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公开(公告)号：US20110033522A1
公开(公告)日：2011-02-10
申请号：US12680052
申请日：2008-09-26
申请人： Ellis L. Reinherz , Kyoung Joon Oh , Mikyung Kim , Gerhard Wagner , Zhen-Yu J. Sun , Darrell J. Irvine , Anna Bershteyn
发明人： Ellis L. Reinherz , Kyoung Joon Oh , Mikyung Kim , Gerhard Wagner , Zhen-Yu J. Sun , Darrell J. Irvine , Anna Bershteyn
IPC分类号： A61K39/21 , A61K9/127 , A61K9/14 , C07K16/08 , C12N5/07 , A61P37/04 , A61P31/18 , G06G7/60 , B82Y5/00
CPC分类号： A61K38/10 , A61K9/127 , A61K9/5123 , A61K9/5153 , A61K38/162 , A61K39/12 , A61K39/21 , A61K47/6907 , A61K47/6911 , A61K47/6913 , A61K2039/54 , A61K2039/545 , A61K2039/55555 , A61K2039/55561 , A61K2039/55566 , A61K2039/6018 , C07K16/1063 , C07K2317/34 , C07K2317/55 , C07K2317/76 , C07K2317/90 , C12N2740/16134
摘要： The present disclosure relates to reagents (antigenic and/or immunogenic reagents) and kits that are useful in a variety of in vitro, in vivo, and ex vivo methods including, e.g., methods for inducing an immune response, or for generating an antibody, in a subject. The reagents described herein can be used in the treatment or prevention of HIV-1 infections. In addition, the disclosure provides methods and compositions useful for designing (or identifying) an agent that binds to an membrane proximal external region (MPER) of an HIV-1 gp160 polypeptide or an agent that inhibits the fusion of an HIV-1 particle to a cell.
摘要翻译： 本公开涉及可用于各种体外，体内和离体方法的试剂（抗原性和/或免疫原性试剂）和试剂盒，包括例如诱导免疫应答的方法或产生抗体， 在一个主题 本文所述的试剂可用于治疗或预防HIV-1感染。 此外，本公开提供了可用于设计（或鉴定）结合HIV-1 gp160多肽的膜近端外部区域（MPER）的试剂或抑制HIV-1颗粒融合的试剂的方法和组合物 一个单元格
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公开(公告)号：US20110229556A1
公开(公告)日：2011-09-22
申请号：US13053101
申请日：2011-03-21
申请人： Darrell J. Irvine , Anna Bershteyn , Jaehyun Moon
发明人： Darrell J. Irvine , Anna Bershteyn , Jaehyun Moon
IPC分类号： A61K9/127 , A61K39/385 , A61P37/04 , B82Y5/00
CPC分类号： A61K39/39 , A61K9/127 , A61K39/385 , A61K47/6921 , A61K47/6935 , A61K2039/55555 , A61K2039/55572 , A61K2039/6093
摘要： The invention provides delivery systems comprised of lipid coated polymer core particles, as well as compositions, methods of synthesis, and methods of use thereof. The particles can be used to carry antigen and adjuvant, resulting in enhanced immune responses.
摘要翻译： 本发明提供由脂质包被的聚合物核心颗粒组成的递送系统，以及组合物，合成方法及其使用方法。 该颗粒可用于携带抗原和佐剂，导致增强的免疫应答。
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公开(公告)号：US20110293705A1
公开(公告)日：2011-12-01
申请号：US13130845
申请日：2009-11-24
IPC分类号： A61K9/127 , A61K9/14 , A61P35/00 , A61P37/06 , A61P31/00 , A61K35/12 , C12N5/0783 , B82Y5/00
CPC分类号： A61K9/127 , A61K9/146 , A61K9/19 , A61K9/5146 , A61K9/5153 , A61K31/7105 , A61K31/711 , A61K35/28 , A61K38/19 , A61K38/20 , A61K38/2086 , A61K39/00 , A61K39/39 , A61K39/395 , A61K45/06 , A61K47/46 , A61K47/6901 , A61K47/6911 , A61K47/6937 , A61K2035/124 , B82Y5/00 , C07K16/00 , C12N5/0006 , C12N5/0636 , C12N5/0647 , C12N15/113 , C12N15/87 , C12N2310/14 , A61K2300/00
摘要： The invention provides compositions and methods for delivering agents to localized regions, tissues, or organs in vivo by conjugating agent-loaded nanoparticles to cells having homing capability. The agents may be therapeutic or diagnostic agents such as cancer chemotherapeutic agents and imaging agents respectively.
摘要翻译： 本发明提供了通过将负载载体的纳米颗粒与具有归巢能力的细胞结合来将药剂递送到体内的局部区域，组织或器官的组合物和方法。 这些试剂可以分别是治疗剂或诊断剂，例如癌症化学治疗剂和成像剂。
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公开(公告)号：US09283184B2
公开(公告)日：2016-03-15
申请号：US13130845
申请日：2009-11-24
IPC分类号： A61K35/17 , A61K38/19 , A61K9/127 , A61K9/51 , A61K31/7105 , A61K31/711 , A61K38/20 , A61K45/06 , A61K47/48 , B82Y5/00 , C12N5/00 , C12N5/0783 , C12N5/0789 , C12N15/87 , A61K39/00 , A61K39/395 , A61K47/46 , A61K35/12
CPC分类号： A61K9/127 , A61K9/146 , A61K9/19 , A61K9/5146 , A61K9/5153 , A61K31/7105 , A61K31/711 , A61K35/28 , A61K38/19 , A61K38/20 , A61K38/2086 , A61K39/00 , A61K39/39 , A61K39/395 , A61K45/06 , A61K47/46 , A61K47/6901 , A61K47/6911 , A61K47/6937 , A61K2035/124 , B82Y5/00 , C07K16/00 , C12N5/0006 , C12N5/0636 , C12N5/0647 , C12N15/113 , C12N15/87 , C12N2310/14 , A61K2300/00
摘要： The invention provides compositions and methods for delivering agents to localized regions, tissues, or organs in vivo by conjugating agent-loaded nanoparticles to cells having homing capability. The agents may be therapeutic or diagnostic agents such as cancer chemotherapeutic agents and imaging agents respectively.
摘要翻译： 本发明提供了通过将负载载体的纳米颗粒与具有归巢能力的细胞结合来将药剂递送到体内的局部区域，组织或器官的组合物和方法。 这些试剂可以分别是治疗剂或诊断剂，例如癌症化学治疗剂和成像剂。
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公开(公告)号：US20100323018A1
公开(公告)日：2010-12-23
申请号：US12456592
申请日：2009-06-17
申请人： Darrell J. Irvine , Soong Ho Um
发明人： Darrell J. Irvine , Soong Ho Um
IPC分类号： A61K9/14 , C07H21/02 , A61K31/7105 , C12P19/34 , A61P43/00
CPC分类号： A61K31/00 , A61K9/0019 , A61K9/06 , A61K9/127 , A61K9/1271 , A61K31/704 , A61K31/7105 , A61K31/711 , A61K49/0002 , C07H21/00 , C12N15/111 , C12N15/88 , C12N2310/14 , C12N2310/3519 , C12N2310/52 , C12N2320/32 , C12N2330/30 , C12P19/34
摘要： The invention provides compositions and methods relating to delivery of agents in vivo or in vitro. More specifically, the invention provides nanoparticles synthesized from crosslinked nucleic acids, optionally having a lipid shell or coating, and may further comprise for example small molecule or high molecular weight compounds as therapeutic or diagnostic agents.
摘要翻译： 本发明提供了与体内或体外递送试剂有关的组合物和方法。 更具体地，本发明提供了由交联的核酸合成的纳米颗粒，任选地具有脂壳或涂层，并且还可以包含例如作为治疗剂或诊断剂的小分子或高分子量化合物。
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公开(公告)号：US08323637B2
公开(公告)日：2012-12-04
申请号：US12421162
申请日：2009-04-09
CPC分类号： C12N5/0006 , C12N5/0634 , C12N2533/30
摘要： Uniform, functional polymer patches can be attached to a fraction of the surface area of living individual cells. These surface-modified cells remain viable after attachment of the functional patch. The patch does not completely occlude the cellular surface from the surrounding environment. Functional payloads carried by the patch may include, for example, drugs or other small molecules, peptides, proteins, thermally responsive polymers, and nanoparticles, or any other material that can be incorporated in a polymer patch of subcellular dimensions. The patch can include one or more polyelectrolyte multilayers (PEMs).
摘要翻译： 均匀的功能性聚合物贴剂可以附着在活细胞表面积的一部分。 这些表面修饰的细胞在附着功能性贴片后保持活性。 贴片不会完全遮挡周围环境中的细胞表面。 由贴片携带的功能性有效载荷可以包括例如药物或其它小分子，肽，蛋白质，热响应聚合物和纳米颗粒，或可并入亚细胞尺寸的聚合物贴片中的任何其它材料。 贴剂可以包括一种或多种聚电解质多层（PEM）。
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7.发明申请公开(公告)号：US20120027837A1
公开(公告)日：2012-02-02
申请号：US13115107
申请日：2011-05-24
CPC分类号： A61K9/0021 , A61M37/0015 , A61M2037/0023 , A61M2037/003 , A61M2037/0046 , A61M2037/0053 , C12N5/0068 , C12N2533/30 , C12N2533/40 , C12N2533/50 , Y10T428/31562 , Y10T428/31725 , Y10T428/31736
摘要： The present invention provides, among other things, multilayer film coating compositions, coated substrates and methods thereof In some embodiments, a structure, comprising a substrate and a multilayer film on the substrate, wherein the multilayer film comprises a first plurality of first units, each first unit comprising a protamine polypeptide. In some embodiments, a structure comprising a microneedle substrate and a multilayer film coated on at least portion of the microneedle substrate, wherein the multilayer film comprises an agent for release and a first plurality of first unit; each first unit comprising a first layer and a second layer, wherein the first layer and the second layer are associated with one another.
摘要翻译： 本发明尤其提供了多层膜涂料组合物，涂覆的基材及其方法。在一些实施方案中，包括基材和基材上的多层膜的结构，其中所述多层膜包括第一多个第一单元，每个第一单元 第一单位包含鱼精蛋白多肽。 在一些实施例中，包括微针基底和涂覆在微针基底的至少部分上的多层膜的结构，其中所述多层膜包括用于释放的试剂和第一多个第一单元; 每个第一单元包括第一层和第二层，其中第一层和第二层彼此相关联。
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公开(公告)号：US20090258057A1
公开(公告)日：2009-10-15
申请号：US12421162
申请日：2009-04-09
CPC分类号： C12N5/0006 , C12N5/0634 , C12N2533/30
摘要： Uniform, functional polymer patches can be attached to a fraction of the surface area of living individual cells. These surface-modified cells remain viable after attachment of the functional patch. The patch does not completely occlude the cellular surface from the surrounding environment. Functional payloads carried by the patch may include, for example, drugs or other small molecules, peptides, proteins, thermally responsive polymers, and nanoparticles, or any other material that can be incorporated in a polymer patch of subcellular dimensions. The patch can include one or more polyelectrolyte multilayers (PEMs).
摘要翻译： 均匀的功能性聚合物贴剂可以附着在活细胞表面积的一部分。 这些表面修饰的细胞在附着功能性贴片后保持活性。 贴片不会完全遮挡周围环境中的细胞表面。 由贴片携带的功能性有效载荷可以包括例如药物或其它小分子，肽，蛋白质，热响应聚合物和纳米颗粒，或可并入亚细胞尺寸的聚合物贴片中的任何其它材料。 贴剂可以包括一种或多种聚电解质多层（PEM）。
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公开(公告)号：US09149432B2
公开(公告)日：2015-10-06
申请号：US13400076
申请日：2012-02-19
申请人： Darrell J. Irvine , Jaehyun Moon
发明人： Darrell J. Irvine , Jaehyun Moon
IPC分类号： A61K9/127 , A61K47/44 , A61P33/06 , C12N5/071 , A61K39/015 , A61K39/21 , A61K39/39 , A61K47/48 , C07K14/005 , C12N15/88 , A61K39/00
CPC分类号： A61K39/385 , A61K9/127 , A61K9/1271 , A61K9/1273 , A61K38/193 , A61K38/20 , A61K38/2013 , A61K38/2046 , A61K38/208 , A61K38/2086 , A61K38/212 , A61K38/217 , A61K38/45 , A61K39/00 , A61K39/015 , A61K39/12 , A61K39/21 , A61K39/39 , A61K39/39533 , A61K47/6811 , A61K47/6911 , A61K2039/55511 , A61K2039/55555 , A61K2039/55572 , A61K2039/57 , A61K2039/572 , A61K2039/575 , A61K2039/6018 , C07K14/005 , C12N15/88 , C12N2740/15034 , C12N2740/16234 , C12Y207/10001 , Y02A50/412
摘要： The invention provides delivery systems comprised of stabilized multilamellar vesicles, as well as compositions, methods of synthesis, and methods of use thereof. The stabilized multilamellar vesicles comprise terminal-cysteine-bearing antigens or cysteine-modified antigens, at their surface and/or internally.
摘要翻译： 本发明提供由稳定的多层泡囊组成的递送系统，以及组合物，合成方法及其使用方法。 稳定的多层囊泡在其表面和/或内部包含带有末端半胱氨酸的抗原或半胱氨酸修饰的抗原。
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公开(公告)号：US08288159B2
公开(公告)日：2012-10-16
申请号：US12725698
申请日：2010-03-17
申请人： William L Warren , Heather Fahlenkamp , Russell Higbee , Anatoly Kachurin , Conan Li , Mike Nguyen , Robert Parkhill , Guzman Sanchez-Schmitz , Darrell J. Irvine , Gwendalyn J. Randolph , Nir Harcohen , Bruce Torbett
发明人： William L Warren , Heather Fahlenkamp , Russell Higbee , Anatoly Kachurin , Conan Li , Mike Nguyen , Robert Parkhill , Guzman Sanchez-Schmitz , Darrell J. Irvine , Gwendalyn J. Randolph , Nir Harcohen , Bruce Torbett
CPC分类号： G01N33/5008 , C12N5/0697 , C12N5/0698 , C12N2501/21 , C12N2502/094 , C12N2502/11 , C12N2502/1107 , C12N2502/1114 , C12N2502/1121 , C12N2502/1157 , C12N2502/1192 , C12N2502/1323 , C12N2502/28 , C12N2503/04 , C12N2513/00 , C12N2531/00 , C12N2533/50 , C12N2533/54 , C12N2535/10 , G01N33/5088 , G01N2500/10
摘要： The present invention relates to methods of constructing an integrated artificial immune system that comprises appropriate in vitro cellular and tissue constructs or their equivalents to mimic the normal tissues that interact with vaccines in mammals. The artificial immune system can be used to test the efficacy of vaccine candidates in vitro and thus, is useful to accelerate vaccine development and testing drug and chemical interaction with the immune system.
摘要翻译： 本发明涉及构建综合人造免疫系统的方法，其包括适当的体外细胞和组织构建体或其等同物以模拟与哺乳动物中的疫苗相互作用的正常组织。 人工免疫系统可用于测试疫苗候选物在体外的功效，因此可用于加速疫苗开发和测试与免疫系统的药物和化学相互作用。
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