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公开(公告)号：US20080139571A1
公开(公告)日：2008-06-12
申请号：US11936380
申请日：2007-11-07
申请人： David B. Belanger , M. Arshad Siddiqui , Timothy J. Guzi , Patrick J. Curran , Praveen K. Tadikonda , Blake Hamann , Panduranga Adulla P. Reddy , Lianyun Zhao
发明人： David B. Belanger , M. Arshad Siddiqui , Timothy J. Guzi , Patrick J. Curran , Praveen K. Tadikonda , Blake Hamann , Panduranga Adulla P. Reddy , Lianyun Zhao
IPC分类号： A61K31/519 , C07D487/04 , A61P35/00
CPC分类号： C07D487/04
摘要： In its many embodiments, the present invention provides a novel class of imidazopyrazine compounds as inhibitors of protein and/or Aurora kinases, methods of preparing such compounds, pharmaceutical compositions including one or more such compounds, methods of preparing pharmaceutical formulations including one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the protein or Aurora kinases using such compounds or pharmaceutical compositions.
摘要翻译： 在其许多实施方案中，本发明提供了一类新颖的咪唑并吡嗪化合物作为蛋白质和/或极光激酶的抑制剂，制备这些化合物的方法，包含一种或多种这样的化合物的药物组合物，制备药物制剂的方法，包括一种或多种这样的化合物 化合物，以及使用这些化合物或药物组合物治疗，预防，抑制或改善与蛋白质或极光激酶相关的一种或多种疾病的方法。
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公开(公告)号：US07511040B2
公开(公告)日：2009-03-31
申请号：US11936380
申请日：2007-11-07
申请人： David B. Belanger , M. Arshad Siddiqui , Timothy J. Guzi , Patrick J. Curran , Praveen K. Tadikonda , Blake Hamann , Panduranga Adulla P. Reddy , Lianyun Zhao
发明人： David B. Belanger , M. Arshad Siddiqui , Timothy J. Guzi , Patrick J. Curran , Praveen K. Tadikonda , Blake Hamann , Panduranga Adulla P. Reddy , Lianyun Zhao
IPC分类号： C07D471/02
CPC分类号： C07D487/04
摘要： In its many embodiments, the present invention provides a novel class of imidazopyrazine compounds as inhibitors of protein and/or Aurora kinases, methods of preparing such compounds, pharmaceutical compositions including one or more such compounds, methods of preparing pharmaceutical formulations including one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the protein or Aurora kinases using such compounds or pharmaceutical compositions. An illustrative compound of the invention is shown below:
摘要翻译： 在其许多实施方案中，本发明提供了一类新颖的咪唑并吡嗪化合物作为蛋白质和/或极光激酶的抑制剂，制备这些化合物的方法，包含一种或多种这样的化合物的药物组合物，制备药物制剂的方法，包括一种或多种这样的化合物 化合物，以及使用这些化合物或药物组合物治疗，预防，抑制或改善与蛋白质或极光激酶相关的一种或多种疾病的方法。 本发明的说明性化合物如下所示：
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公开(公告)号：US08278337B2
公开(公告)日：2012-10-02
申请号：US12519731
申请日：2007-12-17
申请人： David B. Belanger , M. Arshad Siddiqui , Patrick J. Curran , Blake Hamann , Lianyun Zhao , Panduranga Adulla P. Reddy , Praveen K. Tadikonda , Gerald W. Shipps, Jr. , Umar Faruk Mansoor
发明人： David B. Belanger , M. Arshad Siddiqui , Patrick J. Curran , Blake Hamann , Lianyun Zhao , Panduranga Adulla P. Reddy , Praveen K. Tadikonda , Gerald W. Shipps, Jr. , Umar Faruk Mansoor
IPC分类号： A61K31/44
CPC分类号： C07D417/12 , C07D213/81 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/12 , C07D409/04 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04
摘要： Disclosed are compounds of the formula (I) wherein X is N or CH, and Y is N or CR5. Also disclosed are methods of treating JNK and ERK mediated diseases using the compounds of formula 1.0.
摘要翻译： 公开了式（I）的化合物，其中X是N或CH，Y是N或CR 5。 还公开了使用式1.0化合物治疗JNK和ERK介导的疾病的方法。
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公开(公告)号：US20100179141A1
公开(公告)日：2010-07-15
申请号：US12519731
申请日：2007-12-17
申请人： David B. Belanger , M. Arshad Siddiqui , Patrick J. Curran , Blake Hamann , Lianyun Zhao , Panduranga Adulla P. Reddy , Praveen K. Tadikonda , Gerald W. Shipps, JR. , Umar Faruk Mansoor
发明人： David B. Belanger , M. Arshad Siddiqui , Patrick J. Curran , Blake Hamann , Lianyun Zhao , Panduranga Adulla P. Reddy , Praveen K. Tadikonda , Gerald W. Shipps, JR. , Umar Faruk Mansoor
IPC分类号： A61K31/5377 , C07D417/12 , A61K31/4439 , A61K31/4545 , C07D417/14 , C07D401/12 , C07D413/14 , C07D405/12 , A61K31/444 , A61K31/502 , A61K31/497 , C07D213/81 , A61K31/44 , C07D401/14 , A61K31/506 , C07D513/04 , A61K31/517 , C07D471/04 , A61K31/496 , A61P19/02 , A61P29/00 , A61P11/06 , A61P25/28 , A61P1/00 , A61P3/10 , A61P17/06
CPC分类号： C07D417/12 , C07D213/81 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/12 , C07D409/04 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04
摘要： Disclosed are compounds of the formula (I) wherein X is N or CH, and Y is N or CR5. Also disclosed are methods of treating JNK and ERK mediated diseases using the compounds of formula 1.0.
摘要翻译： 公开了式（I）的化合物，其中X是N或CH，Y是N或CR 5。 还公开了使用式1.0化合物治疗JNK和ERK介导的疾病的方法。
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公开(公告)号：US20100298314A1
公开(公告)日：2010-11-25
申请号：US12519733
申请日：2007-12-17
申请人： Panduranga Adulla P. Reddy , M. Arshad Siddiqui , Praveen K. Tadikonda , Umar Faruk Mansoor , Gerald W. Shipps, JR. , David B. Belanger , Lianyun Zhao
发明人： Panduranga Adulla P. Reddy , M. Arshad Siddiqui , Praveen K. Tadikonda , Umar Faruk Mansoor , Gerald W. Shipps, JR. , David B. Belanger , Lianyun Zhao
IPC分类号： A61K31/5377 , C07D471/04 , A61K31/437 , A61K31/496 , A61K31/497 , A61K31/519 , A61K31/4985 , A61P29/00 , A61P19/02 , A61P11/06 , A61P17/06 , A61P3/10 , A61P9/00 , A61P37/00
CPC分类号： C07D471/04 , C07D487/04
摘要： Disclosed are substituted imidazo[1,2-a]pyridines, imidazo[1,2-a]pyrazines, imidazo[1,2-c]pyrimidines and imidazo[1,2-d]triazines compounds of the formula: (1.0) Also disclosed are methods for treating JNK1 and ERK mediated diseases using the compounds of formula 1.0.
摘要翻译： 公开了下式的取代咪唑并[1,2-a]吡啶，咪唑并[1,2-a]吡嗪，咪唑并[1,2-c]嘧啶和咪唑并[1,2-d]三嗪化合物：（1.0） 还公开了使用式1.0化合物治疗JNK1和ERK介导的疾病的方法。
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公开(公告)号：US08293747B2
公开(公告)日：2012-10-23
申请号：US12669334
申请日：2008-07-17
申请人： Panduranga Adulla P. Reddy , Lianyun Zhao , Praveen K. Tadikonda , Tzu Tshin Wong , Shuyi Tang , Luis E. Torres , David F. Cauble, Jr. , Timothy J. Guzi , M. Arshad Siddiqui
发明人： Panduranga Adulla P. Reddy , Lianyun Zhao , Praveen K. Tadikonda , Tzu Tshin Wong , Shuyi Tang , Luis E. Torres , David F. Cauble, Jr. , Timothy J. Guzi , M. Arshad Siddiqui
IPC分类号： A61K31/506 , C07D401/14 , A61K31/496 , A61K31/497 , A61K31/519 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D491/04
CPC分类号： C07D401/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04
摘要： The present invention relates to novel heterocyclic amide compounds of Formula I: as disclosed herein or a pharmaceutically acceptable salt, solvate, ester, prodrug or stereoisomer thereof. Also disclosed are compositions comprising said compounds, and methods for using said compounds for treating or preventing a proliferative disease, an anti-proliferative disorder, inflammation, arthritis, a neurological or neurodegenerative disease, a cardiovascular disease, alopecia, a neuronal disease, an ischemic injury, a viral disease or a fungal disease.
摘要翻译： 本发明涉及式I的新型杂环酰胺化合物：本文所公开的或其药学上可接受的盐，溶剂化物，酯，前药或立体异构体。 还公开了包含所述化合物的组合物，以及使用所述化合物治疗或预防增殖性疾病，抗增殖性疾病，炎症，关节炎，神经性或神经变性疾病，心血管疾病，脱发，神经元疾病，缺血性疾病 损伤，病毒性疾病或真菌性疾病。
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公开(公告)号：US08318735B2
公开(公告)日：2012-11-27
申请号：US12447710
申请日：2007-10-29
申请人： Gerald W. Shipps, Jr. , Cliff C. Cheng , Xiaohua Huang , Thierry O. Fischmann , Jose S. Duca , Matthew Richards , Hongbo Zeng , Binyuan Sun , Panduranga Adulla Reddy , Lianyun Zhao , Shuyi Tang , Tzu T. Wong , Praveen K. Tadikonda , Luis E. Torres , M. Arshad Siddiqui , Michael P. Dwyer , Kartik M. Keertikar , Timothy J. Guzi
发明人： Gerald W. Shipps, Jr. , Cliff C. Cheng , Xiaohua Huang , Thierry O. Fischmann , Jose S. Duca , Matthew Richards , Hongbo Zeng , Binyuan Sun , Panduranga Adulla Reddy , Lianyun Zhao , Shuyi Tang , Tzu T. Wong , Praveen K. Tadikonda , Luis E. Torres , M. Arshad Siddiqui , Michael P. Dwyer , Kartik M. Keertikar , Timothy J. Guzi
IPC分类号： A61K31/5355 , A61K31/496 , C07D401/14 , C07D403/14 , C07D413/14
CPC分类号： C07D277/56 , A61K31/435 , A61K31/439 , A61K31/4439 , A61K31/454 , A61K31/4545 , A61K31/496 , A61K31/5377 , A61K31/551 , A61K45/06 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/04 , C07D471/10 , C07D487/04 , C07D513/04 , A61K2300/00
摘要： The present invention relates to novel Anilinopiperazine Derivatives of formula (I), compositions comprising the Anilinopiperazine Derivatives, and methods for using the Anilinopiperazine Derivatives for treating or preventing a proliferative disorder, an anti-proliferative disorder, inflammation, arthritis, a central nervous system disorder, a cardiovascular disease, alopecia, a neuronal disease, an ischemic injury, a viral disease, a fungal infection, or a disorder related to the activity of a protein kinase.
摘要翻译： 本发明涉及式（I）的新型苯胺基哌嗪衍生物，包含苯胺基哌嗪衍生物的组合物，以及使用苯胺基哌嗪衍生物治疗或预防增殖性病症，抗增殖病症，炎症，关节炎，中枢神经系统疾病 ，心血管疾病，脱发，神经元疾病，缺血性损伤，病毒性疾病，真菌感染或与蛋白激酶活性相关的病症。
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公开(公告)号：US20100130465A1
公开(公告)日：2010-05-27
申请号：US12447710
申请日：2007-10-29
申请人： Gerald W. Shipps, JR. , Cliff C. Cheng , Xiaohua Huang , Thierry O. Fischmann , Jose S. Duca , Matthew Richards , Hongbo Zeng , Binyuan Sun , Panduranga A. Reddy , Lianyun Zhao , Shuyi Tang , Tzu T. Wong , Praveen K. Tadikonda , Luis E. Torres , M. Arshad Siddiqui , Michael P. Dwyer , Kartik M. Keertikar , Timothy J. Guzi
发明人： Gerald W. Shipps, JR. , Cliff C. Cheng , Xiaohua Huang , Thierry O. Fischmann , Jose S. Duca , Matthew Richards , Hongbo Zeng , Binyuan Sun , Panduranga A. Reddy , Lianyun Zhao , Shuyi Tang , Tzu T. Wong , Praveen K. Tadikonda , Luis E. Torres , M. Arshad Siddiqui , Michael P. Dwyer , Kartik M. Keertikar , Timothy J. Guzi
IPC分类号： A61K31/438 , C07D417/14 , A61K31/497 , C07D471/10 , C07D413/14 , A61K31/5377 , A61K31/551
CPC分类号： C07D277/56 , A61K31/435 , A61K31/439 , A61K31/4439 , A61K31/454 , A61K31/4545 , A61K31/496 , A61K31/5377 , A61K31/551 , A61K45/06 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/04 , C07D471/10 , C07D487/04 , C07D513/04 , A61K2300/00
摘要： The present invention relates to novel Anilinopiperazine Derivatives of formula (I), compositions comprising the Anilinopiperazine Derivatives, and methods for using the Anilinopiperazine Derivatives for treating or preventing a proliferative disorder, an anti-proliferative disorder, inflammation, arthritis, a central nervous system disorder, a cardiovascular disease, alopecia, a neuronal disease, an ischemic injury, a viral disease, a fungal infection, or a disorder related to the activity of a protein kinase.
摘要翻译： 本发明涉及式（I）的新型苯胺基哌嗪衍生物，包含苯胺基哌嗪衍生物的组合物，以及使用苯胺基哌嗪衍生物治疗或预防增殖性病症，抗增殖病症，炎症，关节炎，中枢神经系统疾病 ，心血管疾病，脱发，神经元疾病，缺血性损伤，病毒性疾病，真菌感染或与蛋白激酶活性相关的病症。
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公开(公告)号：US20120328691A1
公开(公告)日：2012-12-27
申请号：US12447712
申请日：2007-10-29
申请人： Gerald W. Shipps, JR. , Cliff C. Cheng , Xiaohua Huang , Thierry O. Fischmann , Jose S. Duca , Matthew Richards , Hongbo Zeng , Binyuan Sun , Panduranga Adulla Reddy , Tzu T. Wong , Praveen K. Tadikonda , M. Arshad Siddiqui , Marc A. Labroli , Cory Poker , Timothy J. Guzi
发明人： Gerald W. Shipps, JR. , Cliff C. Cheng , Xiaohua Huang , Thierry O. Fischmann , Jose S. Duca , Matthew Richards , Hongbo Zeng , Binyuan Sun , Panduranga Adulla Reddy , Tzu T. Wong , Praveen K. Tadikonda , M. Arshad Siddiqui , Marc A. Labroli , Cory Poker , Timothy J. Guzi
IPC分类号： A61K31/496 , A61K31/55 , C07D417/12 , A61K31/454 , A61K31/427 , A61K31/541 , A61K31/506 , A61K31/497 , C07D471/10 , A61K31/438 , A61K31/4545 , A61K31/5377 , C07D498/10 , A61K31/5386 , A61K31/551 , A61K33/24 , A61K9/127 , A61K39/395 , A61K31/704 , A61K38/19 , A61K31/7068 , A61K38/50 , A61K38/20 , A61K38/21 , A61P35/00 , A61P35/02 , A61N5/10 , C07D417/14
CPC分类号： C07D277/56 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/10
摘要： The present invention relates to novel Anilinopiperazine Derivatives of Formula (I), compositions comprising the Anilinopiperazine Derivatives, and methods for using the Anilinopiperazine Derivatives for treating or preventing a proliferative disorder, cancer, an anti-proliferative disorder, inflammation, arthritis, a central nervous system disorder, a cardiovascular disease, alopecia, a neuronal disease, an ischemic injury, a viral disease, a fungal infection, or a disorder related to the activity of a protein kinase.
摘要翻译： 本发明涉及式（I）的新型苯胺基哌嗪衍生物，包含苯胺基哌嗪衍生物的组合物，以及使用苯胺基哌嗪衍生物治疗或预防增殖性疾病，癌症，抗增殖性疾病，炎症，关节炎，中枢神经 系统障碍，心血管疾病，脱发，神经元疾病，缺血性损伤，病毒性疾病，真菌感染或与蛋白激酶活性相关的病症。
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10.发明申请公开(公告)号：US20110129440A1
公开(公告)日：2011-06-02
申请号：US12738521
申请日：2008-10-27
IPC分类号： A61K31/5377 , C07D417/14 , A61K31/496 , A61P35/00 , A61P9/04 , A61P9/10 , A61P31/12 , A61P31/18 , A61P31/10 , A61K33/24 , A61K31/7072 , A61K39/395 , A61K38/21 , A61K38/20 , A61K38/50
CPC分类号： C07D417/12
摘要： The present invention relates to novel Heterocyclic Urea and Thiourea Derivatives of formula (I), compositions comprising the Heterocyclic Urea and Thiourea Derivatives, and methods for using the Heterocyclic Urea and Thiourea Derivatives for treating or preventing a proliferative disorder, an anti-proliferative disorder, inflammation, arthritis, a central nervous system disorder, a cardiovascular disease, alopecia, a neuronal disease, an ischemic injury, a viral infection, a fungal infection, or a disorder related to the activity of a protein kinase.
摘要翻译： 本发明涉及式（I）的新型杂环脲和硫脲衍生物，包含杂环脲和硫脲衍生物的组合物，以及使用杂环脲和硫脲衍生物治疗或预防增殖性病症，抗增殖病症， 炎症，关节炎，中枢神经系统疾病，心血管疾病，脱发，神经元疾病，缺血性损伤，病毒感染，真菌感染或与蛋白激酶的活性相关的病症。
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