公开(公告)号：US09938551B2

公开(公告)日：2018-04-10

申请号：US14650285

申请日：2013-12-10

Applicant: Danisco US Inc.

Inventor： Richard R. Bott ,  Maria Foukaraki ,  Ronaldus Wilhelmus Hommes ,  Thijs Kaper ,  Bradley R. Kelemen ,  Slavko Kralj ,  Igor Nikolaev ,  Mats Sandgren ,  Johannes Franciscus Thomas Van Lieshout ,  Sander Van Stigt Thans

IPC: C12P19/14 ,  C12P19/02 ,  C12N9/42

CPC classification number: C12P19/14 ,  C12N9/2434 ,  C12N9/2437 ,  C12P19/02 ,  C12Y302/01091

Abstract: Disclosed are a number of homologs and variants of Hypocrea jecorina Ce17A (formerly Trichoderma reesei cellobiohydrolase I or CBH1), nucleic acids encoding the same and methods for producing the same. The homologs and variant cellulases have the amino acid sequence of a glycosyl hydrolase of family 7A wherein one or more amino acid residues are substituted and/or deleted.

公开(公告)号：US09523087B2

公开(公告)日：2016-12-20

申请号：US14189943

申请日：2014-02-25

Applicant: Danisco US Inc.

Inventor： Wolfgang Aehle ,  Richard R. Bott ,  Benjamin S. Bower ,  Jonathan Caspi ,  David A. Estell ,  Frits Goedegebuur ,  Ronaldus Wilhelmus Joannes Hommes ,  Thijs Kaper ,  Bradley R. Kelemen ,  Slavko Kralj ,  Johannes Franciscus Thomas Van Lieshout ,  Igor Nikolaev ,  Sander Van Stigt Thans ,  Louise Wallace ,  Gudrun Vogtentanz ,  Mats Sandgren

IPC: C12N9/42 ,  C12N9/52 ,  C07H21/04

CPC classification number: C12N9/2437 ,  C12Y302/01091 ,  Y02E50/17

Abstract: The present disclosure relates to cellulase variants. In particular the present disclosure relates to cellulase variants having improved expression, activity and/or stability. Also described are nucleic acids encoding the cellulase variants, compositions comprising the cellulase variants, and methods of use thereof.

Abstract translation: 本公开涉及纤维素酶变体。 特别地，本公开涉及具有改善的表达，活性和/或稳定性的纤维素酶变体。 还描述了编码纤维素酶变体的核酸，包含纤维素酶变体的组合物及其使用方法。

公开(公告)号：US20250051748A1

公开(公告)日：2025-02-13

申请号：US18720046

申请日：2022-12-15

Applicant: Danisco US Inc.

Inventor： Viktor Yuryevich Alekseyev ,  Lilia Babe ,  Lydia Dankmeyer ,  Frits Goedegebuur ,  Roopa Ghirnikar ,  Thijs Kaper ,  Harm Mulder ,  Nils Henning Redestig ,  Sander Van Stigt Thans

IPC: C12N9/54 ,  C11D3/386 ,  C12N9/26

Abstract: Disclosed herein is one or more subtilisin variant, nucleic acid encoding same, and compositions and methods related to the production and use thereof, including one or more subtilisin variant that has improved stability and/or soil removal compared to one or more reference subtilisin.

公开(公告)号：US20240279632A1

公开(公告)日：2024-08-22

申请号：US18640088

申请日：2024-04-19

Applicant: DANISCO US INC.

Inventor： Lilia Maria Babe ,  Viktor Yuryevich Alekseyev ,  Joshua Roy Basler ,  H. Billur Engin ,  David A. Estell ,  Roopa Santosh Ghirnikar ,  Frits Goedegebuur ,  Thijs Kaper ,  Mulder Harm ,  Sina Pricelius ,  Sander Van Stigt Thans ,  Gudrun Vogtentanz

IPC: C12N9/54 ,  C11D3/386 ,  C12N9/52

CPC classification number: C12N9/54 ,  C11D3/386 ,  C11D3/38627 ,  C11D3/38645 ,  C11D3/38654 ,  C12N9/52 ,  C12Y304/21062

Abstract: Disclosed herein is one or more subtilisin variant, nucleic acid encoding same, and compositions and methods related to the production and use thereof, including one or more subtilisin variant that has improved stability compared to one or more reference subtilisin.

公开(公告)号：US10081802B2

公开(公告)日：2018-09-25

申请号：US14909007

申请日：2014-07-24

Applicant: DANISCO US INC.

Inventor： Maria Foukaraki ,  Ronaldus Wilhelmus Hommes ,  Thijs Kaper ,  Bradley R. Kelemen ,  Slavko Kralj ,  Suzanne E. Lantz ,  Igor Nikolaev ,  Wilhelmus Van Der Kley ,  Johannes Franciscus Thomas Van Lieshout ,  Sander Van Stigt Thans

IPC: C12N9/42 ,  C12P19/14 ,  C12P19/02 ,  C12N9/24

Abstract: Disclosed are glycosyl hydrolase enzyme variants, particularly variants of certain oxidoreductases of glycosyl hydrolase family 61. Nucleic acids encoding the glycosyl hydrolyase variants, compositions including the glycosyl hydrolase variants, methods of producing the variants, and methods of using the variants are also described.

公开(公告)号：US10479983B2

公开(公告)日：2019-11-19

申请号：US14909041

申请日：2014-07-24

Applicant: DANISCO US INC

Inventor： Nicholai Douglas ,  Maria Foukaraki ,  Ronaldus Wilhelmus Hommes ,  Thijs Kaper ,  Bradley R. Kelemen ,  Slavko Kralj ,  Suzanne E. Lantz ,  Jonathan K. Lassila ,  Igor Nikolaev ,  Daniel Esteban Torres-Pazmino ,  Wilhelmus Van Der Kley ,  Johannes Franciscus Thomas Van Lieshout ,  Sander Van Stigt Thans

IPC: C12N9/14 ,  C12N15/09 ,  C12N9/42 ,  C12N9/02 ,  C12P19/02 ,  C12P19/14 ,  C12N9/24 ,  A61K38/00

Abstract: Disclosed are glycosyl hydrolase enzyme variants, particularly variants of certain oxidoreductases of glycosyl hydrolase family 61. Nucleic acids encoding the glycosyl hydrolyase variants, compositions including the glycosyl hydrolase variants, methods of producing the variants, and methods of using the variants are also described.

公开(公告)号：US10167460B2

公开(公告)日：2019-01-01

申请号：US14909031

申请日：2014-07-24

Applicant: DANISCO US INC

Inventor： Maria Foukaraki ,  Ronaldus Wilhelmus Hommes ,  Thijs Kaper ,  Bradley R. Kelemen ,  Slavko Kralj ,  Suzanne E. Lantz ,  Igor Nikolaev ,  Wilhelmus Van Der Kley ,  Johan Franciscus Thomas Van Lieshout ,  Sander Van Stigt Thans

IPC: C12N9/02 ,  C12N9/42 ,  C12P19/14 ,  C12P19/02

Abstract: Disclosed are glycosyl hydrolase enzyme variants, particularly variants of certain oxidoreductases of glycosyl hydrolase family 61. Nucleic acids encoding the glycosyl hydrolyase variants, compositions including the glycosyl hydrolase variants, methods of producing the variants, and methods of using the variants are also described.