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公开(公告)号：US10292658B2
公开(公告)日：2019-05-21
申请号：US15190534
申请日：2016-06-23
IPC分类号： A61B5/0402 , A61B5/00 , A61B5/11 , A61B5/0205 , A61B5/02 , A47K13/24 , A61B5/024 , A61B5/053 , A61B5/01
摘要： Apparatus, system and method for medical analysis of a seated individual, includes determining the aortic valve opening; the PTT; and calculating the PWV. Determining the aortic valve opening includes collecting BCG data while sitting on a seat and determining the timing of the aortic valve opening, taking into account posture. Measuring the aortic pulse wave transit time includes collecting BCG data while sitting on a seat capable of measuring changes in apparent weight; determining the timing of the aortic valve opening; detecting the arrival of the pulse wave at the end point; and measuring the relative timings of the two events. Calculating the PWV includes determining a length of the arterial segment through which a pulse wave is to be measured between a start point and an end point; and dividing the determined length of the arterial segment by the PTT.
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公开(公告)号：US20190231271A1
公开(公告)日：2019-08-01
申请号：US16377938
申请日：2019-04-08
IPC分类号： A61B5/00 , A61B5/11 , A61B5/0402 , A61B5/02 , A47K13/24 , A61B5/0205
CPC分类号： A61B5/6891 , A47K13/24 , A61B5/01 , A61B5/02028 , A61B5/02055 , A61B5/02416 , A61B5/0402 , A61B5/053 , A61B5/1102 , A61B5/14551 , A61B5/4561 , A61B5/7246
摘要： Apparatus, system and method for medical analysis of a seated individual, includes determining the aortic valve opening; the PTT; and calculating the PWV. Determining the aortic valve opening includes collecting BCG data while sitting on a seat and determining the timing of the aortic valve opening, taking into account posture. Measuring the aortic pulse wave transit time includes collecting BCG data while sitting on a seat capable of measuring changes in apparent weight; determining the timing of the aortic valve opening; detecting the arrival of the pulse wave at the end point; and measuring the relative timings of the two events. Calculating the PWV includes determining a length of the arterial segment through which a pulse wave is to be measured between a start point and an end point; and dividing the determined length of the arterial segment by the PTT.
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公开(公告)号：US11234651B2
公开(公告)日：2022-02-01
申请号：US16377938
申请日：2019-04-08
IPC分类号： A61B5/0402 , A61B5/00 , A61B5/11 , A61B5/02 , A47K13/24 , A61B5/318 , A61B5/0205 , A61B5/1455 , A61B5/01 , A61B5/024 , A61B5/053
摘要： Apparatus, system and method for medical analysis of a seated individual, includes determining the aortic valve opening; the PTT; and calculating the PWV. Determining the aortic valve opening includes collecting BCG data while sitting on a seat and determining the timing of the aortic valve opening, taking into account posture. Measuring the aortic pulse wave transit time includes collecting BCG data while sitting on a seat capable of measuring changes in apparent weight; determining the timing of the aortic valve opening; detecting the arrival of the pulse wave at the end point; and measuring the relative timings of the two events. Calculating the PWV includes determining a length of the arterial segment through which a pulse wave is to be measured between a start point and an end point; and dividing the determined length of the arterial segment by the PTT.
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公开(公告)号：US20160374619A1
公开(公告)日：2016-12-29
申请号：US15190534
申请日：2016-06-23
IPC分类号： A61B5/00 , A61B5/0402 , A47K13/24 , A61B5/02 , A47K13/12 , A61B5/11 , A61B5/0205
CPC分类号： A61B5/6891 , A47K13/24 , A61B5/01 , A61B5/02028 , A61B5/02055 , A61B5/02416 , A61B5/0402 , A61B5/053 , A61B5/1102 , A61B5/14551 , A61B5/4561 , A61B5/7246
摘要： Apparatus, system and method for medical analysis of a seated individual, includes determining the aortic valve opening; the PTT; and calculating the PWV. Determining the aortic valve opening includes collecting BCG data while sitting on a seat and determining the timing of the aortic valve opening, taking into account posture. Measuring the aortic pulse wave transit time includes collecting BCG data while sitting on a seat capable of measuring changes in apparent weight; determining the timing of the aortic valve opening; detecting the arrival of the pulse wave at the end point; and measuring the relative timings of the two events. Calculating the PWV includes determining a length of the arterial segment through which a pulse wave is to be measured between a start point and an end point; and dividing the determined length of the arterial segment by the PTT.
摘要翻译： 用于就座个体的医学分析的装置，系统和方法包括确定主动脉瓣开口; PTT; 并计算PWV。 确定主动脉瓣开口包括在坐在座位上时收集BCG数据并且考虑到姿势来确定主动脉瓣开放的时间。 测量主动脉脉搏波传播时间包括：坐在能够测量表观重量变化的座位上收集BCG数据; 确定主动脉瓣开放的时间; 检测脉波在终点的到达; 并测量两个事件的相对时间。 计算PWV包括确定在起始点和终点之间测量脉搏波的动脉段的长度; 并将确定的动脉段长度除以PTT。
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公开(公告)号：US20220218286A1
公开(公告)日：2022-07-14
申请号：US17557264
申请日：2021-12-21
摘要： Apparatus, system and method for medical analysis of a seated individual, includes determining the aortic valve opening; the PTT; and calculating the PWV. Determining the aortic valve opening includes collecting BCG data while sitting on a seat and determining the timing of the aortic valve opening, taking into account posture. Measuring the aortic pulse wave transit time includes collecting BCG data while sitting on a seat capable of measuring changes in apparent weight; determining the timing of the aortic valve opening; detecting the arrival of the pulse wave at the end point; and measuring the relative timings of the two events. Calculating the PWV includes determining a length of the arterial segment through which a pulse wave is to be measured between a start point and an end point; and dividing the determined length of the arterial segment by the PTT.
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公开(公告)号：US20170354331A1
公开(公告)日：2017-12-14
申请号：US15527467
申请日：2015-11-17
IPC分类号： A61B5/021 , G09B23/28 , A61B5/02 , G09B23/30 , A61B5/0285 , A61B5/0295 , A61B5/0456
CPC分类号： A61B5/7278 , A61B5/02007 , A61B5/021 , A61B5/02125 , A61B5/0285 , A61B5/0295 , A61B5/0456 , G09B23/28 , G09B23/288 , G09B23/30
摘要： A noninvasive method for monitoring the blood pressure and arterial compliance of a patient based on measurements of a flow velocity and a pulse wave velocity is described. An embodiment uses a photoplethysmograph and includes a method to monitor the dynamic behavior of the arterial blood flow, coupled with a hemodynamic mathematical model of the arterial blood flow motion in a fully nonlinear vessel. A derived mathematical model creates the patient specific dependence of a blood pressure versus PWV and blood velocity, which allows continuous monitoring of arterial blood pressure.
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公开(公告)号：US20120076736A1
公开(公告)日：2012-03-29
申请号：US13234992
申请日：2011-09-16
申请人： David A. Borkholder
发明人： David A. Borkholder
IPC分类号： A61K49/00
CPC分类号： G01N33/542 , C07K2319/00 , C07K2319/20 , G01N33/66
摘要： The present invention relates to an in vivo method of monitoring an analyte in a subject. This method involves providing an expression vector that encodes a biosensor molecule, the biosensor molecule comprising an analyte binding domain and a signal domain. The biosensor molecule produces a signal from the signal domain upon binding of the analyte by the analyte binding domain. The signal is detectable by a non-invasive means. The expression vector is introduced locally into in vivo cells of a subject under conditions effective to express the biosensor molecule in the cells. The signal from the expressed biosensor molecule is detected by a non-invasive means, thereby monitoring the analyte in the subject in vivo.
摘要翻译： 本发明涉及一种监测受试者中分析物的体内方法。 该方法包括提供编码生物传感器分子的表达载体，生物传感器分子包含分析物结合域和信号结构域。 当分析物结合分析物结合域时，生物传感器分子从信号域产生信号。 该信号可通过非侵入性手段检测。 在有效表达细胞内的生物传感器分子的条件下，将表达载体局部引入受试者的体内细胞。 通过非侵入性手段检测来自表达的生物传感器分子的信号，从而在体内监测受试者中的分析物。
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公开(公告)号：US20210219924A1
公开(公告)日：2021-07-22
申请号：US17150920
申请日：2021-01-15
摘要： An integrated bioinstrumentation system, combining an accurate and robust quasi 1D computational model with experimental peripheral measurements, is designed to extract information on other quantities of interest, for which the direct measurements are not feasible. The system is able to quantify and visualize the distributions of a cardiac output (CO), aortic blood pressure (BP), flow, velocity, and aortic arterial compliance, based on a peripheral analysis of a pulse transit time (PTT) measured at the available peripheral sites. A preliminary calibration stage extracts the arterial properties from simultaneous measurements of a pulse transit time, and an upper arm blood pressure. Obtained transfer functions, linking noninvasive peripheral measurements to the aortic pressure, cardiac output, aortic compliance and others serve to quantify the indicators of cardiac morbidity and mortality.
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公开(公告)号：US11035498B2
公开(公告)日：2021-06-15
申请号：US15829565
申请日：2017-12-01
摘要： A capsule is disclosed which includes a flexible outer shell capable of transforming into an asymmetric shape; an internal medium encapsulated by the outer shell, the medium including a plurality of magnetic particles, wherein the magnetic particles can move in response to an applied magnetic field. A valve system includes an in-line valve sized to fit within a flow channel including a capsule having a flexible outer shell containing an internal medium encapsulated by the outer shell, the medium including a plurality of magnetic particles; and a magnetic field source disposed about the exterior wall of the channel.
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公开(公告)号：US10292445B2
公开(公告)日：2019-05-21
申请号：US13371202
申请日：2012-02-10
摘要： A dosimetry apparatus includes at least one sensor in a housing, a cover configured to permit compression waves to pass through, the cover is seated over the at least one sensor, and a dosimetry processing device with a memory. The dosimetry processing device is coupled to the at least one sensor in the housing. The dosimetry processing device is configured to execute programmed instructions stored in the memory comprising: obtaining readings from the at least one sensor; storing the readings with a time and date stamp when obtained; conducting an analysis based on the obtained readings; and outputting at least one of the stored readings or the conducted analysis.
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