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26 条记录 (耗时 0.024 秒)

    Heterocyclic derivatives
    1.
    发明授权
    Heterocyclic derivatives 失效
    杂环衍生物

    公开(公告)号：US4585781A

    公开(公告)日：1986-04-29

    申请号：US567005

    申请日：1983-12-30

    申请人： David Bays ,  Roger Hayes ,  Philip Blatcher

    发明人： David Bays ,  Roger Hayes ,  Philip Blatcher

    IPC分类号： C07D257/04 ,  C07D405/12 ,  C07D417/12 ,  C07D403/12 ,  A61K31/415 ,  A61K31/425

    CPC分类号： C07D257/04 ,  C07D405/12 ,  C07D417/12

    摘要： This invention relates to compounds of the general formula (I) ##STR1## and physiologically acceptable salts and hydrates thereof, in which R.sub.1 represents a hydrogen atom or an alkyl, alkanoyl, aroyl or trifluoroalkyl group;R.sub.2 represents a hydrogen atom or an alkyl or alkenyl group or C.sub.2-6 alkyl group substituted by a hydroxy or alkoxy group;X represents a sulphur atom or NH;Y represents an oxygen or sulphur atom or a bond;m represents 1, 2 or 3; andn represents 2, 3 or 4.The compounds show pharmacological activity as selective histamine H.sub.2 -antagonists.

    摘要翻译： 本发明涉及通式（I）的化合物及其生理学上可接受的盐和水合物，其中R 1表示氢原子或烷基，烷酰基，芳酰基或三氟烷基; R2表示氢原子或被羟基或烷氧基取代的烷基或烯基或C2-6烷基; X表示硫原子或NH; Y表示氧或硫原子或键; m表示1,2或3; 并且n表示2,3或4.化合物显示作为选择性组胺H2拮抗剂的药理活性。

    Heterocyclic derivatives
    5.
    发明授权
    Heterocyclic derivatives 失效

    公开(公告)号：US4410523A

    公开(公告)日：1983-10-18

    申请号：US199522

    申请日：1980-10-22

    申请人： William D. Ollis ,  Barry J. Price ,  Linda Carey ,  Roger Hayes ,  John W. Clitherow ,  John Bradshaw ,  John W. M. Mackinnon

    发明人： William D. Ollis ,  Barry J. Price ,  Linda Carey ,  Roger Hayes ,  John W. Clitherow ,  John Bradshaw ,  John W. M. Mackinnon

    IPC分类号： C07D249/14 ,  A61K31/395 ,  C07D249/10

    CPC分类号： C07D249/14 ,  Y10S514/927

    摘要： The invention provides compounds of the general formula (I) ##STR1## and physiologically acceptable salts, hydrates and bioprecursors thereof, in whichR.sub.1 and R.sub.2, which may be the same or different, each represent hydrogen, C.sub.1-10 alkyl, cycloalkyl, alkenyl, aralkyl, trifluoroalkyl, heteroaralkyl, or alkyl substituted by hydroxy, alkoxy, amino, alkylamino, dialkyamino or cycloalkyl, or R.sub.1 and R.sub.2 may together with the nitrogen atom to which they are attached form a 5 to 10 membered ring which may be saturated or may contain at least one double bond, may be unsubstituted or may be substituted by one or more C.sub.1-3 alkyl groups, or a hydroxy group and/or may contain another heteroatom selected from oxygen and sulphur;Alk represents a straight or branched alkylene chain of 1 to 6 carbon atoms and is attached to the cyclohexadiene ring at either the 4- or 5- position;X represents --CH.sub.2 or --O--;m represents 2, 3, 4 or 5 and when X is --O-- the chain (CH.sub.2).sub.m may be interrupted by an oxygen atom provided that there are at least two methylene groups between any two heteroatoms in the moiety --X(CH.sub.2).sub.m NH--;R.sub.3 represents hydrogen, alkyl, alkenyl, aralkyl, or C.sub.2-6 alkyl substituted by hydroxy or alkoxy; andR.sub.4 represents hydrogen, alkyl, alkenyl, aralkyl, hydroxyalkyl, acyloxyalkyl, alkoxyalkyl, aryloxyalkyl, aralkyloxyalkyl, aminoalkyl, alkylaminoalkyl, dialkylaminoalkyl, hydroxy or alkoxy or the group NR.sub.5 R.sub.6 whereR.sub.5 represents hydrogen, alkyl, alkyl substituted by hydroxy or C.sub.1-3 alkoxy, alkenyl, aralkyl or heteroaralkyl and R.sub.6 represents any of the groups defined for R.sub.5 or may represent the group COR.sub.7 where R.sub.7 represents hydrogen, alkyl, aryl, aralkyl, alkoxy, heteroaryl or monocyclic heteroaralkyl or R.sub.6 represents the group SO.sub.2 R.sub.8 where R.sub.8 represents alkyl or aryl, or R.sub.6 represents the group ##STR2## where Y is oxygen or sulphur and R.sub.9 represents hydrogen, alkyl, cycloalkyl, aryl or aralkyl,or R.sub.5 and R.sub.6 taken together may represent the group .dbd.CR.sub.10 R.sub.11 where R.sub.10 represents aryl or heteroaryl and R.sub.11 represents hydrogen or alkyl.The compounds show activity as selective histamine H.sub.2 -antagonists.

    Hydraulic motor system for liquid transport tank
    6.
    发明授权
    Hydraulic motor system for liquid transport tank 有权

    公开(公告)号：US11608770B2

    公开(公告)日：2023-03-21

    申请号：US17305220

    申请日：2021-07-01

    申请人： Roger Hayes

    发明人： Roger Hayes

    IPC分类号： F01P11/02 ,  F01P3/12 ,  F04D29/58 ,  F01P3/20

    摘要： A motor for driving a liquid end of a pump system. The motor having an inner housing having an outer surface, a mechanical actuator disposed in the inner housing, and a water jacket surrounding at least a portion of the outer surface of the inner housing to define a volume between the inner housing and the water jacket. The volume being sized to circulate water within the water jacket so as to transfer heat from the inner housing to the water.

    TANK FOR TRANSPORTING LIQUIDS
    7.
    发明申请
    TANK FOR TRANSPORTING LIQUIDS 有权

    公开(公告)号：US20220315325A1

    公开(公告)日：2022-10-06

    申请号：US17807846

    申请日：2022-06-20

    申请人： Roger Hayes

    发明人： Roger Hayes

    IPC分类号： B65D90/00 ,  B65D90/52

    摘要： A tank for transporting a liquid is disclosed. In some implementations, the tank includes a carrier having a plurality of compartments, each compartment of the plurality of compartments having an opening for containing one or more baffles. In some implementations, the tank includes a plurality of posts that are securable relative to the tank and configured to support the one or more baffles. In some implementations, the posts are removed from the tank to facilitate installation of the baffles. In some implementations, the posts are rotatable to facilitate installation of the baffles. In some implementations, the tank is a two-piece tank which facilitates access to the one or more baffles.

    HYDRAULIC MOTOR SYSTEM FOR LIQUID TRANSPORT TANK
    8.
    发明申请
    HYDRAULIC MOTOR SYSTEM FOR LIQUID TRANSPORT TANK 有权

    公开(公告)号：US20220003145A1

    公开(公告)日：2022-01-06

    申请号：US17305220

    申请日：2021-07-01

    申请人： Roger Hayes

    发明人： Roger Hayes

    IPC分类号： F01P11/02 ,  F01P3/20

    摘要： A motor for driving a liquid end of a pump system. The motor having an inner housing having an outer surface, a mechanical actuator disposed in the inner housing, and a water jacket surrounding at least a portion of the outer surface of the inner housing to define a volume between the inner housing and the water jacket. The volume being sized to circulate water within the water jacket so as to transfer heat from the inner housing to the water.

    Amine derivatives
    10.
    发明授权
    Amine derivatives 失效
    胺衍生物

    公开(公告)号：US4491586A

    公开(公告)日：1985-01-01

    申请号：US450479

    申请日：1982-12-16

    申请人： Roger Hayes

    发明人： Roger Hayes

    IPC分类号： C07D209/48 ,  C07D249/14 ,  C07D295/096 ,  C07D317/22 ,  A61K31/445 ,  C07D211/14

    CPC分类号： C07D209/48 ,  C07D249/14 ,  C07D295/096 ,  C07D317/22

    摘要： The invention provides compounds of the general formula (I) ##STR1## and physiologically acceptable salts, hydrates and bioprecursors thereof in which the substituents are defined in the specification.The compounds of formula (I) show pharmacologically activity as selective histamine H.sub.2 -antagonists.

    摘要翻译： 本发明提供通式（I）的化合物及其生理学上可接受的盐，水合物和生物前体，其中取代基在说明书中定义。 式（I）的化合物显示出作为选择性组胺H2拮抗剂的药理学活性。