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公开(公告)号:US07910595B2
公开(公告)日:2011-03-22
申请号:US11613810
申请日:2006-12-20
申请人: David A. Betebenner , David A. DeGoey , Clarence J. Maring , Allan C. Krueger , Nobuhiko Iwasaki , Todd W. Rockway , Curt S. Cooper , David D. Anderson , Pamela L. Donner , Brian E. Green , Dale J. Kempf , Dachun Liu , Keith F. McDaniel , Darold L. Madigan , Christopher E. Motter , John K. Pratt , Jason P. Shanley , Michael D. Tufano , Rolf Wagner , Rong Zhang , Akhteruzzaman Molla , Hongmei Mo , Tami J. Pilot-Matias , Sherie V L. Masse , Robert J. Carrick , Wenping He , Liangjun Lu , David J. Grampovnik
发明人: David A. Betebenner , David A. DeGoey , Clarence J. Maring , Allan C. Krueger , Nobuhiko Iwasaki , Todd W. Rockway , Curt S. Cooper , David D. Anderson , Pamela L. Donner , Brian E. Green , Dale J. Kempf , Dachun Liu , Keith F. McDaniel , Darold L. Madigan , Christopher E. Motter , John K. Pratt , Jason P. Shanley , Michael D. Tufano , Rolf Wagner , Rong Zhang , Akhteruzzaman Molla , Hongmei Mo , Tami J. Pilot-Matias , Sherie V L. Masse , Robert J. Carrick , Wenping He , Liangjun Lu , David J. Grampovnik
IPC分类号: C07D471/04 , A01N31/519 , A61P31/12
CPC分类号: C07D471/04 , C07D495/04 , C07D513/04
摘要: Compounds effective in inhibiting replication of Hepatitis C virus (“HCV”) or other viruses are disclosed. This invention is also directed to compositions comprising such compounds, co-formulation or co-administration of such compounds with other anti-viral or therapeutic agents, processes and intermediates for the syntheses of such compounds, and methods of using such compounds for the treatment of HCV or other viral infections.
摘要翻译: 公开了有效抑制丙型肝炎病毒(“HCV”)或其他病毒复制的化合物。 本发明还涉及包含这些化合物的组合物,这些化合物与其它抗病毒剂或治疗剂的共同配制或共同给药,用于合成这些化合物的方法和中间体,以及使用这些化合物治疗 HCV或其他病毒感染。
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公开(公告)号:US08236950B2
公开(公告)日:2012-08-07
申请号:US11960298
申请日:2007-12-19
申请人: David A. Betebenner , Clarence J. Maring , Todd W. Rockway , Curt S. Cooper , David D. Anderson , Rolf Wagner , Rong Zhang , Akhteruzzaman Molla , Hongmei Mo , Tami J. Pilot-Matias , Sherie V L. Masse , Robert J. Carrick , Wenping He , Liangjun Lu
发明人: David A. Betebenner , Clarence J. Maring , Todd W. Rockway , Curt S. Cooper , David D. Anderson , Rolf Wagner , Rong Zhang , Akhteruzzaman Molla , Hongmei Mo , Tami J. Pilot-Matias , Sherie V L. Masse , Robert J. Carrick , Wenping He , Liangjun Lu
IPC分类号: C07D491/02
CPC分类号: C07D471/04 , C07D239/94 , C07D487/04 , C07D487/14 , C07D519/00
摘要: Compounds effective in inhibiting replication of Hepatitis C virus (“HCV”) or other viruses are disclosed. This invention is also directed to compositions comprising such compounds, co-formulation or co-administration of such compounds with other anti-viral or therapeutic agents, processes and intermediates for the syntheses of such compounds, and methods of using such compounds for the treatment of HCV or other viral infections.
摘要翻译: 公开了有效抑制丙型肝炎病毒(“HCV”)或其他病毒复制的化合物。 本发明还涉及包含这些化合物的组合物,这些化合物与其它抗病毒剂或治疗剂的共同配制或共同给药,用于合成这些化合物的方法和中间体,以及使用这些化合物治疗 HCV或其他病毒感染。
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公开(公告)号:US07915411B2
公开(公告)日:2011-03-29
申请号:US11613825
申请日:2006-12-20
申请人: David A. Betebenner , David A. DeGoey , Clarence J. Maring , Allan C. Krueger , Nobuhiko Iwasaki , Todd W. Rockway , Curt S. Cooper , David D. Anderson , Pamela L. Donner , Brian E. Green , Dale J. Kempf , Dachun Liu , Keith F. McDaniel , Darold L. Madigan , Christopher E. Motter , John K. Pratt , Jason P. Shanley , Michael D. Tufano , Rolf Wagner , Rong Zhang , Akhteruzzaman Molla , Hongmei Mo , Tami J. Pilot-Matias , Sherie V L. Masse , Robert J. Carrick , Wenping He , Liangjun Lu , David J. Grampovnik
发明人: David A. Betebenner , David A. DeGoey , Clarence J. Maring , Allan C. Krueger , Nobuhiko Iwasaki , Todd W. Rockway , Curt S. Cooper , David D. Anderson , Pamela L. Donner , Brian E. Green , Dale J. Kempf , Dachun Liu , Keith F. McDaniel , Darold L. Madigan , Christopher E. Motter , John K. Pratt , Jason P. Shanley , Michael D. Tufano , Rolf Wagner , Rong Zhang , Akhteruzzaman Molla , Hongmei Mo , Tami J. Pilot-Matias , Sherie V L. Masse , Robert J. Carrick , Wenping He , Liangjun Lu , David J. Grampovnik
IPC分类号: C07D471/04 , A61P1/16
CPC分类号: C07D487/04 , C07D471/04 , C07D475/06 , C07D495/04 , C07D513/04
摘要: Compounds effective in inhibiting replication of Hepatitis C virus (“HCV”) or other viruses are disclosed. This invention is also directed to compositions comprising such compounds, co-formulation or co-administration of such compounds with other anti-viral or therapeutic agents, processes and intermediates for the syntheses of such compounds, and methods of using such compounds for the treatment of HCV or other viral infections.
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公开(公告)号:US20110160233A1
公开(公告)日:2011-06-30
申请号:US11960298
申请日:2007-12-19
申请人: David A. Betebenner , Clarence J. Maring , Todd W. Rockway , Curt S. Cooper , David D. Anderson , Rolf Wagner , Rong Zhang , Akhteruzzaman Molla , Hongmei Mo , Tami J. Pilot-Matias , Sherie VL. Masse , Robert J. Carrick , Wenping He , Liangjun Lu
发明人: David A. Betebenner , Clarence J. Maring , Todd W. Rockway , Curt S. Cooper , David D. Anderson , Rolf Wagner , Rong Zhang , Akhteruzzaman Molla , Hongmei Mo , Tami J. Pilot-Matias , Sherie VL. Masse , Robert J. Carrick , Wenping He , Liangjun Lu
IPC分类号: A61K31/519 , C07D471/14 , A61P31/14
CPC分类号: C07D471/04 , C07D239/94 , C07D487/04 , C07D487/14 , C07D519/00
摘要: Compounds effective in inhibiting replication of Hepatitis C virus (“HCV”) or other viruses are disclosed. This invention is also directed to compositions comprising such compounds, co-formulation or co-administration of such compounds with other anti-viral or therapeutic agents, processes and intermediates for the syntheses of such compounds, and methods of using such compounds for the treatment of HCV or other viral infections.
摘要翻译: 公开了有效抑制丙型肝炎病毒(“HCV”)或其他病毒复制的化合物。 本发明还涉及包含这些化合物的组合物,这些化合物与其它抗病毒剂或治疗剂的共同配制或共同给药,用于合成这些化合物的方法和中间体,以及使用这些化合物治疗 HCV或其他病毒感染。
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公开(公告)号:US08338605B2
公开(公告)日:2012-12-25
申请号:US12817808
申请日:2010-06-17
申请人: Todd W. Rockway , David A. Betebenner , Allan C. Krueger , Nobuhiko Iwasaki , Curt S. Cooper , David D. Anderson , Dale J. Kempf , Darold L. Madigan , Christopher E. Motter , Jason P. Shanley , Michael D. Tufano , Rolf Wagner , Rong Zhang , Akteruzzaman Molla , Hongmei Mo , Tami J. Pilot-Matias , Sherie V. L. Masse , Robert J. Carrick , Wenping He , Liangjun Lu
发明人: Todd W. Rockway , David A. Betebenner , Allan C. Krueger , Nobuhiko Iwasaki , Curt S. Cooper , David D. Anderson , Dale J. Kempf , Darold L. Madigan , Christopher E. Motter , Jason P. Shanley , Michael D. Tufano , Rolf Wagner , Rong Zhang , Akteruzzaman Molla , Hongmei Mo , Tami J. Pilot-Matias , Sherie V. L. Masse , Robert J. Carrick , Wenping He , Liangjun Lu
IPC分类号: C07D471/02
CPC分类号: C07D471/04
摘要: Compounds effective in inhibiting replication of Hepatitis C virus (“HCV”) or other viruses are disclosed. This invention is also directed to compositions comprising such compounds, co-formulation or co-administration of such compounds with other anti-viral or therapeutic agents, processes and intermediates for the syntheses of such compounds, and methods of using such compounds for the treatment of HCV or other viral infections.
摘要翻译: 公开了有效抑制丙型肝炎病毒(HCV)或其他病毒复制的化合物。 本发明还涉及包含这些化合物的组合物,这些化合物与其它抗病毒剂或治疗剂的共同配制或共同给药,用于合成这些化合物的方法和中间体,以及使用这些化合物治疗 HCV或其他病毒感染。
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公开(公告)号:US07763731B2
公开(公告)日:2010-07-27
申请号:US11613836
申请日:2006-12-20
申请人: Todd W. Rockway , David A. Betebenner , Allan C. Krueger , Nobuhiko Iwasaki , Curt S. Cooper , David D. Anderson , Dale J. Kempf , Darold L. Madigan , Christopher E. Motter , Jason P. Shanley , Michael D. Tufano , Rolf Wagner , Rong Zhang , Akhteruzzaman Molla , Hongmei Mo , Tami J. Pilot-Matias , Sherie VL. Masse , Robert J. Carrick , Wenping He , Liangjun Lu
发明人: Todd W. Rockway , David A. Betebenner , Allan C. Krueger , Nobuhiko Iwasaki , Curt S. Cooper , David D. Anderson , Dale J. Kempf , Darold L. Madigan , Christopher E. Motter , Jason P. Shanley , Michael D. Tufano , Rolf Wagner , Rong Zhang , Akhteruzzaman Molla , Hongmei Mo , Tami J. Pilot-Matias , Sherie VL. Masse , Robert J. Carrick , Wenping He , Liangjun Lu
IPC分类号: C07D471/02
CPC分类号: C07D471/04
摘要: Compounds effective in inhibiting replication of Hepatitis C virus (“HCV”) or other viruses are disclosed. This invention is also directed to compositions comprising such compounds, co-formulation or co-administration of such compounds with other anti-viral or therapeutic agents, processes and intermediates for the syntheses of such compounds, and methods of using such compounds for the treatment of HCV or other viral infections.
摘要翻译: 公开了有效抑制丙型肝炎病毒(“HCV”)或其他病毒复制的化合物。 本发明还涉及包含这些化合物的组合物,这些化合物与其它抗病毒剂或治疗剂的共同配制或共同给药,用于合成这些化合物的方法和中间体,以及使用这些化合物治疗 HCV或其他病毒感染。
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公开(公告)号:US20100256139A1
公开(公告)日:2010-10-07
申请号:US12817808
申请日:2010-06-17
申请人: Todd W. Rockway , David A. Betebenner , Allan C. Krueger , Nobuhiko Iwasaki , Curt S. Cooper , David D. Anderson , Dale J. Kempf , Darold L. Madigan , Christopher E. Motter , Jason P. Shanley , Michael D. Tufano , Rolf Wagner , Rong Zhang , Akhteruzzaman Molla , Hongmei Mo , Tami J. Pilot-Matias , Sherie V.L. Masse , Robert J. Carrick , Wenping He , Liangjun Lu
发明人: Todd W. Rockway , David A. Betebenner , Allan C. Krueger , Nobuhiko Iwasaki , Curt S. Cooper , David D. Anderson , Dale J. Kempf , Darold L. Madigan , Christopher E. Motter , Jason P. Shanley , Michael D. Tufano , Rolf Wagner , Rong Zhang , Akhteruzzaman Molla , Hongmei Mo , Tami J. Pilot-Matias , Sherie V.L. Masse , Robert J. Carrick , Wenping He , Liangjun Lu
IPC分类号: A61K31/5377 , C07D471/04 , A61K31/444 , A61P31/14
CPC分类号: C07D471/04
摘要: Compounds effective in inhibiting replication of Hepatitis C virus (“HCV”) or other viruses are disclosed. This invention is also directed to compositions comprising such compounds, co-formulation or co-administration of such compounds with other anti-viral or therapeutic agents, processes and intermediates for the syntheses of such compounds, and methods of using such compounds for the treatment of HCV or other viral infections.
摘要翻译: 公开了有效抑制丙型肝炎病毒(“HCV”)或其他病毒复制的化合物。 本发明还涉及包含这些化合物的组合物,这些化合物与其它抗病毒剂或治疗剂的共同配制或共同给药,用于合成这些化合物的方法和中间体,以及使用这些化合物治疗 HCV或其他病毒感染。
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公开(公告)号:US08748443B2
公开(公告)日:2014-06-10
申请号:US13260199
申请日:2010-03-25
申请人: David A. Betebenner , John K. Pratt , David A. DeGoey , Pamela L. Donner , Charles A. Flentge , Douglas K. Hutchinson , Warren M. Kati , Allan C. Krueger , Kenton L. Longenecker , Clarence J. Maring , John T. Randolph , Todd W. Rockway , Michael D. Tufano , Rolf Wagner , Dachun Liu
发明人: David A. Betebenner , John K. Pratt , David A. DeGoey , Pamela L. Donner , Charles A. Flentge , Douglas K. Hutchinson , Warren M. Kati , Allan C. Krueger , Kenton L. Longenecker , Clarence J. Maring , John T. Randolph , Todd W. Rockway , Michael D. Tufano , Rolf Wagner , Dachun Liu
IPC分类号: A01N43/54 , A61K31/505 , A61K31/503 , C07D239/54
CPC分类号: C07D409/10 , A61K31/18 , A61K31/27 , A61K31/402 , A61K31/4166 , A61K31/421 , A61K31/425 , A61K31/4418 , A61K31/503 , A61K31/513 , A61K45/06 , C07C311/08 , C07D207/27 , C07D213/64 , C07D233/32 , C07D233/72 , C07D239/10 , C07D239/54 , C07D263/22 , C07D263/24 , C07D275/02 , C07D403/10 , C07D405/10 , Y02P20/55
摘要: This invention relates to: (a) compounds and salts thereof that, inter alia, inhibit HCV; (b) intermediates useful for the preparation of such compounds and salts; (c) compositions comprising such compounds and salts; (d) methods for preparing such intermediates, compounds, salts, and compositions; (e) methods of use of such compounds, salts, and compositions; and (f) kits comprising such compounds, salts, and compositions.
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公开(公告)号:US08691938B2
公开(公告)日:2014-04-08
申请号:US12813301
申请日:2010-06-10
申请人: David A. DeGoey , Warren M. Kati , Charles W. Hutchins , Pamela L. Donner , Allan C. Krueger , John T. Randolph , Christopher E. Motter , Lissa T. Nelson , Sachin V. Patel , Mark A. Matulenko , Ryan G. Keddy , Tammie K. Jinkerson , Yi Gao , Dachun Liu , John K. Pratt , Todd W. Rockway , Clarence J. Maring , Douglas K. Hutchinson , Charles A. Flentge , Rolf Wagner , Michael D. Tufano , David A. Betebenner , Kathy Sarris , Kevin R. Woller , Seble H. Wagaw , Jean C. Califano , Wenke Li , Daniel D. Caspi , Mary E. Bellizzi
发明人: David A. DeGoey , Warren M. Kati , Charles W. Hutchins , Pamela L. Donner , Allan C. Krueger , John T. Randolph , Christopher E. Motter , Lissa T. Nelson , Sachin V. Patel , Mark A. Matulenko , Ryan G. Keddy , Tammie K. Jinkerson , Yi Gao , Dachun Liu , John K. Pratt , Todd W. Rockway , Clarence J. Maring , Douglas K. Hutchinson , Charles A. Flentge , Rolf Wagner , Michael D. Tufano , David A. Betebenner , Kathy Sarris , Kevin R. Woller , Seble H. Wagaw , Jean C. Califano , Wenke Li , Daniel D. Caspi , Mary E. Bellizzi
CPC分类号: C07F9/65583 , C07C33/26 , C07C201/06 , C07C205/19 , C07D207/08 , C07D207/09 , C07D207/16 , C07D401/14 , C07D403/14 , C07D405/14 , C07D413/14 , C07D417/14 , C07D453/00 , C07D471/04 , C07D491/113 , C07K5/06
摘要: Compounds effective in inhibiting replication of Hepatitis C virus (“HCV”) are described. This invention also relates to processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection.
摘要翻译: 描述了有效抑制丙型肝炎病毒(“HCV”)复制的化合物。 本发明还涉及制备这种化合物的方法,包含这些化合物的组合物,以及使用这些化合物治疗HCV感染的方法。
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公开(公告)号:US20120004196A1
公开(公告)日:2012-01-05
申请号:US13100827
申请日:2011-05-04
申请人: David A. DeGoey , Warren M. Kati , Charles W. Hutchins , Pamela L. Donner , Allan C. Krueger , John T. Randolph , Christopher E. Motter , Lissa T. Nelson , Sachin V. Patel , Mark A. Matulenko , Ryan G. Keddy , Tammie K. Jinkerson , Yi Gao , Dachun Liu , John K. Pratt , Todd W. Rockway , Clarence J. Maring , Douglas K. Hutchinson , Charles A. Flentge , Rolf Wagner , Michael D. Tufano , David A. Betebenner , Kathy Sarris , Kevin R. Woller , Seble H. Wagaw , Jean C. Califano , Wenke Li , Daniel D. Caspi , Mary E. Bellizzi , William A. Carroll
发明人: David A. DeGoey , Warren M. Kati , Charles W. Hutchins , Pamela L. Donner , Allan C. Krueger , John T. Randolph , Christopher E. Motter , Lissa T. Nelson , Sachin V. Patel , Mark A. Matulenko , Ryan G. Keddy , Tammie K. Jinkerson , Yi Gao , Dachun Liu , John K. Pratt , Todd W. Rockway , Clarence J. Maring , Douglas K. Hutchinson , Charles A. Flentge , Rolf Wagner , Michael D. Tufano , David A. Betebenner , Kathy Sarris , Kevin R. Woller , Seble H. Wagaw , Jean C. Califano , Wenke Li , Daniel D. Caspi , Mary E. Bellizzi , William A. Carroll
IPC分类号: A61K31/4184 , C07D401/14 , C07D405/14 , C07D413/14 , C07F7/10 , A61K31/454 , A61K31/4439 , A61K31/422 , A61K31/438 , A61K31/4545 , A61K31/695 , A61K31/496 , A61K31/506 , A61K31/5377 , A61P31/14 , C07D403/14
CPC分类号: A61K31/454 , A61K31/4178 , A61K31/4184 , A61K31/422 , A61K31/435 , A61K31/4355 , A61K31/438 , A61K31/4418 , A61K31/4439 , A61K31/4545 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/695 , A61K45/06 , C07D401/14 , C07D403/14 , C07D405/14 , C07D413/14 , C07D417/14 , C07D453/00 , C07D491/113 , C07F7/02 , Y02P20/582
摘要: Compounds effective in inhibiting replication of Hepatitis C virus (“HCV”) are described. This invention also relates to processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection.
摘要翻译: 描述了有效抑制丙型肝炎病毒(“HCV”)复制的化合物。 本发明还涉及制备这种化合物的方法,包含这些化合物的组合物,以及使用这些化合物治疗HCV感染的方法。
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