申请人： Daniela Alberati-Giani , Synese Jolidon , Robert Narquizian , Matthias Nettekoven , Roger Norcross , Emmanuel Pinard , Henri Stadler
发明人： Daniela Alberati-Giani , Synese Jolidon , Robert Narquizian , Matthias Nettekoven , Roger Norcross , Emmanuel Pinard , Henri Stadler
IPC分类号： A61K31/495 , A61K31/496 , A61P25/28 , C07D207/08 , C07D207/12 , C07D207/20 , C07D211/42 , C07D231/12 , C07D233/54 , C07D237/20 , C07D249/08 , C07D257/04 , C07D295/192 , C07D307/14 , C07D309/14 , C07D43/02 , A61K31/501 , A61K31/506 , A61K31/53
CPC分类号： C07D295/192 , A61K31/495 , A61K31/496 , C07D207/08 , C07D207/12 , C07D207/20 , C07D211/42 , C07D231/12 , C07D233/54 , C07D237/20 , C07D249/08 , C07D257/04 , C07D307/14 , C07D309/14
摘要： A compound of formula wherein the substituents are as described in the specification for the treatment of psychoses, pain, neurodegenerative disfunction in memory and learning, schizophrenia, dementia and other diseases in which cognitive processes are impaired, such as attention deficit disorders or Alzheimer's disease.
摘要翻译： 式的化合物，其中取代基如治疗精神病，疼痛，记忆和学习中的神经变性功能障碍，精神分裂症，痴呆和其他认知过程受损的其他疾病（如注意力缺陷障碍或阿尔茨海默病）的治疗方法所述。
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公开(公告)号：US20050209241A1
公开(公告)日：2005-09-22
申请号：US10911359
申请日：2004-08-04
申请人： Synese Jolidon , Robert Narquizian , Matthias Nettekoven , Roger Norcross , Emmanuel Pinard , Henri Stalder
发明人： Synese Jolidon , Robert Narquizian , Matthias Nettekoven , Roger Norcross , Emmanuel Pinard , Henri Stalder
IPC分类号： A61P25/28 , C07D213/85 , C07D239/42 , C07D241/20 , C07D251/42 , C07D257/04 , C07D263/32 , C07D271/06 , C07D295/192 , C07D309/12 , A61K31/497 , A61K31/495 , A61K31/496 , A61K31/506 , C07D43/02
CPC分类号： C07D239/42 , C07D213/85 , C07D241/20 , C07D251/42 , C07D257/04 , C07D263/32 , C07D271/06 , C07D295/192 , C07D309/12
摘要： The invention relates to compounds of formula wherein the substituents are described herein. The compounds may be used in the treatment of illnesses based on the glycine uptake inhibitor, such as psychoses, pain, neurodegenerative disfunction in memory and learning, schizophrenia, dementia and other diseases in which cognitive processes are impaired, such as attention deficit disorders or Alzheimer's disease.
摘要翻译： 本发明涉及下式的化合物，其中取代基在本文中描述。 该化合物可用于基于甘氨酸摄取抑制剂治疗疾病，例如精神病，疼痛，记忆和学习中的神经变性功能障碍，精神分裂症，痴呆等认知过程受损的其他疾病，如注意力缺陷障碍或阿尔茨海默病 疾病。
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公开(公告)号：US07595314B2
公开(公告)日：2009-09-29
申请号：US12177386
申请日：2008-07-22
申请人： Daniela Alberati-Giani , Synese Jolidon , Robert Narquizian , Matthias Heinrich Nettekoven , Roger David Norcross , Emmanuel Pinard , Henri Stalder
发明人： Daniela Alberati-Giani , Synese Jolidon , Robert Narquizian , Matthias Heinrich Nettekoven , Roger David Norcross , Emmanuel Pinard , Henri Stalder
IPC分类号： A61K31/5377 , A61K31/496 , A61K31/55 , C07D413/12
CPC分类号： C07D295/192 , A61K31/495 , A61K31/496 , C07D207/08 , C07D207/12 , C07D207/20 , C07D211/42 , C07D231/12 , C07D233/54 , C07D237/20 , C07D249/08 , C07D257/04 , C07D307/14 , C07D309/14
摘要： A compound of formula wherein the substituents are as described in the specification for the treatment of psychoses, pain, neurodegenerative disfunction in memory and learning, schizophrenia, dementia and other diseases in which cognitive processes are impaired, such as attention deficit disorders or Alzheimer's disease.
摘要翻译： 式的化合物，其中取代基如治疗精神病，疼痛，记忆和学习中的神经变性功能障碍，精神分裂症，痴呆和其他认知过程受损的其他疾病（如注意力缺陷障碍或阿尔茨海默氏病）的描述中所述。
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公开(公告)号：US20090192136A1
公开(公告)日：2009-07-30
申请号：US12177386
申请日：2008-07-22
申请人： Daniela Alberati-Giani , Synese Jolidon , Robert Narquizian , Matthias Heinrich Nettekoven , Roger David Norcross , Emmanuel Pinard , Henri Stalder
发明人： Daniela Alberati-Giani , Synese Jolidon , Robert Narquizian , Matthias Heinrich Nettekoven , Roger David Norcross , Emmanuel Pinard , Henri Stalder
IPC分类号： A61K31/496 , C07D413/10 , C07D241/04 , A61K31/55 , A61K31/5377 , A61P25/00 , A61K31/495 , C07D405/12
CPC分类号： C07D295/192 , A61K31/495 , A61K31/496 , C07D207/08 , C07D207/12 , C07D207/20 , C07D211/42 , C07D231/12 , C07D233/54 , C07D237/20 , C07D249/08 , C07D257/04 , C07D307/14 , C07D309/14
摘要： A compound of formula wherein the substituents are as described in the specification for the treatment of psychoses, pain, neurodegenerative disfunction in memory and learning, schizophrenia, dementia and other diseases in which cognitive processes are impaired, such as attention deficit disorders or Alzheimer's disease.
摘要翻译： 式的化合物，其中取代基如治疗精神病，疼痛，记忆和学习中的神经变性功能障碍，精神分裂症，痴呆和其他认知过程受损的其他疾病（如注意力缺陷障碍或阿尔茨海默病）的治疗方法所述。
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公开(公告)号：US07462617B2
公开(公告)日：2008-12-09
申请号：US10933072
申请日：2004-09-01
申请人： Daniela Alberati-Giani , Synese Jolidon , Robert Narquizian , Matthias Heinrich Nettekoven , Roger David Norcross , Emmanuel Pinard , Henri Stalder
发明人： Daniela Alberati-Giani , Synese Jolidon , Robert Narquizian , Matthias Heinrich Nettekoven , Roger David Norcross , Emmanuel Pinard , Henri Stalder
IPC分类号： A61K31/53 , A61K31/496 , C07D295/192 , C07D409/12 , C07D251/22 , C07D251/24 , A61K31/495
CPC分类号： C07D295/16 , A61K31/495 , A61K31/496 , C07D213/56 , C07D213/69 , C07D213/74 , C07D233/64 , C07D239/26 , C07D239/42 , C07D241/12 , C07D251/42 , C07D251/48 , C07D257/04 , C07D263/32 , C07D277/30 , C07D295/185 , C07D309/04 , C07D309/20 , C07D333/24 , C07D409/12
摘要： The invention relates to compounds of formula wherein the substituents are as defined in the specification and to pharmaceutically acceptable acid addition salts thereof. The invention further relates to methods for the treatment of psychoses, pain, neurodegenerative disfunction in memory and learning, schizophrenia, dementia and other d 1iseases in which cognitive processes are impaired, such as attention deficit disorders or Alzheimer's disease.
摘要翻译： 本发明涉及下式的化合物，其中取代基如说明书中所定义，及其药学上可接受的酸加成盐。 本发明还涉及用于治疗精神病，疼痛，记忆和学习中的神经变性功能障碍，精神分裂症，痴呆和其他认知过程受损的其他疾病的方法，例如注意力缺陷障碍或阿尔茨海默病。
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公开(公告)号：US07427612B2
公开(公告)日：2008-09-23
申请号：US10933103
申请日：2004-09-02
申请人： Daniela Alberati-Giani , Synese Jolidon , Robert Narquizian , Matthias Heinrich Nettekoven , Roger David Norcross , Emmanuel Pinard , Henri Stalder
发明人： Daniela Alberati-Giani , Synese Jolidon , Robert Narquizian , Matthias Heinrich Nettekoven , Roger David Norcross , Emmanuel Pinard , Henri Stalder
IPC分类号： A61K31/55 , A61K31/5377 , A61K31/496 , C07D295/192
CPC分类号： C07D295/192 , A61K31/495 , A61K31/496 , C07D207/08 , C07D207/12 , C07D207/20 , C07D211/42 , C07D231/12 , C07D233/54 , C07D237/20 , C07D249/08 , C07D257/04 , C07D307/14 , C07D309/14
摘要： A compound of formula wherein the substituents are as described in the specification for the treatment of psychoses, pain, neurodegenerative disfunction in memory and learning, schizophrenia, dementia and other diseases in which cognitive processes are impaired, such as attention deficit disorders or Alzheimer's disease.
摘要翻译： 式的化合物，其中取代基如治疗精神病，疼痛，记忆和学习中的神经变性功能障碍，精神分裂症，痴呆和其他认知过程受损的其他疾病（如注意力缺陷障碍或阿尔茨海默氏病）的描述中所述。
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公开(公告)号：US20080119486A1
公开(公告)日：2008-05-22
申请号：US11931379
申请日：2007-10-31
申请人： Synese Jolidon , Robert Narquizian , Matthias Heinrich Nettekoven , Roger David Norcross , Emmanuel Pinard , Henri Stalder
发明人： Synese Jolidon , Robert Narquizian , Matthias Heinrich Nettekoven , Roger David Norcross , Emmanuel Pinard , Henri Stalder
IPC分类号： A61K31/495 , C07D295/03 , A61P25/18 , A61P25/28 , A61P25/00
CPC分类号： C07D239/42 , C07D213/85 , C07D241/20 , C07D251/42 , C07D257/04 , C07D263/32 , C07D271/06 , C07D295/192 , C07D309/12
摘要： The invention relates to compounds of formula wherein the substituents are described herein. The compounds may be used in the treatment of illnesses based on the glycine uptake inhibitor, such as psychoses, pain, neurodegenerative disfunction in memory and learning, schizophrenia, dementia and other diseases in which cognitive processes are impaired, such as attention deficit disorders or Alzheimer's disease.
摘要翻译： 本发明涉及下式的化合物，其中取代基在本文中描述。 该化合物可用于基于甘氨酸摄取抑制剂治疗疾病，例如精神病，疼痛，记忆和学习中的神经变性功能障碍，精神分裂症，痴呆等认知过程受损的其他疾病，如注意力缺陷障碍或阿尔茨海默病 疾病。
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公开(公告)号：US20070213384A1
公开(公告)日：2007-09-13
申请号：US11712783
申请日：2007-03-01
IPC分类号： A61K31/415
CPC分类号： C07D233/92
摘要： The present invention relates to compounds of formula I wherein R1, R2, R3, and R4 are as defined herein and to pharmaceutically acceptable acid addition salts thereof. Compounds of formula I or their tautomeric forms are good inhibitors of the glycine transporter 1 (GlyT-1), and have a good selectivity to glycine transporter 2 (GlyT-2) inhibitors. Such compounds are useful for the treatment of schizophrenia.
摘要翻译： 本发明涉及式I化合物，其中R 1，R 2，R 3和R 4， 如本文所定义及其药学上可接受的酸加成盐。 式I化合物或其互变异构形式是甘氨酸转运蛋白1（GlyT-1）的良好抑制剂，对甘氨酸转运蛋白2（GlyT-2）抑制剂具有良好的选择性。 这些化合物可用于治疗精神分裂症。
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公开(公告)号：US07605163B2
公开(公告)日：2009-10-20
申请号：US11931379
申请日：2007-10-31
申请人： Synese Jolidon , Robert Narquizian , Matthias Heinrich Nettekoven , Roger David Norcross , Emmanuel Pinard , Henri Stalder
发明人： Synese Jolidon , Robert Narquizian , Matthias Heinrich Nettekoven , Roger David Norcross , Emmanuel Pinard , Henri Stalder
IPC分类号： A61K31/495 , C07D295/192
CPC分类号： C07D239/42 , C07D213/85 , C07D241/20 , C07D251/42 , C07D257/04 , C07D263/32 , C07D271/06 , C07D295/192 , C07D309/12
摘要： The invention relates to compounds of formula wherein the substituents are described herein. The compounds may be used in the treatment of illnesses based on the glycine uptake inhibitor, such as psychoses, pain, neurodegenerative disfunction in memory and learning, schizophrenia, dementia and other diseases in which cognitive processes are impaired, such as attention deficit disorders or Alzheimer's disease.
摘要翻译： 本发明涉及下式的化合物，其中取代基在本文中描述。 该化合物可用于基于甘氨酸摄取抑制剂治疗疾病，例如精神病，疼痛，记忆和学习中的神经变性功能障碍，精神分裂症，痴呆等认知过程受损的其他疾病，如注意力缺陷障碍或阿尔茨海默氏症 疾病。
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