-
公开(公告)号：US20110229556A1
公开(公告)日：2011-09-22
申请号：US13053101
申请日：2011-03-21
申请人： Darrell J. Irvine , Anna Bershteyn , Jaehyun Moon
发明人： Darrell J. Irvine , Anna Bershteyn , Jaehyun Moon
IPC分类号： A61K9/127 , A61K39/385 , A61P37/04 , B82Y5/00
CPC分类号： A61K39/39 , A61K9/127 , A61K39/385 , A61K47/6921 , A61K47/6935 , A61K2039/55555 , A61K2039/55572 , A61K2039/6093
摘要： The invention provides delivery systems comprised of lipid coated polymer core particles, as well as compositions, methods of synthesis, and methods of use thereof. The particles can be used to carry antigen and adjuvant, resulting in enhanced immune responses.
摘要翻译： 本发明提供由脂质包被的聚合物核心颗粒组成的递送系统，以及组合物，合成方法及其使用方法。 该颗粒可用于携带抗原和佐剂，导致增强的免疫应答。
-
公开(公告)号：US20110293705A1
公开(公告)日：2011-12-01
申请号：US13130845
申请日：2009-11-24
IPC分类号： A61K9/127 , A61K9/14 , A61P35/00 , A61P37/06 , A61P31/00 , A61K35/12 , C12N5/0783 , B82Y5/00
CPC分类号： A61K9/127 , A61K9/146 , A61K9/19 , A61K9/5146 , A61K9/5153 , A61K31/7105 , A61K31/711 , A61K35/28 , A61K38/19 , A61K38/20 , A61K38/2086 , A61K39/00 , A61K39/39 , A61K39/395 , A61K45/06 , A61K47/46 , A61K47/6901 , A61K47/6911 , A61K47/6937 , A61K2035/124 , B82Y5/00 , C07K16/00 , C12N5/0006 , C12N5/0636 , C12N5/0647 , C12N15/113 , C12N15/87 , C12N2310/14 , A61K2300/00
摘要： The invention provides compositions and methods for delivering agents to localized regions, tissues, or organs in vivo by conjugating agent-loaded nanoparticles to cells having homing capability. The agents may be therapeutic or diagnostic agents such as cancer chemotherapeutic agents and imaging agents respectively.
摘要翻译： 本发明提供了通过将负载载体的纳米颗粒与具有归巢能力的细胞结合来将药剂递送到体内的局部区域，组织或器官的组合物和方法。 这些试剂可以分别是治疗剂或诊断剂，例如癌症化学治疗剂和成像剂。
-
公开(公告)号：US09283184B2
公开(公告)日：2016-03-15
申请号：US13130845
申请日：2009-11-24
IPC分类号： A61K35/17 , A61K38/19 , A61K9/127 , A61K9/51 , A61K31/7105 , A61K31/711 , A61K38/20 , A61K45/06 , A61K47/48 , B82Y5/00 , C12N5/00 , C12N5/0783 , C12N5/0789 , C12N15/87 , A61K39/00 , A61K39/395 , A61K47/46 , A61K35/12
CPC分类号： A61K9/127 , A61K9/146 , A61K9/19 , A61K9/5146 , A61K9/5153 , A61K31/7105 , A61K31/711 , A61K35/28 , A61K38/19 , A61K38/20 , A61K38/2086 , A61K39/00 , A61K39/39 , A61K39/395 , A61K45/06 , A61K47/46 , A61K47/6901 , A61K47/6911 , A61K47/6937 , A61K2035/124 , B82Y5/00 , C07K16/00 , C12N5/0006 , C12N5/0636 , C12N5/0647 , C12N15/113 , C12N15/87 , C12N2310/14 , A61K2300/00
摘要： The invention provides compositions and methods for delivering agents to localized regions, tissues, or organs in vivo by conjugating agent-loaded nanoparticles to cells having homing capability. The agents may be therapeutic or diagnostic agents such as cancer chemotherapeutic agents and imaging agents respectively.
摘要翻译： 本发明提供了通过将负载载体的纳米颗粒与具有归巢能力的细胞结合来将药剂递送到体内的局部区域，组织或器官的组合物和方法。 这些试剂可以分别是治疗剂或诊断剂，例如癌症化学治疗剂和成像剂。
-
公开(公告)号：US20110033522A1
公开(公告)日：2011-02-10
申请号：US12680052
申请日：2008-09-26
申请人： Ellis L. Reinherz , Kyoung Joon Oh , Mikyung Kim , Gerhard Wagner , Zhen-Yu J. Sun , Darrell J. Irvine , Anna Bershteyn
发明人： Ellis L. Reinherz , Kyoung Joon Oh , Mikyung Kim , Gerhard Wagner , Zhen-Yu J. Sun , Darrell J. Irvine , Anna Bershteyn
IPC分类号： A61K39/21 , A61K9/127 , A61K9/14 , C07K16/08 , C12N5/07 , A61P37/04 , A61P31/18 , G06G7/60 , B82Y5/00
CPC分类号： A61K38/10 , A61K9/127 , A61K9/5123 , A61K9/5153 , A61K38/162 , A61K39/12 , A61K39/21 , A61K47/6907 , A61K47/6911 , A61K47/6913 , A61K2039/54 , A61K2039/545 , A61K2039/55555 , A61K2039/55561 , A61K2039/55566 , A61K2039/6018 , C07K16/1063 , C07K2317/34 , C07K2317/55 , C07K2317/76 , C07K2317/90 , C12N2740/16134
摘要： The present disclosure relates to reagents (antigenic and/or immunogenic reagents) and kits that are useful in a variety of in vitro, in vivo, and ex vivo methods including, e.g., methods for inducing an immune response, or for generating an antibody, in a subject. The reagents described herein can be used in the treatment or prevention of HIV-1 infections. In addition, the disclosure provides methods and compositions useful for designing (or identifying) an agent that binds to an membrane proximal external region (MPER) of an HIV-1 gp160 polypeptide or an agent that inhibits the fusion of an HIV-1 particle to a cell.
摘要翻译： 本公开涉及可用于各种体外，体内和离体方法的试剂（抗原性和/或免疫原性试剂）和试剂盒，包括例如诱导免疫应答的方法或产生抗体， 在一个主题 本文所述的试剂可用于治疗或预防HIV-1感染。 此外，本公开提供了可用于设计（或鉴定）结合HIV-1 gp160多肽的膜近端外部区域（MPER）的试剂或抑制HIV-1颗粒融合的试剂的方法和组合物 一个单元格
-
5.发明申请公开(公告)号：US20110172826A1
公开(公告)日：2011-07-14
申请号：US12806637
申请日：2010-05-28
申请人： Dario G. Amodei , Mahalaxmi Gita Bangera , Xiaoyan Robert Bao , Anna Bershteyn , Brett Bethke , Philip A. Eckhoff , Kevin Michael Esvelt , Kyle Gustafson , Edward K.Y. Jung , William Michael Kaminsky , Jordin T. Kare , Lily Yvonne Kim , Eric C. Leuthardt , Erez Lieberman , Ankur Moitra , Christopher Somogyi , Clarence T. Tegreene , Lowell L. Wood, JR. , Jeremiah James Zartman
发明人： Dario G. Amodei , Mahalaxmi Gita Bangera , Xiaoyan Robert Bao , Anna Bershteyn , Brett Bethke , Philip A. Eckhoff , Kevin Michael Esvelt , Kyle Gustafson , Edward K.Y. Jung , William Michael Kaminsky , Jordin T. Kare , Lily Yvonne Kim , Eric C. Leuthardt , Erez Lieberman , Ankur Moitra , Christopher Somogyi , Clarence T. Tegreene , Lowell L. Wood, JR. , Jeremiah James Zartman
IPC分类号： G05B21/00
CPC分类号： C12N1/36 , A61K9/0024 , A61K47/6901 , A61L27/54 , A61L31/16 , A61L2300/258
摘要： Devices, methods, and systems are described for administration to at least one biological tissue of at least one device including at least one altered microorganism. In an embodiment, the altered microorganism includes at least one nucleic acid construct encoding at least one therapeutic agent.
摘要翻译： 描述了将装置，方法和系统用于给予至少一种包含至少一种改变的微生物的装置的至少一种生物组织。 在一个实施方案中，改变的微生物包括至少一种编码至少一种治疗剂的核酸构建体。
-
公开(公告)号：US20110028945A1
公开(公告)日：2011-02-03
申请号：US12802149
申请日：2010-05-28
申请人： Dario G. Amodei , Mahalaxmi Gita Bangera , Xiaoyan Robert Bao , Anna Bershteyn , Brett Bethke , Philip A. Eckhoff , Kevin Michael Esvelt , Kyle B. Gustafson , Edward K.Y. Jung , William Michael Kaminsky , Jordin T. Kare , Lily Yvonne Kim , Eric C. Leuthardt , Erez Lieberman , Ankur Moitra , Christopher Somogyi , Clarence T. Tegreene , Lowell L. Wood, JR. , Jeremiah James Zartman
发明人： Dario G. Amodei , Mahalaxmi Gita Bangera , Xiaoyan Robert Bao , Anna Bershteyn , Brett Bethke , Philip A. Eckhoff , Kevin Michael Esvelt , Kyle B. Gustafson , Edward K.Y. Jung , William Michael Kaminsky , Jordin T. Kare , Lily Yvonne Kim , Eric C. Leuthardt , Erez Lieberman , Ankur Moitra , Christopher Somogyi , Clarence T. Tegreene , Lowell L. Wood, JR. , Jeremiah James Zartman
IPC分类号： A61M37/00
CPC分类号： G01N33/48 , A61K9/0024 , A61K47/6901 , A61L27/54 , A61L31/16 , A61L2300/258 , G06F19/00 , G06F19/3468 , Y02A90/26
摘要： Devices, methods, and systems are described for administration to at least one biological tissue of at least one device including at least one altered microorganism. In an embodiment, the altered microorganism includes at least one nucleic acid construct encoding at least one therapeutic agent.
-
7.发明授权公开(公告)号：US08734823B2
公开(公告)日：2014-05-27
申请号：US12802148
申请日：2010-05-28
申请人： Dario G. Amodei , Mahalaxmi Gita Bangera , Xiaoyan Robert Bao , Anna Bershteyn , Brett Bethke , Philip A. Eckhoff , Kevin Michael Esvelt , Kyle B. Gustafson , Edward K. Y. Jung , William Michael Kaminsky , Jordin T. Kare , Lily Yvonne Kim , Eric C. Leuthardt , Erez Lieberman , Ankur Moitra , Christopher Somogyi , Clarence T. Tegreene , Lowell L. Wood, Jr. , Jeremiah James Zartman
发明人： Dario G. Amodei , Mahalaxmi Gita Bangera , Xiaoyan Robert Bao , Anna Bershteyn , Brett Bethke , Philip A. Eckhoff , Kevin Michael Esvelt , Kyle B. Gustafson , Edward K. Y. Jung , William Michael Kaminsky , Jordin T. Kare , Lily Yvonne Kim , Eric C. Leuthardt , Erez Lieberman , Ankur Moitra , Christopher Somogyi , Clarence T. Tegreene , Lowell L. Wood, Jr. , Jeremiah James Zartman
CPC分类号： A61K9/0024 , A61K47/6901 , A61L27/54 , A61L31/16 , A61L2300/258 , B33Y80/00 , Y02A50/411
摘要： Devices, methods, and systems are described for administration to at least one biological tissue of at least one device including at least one altered microorganism. In an embodiment, the altered microorganism includes at least one nucleic acid construct encoding at least one therapeutic agent.
摘要翻译： 描述了将装置，方法和系统用于给予至少一种包含至少一种改变的微生物的装置的至少一种生物组织。 在一个实施方案中，改变的微生物包括至少一种编码至少一种治疗剂的核酸构建体。
-
公开(公告)号：US08682619B2
公开(公告)日：2014-03-25
申请号：US12802149
申请日：2010-05-28
申请人： Dario G. Amodei , Mahalaxmi Gita Bangera , Xiaoyan Robert Bao , Anna Bershteyn , Brett Bethke , Philip A. Eckhoff , Kevin Michael Esvelt , Kyle B. Gustafson , Edward K. Y. Jung , William Michael Kaminsky , Jordin T. Kare , Lily Yvonne Kim , Eric C. Leuthardt , Erez Lieberman , Ankur Moitra , Christopher Somogyi , Clarence T. Tegreene , Lowell L. Wood, Jr. , Jeremiah James Zartman
发明人： Dario G. Amodei , Mahalaxmi Gita Bangera , Xiaoyan Robert Bao , Anna Bershteyn , Brett Bethke , Philip A. Eckhoff , Kevin Michael Esvelt , Kyle B. Gustafson , Edward K. Y. Jung , William Michael Kaminsky , Jordin T. Kare , Lily Yvonne Kim , Eric C. Leuthardt , Erez Lieberman , Ankur Moitra , Christopher Somogyi , Clarence T. Tegreene , Lowell L. Wood, Jr. , Jeremiah James Zartman
CPC分类号： G01N33/48 , A61K9/0024 , A61K47/6901 , A61L27/54 , A61L31/16 , A61L2300/258 , G06F19/00 , G06F19/3468 , Y02A90/26
摘要： Devices, methods, and systems are described for administration to at least one biological tissue of at least one device including at least one altered microorganism. In an embodiment, the altered microorganism includes at least one nucleic acid construct encoding at least one therapeutic agent.
-
公开(公告)号：US20110027181A1
公开(公告)日：2011-02-03
申请号：US12802148
申请日：2010-05-28
申请人： Dario G. Amodei , Mahalaxmi Gita Bangera , Xiaoyan Robert Bao , Anna Bershteyn , Brett Bethke , Philip A. Eckhoff , Kevin Michael Esvelt , Kyle B. Gustafson , Edward K.Y. Jung , William Michael Kaminsky , Jordin T. Kare , Lily Yvonne Kim , Eric C. Leuthardt , Erez Lieberman , Ankur Moitra , Christopher Somogyi , Clarence T. Tegreene , Lowell L. Wood, JR. , Jeremiah James Zartman
发明人： Dario G. Amodei , Mahalaxmi Gita Bangera , Xiaoyan Robert Bao , Anna Bershteyn , Brett Bethke , Philip A. Eckhoff , Kevin Michael Esvelt , Kyle B. Gustafson , Edward K.Y. Jung , William Michael Kaminsky , Jordin T. Kare , Lily Yvonne Kim , Eric C. Leuthardt , Erez Lieberman , Ankur Moitra , Christopher Somogyi , Clarence T. Tegreene , Lowell L. Wood, JR. , Jeremiah James Zartman
IPC分类号： A61K49/00 , A61K9/00 , A61K35/12 , A61K35/68 , A61K35/74 , A61K35/64 , A61K35/00 , A61P43/00
CPC分类号： A61K9/0024 , A61K47/6901 , A61L27/54 , A61L31/16 , A61L2300/258 , B33Y80/00 , Y02A50/411
摘要： Devices, methods, and systems are described for administration to at least one biological tissue of at least one device including at least one altered microorganism. In an embodiment, the altered microorganism includes at least one nucleic acid construct encoding at least one therapeutic agent.
-
-
-
-
-
-
-
-
搜索结果
9 条记录 (耗时 0.038 秒)
