公开(公告)号：US09523087B2

公开(公告)日：2016-12-20

申请号：US14189943

申请日：2014-02-25

Applicant: Danisco US Inc.

Inventor： Wolfgang Aehle ,  Richard R. Bott ,  Benjamin S. Bower ,  Jonathan Caspi ,  David A. Estell ,  Frits Goedegebuur ,  Ronaldus Wilhelmus Joannes Hommes ,  Thijs Kaper ,  Bradley R. Kelemen ,  Slavko Kralj ,  Johannes Franciscus Thomas Van Lieshout ,  Igor Nikolaev ,  Sander Van Stigt Thans ,  Louise Wallace ,  Gudrun Vogtentanz ,  Mats Sandgren

IPC: C12N9/42 ,  C12N9/52 ,  C07H21/04

CPC classification number: C12N9/2437 ,  C12Y302/01091 ,  Y02E50/17

Abstract: The present disclosure relates to cellulase variants. In particular the present disclosure relates to cellulase variants having improved expression, activity and/or stability. Also described are nucleic acids encoding the cellulase variants, compositions comprising the cellulase variants, and methods of use thereof.

Abstract translation: 本公开涉及纤维素酶变体。 特别地，本公开涉及具有改善的表达，活性和/或稳定性的纤维素酶变体。 还描述了编码纤维素酶变体的核酸，包含纤维素酶变体的组合物及其使用方法。

公开(公告)号：US20200095614A1

公开(公告)日：2020-03-26

申请号：US16469721

申请日：2017-12-15

Applicant: DANISCO US INC.

Inventor： Jeffrey V. Miller ,  Bradley Roger Kelemen ,  Pim Van Der Kley ,  Igor Nikolaev ,  Su Yin Marina Chow ,  Monica Tse ,  Jing Ge ,  Zhongmei Tang ,  Kirstin Yasuko Nose Crotty

IPC: C12P7/14 ,  C12P19/02 ,  C12N9/24

Abstract: Described are compositions and methods relating the use of α-glucosidase to increase the production of ethanol from a corn fiber product in a starch hydrolysis process.

公开(公告)号：US09938551B2

公开(公告)日：2018-04-10

申请号：US14650285

申请日：2013-12-10

Applicant: Danisco US Inc.

Inventor： Richard R. Bott ,  Maria Foukaraki ,  Ronaldus Wilhelmus Hommes ,  Thijs Kaper ,  Bradley R. Kelemen ,  Slavko Kralj ,  Igor Nikolaev ,  Mats Sandgren ,  Johannes Franciscus Thomas Van Lieshout ,  Sander Van Stigt Thans

IPC: C12P19/14 ,  C12P19/02 ,  C12N9/42

CPC classification number: C12P19/14 ,  C12N9/2434 ,  C12N9/2437 ,  C12P19/02 ,  C12Y302/01091

Abstract: Disclosed are a number of homologs and variants of Hypocrea jecorina Ce17A (formerly Trichoderma reesei cellobiohydrolase I or CBH1), nucleic acids encoding the same and methods for producing the same. The homologs and variant cellulases have the amino acid sequence of a glycosyl hydrolase of family 7A wherein one or more amino acid residues are substituted and/or deleted.

公开(公告)号：US20230174998A1

公开(公告)日：2023-06-08

申请号：US17919435

申请日：2021-04-09

Applicant: DANISCO US INC.

Inventor： Yun Luo ,  Igor Nikolaev ,  Robert James Pratt, II

IPC: C12N15/80 ,  C12N1/14 ,  C07K14/37 ,  C12N9/42

CPC classification number: C12N15/80 ,  C12N1/14 ,  C07K14/37 ,  C12N9/2437 ,  C12R2001/885

Abstract: The present disclosure is generally related to mutant and genetically modified filamentous fungal cells and methods thereof for use in the production of proteins of interest. More particularly, as described herein, the mutant and/or modified fungal cells (strains) of the disclosure are well-suited for use in industrial scale fermentation processes for the enhanced expression/production of proteins of interest in the absence and/or in the presence of an inducing substrate.

公开(公告)号：US10479983B2

公开(公告)日：2019-11-19

申请号：US14909041

申请日：2014-07-24

Applicant: DANISCO US INC

Inventor： Nicholai Douglas ,  Maria Foukaraki ,  Ronaldus Wilhelmus Hommes ,  Thijs Kaper ,  Bradley R. Kelemen ,  Slavko Kralj ,  Suzanne E. Lantz ,  Jonathan K. Lassila ,  Igor Nikolaev ,  Daniel Esteban Torres-Pazmino ,  Wilhelmus Van Der Kley ,  Johannes Franciscus Thomas Van Lieshout ,  Sander Van Stigt Thans

IPC: C12N9/14 ,  C12N15/09 ,  C12N9/42 ,  C12N9/02 ,  C12P19/02 ,  C12P19/14 ,  C12N9/24 ,  A61K38/00

Abstract: Disclosed are glycosyl hydrolase enzyme variants, particularly variants of certain oxidoreductases of glycosyl hydrolase family 61. Nucleic acids encoding the glycosyl hydrolyase variants, compositions including the glycosyl hydrolase variants, methods of producing the variants, and methods of using the variants are also described.

公开(公告)号：US10167460B2

公开(公告)日：2019-01-01

申请号：US14909031

申请日：2014-07-24

Applicant: DANISCO US INC

Inventor： Maria Foukaraki ,  Ronaldus Wilhelmus Hommes ,  Thijs Kaper ,  Bradley R. Kelemen ,  Slavko Kralj ,  Suzanne E. Lantz ,  Igor Nikolaev ,  Wilhelmus Van Der Kley ,  Johan Franciscus Thomas Van Lieshout ,  Sander Van Stigt Thans

IPC: C12N9/02 ,  C12N9/42 ,  C12P19/14 ,  C12P19/02

Abstract: Disclosed are glycosyl hydrolase enzyme variants, particularly variants of certain oxidoreductases of glycosyl hydrolase family 61. Nucleic acids encoding the glycosyl hydrolyase variants, compositions including the glycosyl hydrolase variants, methods of producing the variants, and methods of using the variants are also described.

公开(公告)号：US20230002749A1

公开(公告)日：2023-01-05

申请号：US16491078

申请日：2017-11-09

Applicant: Danisco US Inc.

Inventor： Jacob Flyvholm Cramer ,  Jing Ge ,  Marc Anton Bernhard Kolkman ,  Igor Nikolaev ,  Jayarama K. Shetty ,  Zhongmei Tang ,  Wilhelmus Antonius Van Der Kleij ,  Zhiyong Xie ,  Bo Zhang ,  Zhengzheng Zou

IPC: C12N9/34 ,  C12C5/00

Abstract: Described are polypeptides having glucoamylase activity, compositions comprising such polypeptides, and methods of using such polypeptides and compositions.

公开(公告)号：US10081802B2

公开(公告)日：2018-09-25

申请号：US14909007

申请日：2014-07-24

Applicant: DANISCO US INC.

Inventor： Maria Foukaraki ,  Ronaldus Wilhelmus Hommes ,  Thijs Kaper ,  Bradley R. Kelemen ,  Slavko Kralj ,  Suzanne E. Lantz ,  Igor Nikolaev ,  Wilhelmus Van Der Kley ,  Johannes Franciscus Thomas Van Lieshout ,  Sander Van Stigt Thans

IPC: C12N9/42 ,  C12P19/14 ,  C12P19/02 ,  C12N9/24

Abstract: Disclosed are glycosyl hydrolase enzyme variants, particularly variants of certain oxidoreductases of glycosyl hydrolase family 61. Nucleic acids encoding the glycosyl hydrolyase variants, compositions including the glycosyl hydrolase variants, methods of producing the variants, and methods of using the variants are also described.