摘要:
The present invention provides crystalline forms of domain III of the West Nile Virus (“WNV”) envelope protein in complex with a Fab fragment of a neutralizing antibody, methods of obtaining such crystals and high-resolution structures and atomic structure coordinates. The crystals of the invention and the atomic structural information are useful for solving crystal and solution structures of related and unrelated proteins, and for screening for, identifying or designing compounds or antibodies that bind to, modulate a biological activity of, or neutralize infection mediated by flaviviral envelope proteins.
摘要:
The present invention provides crystalline forms of domain III of the West Nile Virus (“WNV”) envelope protein in complex with a Fab fragment of a neutralizing antibody, methods of obtaining such crystals and high-resolution structures and atomic structure coordinates. The crystals of the invention and the atomic structural information are useful for solving crystal and solution structures of related and unrelated proteins, and for screening for, identifying or designing compounds or antibodies that bind to, modulate a biological activity of, or neutralize infection mediated by flaviviral envelope proteins.
摘要:
Multichip graphics processing subsystems include at least three distinct graphics devices (e.g., expansion cards) coupled to a high-speed bus (e.g., a PCI Express bus) and operable in a distributed rendering mode. One of the graphics devices provides pixel data to a display device, and at least one of the other graphics devices transfers the pixel data it generates to another of the devices via the bus to be displayed. Where the high-speed bus provides data transfer lanes, allocation of lanes among the graphics devices can be optimized.
摘要:
A graphics system is disclosed. The graphics system includes at least one GPU (graphics processing unit) for processing a compute workload. The graphics system uses a multi-user manager for allocating the compute workload capability for each one of a plurality of users. Each user will use an access terminal.
摘要:
A die micro electro-mechanical switch management system and method facilitate power conservation by selectively preventing electrical current from flowing in designated components. A present invention semiconductor die comprises a block of transistors for performing switching operations, a bus (e.g., a power bus, a signal bus, etc.) for conveying electrical current and a micro electro-mechanical switch that couples and decouples the block of transistors to and from the bus. The micro electro-mechanical switch is opened and closed depending upon operations (e.g., switching operations) being performed by the block of transistors. Electrical current is prevented from flowing to the block of transistors when the micro electro-mechanical switch is open and the block of transistors is electrically isolated. The micro electro-mechanical switch can interrupt electrical current flow in a plurality of the bus lines and/or can be included in a relay array.
摘要:
A scalable discrete graphics system (DGS) is disclosed. The DGS includes a serial bus bridge configured to couple a plurality of GPUs to a serial bus. A serial bus connector is coupled to the serial bus bridge. A system chassis coupled to the serial bus bridge and the serial bus connector and configured to house the GPUs. The serial bus connector is configured to removably connect to a computer system. The GPUs access the computer system via the serial bus bridge and the serial bus connector to cooperatively execute 3-D graphics instructions from the computer system.
摘要:
A discrete graphics system (DGS) for executing 3D graphics instructions for a computer system is disclosed. The discrete graphics system includes a GPU for executing 3D graphics instructions and a DGS system chassis configured to house the GPU. A serial bus connector coupled is to the GPU and the DGS chassis. The serial bus connector is configured to removably connect the DGS and the GPU to the computer system. The GPU of the DGS accesses the computer system via the serial bus connector to execute the 3D graphics instructions for the computer system.
摘要:
A DGS (discrete graphics system) unit is disclosed. The DGS unit includes a system chassis configured to house a GPU, the GPU for executing 3-D graphics instructions, and a GPU mounting unit coupled to the system chassis and configured to receive the GPU. A serial bus connector is coupled to the chassis and is coupled to the GPU mounting unit, wherein the serial bus connector is configured removably connect the GPU to a computer system to enable the GPU to access the computer system via the serial bus connector and execute the 3-D graphics instructions for the computer system. A power supply coupled to the system chassis for supplying power to the GPU independent of the computer system.
摘要:
Aromatase inhibitors are administered to a female patient prior to endometrial ablation or resection procedures in order to thin the endometrium to a thickness of less than 6 mm, and preferably less than 4 mm, so as to enhance the treatment outcome. Of course, administration of aromatase inhibitors would be useful for other surgical procedures on the endometrial cavity and the uterus. Commercially available aromatase inhibitors, including, the nonsteroidal preparations, anastrozole and letrozole, and a steroidal agent, exemestane, are well-tolerated, and have been shown to decrease serum estrogen levels. The aromatase inhibitor can be used alone, or in combination with other aromatase inhibitors or pharmaceutical agents, such as hormones.
摘要:
The present invention relates to compositions comprising antibodies or fragments thereof that immunospecifically bind to one or more antigens of a flavivirus, particularly of West Nile Virus (WNV), and methods for preventing, treating or ameliorating symptoms associated with a flavivirus, particularly of West Nile Virus (WNV), infection utilizing said compositions. In particular, the present invention relates to methods for preventing, treating or ameliorating symptoms associated with WNV infection, said methods comprising administering to a human subject an effective amount of one or more antibodies or fragments thereof that immunospecifically bind to a WNV antigen. The present invention also relates to detectable or diagnostic compositions comprising antibodies or fragments thereof that immunospecifically bind to a WNV antigen and methods for detecting or diagnosing WNV infection utilizing said compositions.