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公开(公告)号：US09309347B2
公开(公告)日：2016-04-12
申请号：US13253720
申请日：2011-10-05
申请人： Danny Concagh , Chang Cheng You , Greg Zugates
发明人： Danny Concagh , Chang Cheng You , Greg Zugates
IPC分类号： C08G18/42 , C08G18/72 , A61L31/06 , C08G18/73 , C08G63/08 , C08G63/91 , A61F2/90 , A61L31/10 , A61L31/16 , C08G18/77
CPC分类号： C08G18/4266 , A61F2/90 , A61L31/06 , A61L31/10 , A61L31/16 , C08G18/4269 , C08G18/4277 , C08G18/428 , C08G18/72 , C08G18/73 , C08G18/771 , C08G63/08 , C08G63/912 , C08L67/04 , C08L75/04
摘要： Bioresorbable thermoset elastomers and methods of making the same are disclosed. In certain embodiments, the thermoset elastomers include soft segments comprising branched polyesters, and hard segments including urethane and/or urea. The thermoset elastomers are made in certain embodiments by curing a branched prepolymer with a cross-linking agent. In certain embodiments, the mechanical properties of the thermoset elastomers are tailored by selecting the average molecular weight of the prepolymer, or by tuning the ratio of prepolymer to the cross-linking agent during curing, or by selecting a cross-linking agent with specific chemical characteristics.
摘要翻译： 公开了生物可吸收热固性弹性体及其制备方法。 在某些实施方案中，热固性弹性体包括包含支链聚酯的软链段和包括氨基甲酸酯和/或脲的硬链段。 热固性弹性体在某些实施方案中通过用交联剂固化支化预聚物来制备。 在某些实施方案中，热固性弹性体的机械性能通过选择预聚物的平均分子量，或通过在固化期间调节预聚物与交联剂的比例，或通过选择具有特定化学物质的交联剂 特点
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公开(公告)号：US20130317600A1
公开(公告)日：2013-11-28
申请号：US13863632
申请日：2013-04-16
申请人： Maria Palasis , Changcheng You , Danny Concagh , Lee Core , Kicherl Ho , Upma Sharma , Greg Zugates
发明人： Maria Palasis , Changcheng You , Danny Concagh , Lee Core , Kicherl Ho , Upma Sharma , Greg Zugates
IPC分类号： A61F2/06
CPC分类号： A61F2/06 , A61F2/90 , A61F2230/0054 , A61F2250/0067 , A61K47/34 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61L2300/416 , A61L2420/02 , A61L2420/08 , C08L67/04 , C08L75/04
摘要： Disclosed are self-expanding medical implants for placement within a lumen of a patient. The implants comprise a woven or non-woven structure having a substantially tubular configuration, and are designed to be low-profile such that they are deliverable with a small diameter catheter. The implants have a high recoverability and desired mechanical properties.
摘要翻译： 公开了用于放置在患者的内腔内的自扩张医用植入物。 植入物包括具有基本上管状构造的织造或非织造结构，并且被设计为低轮廓，使得它们可以用小直径导管递送。 植入物具有高回收性和所需的机械性能。
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公开(公告)号：US20120142884A1
公开(公告)日：2012-06-07
申请号：US13253720
申请日：2011-10-05
申请人： Danny Concagh , Changcheng You , Greg Zugates
发明人： Danny Concagh , Changcheng You , Greg Zugates
CPC分类号： C08G18/4266 , A61F2/90 , A61L31/06 , A61L31/10 , A61L31/16 , C08G18/4269 , C08G18/4277 , C08G18/428 , C08G18/72 , C08G18/73 , C08G18/771 , C08G63/08 , C08G63/912 , C08L67/04 , C08L75/04
摘要： Bioresorbable thermoset elastomers and methods of making the same are disclosed. In certain embodiments, the thermoset elastomers include soft segments comprising branched polyesters, and hard segments including urethane and/or urea. The thermoset elastomers are made in certain embodiments by curing a branched prepolymer with a cross-linking agent. In certain embodiments, the mechanical properties of the thermoset elastomers are tailored by selecting the average molecular weight of the prepolymer, or by tuning the ratio of prepolymer to the cross-linking agent during curing, or by selecting a cross-linking agent with specific chemical characteristics.
摘要翻译： 公开了生物可吸收热固性弹性体及其制备方法。 在某些实施方案中，热固性弹性体包括包含支链聚酯的软链段和包括氨基甲酸酯和/或脲的硬链段。 热固性弹性体在某些实施方案中通过用交联剂固化支化预聚物来制备。 在某些实施方案中，热固性弹性体的机械性能通过选择预聚物的平均分子量，或通过在固化期间调节预聚物与交联剂的比例，或通过选择具有特定化学物质的交联剂 特点
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公开(公告)号：US20120143300A1
公开(公告)日：2012-06-07
申请号：US13370025
申请日：2012-02-09
申请人： Maria Palasis , Chang Cheng You , Daniel Concagh , Lee Core , Kicherl Ho , Upma Sharma , Greg Zugates
发明人： Maria Palasis , Chang Cheng You , Daniel Concagh , Lee Core , Kicherl Ho , Upma Sharma , Greg Zugates
IPC分类号： A61F2/82
CPC分类号： A61L31/10 , A61F2/07 , A61F2/90 , A61F2210/0004 , A61F2210/0014 , A61F2230/0054 , A61F2250/0018 , A61F2250/0036 , A61F2250/0048 , A61L31/06 , A61L31/16 , A61L2300/606 , A61L2420/02 , C08L67/04
摘要： Disclosed is a self-expanding medical implant for placement within a lumen of a patient. The implant comprises a woven or non-woven structure having a substantially tubular configuration, and is designed to be low-profile such that it is deliverable with a small diameter catheter. The implant has a high recoverability and desired mechanical properties.
摘要翻译： 公开了一种用于放置在患者的内腔内的自扩张医用植入物。 植入物包括具有基本上管状构造的织造或非织造结构，并且被设计为低轮廓，使得其可以用小直径导管递送。 植入物具有高回收性和所需的机械性能。
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公开(公告)号：US08137396B2
公开(公告)日：2012-03-20
申请号：US12783261
申请日：2010-05-19
申请人： Rany Busold , Chang cheng You , Daniel Concagh , Lee Core , Kicherl Ho , Maria Palasis , Upma Sharma , Greg Zugates
发明人： Rany Busold , Chang cheng You , Daniel Concagh , Lee Core , Kicherl Ho , Maria Palasis , Upma Sharma , Greg Zugates
IPC分类号： A61F2/06
CPC分类号： A61F2/86 , A61F2/90 , A61F2/95 , A61F2230/0054 , A61L31/06 , A61L31/10 , A61L31/14 , A61L31/16 , D04C1/06 , D10B2403/0112 , D10B2509/06 , C08L67/04
摘要： Disclosed is a self-expanding medical implant for placement within a lumen of a patient. The implant comprises a woven or non-woven structure having a substantially tubular configuration, and is designed to be low-profile such that it is deliverable with a small diameter catheter. The implant has a high recoverability and desired mechanical properties.
摘要翻译： 公开了一种用于放置在患者的内腔内的自扩张医用植入物。 植入物包括具有基本上管状构造的织造或非织造结构，并且被设计为低轮廓，使得其可以用小直径导管递送。 植入物具有高回收性和所需的机械性能。
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公开(公告)号：US08540765B2
公开(公告)日：2013-09-24
申请号：US13370025
申请日：2012-02-09
申请人： Maria Palasis , Chang Cheng You , Daniel Concagh , Lee Core , Kicherl Ho , Upma Sharma , Greg Zugates
发明人： Maria Palasis , Chang Cheng You , Daniel Concagh , Lee Core , Kicherl Ho , Upma Sharma , Greg Zugates
IPC分类号： A61F2/06
CPC分类号： A61L31/10 , A61F2/07 , A61F2/90 , A61F2210/0004 , A61F2210/0014 , A61F2230/0054 , A61F2250/0018 , A61F2250/0036 , A61F2250/0048 , A61L31/06 , A61L31/16 , A61L2300/606 , A61L2420/02 , C08L67/04
摘要： Disclosed is a self-expanding medical implant for placement within a lumen of a patient. The implant comprises a woven or non-woven structure having a substantially tubular configuration, and is designed to be low-profile such that it is deliverable with a small diameter catheter. The implant has a high recoverability and desired mechanical properties.
摘要翻译： 公开了一种用于放置在患者的内腔内的自扩张医用植入物。 植入物包括具有基本上管状构造的织造或非织造结构，并且被设计为低轮廓，使得其可以用小直径导管递送。 植入物具有高回收性和所需的机械性能。
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公开(公告)号：US20110238162A1
公开(公告)日：2011-09-29
申请号：US13032281
申请日：2011-02-22
申请人： Rany Busold , Chang Cheng You , Daniel Concagh , Lee Core , Kicherl Ho , Maria Palasis , Upma Sharma , Greg Zugates
发明人： Rany Busold , Chang Cheng You , Daniel Concagh , Lee Core , Kicherl Ho , Maria Palasis , Upma Sharma , Greg Zugates
IPC分类号： A61F2/82
CPC分类号： A61F2/86 , A61F2/90 , A61F2/95 , A61F2230/0054 , A61L31/06 , A61L31/10 , A61L31/14 , A61L31/16 , D04C1/06 , D10B2403/0112 , D10B2509/06 , C08L67/04
摘要： Disclosed is a self-expanding medical implant for placement within a lumen of a patient. The implant comprises a woven or non-woven structure having a substantially tubular configuration, and is designed to be low-profile such that it is deliverable with a small diameter catheter. The implant has a high recoverability and desired mechanical properties.
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公开(公告)号：US20110319987A1
公开(公告)日：2011-12-29
申请号：US13183104
申请日：2011-07-14
申请人： Maria Palasis , Chang Cheng You , Daniel Concagh , Lee Core , Kicherl Ho , Upma Sharma , Greg Zugates
发明人： Maria Palasis , Chang Cheng You , Daniel Concagh , Lee Core , Kicherl Ho , Upma Sharma , Greg Zugates
CPC分类号： A61L31/10 , A61F2/07 , A61F2/90 , A61F2210/0004 , A61F2210/0014 , A61F2230/0054 , A61F2250/0018 , A61F2250/0036 , A61F2250/0048 , A61L31/06 , A61L31/16 , A61L2300/606 , A61L2420/02 , C08L67/04
摘要： Disclosed is a self-expanding medical implant for placement within a lumen of a patient. The implant comprises a woven or non-woven structure having a substantially tubular configuration, and is designed to be low-profile such that it is deliverable with a small diameter catheter. The implant has a high recoverability and desired mechanical properties.
摘要翻译： 公开了一种用于放置在患者的内腔内的自扩张医用植入物。 植入物包括具有基本上管状构造的织造或非织造结构，并且被设计为低轮廓，使得其可以用小直径导管递送。 植入物具有高回收性和所需的机械性能。
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公开(公告)号：US20100298952A1
公开(公告)日：2010-11-25
申请号：US12783261
申请日：2010-05-19
申请人： Rany Busold , Chang Cheng You , Daniel Concagh , Lee Core , Kicherl Ho , Maria Palasis , Upma Sharma , Greg Zugates
发明人： Rany Busold , Chang Cheng You , Daniel Concagh , Lee Core , Kicherl Ho , Maria Palasis , Upma Sharma , Greg Zugates
IPC分类号： A61F2/04
CPC分类号： A61F2/86 , A61F2/90 , A61F2/95 , A61F2230/0054 , A61L31/06 , A61L31/10 , A61L31/14 , A61L31/16 , D04C1/06 , D10B2403/0112 , D10B2509/06 , C08L67/04
摘要： Disclosed is a self-expanding medical implant for placement within a lumen of a patient. The implant comprises a woven or non-woven structure having a substantially tubular configuration, and is designed to be low-profile such that it is deliverable with a small diameter catheter. The implant has a high recoverability and desired mechanical properties.
摘要翻译： 公开了一种用于放置在患者的内腔内的自扩张医用植入物。 植入物包括具有基本上管状构造的织造或非织造结构，并且被设计为低轮廓，使得其可以用小直径导管递送。 植入物具有高回收性和所需的机械性能。
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公开(公告)号：US20120040137A1
公开(公告)日：2012-02-16
申请号：US13185550
申请日：2011-07-19
申请人： Maria Palasis , Upma Sharma , Greg Zugates , Daniel Concagh , Toby Freyman , Quynh Pham
发明人： Maria Palasis , Upma Sharma , Greg Zugates , Daniel Concagh , Toby Freyman , Quynh Pham
CPC分类号： A61L27/48 , A61L27/54 , A61L27/58 , A61L31/129 , A61L31/148 , A61L31/16 , Y10T428/24479 , Y10T428/249924
摘要： Disclosed are fiber composite structures comprising a matrix material and at least one polymeric fiber in contact with the matrix material. The fiber(s) are preferably characterized by a diameter of up to about 20 microns. In certain embodiments, the fiber(s) comprise a therapeutic agent in an amount that exceeds the solubility limit of the therapeutic agent in the fiber polymer. In some embodiments, the fiber(s) comprise an inner radial portion and an outer radial portion.
摘要翻译： 公开了包含基质材料和至少一种与基质材料接触的聚合物纤维的纤维复合结构。 优选的纤维的特征在于直径至多约20微米。 在某些实施方案中，纤维包含超过纤维聚合物中治疗剂的溶解度极限的量的治疗剂。 在一些实施例中，纤维包括内径向部分和外径向部分。
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