利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

4 条记录 (耗时 0.036 秒)

    Preparation of a compressed membrane containing immobilized biologically acting material
    2.
    发明授权
    Preparation of a compressed membrane containing immobilized biologically acting material 失效
    制备含有固定的生物作用材料的压缩膜

    公开(公告)号：US5283186A

    公开(公告)日：1994-02-01

    申请号：US815422

    申请日：1991-12-31

    申请人： David D. Cunningham ,  Kenneth S. Johnson

    发明人： David D. Cunningham ,  Kenneth S. Johnson

    IPC分类号： C12N11/04 ,  C12N11/08 ,  G01N33/544 ,  G01N33/545

    CPC分类号： C12N11/04 ,  C12N11/08 ,  Y10S530/815 ,  Y10S530/817

    摘要： A porous carrier containing an immobilized biologically active material is prepared in which a relatively large amount of an enzyme or an antibody has been immobilized in a manner that produces a low diffusion resistance toward reagents and products. The porous carrier is produced by fixing enzymes or antibodies within internal micropores of the carrier and mechanically compressing the carrier to a final thickness which is in the range of about 0.20 to 0.80 times the uncompressed carrier thickness. The compressed carrier may have a density about 1.25 to about 5.0 times the density of the carrier before compressing. Surprisingly, the compressed carrier exhibits less diffusion resistance to specific reagents and products than would an uncompressed carrier. A preferred porous carrier is a semi-permeable membrane made from synthetic polymers, such as polyvinylidine difluoride.

    摘要翻译： 制备含有固定的生物活性物质的多孔载体，其中以对试剂和产物产生低扩散阻力的方式固定有相对大量的酶或抗体。 通过将载体上的酶或抗体固定在载体的内部微孔内并将载体机械压缩至未压缩载体厚度的约0.20至0.80倍的最终厚度来制备多孔载体。 在压缩之前，压缩载体的密度约为载体密度的约1.25至约5.0倍。 令人惊奇的是，与未压缩载体相比，压缩载体对特定试剂和产物的扩散阻力较小。 优选的多孔载体是由合成聚合物如聚偏二氟乙烯制成的半透膜。

    Mouth Shield
    3.
    发明申请
    Mouth Shield 有权

    公开(公告)号：US20210337887A1

    公开(公告)日：2021-11-04

    申请号：US16862190

    申请日：2020-04-29

    申请人： Kenneth S. Johnson

    发明人： Kenneth S. Johnson

    IPC分类号： A41D1/00 ,  A41D13/11 ,  A42B3/30

    摘要： A mouth shield to prevent lip reading of the lips of a user may include a shield to shield the lips of the user; a pivoting fastener device to rotate the partial oval shield between a substantially horizontal position to a substantially vertical position in which the lips of the user substantially are uncovered to where the lips of the user are covered to prevent lip reading; and a clamp device to clamp the pivoting fastener device to a microphone.

    Diagnostic flow cell device
    4.
    发明授权
    Diagnostic flow cell device 失效
    诊断流通池装置

    公开(公告)号：US5520787A

    公开(公告)日：1996-05-28

    申请号：US400412

    申请日：1995-03-03

    申请人： Ted J. Hanagan ,  Lance K. Safford ,  Steven G. Schultz ,  Jay R. Ford ,  Edmund T. Marciniec ,  Kenneth S. Johnson ,  John D. Norlie, Jr.

    发明人： Ted J. Hanagan ,  Lance K. Safford ,  Steven G. Schultz ,  Jay R. Ford ,  Edmund T. Marciniec ,  Kenneth S. Johnson ,  John D. Norlie, Jr.

    IPC分类号： G01N33/48 ,  B01L3/00 ,  C12Q1/00 ,  G01N21/05 ,  G01N27/416 ,  G01N33/483 ,  G01N33/52 ,  G01N27/26

    CPC分类号： B01L3/5027 ,  C12Q1/001 ,  B01L2200/0689 ,  B01L2300/0636 ,  B01L2300/0645 ,  B01L2300/0654 ,  B01L2300/0816 ,  B01L2300/0877 ,  B01L2300/0887 ,  B01L2400/0406 ,  B01L3/502707 ,  Y10S435/817

    摘要： The present invention provides a diagnostic flow cell for determining the presence or amount of an analyte which may be contained in a test sample. The flow cell comprises a spacing layer having a longitudinal void disposed between a pair of opposed substrates. The spacing layer and the opposed substrates define a flow channel wherein reagent means can be immobilized. When the immobilized reagent means is contacted with an analyte, the reagent means can produce an electrically, optically, or electrically and optically detectable response to the analyte. Hence, the reagent means that is immobilized within the flow channel can comprise (i) a counter electrode, a reference electrode and a working electrode, (ii) an optically sensitive dye or (iii) a counter electrode, a reference electrode and a working electrode and an optically sensitive dye. The flow cell can be interfaced with means for introducing a test sample into and out of the flow cell's flow channel and detection means for detecting a signal generated by the immobilized reagent means.The present invention also provides methods for detecting the presence or amount of an analyte which may be contained in a test sample.

    摘要翻译： 本发明提供了一种用于确定可能包含在测试样品中的分析物的存在或量的诊断流动池。 流动池包括具有设置在一对相对基板之间的纵向空隙的间隔层。 间隔层和相对的基底限定了流动通道，其中试剂装置可以被固定。 当固定的试剂装置与分析物接触时，试剂装置可以产生对分析物的电学，光学或电学和光学上可检测的响应。 因此，固定在流路内的试剂装置可以包括（i）对电极，参比电极和工作电极，（ii）光敏染料或（iii）对电极，参比电极和工作 电极和光敏染料。 流动池可以与用于将测试样品引入和流出流动池的流动通道的装置接口，以及用于检测由固定化试剂装置产生的信号的检测装置。 本发明还提供了用于检测可能包含在测试样品中的分析物的存在或量的方法。