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    MEDICAL DEVICES CONTAINING ORIENTED FILMS OF POLY-4-HYDROXYBUTYRATE AND COPOLYMERS
    8.
    发明申请
    MEDICAL DEVICES CONTAINING ORIENTED FILMS OF POLY-4-HYDROXYBUTYRATE AND COPOLYMERS 有权
    含聚-4-羟基丁酸酯和共聚物的靶向膜的医疗装置

    公开(公告)号：US20080132602A1

    公开(公告)日：2008-06-05

    申请号：US11931850

    申请日：2007-10-31

    申请人： Said Rizk ,  David P. Martin ,  Kicherl Ho ,  Simon F. Williams

    发明人： Said Rizk ,  David P. Martin ,  Kicherl Ho ,  Simon F. Williams

    IPC分类号： A61F2/02 ,  A61F2/82

    CPC分类号： A61L27/34 ,  A61L27/18 ,  A61L31/10 ,  B29C55/005 ,  B29C55/04 ,  B29C55/12 ,  B29K2067/00 ,  B29K2067/046 ,  B29K2995/006 ,  C08L67/04

    摘要： Continuous processing methods for making absorbable polymeric films with one or more of the following properties: high toughness, low modulus, high tensile strength, and thickness less than 10 mm, more preferably less than 1 mm, and more preferably less than 100 μm, have been developed. In the preferred embodiment, the polymer is a polyhydroxyalkanoate, and in the most preferred embodiment, the polymer comprises 4-hydroxybutyrate. A particularly preferred embodiment is a film of poly-4-hydroxybutyrate or copolymer thereof, wherein the film has a tensile strength greater than 5.5 kgf/mm2, tensile modulus less than 181 kgf/mm2, and elongation at break from 10-500%, wherein the film is derived by a continuous process such as melt extrusion or solvent casting, followed by orientation to more than 25% of the film's original length in one or more directions. These can be used for a variety of purposes including fabrication of medical devices.

    摘要翻译： 用于制造具有以下特性中的一种或多种的可吸收聚合物膜的连续加工方法：高韧性，低模量，高拉伸强度和小于10mm，更优选小于1mm，更优选小于100μm的厚度具有 已经开发 在优选的实施方案中，聚合物是聚羟基链烷酸酯，并且在最优选的实施方案中，聚合物包含4-羟基丁酸酯。 特别优选的实施方案是聚-4-羟基丁酸酯或其共聚物的膜，其中所述膜的拉伸强度大于5.5kgf / mm 2，拉伸模量小于181kgf / mm 2， 2℃，断裂伸长率为10-500％，其中该膜通过连续方法如熔体挤出或溶剂浇铸得到，然后在一个或多个膜中定向至超过膜的原始长度的25％ 方向。 这些可以用于各种目的，包括制造医疗器械。

    Medical devices containing oriented films of poly-4-hydroxybutyrate and copolymers
    9.
    发明授权
    Medical devices containing oriented films of poly-4-hydroxybutyrate and copolymers 有权
    包含聚-4-羟基丁酸取代膜和共聚物的医疗器械

    公开(公告)号：US08753555B2

    公开(公告)日：2014-06-17

    申请号：US13084388

    申请日：2011-04-11

    申请人： Said Rizk ,  David P. Martin ,  Kicherl Ho ,  Simon F. Williams

    发明人： Said Rizk ,  David P. Martin ,  Kicherl Ho ,  Simon F. Williams

    IPC分类号： B29C55/04 ,  B29C55/12 ,  A61L27/18 ,  A61L27/58 ,  C08L67/04 ,  C08G63/08

    CPC分类号： A61L27/34 ,  A61L27/18 ,  A61L31/10 ,  B29C55/005 ,  B29C55/04 ,  B29C55/12 ,  B29K2067/00 ,  B29K2067/046 ,  B29K2995/006 ,  C08L67/04

    摘要： Continuous processing methods for making absorbable polymeric films with one or more of the following properties: high toughness, low modulus, high tensile strength, and thickness less than 10 mm, more preferably less than 1 mm, and more preferably less than 100 μm, have been developed. In the preferred embodiment, the polymer is a polyhydroxyalkanoate, and in the most preferred embodiment, the polymer comprises 4-hydroxybutyrate. A particularly preferred embodiment is a film of poly-4-hydroxybutyrate or copolymer thereof, wherein the film has a tensile strength greater than 5.5 kgf/mm2, tensile modulus less than 181 kgf/mm2, and elongation at break from 10-500%, wherein the film is derived by a continuous process such as melt extrusion or solvent casting, followed by orientation to more than 25% of the film's original length in one or more directions. These can be used for a variety of purposes including fabrication of medical devices.

    摘要翻译： 用于制造具有以下特性中的一种或多种的可吸收聚合物膜的连续加工方法：高韧性，低模量，高拉伸强度和小于10mm，更优选小于1mm，更优选小于100μm的厚度具有 已经开发 在优选的实施方案中，聚合物是聚羟基链烷酸酯，并且在最优选的实施方案中，聚合物包含4-羟基丁酸酯。 特别优选的实施方案是聚-4-羟基丁酸酯或其共聚物的膜，其中所述膜的拉伸强度大于5.5kgf / mm 2，拉伸模量小于181kgf / mm 2，断裂伸长率为10-500％ 其中所述膜通过连续方法如熔体挤出或溶剂浇铸得到，然后在一个或多个方向上定向至超过膜的原始长度的25％。 这些可以用于各种目的，包括制造医疗器械。