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公开(公告)号：US20120328691A1
公开(公告)日：2012-12-27
申请号：US12447712
申请日：2007-10-29
申请人： Gerald W. Shipps, JR. , Cliff C. Cheng , Xiaohua Huang , Thierry O. Fischmann , Jose S. Duca , Matthew Richards , Hongbo Zeng , Binyuan Sun , Panduranga Adulla Reddy , Tzu T. Wong , Praveen K. Tadikonda , M. Arshad Siddiqui , Marc A. Labroli , Cory Poker , Timothy J. Guzi
发明人： Gerald W. Shipps, JR. , Cliff C. Cheng , Xiaohua Huang , Thierry O. Fischmann , Jose S. Duca , Matthew Richards , Hongbo Zeng , Binyuan Sun , Panduranga Adulla Reddy , Tzu T. Wong , Praveen K. Tadikonda , M. Arshad Siddiqui , Marc A. Labroli , Cory Poker , Timothy J. Guzi
IPC分类号： A61K31/496 , A61K31/55 , C07D417/12 , A61K31/454 , A61K31/427 , A61K31/541 , A61K31/506 , A61K31/497 , C07D471/10 , A61K31/438 , A61K31/4545 , A61K31/5377 , C07D498/10 , A61K31/5386 , A61K31/551 , A61K33/24 , A61K9/127 , A61K39/395 , A61K31/704 , A61K38/19 , A61K31/7068 , A61K38/50 , A61K38/20 , A61K38/21 , A61P35/00 , A61P35/02 , A61N5/10 , C07D417/14
CPC分类号： C07D277/56 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/10
摘要： The present invention relates to novel Anilinopiperazine Derivatives of Formula (I), compositions comprising the Anilinopiperazine Derivatives, and methods for using the Anilinopiperazine Derivatives for treating or preventing a proliferative disorder, cancer, an anti-proliferative disorder, inflammation, arthritis, a central nervous system disorder, a cardiovascular disease, alopecia, a neuronal disease, an ischemic injury, a viral disease, a fungal infection, or a disorder related to the activity of a protein kinase.
摘要翻译： 本发明涉及式（I）的新型苯胺基哌嗪衍生物，包含苯胺基哌嗪衍生物的组合物，以及使用苯胺基哌嗪衍生物治疗或预防增殖性疾病，癌症，抗增殖性疾病，炎症，关节炎，中枢神经 系统障碍，心血管疾病，脱发，神经元疾病，缺血性损伤，病毒性疾病，真菌感染或与蛋白激酶活性相关的病症。
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公开(公告)号：US09206142B2
公开(公告)日：2015-12-08
申请号：US12447712
申请日：2007-10-29
申请人： Gerald W. Shipps, Jr. , Cliff C. Cheng , Xiaohua Huang , Thierry O. Fischmann , Jose S. Duca , Matthew Richards , Hongbo Zeng , Binyuan Sun , Panduranga Adulla Reddy , Tzu T. Wong , Praveen K. Tadikonda , M. Arshad Siddiqui , Marc A. Labroli , Cory S. Poker , Timothy J. Guzi
发明人： Gerald W. Shipps, Jr. , Cliff C. Cheng , Xiaohua Huang , Thierry O. Fischmann , Jose S. Duca , Matthew Richards , Hongbo Zeng , Binyuan Sun , Panduranga Adulla Reddy , Tzu T. Wong , Praveen K. Tadikonda , M. Arshad Siddiqui , Marc A. Labroli , Cory S. Poker , Timothy J. Guzi
IPC分类号： C07D401/14 , C07D403/14 , C07D413/14 , A61K31/5355 , A61K31/496 , C07D277/56 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/10
CPC分类号： C07D277/56 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/10
摘要： The present invention relates to novel Anilinopiperazine Derivatives of Formula (I), compositions comprising the Anilinopiperazine Derivatives, and methods for using the Anilinopiperazine Derivatives for treating or preventing a proliferative disorder, cancer, an anti-proliferative disorder, inflammation, arthritis, a central nervous system disorder, a cardiovascular disease, alopecia, a neuronal disease, an ischemic injury, a viral disease, a fungal infection, or a disorder related to the activity of a protein kinase.
摘要翻译： 本发明涉及式（I）的新型苯胺基哌嗪衍生物，包含苯胺基哌嗪衍生物的组合物，以及使用苯胺基哌嗪衍生物治疗或预防增殖性疾病，癌症，抗增殖性疾病，炎症，关节炎，中枢神经 系统障碍，心血管疾病，脱发，神经元疾病，缺血性损伤，病毒性疾病，真菌感染或与蛋白激酶活性相关的病症。
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公开(公告)号：US08318735B2
公开(公告)日：2012-11-27
申请号：US12447710
申请日：2007-10-29
申请人： Gerald W. Shipps, Jr. , Cliff C. Cheng , Xiaohua Huang , Thierry O. Fischmann , Jose S. Duca , Matthew Richards , Hongbo Zeng , Binyuan Sun , Panduranga Adulla Reddy , Lianyun Zhao , Shuyi Tang , Tzu T. Wong , Praveen K. Tadikonda , Luis E. Torres , M. Arshad Siddiqui , Michael P. Dwyer , Kartik M. Keertikar , Timothy J. Guzi
发明人： Gerald W. Shipps, Jr. , Cliff C. Cheng , Xiaohua Huang , Thierry O. Fischmann , Jose S. Duca , Matthew Richards , Hongbo Zeng , Binyuan Sun , Panduranga Adulla Reddy , Lianyun Zhao , Shuyi Tang , Tzu T. Wong , Praveen K. Tadikonda , Luis E. Torres , M. Arshad Siddiqui , Michael P. Dwyer , Kartik M. Keertikar , Timothy J. Guzi
IPC分类号： A61K31/5355 , A61K31/496 , C07D401/14 , C07D403/14 , C07D413/14
CPC分类号： C07D277/56 , A61K31/435 , A61K31/439 , A61K31/4439 , A61K31/454 , A61K31/4545 , A61K31/496 , A61K31/5377 , A61K31/551 , A61K45/06 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/04 , C07D471/10 , C07D487/04 , C07D513/04 , A61K2300/00
摘要： The present invention relates to novel Anilinopiperazine Derivatives of formula (I), compositions comprising the Anilinopiperazine Derivatives, and methods for using the Anilinopiperazine Derivatives for treating or preventing a proliferative disorder, an anti-proliferative disorder, inflammation, arthritis, a central nervous system disorder, a cardiovascular disease, alopecia, a neuronal disease, an ischemic injury, a viral disease, a fungal infection, or a disorder related to the activity of a protein kinase.
摘要翻译： 本发明涉及式（I）的新型苯胺基哌嗪衍生物，包含苯胺基哌嗪衍生物的组合物，以及使用苯胺基哌嗪衍生物治疗或预防增殖性病症，抗增殖病症，炎症，关节炎，中枢神经系统疾病 ，心血管疾病，脱发，神经元疾病，缺血性损伤，病毒性疾病，真菌感染或与蛋白激酶活性相关的病症。
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![Pyrazolo[1,5-a]pyrimidine derivatives as mTOR inhibitors](/abs-image/US/2013/11/26/US08591943B2/abs.jpg.150x150.jpg)
公开(公告)号：US08591943B2
公开(公告)日：2013-11-26
申请号：US13263193
申请日：2010-04-08
申请人： Yongqi Deng , Binyuan Sun , Hongbo Zeng , Matthew Richards , Gerald W. Shipps, Jr. , Cliff C. Cheng , Yinyan Zhao , Andrew McRiner , Zhaoyang Meng , Yang Nan , Mehul F. Patel , Iwona E. Wrona , Panduranga Adulla Reddy , Brian M. Eklov , Shuyi Tang , Duan Liu , Amit K. Mandal , Lianyun Zhao , M. Arshad Siddiqui
发明人： Yongqi Deng , Binyuan Sun , Hongbo Zeng , Matthew Richards , Gerald W. Shipps, Jr. , Cliff C. Cheng , Yinyan Zhao , Andrew McRiner , Zhaoyang Meng , Yang Nan , Mehul F. Patel , Iwona E. Wrona , Panduranga Adulla Reddy , Brian M. Eklov , Shuyi Tang , Duan Liu , Amit K. Mandal , Lianyun Zhao , M. Arshad Siddiqui
IPC分类号： A61K9/127 , A61K39/395 , A61K31/554 , A61K31/541 , A61K31/5377 , A61K38/50 , A61K31/553 , A61K33/24 , A61K31/704 , A61K31/551 , A61K31/538 , A61K31/519
CPC分类号： C07D487/04 , C07D519/00
摘要： The present invention provides methods for inhibiting mTOR using pyrazolo[1,5-a]pyrimidine compounds and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with mTOR using such compounds.
摘要翻译： 本发明提供使用吡唑并[1,5-a]嘧啶化合物抑制mTOR的方法以及使用这些化合物治疗，预防，抑制或改善与mTOR相关的一种或多种疾病的方法。
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![PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS](/abs-image/US/2012/05/10/US20120114739A1/abs.jpg.150x150.jpg)
公开(公告)号：US20120114739A1
公开(公告)日：2012-05-10
申请号：US13263193
申请日：2010-04-08
申请人： Yongqi Deng , Binyuan Sun , Hongbo Zeng , Matthew Richards , Gerald W. Shipps, JR. , Cliff C. Cheng , Yinyan Zhao , Andrew McRiner , Zhaoyang Meng , Yang Nan , Mehul F. Patel , Iwona E. Wrona , Panduranga Adulla Reddy , Brian M. Eklov , Shuyi Tang , Duan Liu , Amit K. Mandal , Lianyun Zhao , M. Asshad Siddiqui
发明人： Yongqi Deng , Binyuan Sun , Hongbo Zeng , Matthew Richards , Gerald W. Shipps, JR. , Cliff C. Cheng , Yinyan Zhao , Andrew McRiner , Zhaoyang Meng , Yang Nan , Mehul F. Patel , Iwona E. Wrona , Panduranga Adulla Reddy , Brian M. Eklov , Shuyi Tang , Duan Liu , Amit K. Mandal , Lianyun Zhao , M. Asshad Siddiqui
IPC分类号： A61K9/127 , A61K31/519 , A61K31/5377 , C07D491/048 , C07D495/04 , A61K31/538 , A61K31/551 , A61K31/553 , A61K31/541 , A61K31/554 , C07D498/04 , C12N9/99 , A61K31/704 , A61K39/395 , A61K33/36 , A61K38/50 , A61K33/24 , A61P29/00 , A61P37/08 , A61P11/00 , A61P37/06 , A61P35/00 , A61P35/02 , C07D487/04
CPC分类号： C07D487/04 , C07D519/00
摘要： The present invention provides methods for inhibiting mTOR using pyrazolo[1,5-a]pyrimidine compounds and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with mTOR using such compounds.
摘要翻译： 本发明提供使用吡唑并[1,5-a]嘧啶化合物抑制mTOR的方法以及使用这些化合物治疗，预防，抑制或改善与mTOR相关的一种或多种疾病的方法。
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公开(公告)号：US20110212080A1
公开(公告)日：2011-09-01
申请号：US13057505
申请日：2009-07-28
IPC分类号： A61K39/395 , C07D241/04 , A61K31/495 , C07D403/10 , A61K31/496 , C07D413/10 , A61K31/5377 , C07D211/10 , A61K31/451 , C07D401/14 , C07D413/14 , A61K31/497 , A61P31/00
CPC分类号： C07D213/38 , C07C275/24 , C07D207/06 , C07D211/16 , C07D213/61 , C07D213/73 , C07D213/74 , C07D231/12 , C07D241/12 , C07D295/215 , C07D333/20
摘要： This invention relates to compounds of the Formula (I): or a pharmaceutically acceptable salt, solvate, ester or isomer thereof, which is useful for the treatment of diseases or conditions mediated by LpxC.
摘要翻译： 本发明涉及式（I）化合物或其药学上可接受的盐，溶剂化物，酯或异构体，其可用于治疗由LpxC介导的疾病或病症。
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公开(公告)号：US08927562B2
公开(公告)日：2015-01-06
申请号：US13876192
申请日：2011-09-26
IPC分类号： A61K31/519 , C07D487/14 , C07D495/14 , C07D487/04
CPC分类号： C07D495/14 , A61K31/519 , C07D487/04 , C07D487/14
摘要： This invention relates to novel fused tricyclic compounds that are inhibitors of mammalian Target of Rapamycin (mTOR) kinase, which is also known as FRAP, RAFT, RAPT or SEP, and are useful in the treatment of cellular proliferative diseases, for example cancer and other proliferative disorders.
摘要翻译： 本发明涉及新的融合三环化合物，其是哺乳动物雷帕霉素靶标（mTOR）激酶的抑制剂，其也称为FRAP，RAFT，RAPT或SEP，并且可用于治疗细胞增殖性疾病，例如癌症和其它 增生性疾病
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